scholarly journals Prenatal exposure to cocaine in rats: Lack of long-term effects on locomotion and stereotypy

1990 ◽  
Vol 28 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Magda Giordano ◽  
Carole A. Moody ◽  
Eve M. Zubrycki ◽  
Laura Dreshfield ◽  
Andrew B. Norman ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Long Term Effects

scholarly journals Long-term effects of prenatal exposure to earthquake on adult schizophrenia

2019 ◽  
Vol 215 (6) ◽  
pp. 730-735 ◽  
Author(s):  
Chao Guo ◽  
Ping He ◽  
Xinming Song ◽  
Xiaoying Zheng
Keyword(s):  
Prenatal Exposure ◽  
Odds Ratio ◽  
Maternal Stress ◽  
First Trimester ◽  
Sample Survey ◽  
Long Term Effects ◽  
Birth Cohorts ◽  
Tangshan Earthquake ◽  
Major Disaster

BackgroundMaternal exposure to major stressors during pregnancy has been found to increase the risk of neurodevelopmental, cognitive and psychiatric disorders in the offspring. However, the association between prenatal exposure to earthquake and the risk of adult schizophrenia has yet to be examined.AimsTo explore the potential long-term effects of prenatal exposure to maternal stress on the risk of schizophrenia in adulthood, using the Great Tangshan Earthquake in 1976 as a natural experiment.MethodWe obtained data from the Second China National Sample Survey on Disability, and analysed 94 410 Chinese individuals born between 1975 and 1979. We obtained difference-in-differences estimates of the earthquake effects on schizophrenia by exploiting temporal variation in the timing of earthquake exposure across four birth cohorts born between 1975 and 1979, along with geographical variation in earthquake severity at the prefecture level. Schizophrenia was ascertained by psychiatrists using the ICD-10 classification. Earthquake severity was measured by seismic intensity.ResultsEarthquake cohort who experienced prenatal exposure to felt earthquake had higher risk of schizophrenia (odds ratio, 3.38; 95% CI 1.43–8.00) compared with the unexposed reference cohort. After specifying the timing of exposure by the trimester of pregnancy, prenatal exposure to felt earthquake during the first trimester of pregnancy increased the risk of adulthood schizophrenia significantly (odds ratio, 7.45; 95% CI 2.83–19.59).ConclusionsPrenatal (particularly early pregnancy) exposure to maternal stress after a major disaster substantially affects the mental health of Chinese adults.

Maternal COVID-19 Infection and Possible Associated Adverse Neurological Fetal Outcomes, Two Case Reports

2021 ◽  
Author(s):  
Charlotte Archuleta ◽  
Christine Wade ◽  
Becky Micetic ◽  
Ashley Tian ◽  
Kartik Mody
Keyword(s):  
Case Report ◽  
Vertical Transmission ◽  
Prenatal Exposure ◽  
Neurological Disorders ◽  
Neonatal Period ◽  
Case Reports ◽  
Fetal Brain ◽  
Neurological Dysfunction ◽  
Long Term Effects

Introduction: The long-term effects of prenatal COVID-19 infection on the fetal brain are mostly unknown at this time however, there is increasing evidence being published. Case Report: Two cases of severe ventriculomegaly, neurological dysfunction, and seizures were found in neonates with prenatal exposure to COVID-19 infection during the first and third trimesters of pregnancy. Conclusion: Inflammation during the prenatal and neonatal period may be associated with neurological disorders or injury. Despite the presumed lack of vertical transmission, post COVID-19 syndrome and its associated inflammation may have an impact on the unborn fetus. Hyper-vigilance and dissemination of adverse findings is of significant importance as we navigate through this evolving pandemic and its effects.

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