scholarly journals The effect of number of trials per day during sequential alternation of unilateral amygdaloid stimulation

1976 ◽  
Vol 7 (4) ◽  
pp. 403-404 ◽  
Author(s):  
John Gaito
Keyword(s):  
Sequential Alternation ◽  
Amygdaloid Stimulation

scholarly journals Sleep, Subcortical Stimulation and Kindling in the Cat

1975 ◽  
Vol 2 (4) ◽  
pp. 447-455 ◽  
Author(s):  
T. Tanaka ◽  
H. Lange ◽  
R. Naquet
Keyword(s):  
Rem Sleep ◽  
Sleep Stage ◽  
Low Frequency ◽  
Mesencephalic Reticular Formation ◽  
Seizure Threshold ◽  
Sleep Stages ◽  
Central Gray Matter ◽  
Spike Discharge ◽  
Amygdaloid Stimulation ◽  
Stimulation Of

SUMMARY:A longitudinal study of the effects of sleep on amygdaloid kindling showed that kindling disrupted normal sleep patterns by reducing REM sleep and increasing awake time. Few interictal spike discharges were observed during the awake stage, while a marked increase in discharge was observed during the light and deep sleep stages. No discharges were observed during REM sleep. During the immediate post-stimulation period the nonstimulated amygdala showed a much higher rate of spike discharge. On the other hand, there was an increase in spike discharge in the stimulated amygdala during natural sleep without preceding amygdaloid stimulation. Amygdaloid stimulation at the generalized seizure threshold during each sleep stage resulted in a generalized convulsion.The influence of subcortical electrical stimulation on kindled amygdaloid convulsions was investigated in a second experiment. Stimulation of the centre median and the caudate nucleus was without effect on kindled convulsions, while stimulation of the mesencephalic reticular formation at high frequency (300 Hz) reduced the latency of onset of kindled generalized convulsions. Stimulation of the nucleus ventralis lateralis of the thalamus at low frequency (10 Hz) prolonged the convulsion latency, and at high current levels blocked the induced convulsion. Stimulation in the central gray matter at low frequency (10 Hz) also blocked kindled amygdaloid convulsions.

scholarly journals Long Term Induction of Kindled Seizures in Rats: Interhemispheric Factors

1978 ◽  
Vol 5 (2) ◽  
pp. 223-230 ◽  
Author(s):  
José N. Nobrega ◽  
John Gaito
Keyword(s):  
Inhibitory Effects ◽  
Sequential Alternation ◽  
Oscillation Pattern ◽  
Brain Areas ◽  
Implanted Electrodes ◽  
Split Brain ◽  
And Control ◽  
Kindled Seizures ◽  
Stimulation Of

SUMMARY:Previous research indicated that sequential alternation of stimulation of certain homologous brain areas via chronically implanted electrodes resulted in oscillation of high and low latencies for convulsions. This phenomenon suggested the establishment of interhemispheric facilitatory-inhibitory effects as a result of repeated stimulation of the two brain sites. In the present study, the latency oscillation pattern was observed in split-brain rats as well as in bilaterally stimulated controls, but not in rats stimulated on one side only. Significant differences were observed between split-brain and control rats in terms of initial kindling rates, duration of convulsions and type of oscillation. Results are discussed in the context of possible interhemispheric mechanisms involved in long term kindling.

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