scholarly journals Schedule-induced drinking as a function of interpellet interval

1971 ◽  
Vol 23 (1) ◽  
pp. 69-71 ◽  
Author(s):  
J. D. Keehn ◽  
V. A. Colotla
Keyword(s):  
Interpellet Interval

scholarly journals The effects of variations in the interpellet interval on wheel running in the rat

1985 ◽  
Vol 13 (2) ◽  
pp. 201-206 ◽  
Author(s):  
Anthony L. Riley ◽  
Cora Lee Wetherington ◽  
Andrew R. Delamater ◽  
David B. Peele ◽  
Robert J. Dacanay
Keyword(s):  
Wheel Running ◽  
Interpellet Interval

Developmental Analysis of Schedule-Induced Polydipsia

1973 ◽  
Vol 32 (3_suppl) ◽  
pp. 1087-1095 ◽  
Author(s):  
Glen D. King ◽  
Robert W. Schaeffer
Keyword(s):  
Reinforcement Schedule ◽  
Equal Probability ◽  
Albino Rats ◽  
Adventitious Reinforcement ◽  
Interpellet Interval ◽  
Developmental Analysis

In a developmental analysis of schedule-induced polydipsia (SIP), 8 female, albino rats were exposed to either a FI-60-sec. or a VI-60-sec. reinforcement schedule with 4 Ss in each group. Results indicated that the adventitious reinforcement explanation for SIP is not tenable, since licks did not occur with equal probability in all periods of the interpellet interval during SIP development; lick bursts coming in contact with pellet deliveries were a result rather than a cause of SIP; and SIP developed more slowly on the VI than on the FI schedule.

scholarly journals AgRP neurons coordinate the mitigation of activity-based anorexia

2021 ◽  
Author(s):  
Ames K. Sutton ◽  
Sean C. Duane ◽  
Ahmed M. Shamma ◽  
Anna Skillings ◽  
Michael J. Krashes
Keyword(s):  
Food Intake ◽  
Food Restriction ◽  
Body Weight Loss ◽  
Inhibitory Response ◽  
Maladaptive Behaviors ◽  
Interpellet Interval ◽  
Metabolic Phenotypes ◽  
Voluntary Running ◽  
Low Body Mass Index ◽  
And Function

AbstractAnorexia nervosa (AN) is a debilitating and deadly disease characterized by low body mass index due to diminished food intake, and oftentimes concurrent hyperactivity. A high percentage of AN behavioral and metabolic phenotypes can be replicated in rodents given access to a voluntary running wheel and subject to food restriction, termed activity-based anorexia (ABA). Despite the well-documented body weight loss observed in AN human patients and ABA rodents, much less is understood regarding the neurobiological underpinnings of these maladaptive behaviors. Moreover, while exercise has been shown to diminish the activity of hunger-promoting hypothalamic agouti-related peptide (AgRP) neurons, much less is known regarding their activity and function in the mediation of food intake during ABA. Here, feeding microstructure analysis revealed ABA mice decreased food intake due to increased interpellet interval retrieval and diminished meal number. Longitudinal activity recordings of AgRP neurons in ABA animals revealed a maladaptive inhibitory response to food. We then demonstrated that ABA development or progression can be mitigated by chemogenetic AgRP activation through the reprioritization of food intake (increased meal number) over hyperactivity. These results elucidate a potential neural target for the amelioration of behavioral maladaptations present in AN patients.

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