scholarly journals Temperature effect and strain differences in the nest-building behavior of inbred mice

1970 ◽  
Vol 20 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Ching-Tse Lee ◽  
Paul T. P. Wong
2020 ◽  
Vol 177 ◽  
pp. 108254 ◽  
Author(s):  
Moriah L. Jacobson ◽  
Hildegard A. Wulf ◽  
Mumeko C. Tsuda ◽  
Caroline A. Browne ◽  
Irwin Lucki

1969 ◽  
Vol 131 (1) ◽  
pp. 121-124 ◽  
Author(s):  
H.- D. Flad ◽  
J. H. L. Playfair ◽  
A. Ghaffar ◽  
P. A. Miescher

2021 ◽  
Author(s):  
Cory Parks ◽  
Chris M Rogers ◽  
J. Pjotr Prins ◽  
Robert W. Williams ◽  
Hao Chen ◽  
...  

Cannabinoid receptor 1 activation by the major psychoactive component in cannabis, Δ9-tetrahydrocannabinol (THC), produces motor impairments, hypothermia, and analgesia upon acute exposure. In previous work, we demonstrated significant sex and strain differences in acute responses to THC following administration of a single dose (10 mg/kg, i.p.) in C57BL/6J (B6) and DBA/2J (D2) inbred mice. To determine the extent to which these differences are heritable, we quantified acute responses to a single dose of THC (10 mg/kg, i.p.) in males and females from 20 members of the BXD family of inbred strains derived by crossing and inbreeding B6 and D2 mice. Acute THC responses (initial sensitivity) were quantified as changes from baseline for: 1. spontaneous activity in the open field (mobility), 2. body temperature (hypothermia), and 3. tail withdrawal latency to a thermal stimulus (analgesia/antinociception). Initial sensitivity to the immobilizing, hypothermic, and antinociceptive effects of THC varied substantially across the BXD family. Heritability was highest for mobility and hypothermia traits, indicating that segregating genetic variants modulate initial sensitivity to THC. We identified genomic loci and candidate genes, including Ndufs2, Scp2, Rps6kb1 or P70S6K, Pde4d, and Pten, that may control variation in THC initial sensitivity. We also detected strong correlations between initial responses to THC and legacy phenotypes related to intake or response to other drugs of abuse (cocaine, ethanol, and morphine). Our study demonstrates the feasibility of mapping genes and variants modulating THC responses in the BXDs to systematically define biological processes and liabilities associated with drug use and abuse.


Animals ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 105
Author(s):  
Chao Wang ◽  
Qian Han ◽  
Runze Liu ◽  
Wenbo Ji ◽  
Yanju Bi ◽  
...  

This study investigated the effects of two factors, enriched environment (EE) and different crossbreeds, on the maternal behavior and physiology of Min-pig hybrid sows. The analysis was performed on a total of 72 multiparous sows, including Duroc × Min pig (DM), Landrace × Min pig (LM), and Landrace × Yorkshire (LY) sows, using a total of 24 sows per cross. The sows were housed in two different farrowing pens, one with straw (EE) and one without straw (barren environment (BE)). The results showed that nest-building behavior, including the frequency, total duration, and bout duration, was significantly higher in EE sows than in BE sows (p < 0.01). The frequency and duration of prepartum nest-building behavior were higher in DM and LM sows than in LY sows (p < 0.0001). During the first three days postpartum, EE sows spent a shorter time in ventral recumbency compared with BE sows (p < 0.05). The oxytocin (p < 0.05) and prolactin (p < 0.01) concentrations of EE sows were significantly higher than in BE sows; however, the concentration of cortisol followed the opposite (p < 0.01). The concentration of oxytocin was significantly higher in DM and LM sows than in LY sows (p < 0.01). In conclusion, both EE increased the expression of hormones related to parental behaviors and prenatal nesting and nursing behavior of sows. Furthermore, an EE can also reduce stress in sows. Min-pig hybrids may inherit highly advantageous characteristics of maternal behavior of Min-pig sows.


1978 ◽  
Vol 58 (2) ◽  
pp. 181-183 ◽  
Author(s):  
A. Moschovakis ◽  
D. Liakopoulos ◽  
A. Armaganidis ◽  
V. Kapsambelis ◽  
G. Papanikolaou ◽  
...  

1982 ◽  
Vol 36 (1) ◽  
pp. 94-97 ◽  
Author(s):  
Karen Bulloch ◽  
Robert N. Hamburger ◽  
Rebekah Loy

Sign in / Sign up

Export Citation Format

Share Document