scholarly journals Temperature effect and strain differences in the nest-building behavior of inbred mice

1970 ◽  
Vol 20 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Ching-Tse Lee ◽  
Paul T. P. Wong
Keyword(s):  
Temperature Effect ◽  
Inbred Mice ◽  
Strain Differences ◽  
Nest Building ◽  
Building Behavior

Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling

2020 ◽  
Vol 177 ◽  
pp. 108254 ◽  
Author(s):  
Moriah L. Jacobson ◽  
Hildegard A. Wulf ◽  
Mumeko C. Tsuda ◽  
Caroline A. Browne ◽  
Irwin Lucki
Keyword(s):  
Sex Differences ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Nest Building ◽  
Receptor Signaling ◽  
Kappa Opioid ◽  
Building Behavior

Strain Differences in the Liver Autoantibody Response of Inbred Mice

1969 ◽  
Vol 131 (1) ◽  
pp. 121-124 ◽  
Author(s):  
H.- D. Flad ◽  
J. H. L. Playfair ◽  
A. Ghaffar ◽  
P. A. Miescher
Keyword(s):  
Inbred Mice ◽  
Strain Differences ◽  
Autoantibody Response

scholarly journals Genetic modulation of initial sensitivity to Δ9-tetrahydrocannabinol (THC) among the BXD family of mice

2021 ◽  
Author(s):  
Cory Parks ◽  
Chris M Rogers ◽  
J. Pjotr Prins ◽  
Robert W. Williams ◽  
Hao Chen ◽  
...  
Keyword(s):  
Single Dose ◽  
Drugs Of Abuse ◽  
Cannabinoid Receptor ◽  
Inbred Mice ◽  
Strain Differences ◽  
Inbred Strains ◽  
Thermal Stimulus ◽  
Motor Impairments ◽  
Initial Sensitivity ◽  
Acute Responses

Cannabinoid receptor 1 activation by the major psychoactive component in cannabis, Δ9-tetrahydrocannabinol (THC), produces motor impairments, hypothermia, and analgesia upon acute exposure. In previous work, we demonstrated significant sex and strain differences in acute responses to THC following administration of a single dose (10 mg/kg, i.p.) in C57BL/6J (B6) and DBA/2J (D2) inbred mice. To determine the extent to which these differences are heritable, we quantified acute responses to a single dose of THC (10 mg/kg, i.p.) in males and females from 20 members of the BXD family of inbred strains derived by crossing and inbreeding B6 and D2 mice. Acute THC responses (initial sensitivity) were quantified as changes from baseline for: 1. spontaneous activity in the open field (mobility), 2. body temperature (hypothermia), and 3. tail withdrawal latency to a thermal stimulus (analgesia/antinociception). Initial sensitivity to the immobilizing, hypothermic, and antinociceptive effects of THC varied substantially across the BXD family. Heritability was highest for mobility and hypothermia traits, indicating that segregating genetic variants modulate initial sensitivity to THC. We identified genomic loci and candidate genes, including Ndufs2, Scp2, Rps6kb1 or P70S6K, Pde4d, and Pten, that may control variation in THC initial sensitivity. We also detected strong correlations between initial responses to THC and legacy phenotypes related to intake or response to other drugs of abuse (cocaine, ethanol, and morphine). Our study demonstrates the feasibility of mapping genes and variants modulating THC responses in the BXDs to systematically define biological processes and liabilities associated with drug use and abuse.

scholarly journals Equipping Farrowing Pens with Straw Improves Maternal Behavior and Physiology of Min-Pig Hybrid Sows

Animals ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 105
Author(s):  
Chao Wang ◽  
Qian Han ◽  
Runze Liu ◽  
Wenbo Ji ◽  
Yanju Bi ◽  
...  
Keyword(s):  
Maternal Behavior ◽  
Total Duration ◽  
Enriched Environment ◽  
Nest Building ◽  
Parental Behaviors ◽  
Bout Duration ◽  
Two Factors ◽  
Building Behavior

This study investigated the effects of two factors, enriched environment (EE) and different crossbreeds, on the maternal behavior and physiology of Min-pig hybrid sows. The analysis was performed on a total of 72 multiparous sows, including Duroc × Min pig (DM), Landrace × Min pig (LM), and Landrace × Yorkshire (LY) sows, using a total of 24 sows per cross. The sows were housed in two different farrowing pens, one with straw (EE) and one without straw (barren environment (BE)). The results showed that nest-building behavior, including the frequency, total duration, and bout duration, was significantly higher in EE sows than in BE sows (p < 0.01). The frequency and duration of prepartum nest-building behavior were higher in DM and LM sows than in LY sows (p < 0.0001). During the first three days postpartum, EE sows spent a shorter time in ventral recumbency compared with BE sows (p < 0.05). The oxytocin (p < 0.05) and prolactin (p < 0.01) concentrations of EE sows were significantly higher than in BE sows; however, the concentration of cortisol followed the opposite (p < 0.01). The concentration of oxytocin was significantly higher in DM and LM sows than in LY sows (p < 0.01). In conclusion, both EE increased the expression of hormones related to parental behaviors and prenatal nesting and nursing behavior of sows. Furthermore, an EE can also reduce stress in sows. Min-pig hybrids may inherit highly advantageous characteristics of maternal behavior of Min-pig sows.

Cannabis interferes with nest-building behavior in mice

1978 ◽  
Vol 58 (2) ◽  
pp. 181-183 ◽  
Author(s):  
A. Moschovakis ◽  
D. Liakopoulos ◽  
A. Armaganidis ◽  
V. Kapsambelis ◽  
G. Papanikolaou ◽  
...  
Keyword(s):  
Nest Building ◽  
Building Behavior

Nest-building behavior in two cerebellar mutant mice: Staggerer and weaver

1982 ◽  
Vol 36 (1) ◽  
pp. 94-97 ◽  
Author(s):  
Karen Bulloch ◽  
Robert N. Hamburger ◽  
Rebekah Loy
Keyword(s):  
Nest Building ◽  
Mutant Mice ◽  
Building Behavior ◽  
Cerebellar Mutant
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