scholarly journals Approach-avoidance behavior of rats with septal lesions under massed and distributed trials

1972 ◽  
Vol 26 (3) ◽  
pp. 155-157 ◽  
Author(s):  
Peter A. Fried
Keyword(s):  
Avoidance Behavior ◽  
Approach Avoidance ◽  
Septal Lesions ◽  
Behavior Of Rats

scholarly journals The effects of cortisol administration on approach–avoidance behavior: An event-related potential study

2007 ◽  
Vol 76 (3) ◽  
pp. 135-146 ◽  
Author(s):  
Jacobien M. van Peer ◽  
Karin Roelofs ◽  
Mark Rotteveel ◽  
J. Gert van Dijk ◽  
Philip Spinhoven ◽  
...  
Keyword(s):  
Avoidance Behavior ◽  
Event Related Potential ◽  
Potential Study ◽  
Approach Avoidance

scholarly journals Fronto-striatal projections regulate approach-avoidance conflict

2020 ◽  
Author(s):  
Adrienne C. Loewke ◽  
Adelaide R. Minerva ◽  
Alexandra B. Nelson ◽  
Anatol C. Kreitzer ◽  
Lisa A. Gunaydin
Keyword(s):  
Anxiety Disorders ◽  
Avoidance Behavior ◽  
D1 Receptor ◽  
Projection Neurons ◽  
Medium Spiny Neurons ◽  
Neural Pathways ◽  
Spiny Neurons ◽  
Striatal Projection Neurons ◽  
Neural Computations ◽  
Approach Avoidance

ABSTRACTThe dorsomedial prefrontal cortex (dmPFC) has been linked to approach-avoidance behavior and decision-making under conflict, key neural computations thought to be altered in anxiety disorders. However, the heterogeneity of efferent prefrontal projections has obscured identification of the specific top-down neural pathways regulating these anxiety-related behaviors. While the dmPFC-amygdala circuit has long been implicated in controlling reflexive fear responses, recent work suggests that this circuit is less important for avoidance behavior. We hypothesized that dmPFC neurons projecting to the dorsomedial striatum (DMS) represent a subset of prefrontal neurons that robustly encode and drive approach-avoidance behavior. Using fiber photometry recording during the elevated zero maze (EZM) task, we show heightened neural activity in prefrontal and fronto-striatal projection neurons, but not fronto-amydalar projection neurons, during exploration of the anxiogenic open arms of the maze. Additionally, through pathway-specific optogenetics we demonstrate that this fronto-striatal projection preferentially excites postsynaptic D1 receptor-expressing medium spiny neurons in the DMS and bidirectionally controls avoidance behavior. We conclude that this striatal-projecting subpopulation of prefrontal neurons regulates approach-avoidance conflict, supporting a model for prefrontal control of defensive behavior in which the dmPFC-amygdala projection controls reflexive fear behavior and the dmPFC-striatum projection controls anxious avoidance behavior. Our findings identify this fronto-striatal circuit as a valuable therapeutic target for developing interventions to alleviate excessive avoidance behavior in anxiety disorders.

Does Approach-Avoidance Behavior in Response to Ambiguous Cues Reflect Depressive Interpretation Bias? Related but Distinct

2020 ◽  
Vol 44 (6) ◽  
pp. 1091-1105
Author(s):  
Xiao-Xiao Lin ◽  
Shang-Wen Si ◽  
Rui-Rui Gao ◽  
Ya-Bin Sun ◽  
Yu-Zheng Wang ◽  
...  
Keyword(s):  
Avoidance Behavior ◽  
Interpretation Bias ◽  
Approach Avoidance

scholarly journals A Quantitative Relationship between Signal Detection in Attention and Approach/Avoidance Behavior

2017 ◽  
Vol 8 ◽  
Author(s):  
Vijay Viswanathan ◽  
John P. Sheppard ◽  
Byoung W. Kim ◽  
Christopher L. Plantz ◽  
Hao Ying ◽  
...  
Keyword(s):  
Signal Detection ◽  
Avoidance Behavior ◽  
Quantitative Relationship ◽  
Approach Avoidance
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