scholarly journals The presence of home-cage stimuli attenuates spontaneous-alternation deficits in rats with septal lesions

1983 ◽  
Vol 11 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Gregory J. Smith ◽  
Charles R. Goodlett ◽  
Richard G. Burright ◽  
Peter J. Donovick ◽  
Norman E. Spear
1978 ◽  
Vol 42 (2) ◽  
pp. 627-631 ◽  
Author(s):  
William S. Terry

Across the many studies of spontaneous alternation of rats in their choice behavior in successive exposures to a T-maze, there has been little consistency in where the subjects are detained from one trial to the next. The present study showed that alternation is most likely if subjects are retained in the goal box between paired runs, with lesser but significant alternation if detention occurs either in the start box or home cage. No alternation occurs if subjects are detained in an unfamiliar, novel container. The implications of these results for method and theory of spontaneous alternation are discussed.


1972 ◽  
Vol 8 (5) ◽  
pp. 847-851 ◽  
Author(s):  
T.L. Holdstock ◽  
Lynda T. Blesovsky ◽  
G.J. Verschoor

1966 ◽  
Vol 62 (2) ◽  
pp. 320-322 ◽  
Author(s):  
Robert J. Douglas ◽  
Alfred C. Raphelson

2016 ◽  
Vol 86 (1-2) ◽  
pp. 36-47 ◽  
Author(s):  
Imen Dridi ◽  
Nidhal Soualeh ◽  
Torsten Bohn ◽  
Rachid Soulimani ◽  
Jaouad Bouayed

Abstract.This study examined whether perinatal exposure to polluted eels (Anguilla anguilla L.) induces changes in the locomotor activity of offspring mice across lifespan (post-natal days (PNDs) 47 – 329), using the open field and the home cage activity tests. Dams were exposed during gestation and lactation, through diets enriched in eels naturally contaminated with pollutants including PCBs. Analysis of the eel muscle focused on the six non-dioxin-like (NDL) indicator PCBs (Σ6 NDL-PCBs: 28, 52, 101, 138, 153 and 180). Four groups of dams (n = 10 per group) received either a standard diet without eels or eels (0.8 mg/kg/day) containing 85, 216, or 400 ng/kg/day of ϵ6 NDL-PCBs. The open field test showed that early-life exposure to polluted eels increased locomotion in female offspring of exposed dams but not in males, compared to controls. This hyperlocomotion appeared later in life, at PNDs 195 and 329 (up to 32 % increase, p < 0.05). In addition, overactivity was observed in the home cage test at PND 305: exposed offspring females showed a faster overall locomotion speed (3.6 – 4.2 cm/s) than controls (2.9 cm/s, p <0.05); again, males remained unaffected. Covered distances in the home cage test were only elevated significantly in offspring females exposed to highest PCB concentrations (3411 ± 590 cm vs. 1377 ± 114 cm, p < 0.001). These results suggest that early-life exposure to polluted eels containing dietary contaminants including PCBs caused late, persistent and gender-dependent neurobehavioral hyperactive effects in offspring mice. Furthermore, female hyperactivity was associated with a significant inhibition of acetylcholinesterase activity in the hippocampus and the prefrontal cortex.


1973 ◽  
Author(s):  
Marian Monyok Wilson ◽  
Harry Fowler

1970 ◽  
Vol 71 (2, Pt.1) ◽  
pp. 340-340
Author(s):  
Leonard W Hamilton ◽  
John E Kelsey ◽  
Sebastian P Grossman

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