scholarly journals Evidence for a shift in the choice criterion of rats in a 12-arm radial maze

1989 ◽  
Vol 17 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Michael F. Brown ◽  
Evangeline A. Wheeler ◽  
Donald A. Riley
Keyword(s):  
Radial Maze ◽  
Choice Criterion

Effects of ethanol on enforced spatial variability in the 8-arm radial maze

1983 ◽  
Vol 18 (1) ◽  
pp. 55-59 ◽  
Author(s):  
L.D. Devenport ◽  
V.J. Merriman ◽  
J.A. Devenport
Keyword(s):  
Spatial Variability ◽  
Radial Maze

scholarly journals Effect of KW-6055 on spatial cognitive disruption in 8-arm radial maze performance in rats

1989 ◽  
Vol 49 ◽  
pp. 267
Author(s):  
Katsunori Iwasaki ◽  
Yoshiaki Matsumoto ◽  
Michihiro Fujiwara
Keyword(s):  
Radial Maze ◽  
Maze Performance ◽  
Radial Maze Performance

Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

1999 ◽  
Vol 839 (1) ◽  
pp. 186-189 ◽  
Author(s):  
Zhong Chen ◽  
Quie Zhao ◽  
Yukio Sugimoto ◽  
Yoko Fujii ◽  
Chiaki Kamei
Keyword(s):  
Radial Maze ◽  
Memory Deficits ◽  
Maze Performance ◽  
Mk 801 ◽  
Radial Maze Performance

Effects of altered cholinergic function on working and reference memory in the rat

1986 ◽  
Vol 64 (3) ◽  
pp. 376-382 ◽  
Author(s):  
Richard J. Beninger ◽  
B. A. Wirsching ◽  
Khem Jhamandas ◽  
Roland J. Boegman ◽  
Sherif R. El-Defrawy
Keyword(s):  
Working Memory ◽  
Choline Acetyltransferase ◽  
Radial Maze ◽  
Cholinergic Neurons ◽  
Reference Memory ◽  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis ◽  
Memory Errors ◽  
Biochemical Assays ◽  
Alternation Task

Many data suggest that the brain's cholinergic neurons participate in the control of memory and it has been suggested that cholinergic systems are involved differentially in working and reference memory. To test this hypothesis the effects on memory of unilateral injections of the neurotoxins, quinolinic acid or kainic acid into the cortically projecting cholinergic cells of the nucleus basalis magnocellularis (nbm) were evaluated. In experiment 1, quinolinate-injected (n = 7) and sham-operated (n = 7) rats were tested in a T-maze alternation task that requires working memory. Lesion rats performed significantly more poorly than shams and subsequent biochemical assays of cortical choline acetyltransferase (CAT) activity revealed significant reductions in the lesion rats. In experiment 2, kainate-injected (n = 9) and sham-operated (n = 8) rats were trained in an eight-arm radial maze with only four arms baited. Lesion rats made significantly more working memory errors (entries into baited arms from which the food had already been collected) than reference memory errors (entries into never baited arms). CAT assays showed that the lesion led to a decrease in cortical CAT with no significant change in hippocampal CAT. The results of these studies support the hypothesis that cholinergic neurons of the basocortical system may be differentially involved in working and reference memory.

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