scholarly journals Influence of conspecific stress odors and shock controllability on conditioned defensive burying

1987 ◽  
Vol 15 (3) ◽  
pp. 333-341 ◽  
Author(s):  
Jon L. Williams
Keyword(s):  
Conditioned Defensive ◽  
Defensive Burying ◽  
Conditioned Defensive Burying

Extinction of conditioned defensive burying

1985 ◽  
Vol 10 (1-2) ◽  
pp. 101-110 ◽  
Author(s):  
J.P.J. Pinel ◽  
S. Puttaswamaiah ◽  
D.M. Wilkie
Keyword(s):  
Conditioned Defensive ◽  
Defensive Burying ◽  
Conditioned Defensive Burying

Effect of septal lesions on conditioned defensive burying

1981 ◽  
Vol 27 (6) ◽  
pp. 1051-1056 ◽  
Author(s):  
D. Shaun Gray ◽  
Lori J. Terlecki ◽  
Dallas Treit ◽  
John P.J. Pinel
Keyword(s):  
Conditioned Defensive ◽  
Defensive Burying ◽  
Septal Lesions ◽  
Conditioned Defensive Burying

scholarly journals Fast Anxiolytic-Like Effect Observed in the Rat Conditioned Defensive Burying Test, after a Single Oral Dose of Natural Protein Extract Products

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2445
Author(s):  
Thomas Freret ◽  
Stacy Largilliere ◽  
Gerald Nee ◽  
Melanie Coolzaet ◽  
Sophie Corvaisier ◽  
...  
Keyword(s):  
Natural Products ◽  
Oral Dose ◽  
Anxiety Disorders ◽  
Care Pathway ◽  
Casein Hydrolysate ◽  
Anxiolytic Effect ◽  
Oral Gavage ◽  
Conditioned Defensive ◽  
Defensive Burying ◽  
Conditioned Defensive Burying

Anxiety appears among the most frequent psychiatric disorders. During recent years, a growing incidence of anxiety disorders can be attributed, at least in part, to the modification of our eating habits. To treat anxiety disorders, clinicians use benzodiazepines, which unfortunately display many side effects. Herein, the anxiolytic-like properties of two natural products (αS1–casein hydrolysate and Gabolysat®) were investigated in rats and compared to the efficacy of benzodiazepine (diazepam). Thus, the conditioned defensive burying test was performed after a unique oral dose of 15 mg/kg, at two time-points (60 min and then 30 min post oral gavage) to show potential fast-onset of anxiolytic effect. Both natural products proved to be as efficient as diazepam to reduce the time rats spent burying the probe (anxiety level). Additionally, when investigated as early as 30 min post oral gavage, Gabolysat® also revealed a fast-anxiolytic activity. To date, identification of bioactive peptide, as well as how they interact with the gut–brain axis to sustain such anxiolytic effect, still remains poorly understood. Regardless, this observational investigation argues for the consideration of natural compounds in care pathway.

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