Role of Intestinal Microbiota and its Virulence Factors in Pathogenesis of Inflammatory Bowel Disease

2021 ◽  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Virulence Factors ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Role of intestinal microbiota in pathogenesis of inflammatory bowel disease

2016 ◽  
Vol 24 (33) ◽  
pp. 4505
Author(s):  
Jing-Zhi Zhang ◽  
Chun-Hui Bao ◽  
Zheng Shi ◽  
Zhi-Jun Weng ◽  
Xiao-Mei Wang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Role of intestinal microbiota and metabolites in inflammatory bowel disease

2019 ◽  
Vol 132 (13) ◽  
pp. 1610-1614 ◽  
Author(s):  
Li-Na Dong ◽  
Mu Wang ◽  
Jian Guo ◽  
Jun-Ping Wang
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Inflammatory Bowel

Extra-articular manifestations: inflammatory bowel disease

2016 ◽  
Author(s):  
Dirk Elewaut ◽  
Heleen Cypers ◽  
Matthew L. Stoll ◽  
Charles O. Elson
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Intestinal Barrier ◽  
Innate Immune ◽  
Intestinal Barrier Function ◽  
Innate Immune Responses ◽  
Susceptible Host ◽  
Inflammatory Bowel

A significant overlap exists between spondyloarthritis (SpA) and inflammatory bowel disease (IBD), particularly in the IL-23/IL-17 pathway. Shared immunologic mechanisms include aberrant innate immune responses, an excess of Th1/Th17-mediated immunity, and inadequate immune regulation. Many genetic factors associated with IBD are involved in host–pathogen interactions and intestinal barrier function, and the intestinal microbiota do appear to play an important role in disease development. Hence the current hypothesis for IBD pathogenesis is that it stems from a dysregulated immune response to intestinal microbiota in a genetically susceptible host. In SpA, evidence for a role of intestinal microbiota is less abundant, but given the overlap with IBD, it is plausible that gut microbiota are important players in SpA pathogenesis as well. However, there are significant genetic differences between these two conditions, as well as differing responses to biologic therapy.

Su1842 - Examining the Role of Air Quality on Intestinal Microbiota and its Associated Impact on Inflammatory Bowel Disease

2018 ◽  
Vol 154 (6) ◽  
pp. S-603-S-604
Author(s):  
Angela Park ◽  
Sirtaj Singh ◽  
Peiqi Wang ◽  
Joanna Melia ◽  
Alyssa Parian ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Air Quality ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Increasing incidence of inflammatory bowel disease in children and adolescents: significance of environmental factors

2020 ◽  
Vol 63 (9) ◽  
pp. 337-344 ◽  
Author(s):  
Sowon Park ◽  
Yunkoo Kang ◽  
Hong Koh ◽  
Seung Kim
Keyword(s):  
Inflammatory Bowel Disease ◽  
Environmental Factors ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Intestinal Tract ◽  
Immune Dysregulation ◽  
Immune Mediated ◽  
Inflammatory Bowel ◽  
Dietary Treatments

Inflammatory bowel disease (IBD) is a chronic relapsing immune-mediated disease of the intestinal tract. Although its prevalence is reportedly lower in Asia than in Western countries, the rapid increase in the incidence of IBD has drawn attention to its etiology, including genetic susceptibility and environmental factors. Specifically, recent studies concerning dietary treatments and intestinal microbiota suggest that these factors may interact with the immune system, and the imbalance of this relationship may lead to immune dysregulation in IBD. Changes in diet or alterations in the composition of the intestinal microbiota may be associated with the increasing incidence of IBD in Asia. Here, we aim to review recent studies on the role of diet and intestinal microbiota in IBD pathogenesis and the results of the investigations performed to modulate these factors.

The role of osteopontin (OPN/SSP1) gene variants in inflammatory bowel disease

2009 ◽  
Vol 47 (09) ◽  
Author(s):  
J Glas ◽  
J Seiderer ◽  
HP Török ◽  
B Göke ◽  
T Ochsenkühn ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gene Variants ◽  
Inflammatory Bowel

Nutrition in inflammatory bowel disease

2009 ◽  
Vol 150 (18) ◽  
pp. 839-845 ◽  
Author(s):  
János Banai
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fast Food ◽  
Optimal Growth ◽  
Developed Countries ◽  
Aetiological Factor ◽  
Artificial Nutrition ◽  
Food Preservatives ◽  
Inflammatory Bowel

Aetiology of inflammatory bowel disease (IBD) is complex and probably multifactorial. Nutrition has been proposed to be an important aetiological factor for development of IBD. Several components of the diet (such as sugar, fat, fibre, fruit and vegetable, protein, fast food, preservatives etc.) were examined as possible causative agents for IBD. According to some researchers infant feeding (breast feeding) may also contribute to the development of IBD. Though the importance of environmental factors is evidenced by the increasing incidence in developed countries and in migrant population in recent decades, the aetiology of IBD remained unclear. There are many theories, but as yet no dietary approaches have been proved to reduce the risk of developing IBD. The role of nutrition in the management of IBD is better understood. The prevention and correction of malnutrition, the provision of macro- and micronutrients and vitamins and the promotion of optimal growth and development of children are key points of nutritional therapy. In active disease, the effective support of energy and nutrients is a very important part of the therapy. Natural and artificial nutrition or the combination of two can be choosen for supporting therapy of IBD. The author summarises the aetiological and therapeutic role of nutrition in IBD.

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