scholarly journals Effect of Organic Cation Transporter 1 (OCT1) Polymorphism on Metabolic Response of Metformin in Iraqi Women with Polycystic Ovary Syndrome

2021 ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Organic Cation ◽  
Metabolic Response ◽  
Polycystic Ovary ◽  
Organic Cation Transporter ◽  
Ovary Syndrome ◽  
Iraqi Women ◽  
Organic Cation Transporter 1

scholarly journals Organic Cation Transporter 1 Polymorphisms Predict the Metabolic Response to Metformin in Women with the Polycystic Ovary Syndrome

2010 ◽  
Vol 95 (10) ◽  
pp. E204-E208 ◽  
Author(s):  
Alessandra Gambineri ◽  
Federica Tomassoni ◽  
Daniela Ibarra Gasparini ◽  
Antonio Di Rocco ◽  
Vilma Mantovani ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Organic Cation ◽  
Metabolic Response ◽  
Polycystic Ovary ◽  
Organic Cation Transporter ◽  
Ovary Syndrome ◽  
Organic Cation Transporter 1

scholarly journals Association between Polymorphisms of OCT1 and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome

2019 ◽  
Vol 20 (7) ◽  
pp. 1720 ◽  
Author(s):  
Hui Chang ◽  
Yuan-Shuo Hsueh ◽  
Yung Cheng ◽  
Huang-Tz Ou ◽  
Meng-Hsing Wu
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Treatment Effectiveness ◽  
Metabolic Response ◽  
Polycystic Ovary ◽  
Organic Cation Transporter ◽  
Oral Glucose ◽  
Metformin Treatment ◽  
Nucleotide Polymorphisms ◽  
Ovary Syndrome ◽  
Insulin Sensitizer

Insulin-sensitizer treatment with metformin is widely used in polycystic ovary syndrome (PCOS). However, the treatment effectiveness shows individual differences in PCOS patients. Organic cation transporter (OCT) 1 and 2 have been reported to mediate metformin transport in the liver and kidney, respectively. In this study, we investigated the association between the polymorphisms of OCT1 and OCT2 and the treatment effectiveness of metformin in PCOS patients. The single nucleotide polymorphisms (SNPs) of OCT1 (rs683369 and rs628031) and OCT2 (rs316019) were analyzed in 87 PCOS and 113 control women. Oral glucose tolerance tests (OGTTs), which represented metformin treatment response, were conducted at the start of treatment and after six-month treatment. The results demonstrated that the SNP frequencies of OCT1 and OCT2 were not associated with PCOS pathophysiology, and that the polymorphisms of OCT1 and OCT2 were not associated with the OGTT parameters at baseline. However, PCOS patients with the G allele of OCT1 rs683369 and/or with the A allele of OCT1 rs628031 had increased insulin sensitivity compared to those with wild-type genotype after receiving metformin treatment. Moreover, the interactions of metformin*SNP were significant in both OCT1 rs683369 (p < 0.001) and rs628031 (p = 0.001) during the treatment period. Taken together, genetic polymorphisms of OCT1 contributed to different metformin treatment responses, and further study is needed to establish personalized treatment programs using a pharmacogenomic algorithm approach in PCOS patients.

scholarly journals Serum prolactin, Preptin, CCL 18 and genetic polymorphisms in Iraqi women with polycystic ovary syndrome.

2021 ◽  
Vol 18 (4(Suppl.)) ◽  
pp. 1552
Author(s):  
Israa F. Ascar ◽  
Areej Sh. Hameed
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Prolactin ◽  
Control Group ◽  
Serum Samples ◽  
Ovary Syndrome ◽  
Private Laboratory ◽  
Iraqi Women ◽  
Automated Immunoassay ◽  
Gene Expression Levels

The polycystic ovary syndrome is an endocrine condition. One of the leading causes of female infertility and the most common disorder among women. The work was being carried out on 100 Iraqi women (50 cases confirmed with PCOS and 50 controls). Between October 2019 and March 2020, blood samples were collected from the Advanced Institute of Infertility Diagnosis and Assisted Reproductive Technology at AL-Nahrain University and a private laboratory. ELISA was used to evaluate the biochemical parameters of preptin, FSH, insulin, LH, and CCL 18 in serum samples from the AFIAS-6 (AFIAS Automated Immunoassay System). The findings of the analysis indicate that, as opposed to the control group, values of prolactin (ng/ml), LH (mIU/ml), Preptin (pg/ml) and CCL 18 (ng/ml) Quite higher in PCOS sickness (p < 0.001) Compared with the patient group, the values of testosterone (ng/ml) and FSH (mIU/ml) was noticeably higher (p <0.05), and PRLR gene expression levels in PCOS patients were significantly increased by 3.6 times. I n summary, the levels of Preptin and CCL18 can be regarded as PCOS markers.

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