scholarly journals Simultaneous Estimation of Atorvastatin Calcium, Aspirin, Ramipril and Metoprolol Tartrate in Bulk and in its Capsule Formulation by First Order Derivative Spectrophotometry

2016 ◽  
Vol 03 (02) ◽  
pp. 45-52
Author(s):  
Anandakumar Karunakaran ◽  
Ananda T Subramaniam ◽  
Jambulingam Munusamy ◽  
Kamalakannan Dhanapal
Keyword(s):  
Derivative Spectrophotometry ◽  
Order Derivative ◽  
Simultaneous Estimation ◽  
Metoprolol Tartrate ◽  
Capsule Formulation ◽  
Atorvastatin Calcium ◽  
First Order

scholarly journals Simultaneous Estimation of Paracetamol, Ambroxol Hydrochloride, Levocetirizine Dihydrochloride, and Phenylephrine Hydrochloride in Combined Tablet Formulation by First-Order Derivative Spectrophotometry

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
K. Anandakumar ◽  
P. Veerasundari
Keyword(s):  
Tablet Formulation ◽  
Derivative Spectrophotometry ◽  
Order Derivative ◽  
Simultaneous Estimation ◽  
Nasal Discharge ◽  
Pharmaceutical Dosage Forms ◽  
Phenylephrine Hydrochloride ◽  
First Order ◽  
Relative Standard ◽  
Ambroxol Hydrochloride

Paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride are used in combination for the treatment of chronic sinusitis, rhinitis, fever, nasal discharge, sore throat, and wheezing. The present work deals with method development for simultaneous estimation of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride in tablet formulation by first-order derivative spectrosphotometry. For determination of sampling wavelength, 10 μg/mL of each of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride was scanned in 200–400 nm ranges and sampling wavelengths were found to be 305.5 nm for paracetamol, 321 nm for ambroxol hydrochloride, 244 nm for levocetirizine dihydrochloride, and 280 nm for phenylephrine hydrochloride in first-order derivative spectrophotometry. In this method, linearity was observed in the ranges of 20–140 μg/mL for paracetamol and 10–70 μg/mL for ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride. The % recovery was within the range between 98 and 102%, and % relative standard deviation for precision and accuracy of the method was found to be less than 2%. The method is validated as per International Conference on Harmonization Guidelines. The method can be successfully applied for the simultaneous analysis of these drugs in pharmaceutical dosage forms.

QUANTITATIVE DETERMINATION OF FLUCONAZOLE IN SYRUPS BY FIRST ORDER DERIVATIVE SPECTROPHOTOMETRY

2002 ◽  
Vol 35 (7) ◽  
pp. 1193-1204 ◽  
Author(s):  
Hassan Y. Aboul-Enein ◽  
Nilgün Günden Göğer ◽  
Alphun Türkalp
Keyword(s):  
Quantitative Determination ◽  
Derivative Spectrophotometry ◽  
Order Derivative ◽  
First Order

scholarly journals Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Kaminee Parmar ◽  
Sunil Baldania ◽  
Dimal Shah ◽  
Usmangani Chhalotiya ◽  
Naimin Parmar
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Correlation Coefficients ◽  
Order Derivative ◽  
Simultaneous Estimation ◽  
Pharmaceutical Dosage Form ◽  
Zero Crossing ◽  
Phenylephrine Hydrochloride ◽  
First Order ◽  
Crossing Point

A simple, precise, accurate, and economical spectrophotometric method has been developed for simultaneous estimation of levocetirizine dihydrochloride (LCT) and phenylephrine hydrochloride (PHE) by employing first-order derivative spectrophotometric method. The first-order derivative absorption at 240 nm (zero crossing point of PHE) was used for quantification of LCT and 283.2 nm (zero crossing point of LCT) for quantification of PHE. The linearity was established over the concentration range of 4–24 μg/mL and 8–48 μg/mL for LCT and PHE with correlation coefficients (r2) 0.9964 and 0.9972, respectively. The mean % recoveries were found to be in the range of 99.14%–100.43% for LCT and 98.73%–100.83% for PHE. The proposed method has been validated as per ICH guideline and successfully applied for the simultaneous estimation of LCT and PHE in combined tablet dosage form.

scholarly journals Determination of Nebivolol Hydrochloride and Hydrochlorothiazide in Tablets by First-Order Derivative Spectrophotometry and Liquid Chromatography

2008 ◽  
Vol 91 (5) ◽  
pp. 1075-1082 ◽  
Author(s):  
Dimal A Shah ◽  
Kashyap K Bhatt ◽  
Rajendra S Mehta ◽  
Sunil L Baldania
Keyword(s):  
Liquid Chromatography ◽  
Internal Standard ◽  
Reversed Phase ◽  
Dosage Forms ◽  
Derivative Spectrophotometry ◽  
Order Derivative ◽  
First Order ◽  
Calibration Curves ◽  
Phase Liquid ◽  
Nebivolol Hydrochloride

Abstract Two simple and accurate methods for analysis of nebivolol hydrochloride (NEB) and hydrochlorothiazide (HCTZ) in their combined dosage forms were developed using first-order derivative spectrophotometry and reversed-phase liquid chromatography (LC). NEB and HCTZ in their combined dosage forms (tablets) were quantified using first-derivative responses at 294.6 and 334.6 nm in the spectra of their solutions in methanol. The calibration curves were linear in the concentration range of 840 g/mL for NEB and 1060 g/mL for HCTZ. LC analysis was performed on a Phenomenex Gemini C18 column (250 4.6 mm id, 5 m particle size) in the isocratic mode with 0.05 M potassium dihydrogen phosphateacetonitrilemethanol (30 + 20 + 50, v/v/v; pH 4) mobile phase at a flow rate of 1 mL/min. Detection was made at 220 nm. Both of the drugs and the internal standard (ezetimibe) were well resolved with retention times of 5.1 min for NEB, 2.9 min for HCTZ, and 8.2 min for ezetimibe. The calibration curves were linear in the concentration range of 114 g/mL for NEB and 0.328 g/mL for HCTZ. Both methods were validated and found to be accurate, precise, and specific, and results were compared statistically. Developed methods were successfully applied for the estimation of NEB and HCTZ in their combined dosage forms.

Novel First Order Derivative UV Spectrophotometric Method for the Determination of Glimepiride in Solid Dosage Forms

2018 ◽  
Vol 8 (3) ◽  
Author(s):  
Santosh Karajgi . ◽  
Sunayana Mali ◽  
Ramaling Kotnal
Keyword(s):  
Dosage Forms ◽  
Order Derivative ◽  
Simultaneous Estimation ◽  
Drug Form ◽  
Solid Dosage Forms ◽  
First Order ◽  
Solid Dosage ◽  
Tablet Dosage ◽  
Guide Lines

Objective: An easy, perfect, specific and exact process has been studied for the simultaneous estimation of Glimepiride pure drug form as well as tablet dosage forms. Methods: A UV method for quantitative evaluation of Glimepiride by first order derivative peak detect method for determination in bulk as well as tablet dosage form is reported as there was a need to expand novel methods to analyze the drug. Results: Glimepiride has absorbance first derivative maxima at 225 nm in Methanol. Glimepiride follows Beer’s law in concentration range of 5-25µg/ml. The outcomes of the study were validated statistically and recovery studies were performed as per ICH guide lines. Conclusion: Thus the projected method can be applied competently for the estimation of Glimepiride in regular analysis in its dosage forms.

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