scholarly journals Epithelial restitution and wound healing in inflammatory bowel disease

2008 ◽  
Vol 14 (3) ◽  
pp. 348 ◽  
Author(s):  
Andreas Sturm ◽  
Axel U Dignass
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Bowel Disease ◽  
Epithelial Restitution ◽  
Inflammatory Bowel

Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

2018 ◽  
Vol 13 (5) ◽  
pp. 659-668 ◽  
Author(s):  
Sara Lovisa ◽  
Giannicola Genovese ◽  
Silvio Danese
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Bowel Disease ◽  
Molecular Mechanisms ◽  
Epithelial To Mesenchymal Transition ◽  
Clinical Manifestations ◽  
Mesenchymal Transition ◽  
Intestinal Fibrosis ◽  
Inflammatory Bowel

Abstract Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn’s disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation, which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition [EMT] represents an embryonic program relaunched during wound healing, fibrosis and cancer. Here we discuss the initial observations and the most recent findings highlighting the role of EMT in IBD-associated intestinal fibrosis and fistulae formation. In addition, we briefly review knowledge on the cognate process of endothelial-to-mesenchymal transition [EndMT]. Understanding EMT functionality and the molecular mechanisms underlying the activation of this mesenchymal programme will permit designing new therapeutic strategies to halt the fibrogenic response in the intestine.

Perineal wound healing after proctectomy for inflammatory bowel disease

1978 ◽  
Vol 21 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Marvin L. Corman ◽  
Malcolm C. Veidenheimer ◽  
John A. Coller ◽  
Virginia H. Ross
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Bowel Disease ◽  
Perineal Wound ◽  
Perineal Wound Healing ◽  
Inflammatory Bowel

Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease

1998 ◽  
Vol 185 (4) ◽  
pp. 413-418 ◽  
Author(s):  
Anastasios J. Karayiannakis ◽  
Konstantinos N. Syrigos ◽  
Jason Efstathiou ◽  
Ali Valizadeh ◽  
Masao Noda ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Epithelial Restitution ◽  
Inflammatory Bowel ◽  
E Cadherin

IL-28-Dependent Activation of Epithelial STAT1 Drives Epithelial Wound Healing in Inflammatory Bowel Disease

2017 ◽  
Vol 152 (5) ◽  
pp. S90 ◽  
Author(s):  
Mircea Chiriac ◽  
Claudia Günther ◽  
Christoph Becker ◽  
Jürgen Siebler ◽  
Markus Neurath
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Bowel Disease ◽  
Epithelial Wound Healing ◽  
Inflammatory Bowel
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