scholarly journals The north–south and east–west gradient in colorectal cancer risk: a look at the distribution of modifiable risk factors and incidence across Canada

2018 ◽  
Vol 25 (3) ◽  
pp. 231 ◽  
Author(s):  
J. Tung ◽  
C.E. Politis ◽  
J. Chadder ◽  
J. Han ◽  
J. Niu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Vegetable Consumption ◽  
Current Knowledge ◽  
Incidence Rates ◽  
Lifestyle Changes ◽  
Modifiable Risk Factors ◽  
Excessive Alcohol Consumption ◽  
Positive Effects ◽  
East West

Colorectal cancer (crc) is the 2nd most common cancer in Canada and the 2nd leading cause of cancer death. That heavy burden can be mitigated given the preventability of crc through lifestyle changes and screening. Here, we describe the extent of the variation in crc incidence rates across Canada and the disparities, by jurisdiction, in the prevalence of modifiable risk factors known to contribute to the crc burden.Findings suggest that there is a north–south and east–west gradient in crc modifiable risk factors, including excess weight, physical inactivity, excessive alcohol consumption, and low fruit and vegetable consumption, with the highest prevalence of risk factors typically found in the territories and Atlantic provinces. In general, that pattern reflects the crc incidence rates seen across Canada. Given the substantial interjurisdictional variation, more work is needed to increase prevention efforts, including promoting a healthier diet and lifestyle, especially in jurisdictions facing disproportionately higher burdens of crc.Based on current knowledge, the most effective approaches to reduce the burden of crc include adopting public policies that create healthier environments in which people live, work, learn, and play; making healthy choices easier; and continuing to emphasize screening and early detection. Strategic approaches to modifiable risk factors and mechanisms for early cancer detection have the potential to translate into positive effects for population health and fewer Canadians developing and dying from cancer.

scholarly journals Geographic Variation in Colorectal Cancer Incidence and the Disparities in the Prevalence of Modifiable Risk Factors Across Canada

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 15s-15s
Author(s):  
J. Tung ◽  
C. Politis ◽  
J. Chadder ◽  
J. Han ◽  
J. Niu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
New Brunswick ◽  
Geographic Variation ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Modifiable Risk Factors ◽  
Colorectal Cancer Incidence ◽  
Incident Cases ◽  
Cancer Incidence Rates

Background: Colorectal cancer is the third most common cancer worldwide. There is wide geographic variation in incidence with rates varying ten-fold between high- and low-income countries. This heavy burden can be mitigated given previous research has estimated that nearly half of all colorectal cancer cases could have been prevented through healthier diets and physically active lifestyles. In Canada, there is considerable geographic variation in age-adjusted incidence rates for colorectal cancer between jurisdictions, greater than that seen for many other cancers. These wide variations likely reflect differences in the prevalence of risk factors across provinces and territories. Aim: To describe the extent of the variation in colorectal cancer incidence rates across Canada and the disparities in the prevalence of modifiable risk factors across jurisdictions known to contribute to this burden. Methods: Colorectal cancer incident cases were obtained from the Canadian Cancer Registry; 2014 was used for provinces (except Quebec where 2010 was the most recent year available) and years 2012 to 2014 were combined to achieve more stable rates for the territories, which are much smaller in population. Data on four known modifiable risk factors for colorectal cancer (excess weight, physical inactivity, alcohol intake and low fruit and vegetable consumption) were obtained from the 2015-16 combined Canadian Community Health Survey. Results: Findings suggest that there is a north-south and east-west gradient in colorectal cancer modifiable risk factors in Canada. For instance, the percentage of adults with excess body weight ranged from 56.8% in British Columbia (west) to 73.1% in New Brunswick (east) and the percentage of adults not meeting physical activity guidelines ranged from 31.8% in Yukon (north) to 50.3% in New Brunswick (east). Generally, this pattern also reflects colorectal cancer incidence rates. The highest prevalence of modifiable risk factors and rates of colorectal cancer are typically in the northern (territories) and eastern provinces of Canada. Conclusion: The global burden of colorectal cancer is expected to increase by nearly 60% by 2030; therefore, targeted interventions are needed to ensure there is not a widening gap in colorectal cancer burden worldwide. Based on current knowledge, the most effective approaches to reduce the burden of colorectal cancer include: 1) adopting public policies that make healthy choices easier and create healthier environments where people live, work and play, and 2) continuing emphasis on screening and early detection. Strategic approaches to addressing modifiable risk factors, as well as mechanisms for detecting colorectal cancer before it develops, have the potential to translate into positive effects on population health and less people developing and dying from cancer.

Prevention of atrial fibrillation – non-modifiable and modifiable risk factors for AF

2020 ◽  
Vol 2 (55) ◽  
pp. 14-19
Author(s):  
Agnieszka Wojdyła-Hordyńska ◽  
Grzegorz Hordyński
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Combined Treatment ◽  
Lifestyle Changes ◽  
Modifiable Risk Factors

Atrial fibrillation is one of the most common arrhythmias, with a significant increase in incidence in recent years. AF is a major cause of stroke, heart failure, sudden cardiac death, and cardiovascular disease. Timely intervention and modification of risk factors increase chance to stop the disease. Aggressive, multilevel prevention tactics are a component of combined treatment, including – in addition to lifestyle changes, anticoagulant therapy, pharmacotherapy and invasive anti-arrhythmic treatment – prevention of cardiovascular diseases, hypertension, ischemia, valvular disease and heart failure.

scholarly journals Colorectal cancer in the world: incidence, mortality and risk factors

2017 ◽  
Vol 4 (10) ◽  
pp. 1656 ◽  
Author(s):  
Hamidreza Sadeghi Gandomani ◽  
Seyed Majid Yousefi ◽  
Mohammad Aghajani ◽  
Abdollah Mohammadian-Hafshejani ◽  
Abed Asgari Tarazoj ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Medical History ◽  
Peer Review ◽  
Search Strategy ◽  
Mortality Rates ◽  
Incidence Rates ◽  
Screening Programs ◽  
The World ◽  
Peer Reviewers

A rapid literature search strategy was conducted for all English language literature published before July 2017. The search was conducted using the electronic databases PubMed, Scopus and Web of Science. The search strategy included the keywords ‘colorectal cancer’, ‘epidemiology’, ‘incidence’, ‘mortality’, ‘risk factor’, and ‘world’. In 2012, the highest CRC incidence rates were observed in the Republic of Korea, Slovakia and Hungary while the lowest incidence rates were seen in Singapore, Serbia and Japan. The highest CRC mortality rates in both sexes were seen in Central and Eastern Europe and the lowest mortality rates were found in Middle Division of Africa. The main risk factors for CRC include nutritional factors, past medical history, smoking, socioeconomic status, and family medical history. According to the increasing trend of CRC incidence and mortality in the world, implementation of prevention programs such as screening programs, diet modification, and healthy lifestyle education is necessary. Peer Review Details Peer review method: Single-Blind (Peer-reviewers: 02) Peer-review policy Plagiarism software screening?: Yes Date of Original Submission: 26 August 2017 Date accepted: 20 Sept 2017 Peer reviewers approved by: Dr. Lili Hami Editor who approved publication: Dr. Phuc Van Pham  

Sport als Prävention von Demenz und ­funktionellem Verlust im Alter

2014 ◽  
Vol 62 (4) ◽  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cognitive Abilities ◽  
Lifestyle Changes ◽  
Cognitive Domains ◽  
Dementia Prevalence ◽  
Positive Effects ◽  
Preventative Measures ◽  
Wide Range ◽  
Study Designs

As a consequence of the demographically related increase of dementia prevalence, modifiable risk factors are gaining in importance as possible preventative measures. Medical treatment cannot yet heal dementia. The effects of vascular risk factors as well as behaviour and lifestyle changes on cognitive decline are the subject of a wide range of current literature. The role of physical activity has proved to be especially beneficial. Multiple studies with different study designs describe direct or indirect positive effects of physical activity on cognitive abilities. The positive effects of physical activity are particularly notable in cognitive domains such as attention or executive functions, which are often impaired in dementia. However, ideal training sessions in terms of type, duration and intensity are currently unknown.

Incidence of and risk factors for hospitalizations from chemotherapy among patients with stage III and stage IV colorectal cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16090-e16090
Author(s):  
April Falconi ◽  
Ezra Fishman ◽  
John Barron ◽  
Michael Eleff ◽  
Michael Jordan Fisch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Treatment ◽  
Stage Iv ◽  
Incidence Rates ◽  
Stage Iii ◽  
Treatment Regimens ◽  
Medical Needs ◽  
Stage Iv Colorectal Cancer ◽  
Patients With Diabetes

e16090 Background: Despite the decreasing colorectal cancer (CRC) mortality rate over the past decade, complications from CRC treatment remain a challenge. Prior research has shown that a majority of patients with stage III CRC in the adjuvant setting experience hospitalizations due to chemotherapy-related toxicity. Minimal research, however, has examined risk factors of these events and the prevalence of hospitalization among stage IV CRC patients. Methods: We used claims data from a geographically-diverse private health insurer—including both commercially-insured and Medicare Advantage patients—to estimate and characterize risk factors of hospitalizations among Stage III or IV CRC patients. We compared sociodemographic, clinical, as well as provider characteristics and cancer treatment regimens between patients with and without hospitalizations from the initiation of chemotherapy to 60 days after the end of chemotherapy. Results: Incidence rates for hospitalization from chemotherapy were 49% and 70% for stage III and IV CRC patients, respectively. Although the oldest stage III CRC patients (age 75+) were the most likely to experience hospitalizations, the youngest age group (age 18-49) of stage IV patients experienced the highest incidence (74%) of hospitalizations (p < 0.05). Higher values of the Elixhauser comorbidity index was associated with a higher risk for hospitalizations among patients with stage III CRC (p < 0.001). Both stage III and stage IV patients with diabetes were more likely (p < 0.05) to have hospitalizations from chemotherapy (55% and 73%, respectively). Conclusions: Hospitalization from chemotherapy is very common among stage III and IV CRC patients. These data identify subgroups at higher risk. Study findings may inform choice of cancer treatment regimen and focus on key underlying medical needs

scholarly journals Recent evidence on modifiable and non-modifiable risk factors for colorectal cancer (CRC): a systematic synopsis of meta-analyses from 2015 to 2017

2019 ◽  
Vol 28 (2) ◽  
pp. 188-95
Author(s):  
Teguh Kristian Perdamaian
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Systematic Reviews ◽  
Modifiable Risk Factors ◽  
Ovid Medline ◽  
Prevention And Early Detection ◽  
Common Cancer ◽  
Huge Impact ◽  
Meta Analyses

Colorectal cancer (CRC) is a common cancer with a huge impact on international public health. This review discusses recent evidence on modifiable and non-modifiable risk factors for CRC using a systematic review method. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines on systematic reviews and meta-analyses of observational studies. The literature search was performed on the Ovid MEDLINE database and included publications from 2015 to 2017, followed by a quality assessment and a narrative synthesis. Of the 90 identified articles, there were 13 meta-analyses with statistically significant results. Seven articles discussed modifiable risk factors and six articles discussed non-modifiable risk. The modifiable risk factors with the highest risk were radiotherapy of prostate cancer (pooled odds ratio 1.68; 95% confidence interval [CI] 1.33–2.12). The non-modifiable risk factors with the highest risk was Lynch syndrome (hazard ratio 135.49; 95% CI 111.55–164.57). This review discovered new and previously known risk factors for CRC. Recent evidence shows that research on CRC risk factors is continuing to grow indicating that more studies on risk factors are needed to optimize CRC prevention and early detection.

Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk?

Urology ◽  
2000 ◽  
Vol 56 (2) ◽  
pp. 302-306 ◽  
Author(s):  
Carol A Derby ◽  
Beth A Mohr ◽  
Irwin Goldstein ◽  
Henry A Feldman ◽  
Catherine B Johannes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Erectile Dysfunction ◽  
Lifestyle Changes ◽  
Modifiable Risk Factors

scholarly journals Prevalence and coprevalence of modifiable risk factors for upper digestive tract cancer among residents aged 40–69 years in Yangzhong city, China: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042006
Author(s):  
Xiang Feng ◽  
Zhao-Lai Hua ◽  
Qin Zhou ◽  
Ai-Wu Shi ◽  
Tong-Qiu Song ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Fruit Intake ◽  
Modifiable Risk Factors ◽  
Sectional Study ◽  
Excessive Alcohol Consumption ◽  
Cross Sectional ◽  
Current Smoking ◽  
Tract Cancer ◽  
Excessive Alcohol

ObjectivesTo describe the prevalence of modifiable risk factors for upper digestive tract cancer (UDTC) and its coprevalence, and investigate relevant influencing factors of modifiable UDTC risk factors coprevalence among residents aged 40–69 years in Yangzhong city, China.DesignCross-sectional study.ParticipantsA total of 21 175 participants aged 40–69 years were enrolled in the study. 1962 subjects were excluded due to missing age, marital status or some other selected information. Eventually, 19 213 participants were available for the present analysis.Main outcomes measuresPrevalence and coprevalence of eight modifiable UDTC risk factors (overweight or obesity, current smoking, excessive alcohol consumption, insufficient vegetables intake, insufficient fruit intake and the consumption of pickled, fried and hot food) were analysed.ResultsThe prevalence of overweight/obesity, current smoking, excessive alcohol consumption, insufficient vegetables intake, insufficient fruit intake and the consumption of pickled, fried and hot food in this study was 45.3%, 24.1%, 16.2%, 66.1%, 94.5%, 68.1%, 36.0% and 88.4%, respectively. Nearly all (99.9%) participants showed one or more UDTC risk factors, 98.6% of the participants showed at least two risk factors, 92.2% of the participants had at least three risk factors and 69.7% of the participants had four or more risk factors. Multivariate logistic regression analysis revealed that men, younger age, single, higher education, higher annual family income and smaller household size were more likely to present modifiable UDTC risk factors coprevalence.ConclusionsThe prevalence and coprevalence of modifiable UDTC risk factors are high among participants in Yangzhong city. Extra attention must be paid to these groups who are susceptible to risk factors coprevalence during screening progress. Relative departments also need to make significant public health programmes that aim to decrease modifiable UDTC risk factors coprevalence among residents aged 40–69 years from high-risk areas of UDTC.

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