scholarly journals Quality of life of nasopharyngeal cancer survivors in China

2015 ◽  
Vol 22 (3) ◽  
pp. 142 ◽  
Author(s):  
J.S. Hong ◽  
J. Tian ◽  
Q.F. Han ◽  
Q.Y. Ni
Keyword(s):  
Quality Of Life ◽  
Survival Time ◽  
Education Level ◽  
Psychological Problems ◽  
Disease Stage ◽  
Life Questionnaire ◽  
Prevalence Rates ◽  
Mouth Dryness ◽  
Factors Influencing

Purpose We assessed the quality of life (qol) of nasopharyngeal carcinoma (npc) survivors with a survival time of more than 2 years in Fujian, China, and we analyzed factors influencing qol.Methods We calculated the prevalence of psychological distress and radiotherapy (rt)–induced symptoms in 216 npc survivors who participated in a cross-sectional survey. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (version 3.0) was used to assess the qol of npc survivors. Multiple linear regression was applied to analyze the factors influencing qol.Results The prevalence rates of rt-induced symptoms and psychological problems were 11.58% (95% ci: 7.21% to 15.58%) for difficulty in swallowing, 17.59% (95% ci: 12.51% to 22.67%) for mouth dryness or sores, 13.89% (95% ci: 9.28% to 18.50%) for nasal dryness or congestion, 18.52% (95% ci: 13.34% to 23.70%) for fatigue, 11.11% (95% ci: 6.92% to 15.30%) for frequent dizziness, 18.06% (95% ci: 12.93% to 23.19%) for decline in hearing, 14.81% (95% ci: 10.07% to 19.55%) for poor sleep quality, 18.52% (95% ci: 13.34% to 23.70%) for worry about disease recurrence, 18.98% (95% ci: 13.75% to 24.21%) for anxiety, and 25.00% (95% ci: 19.23% to 30.77%) for depression. Mean survival times were 4.32 ± 2.63 years in patients with mouth dryness or sores, 4.26 ± 2.90 years in patients with fatigue, and 5.60 ± 2.94 years in patients with a decline in hearing. The mean global qol score was 74.21 (95% ci: 72.22 to 76.20). At a significance level of α = 0.05, the factors influencing qol were age (p = 0.032), education level (p = 0.001), anxiety score (p < 0.001), depression score (p < 0.001), mouth dryness or sores (p < 0.001), fatigue (p = 0.027), and disease stage (p = 0.044).Conclusions The prevalence rates of mouth dryness or sores, fatigue, decline in hearing, depression, and anxiety were high in npc survivors with a survival time of more than 2 years. These rt-induced symptoms and psychological problems can last for many years after rt. The qol of the npc survivors was good. Factors influencing qol were age, education level, anxiety, depression, mouth dryness or sores, fatigue, and disease stage. Our results suggest that during clinical treatment, doctors should minimize the radiation dose to the ears of patients. In addition, our results emphasize the importance of providing oral and ear nursing and psychological care to npc survivors.

scholarly journals Establishing anchor-based minimally important differences (MID) with the EORTC quality-of-life measures: a meta-analysis protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. e019117 ◽  
Author(s):  
Zebedee Jammbe Musoro ◽  
Jean-Francois Hamel ◽  
Divine Ewane Ediebah ◽  
Kim Cocks ◽  
Madeleine T King ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Patient Data ◽  
Disease Stage ◽  
Healthcare Intervention ◽  
Life Questionnaire ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Eortc Quality

IntroductionAs patient assessment of health-related quality of life (HRQOL) in cancer clinical trials has increased over the years, so has the need to attach meaningful interpretations to differences in HRQOL scores between groups and changes within groups. Determining what represents a minimally important difference (MID) in HRQOL scores is useful to clinicians, patients and researchers, and can be used as a benchmark for assessing the success of a healthcare intervention. Our objective is to provide an evidence-based protocol to determine MIDs for the European Organisation for Research and Treatment for Cancer Quality of life Questionnaire core 30 (EORTC QLQ-C30). We will mainly focus on MID estimation for group-level comparisons. Responder thresholds for individual-level change will also be estimated.Methods and analysisData will be derived from published phase II and III EORTC trials that used the QLQ-C30 instrument, covering several cancer sites. We will use individual patient data to estimate MIDs for different cancer sites separately. Focus is on anchor-based methods. Anchors will be selected per disease site from available data. A disease-oriented and methodological panel will provide independent guidance on anchor selection. We aim to construct multiple clinical anchors per QLQ-C30 scale and also to compare with several anchor-based methods. The effects of covariates, for example, gender, age, disease stage and so on, will also be investigated. We will examine how our estimated MIDs compare with previously published guidelines, hence further contributing to robust MID guidelines for the EORTC QLQ-C30.Ethics and disseminationAll patient data originate from completed clinical trials with mandatory written informed consent, approved by local ethical committees. Our findings will be presented at scientific conferences, disseminated via peer-reviewed publications and also compiled in a MID ‘blue book’ which will be made available online on the EORTC Quality of Life Group website as a free guideline document.

scholarly journals Chemotherapy and other Factors Affecting Quality of Life in Non-Small Cell Lung Cancer (NSCLC) Patients

2019 ◽  
Vol 70 (1) ◽  
pp. 33-35 ◽  
Author(s):  
Laura Mazilu ◽  
Dana Lucia Stanculeanu ◽  
Andreea Daniela Gheorghe ◽  
Adrian Paul Suceveanu ◽  
Irinel Raluca Parepa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Performance Status ◽  
Well Being ◽  
Study Data ◽  
Disease Stage ◽  
Treatment Modalities ◽  
Factors Influencing ◽  
Nsclc Patients

NSCLC accounts around 80% of all lung cancers. NSCLC patients have usually a lousy quality of life (QoL), influenced by the malignant disease itself and by cancer treatment modalities. We conducted an observational study in Oncology Department, Clinical Emergency Hospital, Constanta, on a sample of 50 patients diagnosed with NSCLC one year. Our study data showed that younger patients have a better QoL regarding social/family well-being, but without other significant differences. Also, patients living in the urban area have a better QoL regarding social/family well-being. Patients having better performance status obtain higher scores from all subscales of the FACT- G questionnaire and, also a higher FACT-G total scale, these results are showing that better the performance status and general status of the patient, better the QoL. We detected a significant relationship between QoL and disease stage or presence of metastasis. We found no clinical significance between QoL scores with respect with chemotherapy protocol or the number of cycles of chemotherapy. We aimed to show that factors influencing the QoL of NSCLC patients are stage of the disease and performance status of the patients. To diminish the negative impact, one important step in ameliorating the QoL of NSCLC patients is to detect all factors influencing it and offer psychological spiritual and social support.

scholarly journals A Path Analysis of Factors Influencing the First Childbearing Decision-Making in Women in Shahrood in 2014

2016 ◽  
Vol 8 (10) ◽  
pp. 24 ◽  
Author(s):  
Nourossadat Kariman ◽  
Maliheh Amerian ◽  
Padideh Jannati ◽  
Fatemeh Salmani ◽  
Mazlumeh Hamzekhani
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Decision Making ◽  
Marital Satisfaction ◽  
Time Frame ◽  
Life Questionnaire ◽  
Satisfaction Scale ◽  
Cross Sectional ◽  
Factors Influencing

<p><strong>Background and Objectives:</strong> Normal fertility follows a set of biological, social and cultural rules and regulations; controlled fertility, however, follows the rules and regulations of the family. The present study was therefore conducted to identify the factors influencing the first childbearing decision-making in women living in Shahroud, Iran, in 2014. <strong></strong></p><p><strong>Materials and Methods:</strong> The present descriptive cross-sectional study was conducted on 300 randomly-selected pregnant women admitted to health centers in Shahroud. The utilized data collection tools included a demographic and obstetrics questionnaire, a quality of life questionnaire, the ENRICH Marital Satisfaction Scale, the Snyder Hope Scale and the Multidimensional Scale of Perceived Social Support. Data were analyzed in SPSS-17 and the direct or inverse effects of the factors influencing the first childbearing decision-making were examined in AMOS-20.<strong></strong></p><p><strong>Results:</strong> The results obtained revealed marital age to have the highest degree of correlation with the first childbearing decision-making in women (r=0.90 and P&lt;0.001).Once the statistically insignificant paths were eliminated, marital age was found to have the highest direct effect (β=0.63) on the first childbearing decision-making, followed by other factors including economic status (β=0.07), hopefulness (β=-0.07) and quality of life (β=-0.05). The inverse effects of marital age (β=0.01), social support (β= -0.01) and quality of life (β=-0.01) on the first childbearing decision-making were found to be significant in women (P&lt;0.001).<strong></strong></p><p><strong>Conclusion:</strong> Many factors are involved in the process of childbearing decision-making, including individual factors (marital age, hopefulness and quality of life), familial factors (marital satisfaction) and social factors (social support). Healthcare institutions and policymakers should adopt strategies that can help couples bear their desired number of children within an appropriate time frame through ameliorating their social, economic and familial conditions.<strong></strong></p>

scholarly journals Symptom Burden in Oral Cancer Patients During and Postcancer Treatment

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 113s-113s
Author(s):  
C. Sundaramoorthy ◽  
V. Pooja ◽  
V. Surendran
Keyword(s):  
Quality Of Life ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Symptom Burden ◽  
Demographic Variables ◽  
Disease Stage ◽  
Life Questionnaire ◽  
Oral Cancer Patients ◽  
C 30

Background: Oral cancer is one of the most common cancers seen in India which accounts for about 30% of all type cancers, with ranking as the top most among male. Due to advancements in diagnostic and treatment modalities, the survivorship of oral cancer patients has increased significantly during the last decade. Yet, the treatment of cancer accompanies symptom burden and psychosocial problems that impacts the quality of life of the patients. Aim: To assess the symptom burden among oral cancer patients during and post cancer treatment. Methods: A cross-sectional investigation was conducted to assess the symptom burden of 100 oral cancer patients (age range= 18-65 years, mean age=49.76) from a regional cancer institute (WIA), Chennai, India. Among them, 59 patients were under treatment and 41 had completed the treatment. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and QLQ-H & N 35 module were used. The dependent t-test was used to compare two groups and Spearman correlation coefficients were used to assess the relationship between symptoms and demographic variables. Results: Significant difference was observed in the levels of pain and insomnia on symptoms scale of QLQ-C 30 between patients receiving and completed treatment ( P < 0.05). Similarly, pain score on QLQ-HN 35 differed significantly between the patients on and after treatment ( P < 0.05). In the QLQ-HN 35 module, dry mouth, opening mouth, sticky saliva, pain and tooth problems ranked as most worsening symptoms among oral cancer patients. However, in the QLQ-C 30, financial difficulties, fatigue and pain were ranked as the most worsening symptoms among oral cancer patients. Scores were significantly associated with a number of demographic variables such as age, gender, education, disease stage, time since diagnosis and treatment ( P < 0.05). Conclusion: Oral cancer patients experience numerous worsening symptoms during as well as, posttreatment. This study emphasis the importance of assessing the symptom burden of the patients throughout the course of and completion of treatment as effective management could be implemented.

scholarly journals Humanistic burden and economic impact of chronic kidney disease: a systematic literature review

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 2142 ◽  
Author(s):  
Caroline Freeman ◽  
Lucia Giles ◽  
Polly Field ◽  
Elisabeth Sörstadius ◽  
Heleen van Haalen
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Resource Use ◽  
Healthcare Costs ◽  
Symptom Burden ◽  
Disease Stage ◽  
Life Questionnaire ◽  
Quality Of Life Questionnaire ◽  
Reported Data

Background: Chronic kidney disease (CKD) is increasing in prevalence worldwide. Progression of CKD to end-stage renal disease (ESRD) can result in the requirement for renal replacement therapy, which incurs considerable healthcare costs and imposes restrictions on patients’ daily living. This systematic review was conducted to inform understanding of the humanistic and economic burden of CKD by collecting quality of life (QoL), symptom burden, and cost and resource use data, with a focus on the impact of disease progression. Methods: Embase, MEDLINE, the Cochrane Library, and conference proceedings were searched in May 2017 according to predefined inclusion criteria. Data were extracted for full publications reporting either QoL or symptom burden (published 2007–2017; reporting data from ≥ 100 patients) or costs and resource use (published 2012–2017). Relevant QoL studies were those that used the 6-dimension or 8-, 12-, or 36-item Short-Form Health Surveys, 5-dimension EuroQol questionnaire, Healthy Days/Health-Related Quality of Life questionnaire, or Kidney Disease Quality of Life Questionnaire. Results: Data were extracted from 95 studies reporting QoL data, 47 studies reporting cost and resource use data, and eight studies reporting descriptions of symptoms; 12 studies (seven QoL; five costs/resource use) reported data for patients with and without CKD, and 15 studies (seven QoL; eight costs/resource use) reported data by disease stage. Patients with CKD, including those with ESRD, had worse QoL than those with normal kidney function, and incurred higher healthcare costs. Disease progression was associated with cost increases, particularly for later stages and in patients receiving dialysis. Increasing CKD severity was also associated with reductions in QoL, although not all studies identified showed a consistent decrease with increasing disease stage. Conclusions: The presence of CKD and CKD progression are associated with reductions in patients’ QoL and increased economic impact. This may be mitigated by interventions that slow progression.

scholarly journals Cancer Rehabilitation Publications (2008–2018) With a Focus on Physical Function: A Scoping Review

2020 ◽  
Vol 100 (3) ◽  
pp. 363-415 ◽  
Author(s):  
Shana E Harrington ◽  
Nicole L Stout ◽  
Elizabeth Hile ◽  
Mary Insana Fisher ◽  
Melissa Eden ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Treatment ◽  
Physical Function ◽  
Scoping Review ◽  
Cancer Rehabilitation ◽  
Assessment Tools ◽  
Disease Stage ◽  
Life Questionnaire ◽  
Study Selection

Abstract Background Cancer rehabilitation research has accelerated over the last decade. However, closer examination of the published literature reveals that the majority of this work has focused on psychological interventions and cognitive and behavioral therapies. Recent initiatives have aggregated expert consensus around research priorities, highlighting a dearth in research regarding measurement of and interventions for physical function. Increasingly loud calls for the need to address the myriad of physical functional impairments that develop in people living with and beyond cancer have been published in the literature. A detailed survey of the landscape of published research has not been reported to our knowledge. Purpose This scoping review systematically identified literature published between 2008 and 2018 related to the screening, assessment, and interventions associated with physical function in people living with and beyond cancer. Data Sources PubMed and CINAHL were searched up to September 2018. Study Selection Study selection included articles of all levels of evidence on any disease stage and population. A total of 11,483 articles were screened for eligibility, 2507 full-text articles were reviewed, and 1055 articles were selected for final inclusion and extraction. Data Extraction Seven reviewers recorded type of cancer, disease stage, age of participants, phase of treatment, time since diagnosis, application to physical function, study design, impairments related to physical function, and measurement instruments used. Data Synthesis Approximately one-third of the articles included patients with various cancer diagnoses (30.3%), whereas the rest focused on a single cancer, most commonly breast (24.8%). Most articles (77%) measured physical function following the completion of active cancer treatment with 64% representing the assessment domain. The most commonly used measures of physical function were the Medical Outcomes Study 36-Item Health Survey Questionnaire (29%) and the European Organization for Research and Treatment of cancer Quality of Life Questionnaire-Cancer 30 (21.5%). Limitations Studies not written in English, study protocols, conference abstracts, and unpublished data were excluded. Conclusions This review elucidated significant inconsistencies in the literature regarding language used to define physical function, measurement tools used to characterize function, and the use of those tools across the cancer treatment and survivorship trajectory. The findings suggested that physical function in cancer research is predominantly measured using general health-related quality-of-life tools rather than more precise functional assessment tools. Interdisciplinary and clinician-researcher collaborative efforts should be directed toward a unified definition and assessment of physical function.

scholarly journals ASSESSMENT AND COMPARISON OF QUALITY OF LIFE AND SYMPTOM RELIEF IN PATIENT OF INOPERABLE NON-METASTATIC NON SMALL CELL LUNG CANCER UNDERGOING DIFFERENT PALLIATIVE RADIATION THERAPY.

2020 ◽  
pp. 62-64
Author(s):  
Shampa Maity ◽  
Apurba Bikash Pramanik ◽  
Partha Dasgupta ◽  
Pulakesh Sinha ◽  
Debarshi Jana
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Survival Time ◽  
Performance Status ◽  
Symptom Relief ◽  
Locally Advanced ◽  
Poor Performance Status ◽  
Life Questionnaire ◽  
Health Related

Lung cancer incidence in Indian men is 54000, with mortality at 49000 and in females at much less 17000 with mortality at 15,000. The aim of our study is Health related QoL changes: By using EORTC Quality of Life Questionnaire (QLQ)-C30 and QLQ-LC13. All histology proven patients of locally advanced NSCLC attending Department of Radiotherapy, R.G.Kar Medical College & Hospital during study period from January, 2017 to July 2018. Patient with poor performance status and inoperable NSCLC causing pulmonary symptoms, hypofractionated, involved field radiotherapy 8.5 Gy in two fractions offer acceptable palliation with minimal toxicity. A clear advantage of the very short hypofractionated regimen is that it enable patients with a short expected survival time to spend more of their remaining time away from their hospital. Palliative radiotherapy plays an important role of palliation of symptomatic intrathoracic disease and in preservation of health related quality of life (HRQOL) in patients who have limited expected survival time and/or intolerance to combined chemotherapy and radical radiotherapy regimen.

The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study.

1996 ◽  
Vol 14 (10) ◽  
pp. 2756-2768 ◽  
Author(s):  
M A Sprangers ◽  
M Groenvold ◽  
J I Arraras ◽  
J Franklin ◽  
A te Velde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Performance Status ◽  
The United States ◽  
Disease Stage ◽  
Scaling Analysis ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire

PURPOSE To construct a breast cancer-specific quality-of-life questionnaire (QLQ) module to be used in conjunction with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and to test its reliability and validity cross-culturally. PATIENTS AND METHODS Module construction took place after the EORTC guidelines for module development. The module--the QLQ-BR23--consists of 23 items covering symptoms and side effects related to different treatment modalities, body image, sexuality, and future perspective. This module was tested in 170 Dutch, 168 Spanish, and 158 American cancer patients at two points in time. The timing for the Dutch and Spanish patients was before and during treatment with radiotherapy or chemotherapy. For the American patients, the questionnaire was administered at admission at the breast clinic and 3 months after the first assessment. RESULTS Multitrait scaling analysis confirmed the hypothesized structure of four of the five scales. Cronbach's alpha coefficients were, in general, lowest in Spain (range; .46 to .94) and highest in the United States (range; .70 to .91). On the basis of known-groups comparisons, selective scales distinguished clearly between patients differing in disease stage, previous surgery, performance status, and treatment modality, according to expectation. Additionally, selective scales detected change over time as a function of changes in performance status and treatment-induced change. CONCLUSION These results lend support to the clinical and cross-cultural validity of the QLQ-BR23 as a supplementary questionnaire for assessing specific quality-of-life issues relevant to patients with breast cancer.

Alexithyme Patientenmerkmale und Lebensqualität – Eine Querschnittsstudie an 79 ambulanten Patienten mit Angststörungen

2013 ◽  
Vol 61 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Katrin Leenen ◽  
Michael Rufer ◽  
Hanspeter Moergeli ◽  
Hans-Jörgen Grabe ◽  
Josef Jenewein ◽  
...  
Keyword(s):  
Quality Of Life ◽  
World Health ◽  
Life Questionnaire ◽  
World Health Organization Quality ◽  
Fand Sich ◽  
Quality Of Life Questionnaire ◽  
Organization Quality ◽  
Health Organization ◽  
Tas 20

Aus Untersuchungen in der Normalbevölkerung ist bekannt, dass Menschen mit erhöhten Alexithymiewerten eine verminderte Lebensqualität (LQ) aufweisen. Für Patienten mit psychischen Störungen wurde dieser Zusammenhang jedoch kaum untersucht. Ziel dieser Studie war es, den möglichen Zusammenhang zwischen alexithymen Patientenmerkmalen und der LQ bei Patienten mit Angststörungen zu überprüfen. Bei 79 ambulanten Patienten mit Angststörungen wurden alexithyme Charakteristika mit der Toronto Alexithymia Scale (TAS-20), die LQ mit der Kurzversion des World Health Organization Quality of Life Questionnaire 100 (WHOQOL-BREF) erfasst. Darüber hinaus fand eine Erhebung der psychischen Symptombelastung (SCL-90-R) und depressiven Symptomatik (MADRS) statt. Mittels hierarchischer Regressionsanalysen wurde der Zusammenhang zwischen der alexithymen Charakteristika und den unterschiedlichen LQ-Domänen berechnet. Die Patienten zeigten eine im Vergleich zur Normalbevölkerung deutlich verminderte LQ. Als Hauptergebnis fand sich, auch nach Kontrolle von Depression, Ängstlichkeit und Geschlecht, ein signifikanter Zusammenhang zwischen den beiden TAS-20 Subskalen Schwierigkeiten, Gefühle zu identifizieren und zu beschreiben und vor allem der psychischen LQ. Unsere Ergebnisse sprechen dafür, bei der Diagnostik und Therapieplanung von Patienten mit Angststörungen alexithyme Merkmale einzubeziehen. Im Falle von ausgeprägten alexithymen Merkmalen sollten psychotherapeutische Interventionen zur Verbesserung der Schwierigkeiten Gefühle wahrzunehmen und zu kommunizieren in Betracht gezogen werden.

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