Treasing on Tylvamyco® as a Novel Immunomodulatory Medication on Broiler Chickens

2020 ◽  
Keyword(s):  
Broiler Chickens ◽  
Inhibitory Concentration ◽  
Immune Status ◽  
Treated Group ◽  
Occurrence Rate ◽  
Test Results ◽  
Feed Conversion ◽  
Immunological Parameters ◽  
Avian Mycoplasmosis ◽  
Feed Conversion Rate

Present study aims at the evaluation of the efficacy of Tylvamyco® as a new macrolides generation in control of avian mycoplasmosis in broilers chickens with special attention to its immunomodulation effects. A total of 500 day old broiler Ross 308 chicks were equally subdivided into two treatments of 250 birds in each. The Tylvamyco® treated group, and the control non treated group were kept in a separate house. Blood samples and tracheal tissues collected at one day old and also each week till the end of the trials for isolation M. gallisepticum and also measuring the immune status of the experimental chicks. M.gallisepticum occurrence rate in broilers chickens was 12% which confirmed by PCR. The minimal inhibitory concentration values Tylvamyco® against recovered 12 M.gallisepticum isolates standard strain showed that the Tylvamyco® has MIC90 value of 0.008. In the Tylvamyco® treated group the immune status profiles record that there are marked increase in the immunological parameters by age as; HI test results for Mycoplasma ,NDV , AI, INF-γ conc. ,IL-6 conc. ,Phagocytic cell count ,Nitric oxide conc. and Lysozyme conc. at 1, 15, 30 day old respectively. The molecular analysis of CXCL8 gene as an indicator for inflammation reduction potency in In the Tylvamyco® treated group by using real-time PCR showed that the Cycle Threshold of CXCL8 gene reduced by age from 13.6 to 10.7 at 15 day old and 30 day old with fold change 0.57 and 1.4 respectively. Performance parameter in Tylvamyco® treated group as 3.22 kg/bird, with mean weight gain 2.33 kg/bird and feed conversion rate 1.4. The mortality rate was 5% with slight air saculitis, as post-mortum records, in conclusion our study proved that Tylvamyco® act as a potent immunomodulatory medication in broilers.

scholarly journals Enterococcus faecium PNC01 isolated from the intestinal mucosa of chicken as an alternative for antibiotics to reduce feed conversion rate in broiler chickens

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yang He ◽  
Xuan Liu ◽  
Yuanyang Dong ◽  
Jiaqi Lei ◽  
Koichi Ito ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Mucosa ◽  
Conversion Rate ◽  
Broiler Chickens ◽  
Intestinal Epithelial Cells ◽  
Relative Length ◽  
Intestinal Epithelial ◽  
Feed Conversion ◽  
Broiler Production ◽  
Feed Conversion Rate

Abstract Background The development and utilization of probiotics had many environmental benefits for replacing antibiotics in animal production. Bacteria in the intestinal mucosa have better adhesion to the host intestinal epithelial cells compared to bacteria in the intestinal contents. In this study, lactic acid bacteria were isolated from the intestinal mucosa of broiler chickens and investigated as the substitution to antibiotic in broiler production. Results In addition to acid resistance, high temperature resistance, antimicrobial sensitivity tests, and intestinal epithelial cell adhesion, Enterococcus faecium PNC01 (E. faecium PNC01) was showed to be non-cytotoxic to epithelial cells. Draft genome sequence of E. faecium PNC01 predicted that it synthesized bacteriocin to perform probiotic functions and bacteriocin activity assay showed it inhibited Salmonella typhimurium from invading intestinal epithelial cells. Diet supplemented with E. faecium PNC01 increased the ileal villus height and crypt depth in broiler chickens, reduced the relative length of the cecum at day 21, and reduced the relative length of jejunum and ileum at day 42. Diet supplemented with E. faecium PNC01 increased the relative abundance of Firmicutes and Lactobacillus, decreased the relative abundance of Bacteroides in the cecal microbiota. Conclusion E. faecium PNC01 replaced antibiotics to reduce the feed conversion rate. Furthermore, E. faecium PNC01 improved intestinal morphology and altered the composition of microbiota in the cecum to reduce feed conversion rate. Thus, it can be used as an alternative for antibiotics in broiler production to avoid the adverse impact of antibiotics by altering the gut microbiota. Graphic Abstract

scholarly journals PENGGUNAAN PROTEASE DALAM PAKAN YANG MENGGUNAKAN LIMBAH PERTANIAN-PETERNAKAN UNTUK MENINGKATKAN KINERJA PERTUMBUHAN AYAM BROILER

2017 ◽  
Vol 41 (3) ◽  
pp. 243 ◽  
Author(s):  
Apriliana Devi Anggraini ◽  
Ferry Poernama ◽  
Chusnul Hanim ◽  
Nanung Danar Dono
Keyword(s):  
Growth Performance ◽  
Broiler Chickens ◽  
Basal Diet ◽  
Test Results ◽  
Feed Conversion ◽  
Bone Meal ◽  
Protein Energy ◽  
Randomized Design ◽  
By Products ◽  
Meat Bone Meal

This study was aimed to determine the effects of protease supplementation in diets with agricultural-livestock by products on the growth performance in broiler chickens. The commercial protease used in current study was produced by Bacillus licheniformis which based on keratinase. The treatment diets were a control basal diet without agricultural-livestock by-products and protease supplementation (P1); P1 + 0.05% protease; basal diet with meat bone meal (MBM) and distiller’s dried grain with soluble (DDGS) suppementation (P3); P3 + 0.05% protease (P4); basal diet with hydrolized chicken feather meal (HCFM) and DDGS supplementation (P5); P5 + 0.05% protease. The obtained data were statistically analyzed using Complete Randomized Design, and analyzed subsequently by Orthogonal Contrats Test. Results showed that protease supplementation in the diets containing agricultural-livestock by-products did not affect growth performance of broiler chickens in starter phase and overall age phase. However, in diets containing MBM, protease supplementation reduced the nett gain and feed conversion ratio (FCR) in finisher phase (P<0.05). In diets containing HCFM, protease supplementation increased nett gain and FCR (P<0.05), compared to those of containing MBM. It could be concluded that qualified HCFM, MBM, and DDGS can be used as alternatives for protein-energy source feed stuffs in starter phase, as they did not reduce growth performance of broiler chickens. Protease used in this study might be more effective in diets containing HCFM than those of containing MBM and DDGS.Keywords: Agricultural-livestock by-products, Broilers chickens, Growth performance, Protease.

scholarly journals Effect of phytogenic additives on performance, morphology and caecal microflora of broiler chickens

2013 ◽  
Vol 29 (2) ◽  
pp. 311-319 ◽  
Author(s):  
M. Vukic-Vranjes ◽  
N. Tolimir ◽  
Dj. Vukmirovic ◽  
R. Colovic ◽  
V. Stanacev ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Control Diet ◽  
Feed Additives ◽  
Morphological Parameters ◽  
Feed Conversion ◽  
Supplemental Feed ◽  
Villous Height ◽  
The Subject ◽  
Feed Conversion Rate ◽  
Positive Effect

The objective of the research is to investigate effects of phytogenic additives as broiler feed supplements on production and slaughtering performances, morphological parameters and caecal microflora of fattening chickens of Ross 308 provenance. The research was based on two trials. In both trials, two feeding treatments were studied: a control diet with no supplemental feed additives (K) and a diet with a phytogenic additive supplemented to the control diet (1000g/t of Biomin PEP 1000, during the whole period). In the first trial, a total of 304 chickens were studied, in two treatments with four repetitions per pen with 38 chickens. The second trial included 16800 chickens, and it was conducted as a macro trial, that is, a pen with 8400 chickens was the subject of the trial. The results have shown that the chickens fed with the supplemental phytogenic additive have achieved significantly more favourable feed conversion rate. Differences in body mass and mortality rate between the trial group and the control were not statistically significant. Phytogenic additives did not have significant effects on breast portion and abdominal fat. Adding the phytogenic additive did not have significant effects on morphological parameters, but there was a tendency to increasing villous height and crypt depth. In both trials, the chicken groups fed with the supplemental phytogenic additive had less of all investigated groups of bacteria, and the differences were statistically significant for Enterobacteriaceae and Staphylococcus in the first, and Enterobacteriaceae and Enterococcus in the second trial. It can be concluded that the diet with the supplemental phytogenic additive had a positive effect on broiler performances, jejunum morphology parameters and caecal microflora.

scholarly journals Effects of Pre and Probiotic on Growth Performance and Haematological Parameters in Pigs

2016 ◽  
Vol 73 (2) ◽  
pp. 295
Author(s):  
Andrei Radu Szakacs ◽  
Sorana Matei ◽  
Laura Stefanut ◽  
Zoltan Moni ◽  
Adrian Macri
Keyword(s):  
Conversion Rate ◽  
Animal Health ◽  
Treated Group ◽  
Feed Consumption ◽  
Haematological Parameters ◽  
Control Group ◽  
Feed Conversion ◽  
Physiological Limits ◽  
Pig Performance ◽  
Feed Conversion Rate

The present study investigates the effects of dietary supplementation with feed supplements (prebiotics and probiotics) on pig performance, the feed conversion ratio and some haematological parameters.The research was conducted on hybrid pigs [(Yorkshire × Landrace) × Duroc] in a farm from Sălaj County, Romania. Pigs of 11 weeks (n = 200) were divided into 4 equal groups: a group fed with the probiotic, a prebiotic-fed group, a control group and a synbiotic (pre- and probiotic) treated group. The control group was fed with a feed without the specified additives. Probiotic treated group was fed the same feedstuff but containing the additive Beta Plus® Ultra (Biochem)( 5.12x1012 CFU / kg - Bacillus subtilis DSM 5750, 5.12x1012UFC / kg - Bacillus licheniformis (DSM 5749 ) and 921 g of betaine), in an amount of 1 kg / tonne of feed.  Prebiotic group had added to the feed an extract derived from the cell wall of Saccharomyces cerevisiae (TechnoMos® - Biochem) in a dose of 250 g / ton of feed. The weight of 25 pigs in each compartment was recorded 9 times (over 85 days). Animal health was evaluated via clinical, haematological, and parasitological examinations. 5 rectal swabs were collected on day 11 and day 77 and faeces samples were taken in day 77 from each investigated group. Growth rate, feed consumption and some haematological parameters were measured.The body weight, average total weight gain and feed conversion rate increase by the dietary inclusion of the both pre and probiotic (p˃0.05). In the compartment treated with prebiotic the weight of the pigs has increased by 1030 g/day compared with 982 g/day value recorded in the control group. The average feed consumption was 3.21 kg/day in the control group while the group treated with prebiotic was only 2.99 kg/day. Feed conversion rate for all treated groups were lower than the one of control. Haematological parameters varied in physiological limits of species.Conclusion: These products show promising effects as an alternative for antibiotics in order to eliminate the use of these drugs as growth-promoting additives.

scholarly journals Bioremidation of Spirulina Plantesis Against Deltamethrin Mediated Toxicity and Its Chemical Residues in Chicken Meat

2021 ◽  
Author(s):  
Samar Saber Ibrahim ◽  
Rasha Elsabagh ◽  
Ali Allam ◽  
Gehan Youssef ◽  
Sabreen Ezzat Fadl ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Basal Diet ◽  
Synthetic Pyrethroid ◽  
Control Group ◽  
Broiler Chicks ◽  
Protective Effects ◽  
Histopathological Changes ◽  
Feed Conversion ◽  
Chemical Residues ◽  
Feed Conversion Rate

Abstract Deltamethrin (DM) is a synthetic pyrethroid insecticide commonly used in veterinary and agriculture. However, both animal and human exposure is associated with hepatorenal toxicity. Our experimental goal was to assess the protective effects of Spirulina plantesis (SP) against DM-induced hepato-renal injury, growth performance, meat chemical composition and its residues in meat, liver and skin of broiler chickens. Sixty one-day-old Cobb broiler chicks were assigned to 4 experimental groups, each was divided into 3 replicates with five chicks each; 1st group received basal diet alone (Control), 2nd group supplemented with SP 20 g/kg diet, 3rd group supplemented with DM 300 mg/kg diet, and 4th group supplemented with DM and SP diet. All groups were received the treatment for 35 days. DM, decreased body weight, weight gain, and increased feed conversion rate. DM showed significant increase in ALT, AST, urea, creatinine and MDA and significant decrease in SOD, and GSH levels. Also, significant decrease in DM levels in meat, skin, and liver by SP with a reduction % 63.01, 63.00 and 62.90 % in meat, skin and liver, respectively. The DM intoxicated group showed significant decrease in protein and significant increase in fat, cholesterol and triglycerides when compared to control group. Histopathological changes were also recorded. Dietary SP improved these parameters parameters. Dietary inclusion of SP can be recommended due to the protective effects on DM induced toxicity in broiler chickens.

scholarly journals Improvement in broiler performance by feeding a nutrient-dense diet after a mild feed restriction

2020 ◽  
Vol 34 (3) ◽  
pp. 189-199
Author(s):  
Mohammad Hadaeghi ◽  
Carmen Avilés-Ramírez ◽  
Alireza Seidavi ◽  
Leila Asadpour ◽  
Nieves Núñez-Sánchez ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Body Weight Gain ◽  
Control Treatment ◽  
Nutrient Restriction ◽  
Feed Restriction ◽  
Standard Diet ◽  
Feed Conversion ◽  
Broiler Performance ◽  
Nutrient Density ◽  
Feed Conversion Rate

Background: The use of early nutrient-restriction programs in broilers can prevent complications such as increased body fat deposition and its consequences. However, feed restriction not always gives the expected results. Objective: To assess the effect of two levels of feed restriction followed by a re-alimentation period with five increasing nutrient levels on growth performance and immune response of broiler chickens. Methods: A total of 330 animals were used. The treatments were: 25 (T25) and 35% (T35) quantitative feed restriction during the starting period, and 0, 2.5, 5, 7.5, 10, and 15% increased energy and protein contents during the growing and finishing periods. Results: For all the T25 treatments, except for T25-0, feed intake (FI) and body weight gain (BWG) were higher, and feed conversion rate (FCR) was lower (p<0.05) compared to the control treatment. In that group, the response of FI and BWG to the increased nutrient density was mostly quadratic (p<0.001), whereas that of FCR was linear (p<0.001). The FI and BWG results were less homogeneous in the T35 treatments, but FCR was lower compared to the control treatment (p<0.05) in all of them. The FCR showed no differences (p>0.05) between treatments during the finishing period. Conclusion: Feeding a nutrient-dense diet after a period of mild feed restriction gives the best results, while increasing nutrient density after a more severe feed restriction does not improve productive results compared to a standard diet. Carcass traits and immune function were not affected by restriction level or nutrient density.

scholarly journals Enhancing the Productive Performance of Broiler Chickens by Adding Spirulina platensis Compared with Probiotic, Prebiotics, and Oxytetracycline

2021 ◽  
Vol 45 (1) ◽  
pp. 31-36
Author(s):  
Wisam R Atiyah ◽  
Mohanad F Hamood
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Feed Intake ◽  
Spirulina Platensis ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Feed Conversion ◽  
Live Body Weight ◽  
Feed Conversion Rate

This study was conducted in order to find out the effect of Spirulina platensis (S. platensis) algae mixed with drinking water (2%) on the production performance of broiler chickens infected with or without Enterococcus faecalis (E. faecalis) and compare it with the effects of probiotics (containing Lactobacillus acidophilus, L. casi, L. reuteri, and Bacillus subtillis), prebiotics (containing antioxidants and a group of vitamins) as well as oxytetracycline. The experiment included 350 one day old (Ross-308) broiler chicks, randomly divided into 7 groups by 50 chicks per group for 35 days. The groups were divided as follows: T1: infected experimentally with E. faecalis only, T2: treated with S. platensis, T3: infected experimentally with E. faecalis and treated with 2% S. platensis, T4: infected experimentally with E. faecalis and treated with probiotic, T5: infected experimentally with E. faecalis and treated with prebiotic, T6: infected experimentally with E. faecalis and treated with oxytetracycline. T7: control group without any addition. Weekly live body weight and weekly body weight gain were measured as well as weekly feed intake and feed conversion rate for broiler chickens were estimated. The current study proved that S. platensis algae added to drinking water (2%) in T2 and T3 groups had caused a significant increase (P<0.05) in the weekly live body weight and weekly body weight gain, Spirulina also caused a significant decrease (P<0.05) in weekly feed intake and feed conversion rate for broiler chickens. Therefore, S. platensis could be a suitable alternative to some feed additives such as probiotics, prebiotics, and antibiotics in addition to the ability of Spirulina to reduce the symptoms of E. faecalis.

scholarly journals Effect of Sargassum wightii on Growth, Carcass and Serum Qualities of Broiler Chickens

2018 ◽  
Vol 3 (2) ◽  
pp. 1-10
Author(s):  
Athis Kumar K
Keyword(s):  
Feed Intake ◽  
Conversion Rate ◽  
Broiler Chickens ◽  
Plasma Cholesterol ◽  
Heart Weight ◽  
Total Serum Protein ◽  
Total Serum ◽  
Control Group ◽  
Feed Conversion ◽  
Feed Conversion Rate

The basic feed supplemented with Sargassum powder (1%, 2%, 3% and 4%) provided more amount of essential amino acids, long chain fatty acids and minerals necessary for the growth of poultry than the basic feed. The growth promoting ability of Sargassum increased from 1% to 2% and then there was ste ady state, which is reflected in the weight gain, feed intake, feed conversion rate, carcass qualities and serum parameters of poultry. Sargassum powder had increased the growth to gain about 1265g more weight compared to the control and the supplementing effect was the maximum at 2% Sargassum powder. The feed intake per bird increased from 4647g at 1% Sargassum powder to 4813g at 4% Sargassum powder while it was 3042g in the control group. The feed conversion rate increased from 51.5 to 51.8 instead of 33. 9% in the control. Sargassum treatment increased the liver weight from 2.26% to 2.30%, the heart weight from 0.53% - 0,45%, the gizzard from 1.76% to 1.83%, the intestinal weight from 210.2 to 226.18%, the leg proportion from 3.77% to 4.57%, the breast weigh t from 28.26% to 30.27%, the thigh weight from 13.37% to 14.68%, the drumstick from 14.16% to 15.28% and the dressing from 70.32% to 81.12%. The maximum supplementary effect was noted at 1% and 2% of the Sargassum powder. Dietary treatment of broiler chick s with Sargassum powder significantly (P<0.05) decreased plasma cholesterol and globulin while increased the total serum protein, albumin, calcium, phosphorus and triglyceride compared to control. The 1% Sargassum gave 1.8 fold profits while 2%, 3% and 4% Sargassum powder gave 1.95 fold profit compared to the control. Meat qualities of chicks fed with 1% and 2% Sargassum were superior to the meat of poultry fed only with the basic feed.

Bioavailability of Water- and Lipid-Soluble Thiamin Compounds in Broiler Chickens

2000 ◽  
Vol 70 (6) ◽  
pp. 311-316 ◽  
Author(s):  
Joachim Geyer ◽  
Michael Netzel ◽  
Irmgard Bitsch ◽  
Thomas Frank ◽  
Roland Bitsch ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Water Soluble ◽  
Feed Consumption ◽  
Soluble Salts ◽  
Feed Conversion ◽  
Deficient Diet ◽  
Dietary Level ◽  
Activation Coefficient ◽  
Biochemical Indices ◽  
Feed Conversion Rate

The bioavailability of thiamin mononitrate, thiamin chloride-hydrochloride and benfotiamin was compared in broiler chickens. A thiamin-deficient diet was supplemented with either 1.8 and 1.5 mg/kg thiamin equivalent as water-soluble salts, or with 1.5 and 1.2 mg/kg thiamin equivalent as benfotiamin, respectively, and fed to 3 replicate groups/treatment for 21 days. Weight gain, feed consumption and feed conversion rate were not significantly affected by solubility or dietary level of thiamin. Likewise, using biochemical indices of thiamin status (erythrocyte transketolase activation coefficient, and thiamin concentrations in blood and liver), no differences were found between the water-soluble thiamin salts, indicating that they have identical potency. In contrast, biochemical indices of thiamin status showed a significantly higher bioavailability for benfotiamin than for the water-soluble sources.

scholarly journals Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens

2020 ◽  
pp. 1-8
Author(s):  
W. Van der Veken ◽  
V. Hautekiet ◽  
E.A. Kimminau ◽  
C. Hofacre ◽  
G.F. Mathis
Keyword(s):  
Clostridium Perfringens ◽  
Bacillus Licheniformis ◽  
Broiler Chickens ◽  
Basal Diet ◽  
Treated Group ◽  
Negative Control ◽  
Necrotic Enteritis ◽  
Feed Conversion ◽  
Colony Forming Units ◽  
The Impact

The aim of this study was to evaluate the impact of a probiotic Bacillus licheniformis strain (DSM 28710; B-Act®) on growth performance and its capacity to mitigate necrotic enteritis (NE; induced via a Clostridium perfringens challenge) in poultry. A broiler trial was conducted, examining three treatments for 42 days under an induced NE challenge; a negative control (basal diet only); an antibiotic treated group (oxytetracycline hydrochloride (OXT), therapeutic dose of 105 mg OXT/litre in drinking water, for three days after C. perfringens challenge); and a B-Act group (500 g B-Act/tonne of feed, equalling 1.6×1012 colony forming units B. licheniformis DSM 28710/tonne of feed, supplemented from start until finish). Despite the induced NE challenge, weight gains of the B-Act and OXT groups were similar to each other but significantly higher compared to the control at the end of the study (P<0.05). Weight gain of the B-Act group was already significantly higher compared to the control on day 21 (P<0.05), indicating a potential benefit of the probiotic even before clinical establishment of NE. Feed conversion ratio (FCR) values followed a similar pattern throughout the study, with a significantly lower overall FCR for the B-Act and OXT groups compared to the control (P<0.05; d0-42). Birds fed B-Act had significantly (P<0.05) lower NE lesions compared to the control and OXT group on day 21, although OXT was not supplemented to the animals at this stage yet. Both B-Act and OXT groups had significantly (P<0.05) lower NE scores than the control on day 28, demonstrating the effectiveness of the antibiotic treatment and the mitigating effect of B-Act on the effects of a Clostridium perfringens induced NE challenge.

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