Medicated serum prepared with Chinese herbal medicine Zhizhen Recipe down-regulates activity of nuclear factor-κB and expression of P-glycoprotein in human colorectal cancer multidrug-resistant cell line HCT-8/VCR

2011 ◽  
Vol 9 (12) ◽  
pp. 1353-1359 ◽  
Author(s):  
SB Cai
Keyword(s):  
Colorectal Cancer ◽  
Herbal Medicine ◽  
Nuclear Factor Κb ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Nuclear Factor ◽  
Human Colorectal Cancer ◽  
Chinese Herbal ◽  
P Glycoprotein

Differences in Sensitivity to UVC, UVB and UVA Radiation of a Multidrug-Resistant Cell Line Overexpressing P-Glycoprotein

1999 ◽  
Vol 69 (6) ◽  
pp. 694-699 ◽  
Author(s):  
G. S. Trindade ◽  
M. A. M. Capella ◽  
L. S. Capella ◽  
O. R. Affonso-Mitidieri ◽  
V. M. Rumjanek
Keyword(s):  
Cell Line ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
P Glycoprotein ◽  
Uva Radiation

scholarly journals Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to γ-Radiation by Targeting Nuclear Factor-κB–Regulated Gene Products

2008 ◽  
Vol 14 (7) ◽  
pp. 2128-2136 ◽  
Author(s):  
Ajaikumar B. Kunnumakkara ◽  
Parmeswaran Diagaradjane ◽  
Sushovan Guha ◽  
Amit Deorukhkar ◽  
Shujun Shentu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Nude Mice ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Gene Products ◽  
Human Colorectal Cancer ◽  
Γ Radiation

scholarly journals Multidrug resistance in tumour cells: characterisation of the multidrug resistant cell line K562-Lucena 1

2001 ◽  
Vol 73 (1) ◽  
pp. 57-69 ◽  
Author(s):  
VIVIAN M. RUMJANEK ◽  
GILMA S. TRINDADE ◽  
KAREN WAGNER-SOUZA ◽  
MICHELE C. MELETTI-DE-OLIVEIRA ◽  
LUIS F. MARQUES-SANTOS ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cell Line ◽  
Anticancer Agents ◽  
Vinca Alkaloid ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Resistant Cell ◽  
Cross Reactivity ◽  
Resistant Cell Line ◽  
P Glycoprotein

Multidrug resistance to chemotherapy is a major obstacle in the treatment of cancer patients. The best characterised mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein. However, the resistance process is multifactorial. Studies of multidrug resistance mechanisms have relied on the analysis of cancer cell lines that have been selected and present cross-reactivity to a broad range of anticancer agents. This work characterises a multidrug resistant cell line, originally selected for resistance to the Vinca alkaloid vincristine and derived from the human erythroleukaemia cell K562. This cell line, named Lucena 1, overexpresses P-glycoprotein and have its resistance reversed by the chemosensitisers verapamil, trifluoperazine and cyclosporins A, D and G. Furthermore, we demonstrated that methylene blue was capable of partially reversing the resistance in this cell line. On the contrary, the use of 5-fluorouracil increased the resistance of Lucena 1. In addition to chemotherapics, Lucena 1 cells were resistant to ultraviolet A radiation and hydrogen peroxide and failed to mobilise intracellular calcium when thapsigargin was used. Changes in the cytoskeleton of this cell line were also observed.

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