Effects of Chinese herbal medicine Yiqi Zengmin Formula on expression of glucose transporter 4 in skeletal muscle in type 2 diabetic rats

2011 ◽  
Vol 9 (10) ◽  
pp. 1133-1137 ◽  
Author(s):  
HL Xue
Keyword(s):  
Skeletal Muscle ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Glucose Transporter ◽  
Diabetic Rats ◽  
Glucose Transporter 4 ◽  
Chinese Herbal ◽  
Type 2 Diabetic

Hypoglycemic, hypolipidemic and antioxidant effects of Sarcandra glabra polysaccharide in type 2 diabetic mice

2014 ◽  
Vol 5 (11) ◽  
pp. 2850-2860 ◽  
Author(s):  
Wei Liu ◽  
Ying Zheng ◽  
Zhenzhen Zhang ◽  
Wenbing Yao ◽  
Xiangdong Gao
Keyword(s):  
Herbal Medicine ◽  
Dietary Supplement ◽  
Chinese Herbal Medicine ◽  
Diabetic Mice ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Antioxidant Effects ◽  
Type 2 Diabetic

Sarcandra glabra(Thunb.) Nakai is a traditional Chinese herbal medicine and dietary supplement used for treating several diseases.

scholarly journals Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats

2018 ◽  
Vol 52 (1) ◽  
pp. 6-16 ◽  
Author(s):  
Ayodele Olufemi Morakinyo ◽  
Titilola Aderonke Samuel ◽  
Daniel Abiodun Adekunbi
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Glucose Transporter ◽  
Diabetic Rats ◽  
Glucose Transporter 4 ◽  
Magnesium Supplementation ◽  
Glucose Levels ◽  
Type 2 Diabetic

Abstract Objective. We investigated the effects of magnesium supplementation on glucose tolerance, insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide induced type-2 diabetic (T2D) rats. Methods. Rats were divided into four groups designated as: 1) control (CTR); 2) diabetic untreated (DU); 3) diabetic treated with 1 mg of Mg/kg diet (Mg1-D); and 4) diabetic treated with 2 mg of Mg/kg diet (Mg2-D). T2D was induced with a single intraperitoneal (i.p.) injection of freshly prepared streptozotocin (55 mg/kg) aft er an initial i.p. injection of nicotinamide (120 mg/kg). Glucose tolerance, insulin sensitivity, lipid profile, malondialdehyde (MAD) and glutathione content, insulin receptors (INSR) and glucose transporter-4 (GLUT4), fasting insulin and glucose levels were measured, and insulin resistance index was calculated using the homeostatic model assessment of insulin resistance (HOMA-IR). Results. Magnesium supplementation improved glucose tolerance and lowered blood glucose levels almost to the normal range. We also recorded a noticeable increase in insulin sensitivity in Mg-D groups when compared with DU rats. Lipid perturbations associated T2D were significantly attenuated by magnesium supplementation. Fasting glucose level was comparable to control values in the Mg-D groups while the HOMA-IR index was significantly lower compared with the DU rats. Magnesium reduced MDA but increased glutathione concentrations compared with DU group. Moreover, INSR and GLUT4 levels were elevated following magnesium supplementation in T2D rats. Conclusion. These findings demonstrate that magnesium may mediate effective metabolic control by stimulating the antioxidant defense, and increased levels of INSR and GLUT4 in diabetic rats.

scholarly journals SAT-659 Micro/Nanoparticles from Antidiabetic Chinese Herbal Medicine Soup Increase Bioavailability of Phytochemicals and Regulate Glucose and Lipid Metabolism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Lijing Ke ◽  
Pingfan Rao
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Herbal Medicine ◽  
Glucose Tolerance ◽  
Chinese Herbal Medicine ◽  
Therapeutic Effects ◽  
Chinese Herbal ◽  
Glucose And Lipid Metabolism

Abstract Herbal soups have always been a popular option for treating oxidative stress-related chronic diseases including diabetes. Various components of these soups have been studied in the hope to identify the active principles, mainly focusing on the individual phytochemicals. As we have revealed previously, the micro/nanoparticles (MNPs) formed incidentally during the boiling water extraction of herbal soups may be bioactive and functional. This study aims to elucidate the underlying mechanism of the biological functions of these MNPs. A Chinese herbal medicine soup prepared by Radix Puerariae lobatae, ginger and other three herbs, namely Ge-Gen-Qin-Lian-Tang, was employed here, as it was proven to be effective in treating type 2 diabetes clinically. The soup was separated with high-speed centrifuge (15600×g) to obtain the supernatant (solutes and nanoparticles) and sediments (MNPs), and determined for the content of three bioactive phytochemicals, e.g. puerarin, berberine and baicalin. Their hypoglycemic, hypolipidemic and antioxidant effects were determined on streptozotocin (STZ)-induced Type 2 diabetic Wistar male rats fed on high fat-high sugar diet. The animals were divided into six groups (normal control, diabetic model, whole soup, supernatant, MNPs and metformin, 8 rats each), recording weight, diet, excretion, mental status, etc. The fasting blood glucose and oral glucose tolerance test were conducted regularly. Eight weeks after the administration, the rats were sacrificed after anesthesia. Abdominal aorta blood and tissue samples of pancreas, heart, skeletal muscle, liver, kidney, spleen were collected. The glycated hemoglobin, glucose, lipid, insulin, glucagon, AMPK, SOD, puerarin, berberine, baicalin in blood plasma, insulin in pancreas, SOD in tissues, AMPK in skeletal muscle were measured. Liver tissue sections were observed with HE staining. Statistical analysis (t-test) were performed. The MNPs reduced blood glucose, ameliorated glucose tolerance, elevated insulin secretion and significantly improve glucose and lipid metabolism (P <0.05), showing stronger effects than the supernatant components. Notably, MNPs elevated the AMPK level in skeletal muscle, even more potently than the whole soup. The therapeutic effects of MNPs on the liver damage were even stronger than metformin. Meanwhile, MNPs promoted absorption of puerarin, berberine and baicalin and increase their concentration in blood (P <0.05). Therefore, the MNPs from the herbal soup exhibited more potent effects than the soluble components on ameliorating glucose and lipid metabolism and pancreatic functions of diabetic rats. The actions of these MNPs provide a new perspective for understanding the antidiabetic effects of herbal soups and serve as a vehicle for the multiple phytochemicals to synergistically possess therapeutic effects.

Effect of endogenous galanin on glucose transporter 4 expression in cardiac muscle of type 2 diabetic rats

Peptides ◽  
2014 ◽  
Vol 62 ◽  
pp. 159-163 ◽  
Author(s):  
Penghua Fang ◽  
Mingyi Shi ◽  
Lili Guo ◽  
Biao He ◽  
Qian Wang ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Glucose Transporter ◽  
Diabetic Rats ◽  
Glucose Transporter 4 ◽  
Type 2 Diabetic
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