Anticancer potentials of root extract of Polygala senega against benzo［a］pyrene-induced lung cancer in mice

2011 ◽  
Vol 9 (3) ◽  
pp. 320-327 ◽  
Author(s):  
Saili Paul
Keyword(s):  
Lung Cancer ◽  
Root Extract ◽  
Polygala Senega

scholarly journals Anticancer Potentials of Root Extract ofPolygala senegaand Its PLGA Nanoparticles-Encapsulated Form

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Saili Paul ◽  
Soumya Sundar Bhattacharyya ◽  
Naoual Boujedaini ◽  
Anisur Rahman Khuda-Bukhsh
Keyword(s):  
Lung Cancer ◽  
A549 Cells ◽  
Cancer Cell Line ◽  
Ethanolic Extract ◽  
Aqueous Dispersion ◽  
Plga Nanoparticles ◽  
Lung Cancer Cell Line ◽  
Normal Lung ◽  
Root Extract ◽  
Induced Apoptosis

Ethanolic extract ofPolygala senega(EEPS) had little or no cytotoxic effects on normal lung cells, but caused cell death and apoptosis to lung cancer cell line A549. In the present paper, ethanolic root extract ofP. senega(EEPS) was nanoencapsulated (size: 147.7 nm) by deploying a biodegradable poly-(lactic-co-glycolic) acid (PLGA). The small size of the NEEPS resulted in an enhanced cellular entry and greater bioavailability. The growth of cancer cells was inhibited better by NEEPS than EEPS. Both EEPS and NEEPS induced apoptosis of A549 cells, which was associated with decreased expression of survivin, PCNA mRNA, and increased expression of caspase-3, p53 mRNAs of A549 cells. The results show that the anticancer potential of the formulation of EEPS-loaded PLGA nanoparticles was more effective than EEPS per se, probably due to more aqueous dispersion after nanoencapsulation. Therefore, nanoencapsulated ethanolic root extract ofP. senegamay serve as a potential chemopreventive agent against lung cancer.

scholarly journals The Root Extract of Scutellaria baicalensis Induces Apoptosis in EGFR TKI-Resistant Human Lung Cancer Cells by Inactivation of STAT3

2021 ◽  
Vol 22 (10) ◽  
pp. 5181
Author(s):  
Hyun-Ji Park ◽  
Shin-Hyung Park ◽  
Yung-Hyun Choi ◽  
Gyoo-Yong Chi
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Human Lung ◽  
Scutellaria Baicalensis ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Root Extract ◽  
Egfr Tki ◽  
Resistant Cells

Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) is a major obstacle in managing lung cancer. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. The purpose of this study was to investigate whether SB exhibited anticancer activity in EGFR TKI-resistant lung cancer cells and to explore the underlying mechanism. We used four types of human lung cancer cell lines, including H1299 (EGFR wildtype; EGFR TKI-resistant), H1975 (acquired TKI-resistant), PC9/ER (acquired erlotinib-resistant), and PC9/GR (acquired gefitinib-resistant) cells. The ethanol extract of SB (ESB) decreased cell viability and suppressed colony formation in the four cell lines. ESB stimulated nuclear fragmentation and the cleavage of poly(ADP-ribose) polymerase (PARP) and caspase-3. Consistently, the proportion of sub-G1 phase cells and annexin V+ cells were significantly elevated by ESB, indicating that ESB induced apoptotic cell death in EGFR TKI-resistant cells. ESB dephosphorylated signal transducer and activator of transcription 3 (STAT3) and downregulated the target gene expression. The overexpression of constitutively active STAT3 reversed ESB-induced apoptosis, suggesting that ESB triggered apoptosis in EGFR TKI-resistant cells by inactivating STAT3. Taken together, we propose the potential use of SB as a novel therapeutic for lung cancer patients with EGFR TKI resistance.

scholarly journals In Vitro and In Vivo Studies Demonstrate Anticancer Property of Root Extract of Polygala senega

2010 ◽  
Vol 3 (3) ◽  
pp. 188-196 ◽  
Author(s):  
Saili Paul ◽  
Sushil Kumar Mandal ◽  
Soumya Sundar Bhattacharyya ◽  
Naoual Boujedaini ◽  
Anisur Rahman Khuda-Bukhsh
Keyword(s):  
In Vivo Studies ◽  
Root Extract ◽  
Polygala Senega

scholarly journals Regulatory roles of HSPA6 in Actinidia chinensis Planch. root extract (acRoots)‐inhibited lung cancer proliferation

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Lingyan Wang ◽  
Jiayun Hou ◽  
Jianxin Wang ◽  
Zhenghua Zhu ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Root Extract ◽  
Actinidia Chinensis ◽  
Cancer Proliferation

The question of irradiation therapy in lung cancer

JAMA ◽  
1966 ◽  
Vol 195 (6) ◽  
pp. 471-475 ◽  
Author(s):  
M. J. Krant
Keyword(s):  
Lung Cancer ◽  
Irradiation Therapy
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