scholarly journals Hyperuricemia and Cardiovascular Diseases Clinical and paraclinical correlations

2019 ◽  
Vol 70 (3) ◽  
pp. 1045-1046 ◽  
Author(s):  
Delia Timofte ◽  
Adina Mandita ◽  
Andra-Elena Balcangiu-Stroescu ◽  
Daniela Balan ◽  
Laura Raducu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cardiovascular Diseases ◽  
National Health ◽  
Renal Excretion ◽  
Nutrition Examination Survey ◽  
Purine Nucleotides ◽  
Target Value ◽  
The Past ◽  
Health And Nutrition

Uric acid is the end product of endogenous and exogenous of purine nucleotides catabolism, the serum concentrate being determined by the production and elimination ratio. Elimination is achieved through renal excretion � two thirds- and the rest through digestive way. In most studies, hyperuricemia is defined as ] 7 mg/dL uric acid in men and ] 6 mg/dL in women, and the guides for gout treatment recommend target value of uric acid under 6 mg/dL [1]. According to the NHANES ( National Health and Nutrition Examination Survey) register, the prevalence of hyperuricemia has increased by 3.2% and that of gout by 1.2% during the past twenty years[1].

scholarly journals Elevated Serum Uric Acid and Self-Reported Heart Failure in US Adults: 2007–2016 National Health and Nutrition Examination Survey

2019 ◽  
Vol 9 (6) ◽  
pp. 344-353 ◽  
Author(s):  
Michelle L. Stone ◽  
Michael R. Richardson ◽  
Larry Guevara ◽  
Bethany G. Rand ◽  
James R. Churilla
Keyword(s):  
Heart Failure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
National Health ◽  
Representative Sample ◽  
Elevated Serum ◽  
Activity Level ◽  
Nutrition Examination Survey ◽  
Men And Women ◽  
Health And Nutrition

Introduction: There is limited evidence examining the relationship between elevated serum uric acid (sUA) concentration and heart failure (HF) in United States (US) adults. The aim of the present study was to examine the association(s) between elevated sUA and HF using a nationally representative sample of US adults. Methods: The final sample with complete data for this analysis (n = 17,349) included men and women aged ≥40 years who participated in the 2007–2016 National Health and Nutrition Examination Survey. Self-reported diagnosis of HF was assessed via interview. Elevated sUA was defined as values >6.0 mg/dL for women and >7.2 mg/dL for men. Multivariable gender-stratified logistic regression was utilized to examine the odds of self-reported HF. Results: The estimated prevalence of HF was 3.9 and 3.4% among men and women, respectively. Age-adjusted analysis revealed significantly increased odds of HF in men (OR 2.79; 95% CI 2.15–3.84, p < 0.01) and women (OR 3.24; 95% CI 2.37–4.44, p < 0.01) with elevated sUA. This relationship remained statistically significant following adjustment for age, race, education, income, alcohol consumption, smoking status, blood pressure, diabetes, physical activity level, cholesterol, creatinine level, and body mass index in men (OR 1.70; 95% CI 1.13–2.57 p < 0.05) and women (OR 1.74; 95% CI 1.18–2.58, p < 0.05). Conclusions: In a representative sample of US adults, having an elevated sUA concentration was associated with significantly increased odds of HF when compared to adults with normal sUA.

Short Sleep Duration as a Risk Factor of Cardiovascular Disease in Korean Adults: Secondary Analysis of the Fifth Korean National Health and Nutrition Examination Survey

2020 ◽  
Author(s):  
Wonjung NOH ◽  
Heakyung MOON
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Sleep Duration ◽  
National Health ◽  
Large Scale ◽  
Nutrition Examination Survey ◽  
Short Sleep Duration ◽  
Cross Sectional ◽  
Korean Adults ◽  
Health And Nutrition

Background: Sleep durations shorter or longer than 7 h are associated with cardiovascular diseases. We aimed to investigate the association among sleep duration, risk factors of hypertension, and cardiovascular disease in South Korea using data from a recent large-scale survey. Methods: Data produced by the Korea National Health and Nutrition Examination Survey (KNHANES) were subjected to multivariate logistic analysis. This cross-sectional, nationally representative survey was conducted from Jan 1 to Dec 31, 2011, by the Korean Center for Disease Control and Prevention. Overall, 6,466 participated. Data were analyzed using STATA version 13.0 (STATA Corp LP). Results: The participants’ socioeconomic, physical, and lifestyle factors were statistically different between the two age groups (<65 yr and ≥65 yr). Shorter sleep durations were associated with hypertension in individuals younger than 65 yr of age. On the other hand, in participants aged ≥65 yr, both shorter and longer sleep durations were associated with hypertension, while shorter sleep durations were associated with cardiovascular diseases. Conclusion: Unusual sleep durations are associated with an increased prevalence of cardiovascular disease among Korean adults. The effect of sleep duration appears to be more significant in individuals with hypertension, suggesting that the management of hypertension should be prioritized in patients older than 65 year.

scholarly journals Sex-specific in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey

2021 ◽  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Confidence Interval ◽  
National Health ◽  
Pulse Pressure ◽  
Nutrition Examination Survey ◽  
Korean Adults ◽  
Health And Nutrition ◽  
The Relationship ◽  
Significant Factors

Background and objective: The present study assesses the relationship between hyperuricemia and pulse pressure (PP) in non-diabetic Korean adults. Material and methods: Data from 5122 subjects (2251 men and 2871 women) in the seventh Korean National Health and Nutrition Examination Survey (KNHANES VII-2, 2017) were analyzed. Results: Systolic blood pressure (SBP) and PP were significant factors determining the odds ratios (ORs) for hyperuricemia (uric acid ≥7.0 mg/dL in men or ≥6.0 mg/dL in women) in men and the overall population. In women, SBP, diastolic blood pressure (DBP), and PP were not significant factors determining the OR for hyperuricemia. After adjusting for related variables, the OR of hyperuricemia was significantly higher in the high PP group (PP >60.0 mmHg) for men (OR, 1.760; 95% confidence interval [CI], 1.152--2.688) and the overall population (OR, 1.557; 95% CI, 1.132--2.140) compared with the normal PP group, but this trend was not seen in women (OR, 1.060; 95% CI, 0.646--1.740). Conclusions: Hyperuricemia was positively associated with PP in non-diabetic Korean men but not in women.

scholarly journals Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hye Jin Joo ◽  
Gyu Ri Kim ◽  
Dong-Woo Choi ◽  
Jae Hong Joo ◽  
Eun-Cheol Park
Keyword(s):  
Uric Acid ◽  
Kidney Disease ◽  
Confidence Intervals ◽  
Kidney Function ◽  
National Health ◽  
Uric Acid Level ◽  
Acid Level ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Reduced Kidney Function

AbstractKidney disease is expected to become the fifth leading cause of premature death globally by 2040. Uric acid level is a risk factor for kidney disease. The current study aims to investigate the association between uric acid levels and kidney function in the Korean population. The data of 11,042 participants of the 2016–2017 Korea National Health and Nutrition Examination Survey were analysed. The estimated glomerular filtration rate was calculated using the modification of diet in renal disease formula for Koreans. For each sex, uric acid levels were divided into five subsequent categories of increasing levels (Q1, Q2, Q3, Q4, and hyperuricemia). The association between uric acid level and kidney function was investigated using multiple logistic regression. The results showed that the higher the uric acid levels, the greater the odds of reduced kidney function in both sexes. In men, the adjusted odds ratios (95% confidence intervals) for reduced eGFR comparing the hyperuricemia group to the lowest serum uric acid quartile was 5.55 (3.27–9.44), and in women, the odds ratios (95% confidence intervals) was 7.52 (4.39–12.87). Normal weight or underweight in men and overweight in women, as well as diabetes mellitus, hypertension, and physical inactivity were highly associated with reduced kidney function. Our study revealed a dose–response relationship between uric acid levels and kidney function. Therefore, high uric acid level should be considered as a factor that is potentially related to kidney dysfunction in the Korean population.

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