scholarly journals A Step Forward Standardization of Biocompatibility Testing on Tissue Culture Polystyrene

2018 ◽  
Vol 55 (3) ◽  
pp. 303-307
Author(s):  
Andrei Marian Feier ◽  
Doina Ramona Manu ◽  
Gabriela Strnad ◽  
Minodora Dobreanu ◽  
Octav Marius Russu ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Key Factors ◽  
Osteoblast Cells ◽  
Tissue Culture Polystyrene ◽  
Standard Procedures ◽  
Biocompatibility Testing ◽  
First Time ◽  
Substrate Nature

Standard procedures regarding osteoblast cells deposition on different subtrates to test the biocompatibility of materials are not available. Aspects related to cells morphology depending on their number on the surface area of the substrate were studied for the first time. Osteoblasts were successfully isolated from residual bone resulted from two different patients after total hip arthroplasty. Different numbers of osteoblasts in populations (3x104 cells/cm2, 6x104 cells/cm2, 1x105 cells/cm2) were deposited on tissue culture polystyrene for 7 and 10 days of incubation. Results suggested that the protocol of osteoblasts deposition should be adjusted to assure a fair distribution of cells on the entire available area of the substrate, possible if a very good dispersion in the medium is achieved prior to deposition. Some other key factors in cells appropriate development, such as substrate nature, topography and incubation time,were detected. The present investigation helps declaring specific standards with respect to the biocompatibility testing of materials using osteoblast populations. Further investigations may lead to the creation of databases and the establishment of standards regarding bicompatibility researches that involve osteoblasts populations.

scholarly journals Identification of risk factors for treatment failure of closed reduction and abduction bracing after first-time total hip arthroplasty dislocation

2021 ◽  
Author(s):  
Viktor Janz ◽  
Georgi Wassilew ◽  
Michael Putzier ◽  
Geraldine Kath ◽  
Carsten Perka
Keyword(s):  
Risk Factors ◽  
Total Hip Arthroplasty ◽  
Conservative Treatment ◽  
Hip Arthroplasty ◽  
Closed Reduction ◽  
Conservative Therapy ◽  
Statistical Significance ◽  
Total Hip ◽  
First Time ◽  
Cup Position

IntroductionAfter a first-time total hip arthroplasty (THA) dislocation, a closed reduction followed by partial immobilization in an abduction brace is the recommended therapy. Despite modern abduction braces the success rate of conservative therapy is limited and evidence is scarce. The aim of this study was to identify risk factors for failure of conservative treatment after THA dislocation.Material and methodsEighty-seven patients, with conservative treatment of a first-time dislocation of a primary or revision THA, were included in this retrospective cohort study. Success was defined as a stable THA for a minimum of six months. Re-dislocation, open reduction or revision was defined as failure. The following risk factors were analyzed: gender, age, body mass index (BMI), ASA (American Society of Anesthesiologists) score, time of dislocation, head size, cup orientation, leg length, center of rotation and offset.ResultsSixty-seven percent of all patients experienced a re-dislocation, despite standardized conservative therapy. A BMI ≥ 25, early THA dislocation, and low cup anteversion were associated with a statistically significantly higher risk for re-dislocation. None of the other risk-factors achieved statistical significance. A multifactorial risk-factor analysis was performed to assess whether a cup position outside of Lewinnek’s safe zone in combination with gender, BMI and time to dislocation showed statistical significance for re-dislocation. Both BMI ≥ 25 and early dislocation showed a statistically higher failure rate. Cup position and gender were not significant.ConclusionsBMI ≥ 25, early THA dislocation and low cup anteversion were identified as significant risk factors for failure of conservative treatment with an abduction brace for first-time THA dislocation.

scholarly journals Contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty with emphasis on early failures

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Goro Motomura ◽  
Satoshi Hamai ◽  
Satoshi Ikemura ◽  
Masanori Fujii ◽  
Shinya Kawahara ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Revision Surgery ◽  
Periprosthetic Fracture ◽  
Polyethylene Wear ◽  
Total Hip ◽  
Cementless Total Hip Arthroplasty ◽  
Essential Form ◽  
Early Failures ◽  
First Time

Abstract Background To clarify contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty (THA) for addressing potential issues with cementless THA. Methods Data for 101 consecutive hips in 94 patients who underwent primary cementless THA at our institution and subsequently underwent first-time revision surgery were retrospectively reviewed. Baseline characteristics, indications for first-time revision surgery, and time from the primary THA to first-time revision surgery were evaluated. Results The overall mean time to first-time revision surgery was 10.3 years (range, 0–33 years). The indications for first-time revision surgery were polyethylene wear and osteolysis in 33 hips, aseptic loosening in 25 hips, infection in 17 hips, periprosthetic fracture in 13 hips, instability in 8 hips, and component failure (liner dissociation or stem fracture) in 5 hips. Thirty-seven hips (37%) had undergone first-time revision surgery within 5 years of primary THA, of which the most common indications were infection and periprosthetic fracture. Conclusion The current results suggested that reducing the number of early failures seems to be essential form improving THA outcomes.

MR Imaging with Metal Artifact Reduction to Differentiate between Patients with and without Infected Total Hip Arthroplasty

2018 ◽  
Author(s):  
Benedikt Schwaiger ◽  
Alexandra Gersing ◽  
Daniela Muenzel ◽  
Julia Dangelmaier ◽  
Peter Prodinger ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Mr Imaging ◽  
Hip Arthroplasty ◽  
Artifact Reduction ◽  
Metal Artifact ◽  
Metal Artifact Reduction ◽  
Total Hip

Plasma Prekallikrein Activity in Patients with Total Hip Arthroplasty

1987 ◽  
Vol 58 (04) ◽  
pp. 1040-1042
Author(s):  
J J M L Hoffmann ◽  
J H J P M Kortmann
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Hip Prosthesis ◽  
Contact System ◽  
Factor Xii ◽  
Total Hip ◽  
Activity Factor ◽  
Patient Groups ◽  
Kallikrein Activity

SummaryThe behaviour of the contact system was studied in 40 patients with total hip arthroplasty, by measuring plasma prekallikrein, spontaneous kallikrein activity and factor XII. In the literature it had been shown that patients with complications from this operation had decreased prekallikrein and increased kallikrein activity (M. Nakahara. Acta orthop scand 1982; 53: 591-6). In the present study, comprising patients with and without pain and proven loosening of the hip prosthesis, these findings could only partially be confirmed. Patients with a loosened prosthesis had significantly lower prekallikrein (mean 0.78 ± 0.28 U/ml; p <0.01) than patients without problems, but no detectable kallikrein activity in plasma. Patients with pain but no loosening had normal prekallikrein (1.04 ±0 0.26 U/ml) and also no demonstrable kallikrein activity. Factor XII was normal in all patient groups. It is concluded that decreased prekallikrein is limited to patients with a loosened hip prosthesis, with or without pain.

A Comparative Analysis of Patient Satisfaction following Total Knee Arthroplasty and Total Hip Arthroplasty Using the Forgotten Joint Score

2020 ◽  
Vol 04 (02) ◽  
pp. 084-089
Author(s):  
Vivek Singh ◽  
Stephen Zak ◽  
Ran Schwarzkopf ◽  
Roy Davidovitch
Keyword(s):  
Total Knee Arthroplasty ◽  
Patient Satisfaction ◽  
Total Hip Arthroplasty ◽  
Knee Arthroplasty ◽  
Hip Arthroplasty ◽  
Demographic Data ◽  
Demographic Differences ◽  
Total Hip ◽  
Forgotten Joint Score ◽  
Total Knee

AbstractMeasuring patient satisfaction and surgical outcomes following total joint arthroplasty remains controversial with most tools failing to account for both surgeon and patient satisfaction in regard to outcomes. The purpose of this study was to use “The Forgotten Joint Score” questionnaire to assess clinical outcomes comparing patients who underwent a total hip arthroplasty (THA) with those who underwent a total knee arthroplasty (TKA). We conducted a retrospective review of patients who underwent primary THA or TKA between September 2016 and September 2019 and responded to the Forgotten Joint Score-12 (FJS-12) questionnaire at least at one of three time periods (3, 12, and 21 months), postoperatively. An electronic patient rehabilitation application was used to administer the questionnaire. Collected variables included demographic data (age, gender, race, body mass index [BMI], and smoking status), length of stay (LOS), and FJS-12 scores. t-test and chi-square were used to determine significance. Linear regression was used to account for demographic differences. A p-value of less than 0.05 was considered statistically significant. Of the 2,359 patients included in this study, 1,469 underwent a THA and 890 underwent a TKA. Demographic differences were observed between the two groups with the TKA group being older, with higher BMI, higher American Society of Anesthesiologists scores, and longer LOS. Accounting for the differences in demographic data, THA patients consistently had higher scores at 3 months (53.72 vs. 24.96; p < 0.001), 12 months (66.00 vs. 43.57; p < 0.001), and 21 months (73.45 vs. 47.22; p < 0.001). FJS-12 scores for patients that underwent THA were significantly higher in comparison to TKA patients at 3, 12, and 21 months postoperatively. Increasing patient age led to a marginal increase in FJS-12 score in both cohorts. With higher FJS-12 scores, patients who underwent THA may experience a more positive evolution with their surgery postoperatively than those who had TKA.

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