scholarly journals Evaluations of Two Reinforced Polymers Used as Metal-Free Substructures in Fixed Dental Restorations

2018 ◽  
Vol 55 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Carmen Biris ◽  
Edwin Sever Bechir ◽  
Anamaria Bechir ◽  
Farah Curt Mola ◽  
Adrian Viorel Badiu ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Oral Health ◽  
Dental Materials ◽  
Evaluation Criteria ◽  
Prosthetic Rehabilitation ◽  
Reinforced Polymers ◽  
Metal Free ◽  
Dental Restorations ◽  
Comparative Results

The development of new classes of dental materials determined the apparition of reinforced polymers, as BioHPP and Trinia, used for core in non-metallic prosthetic restorations, including in implants non-metallic superstructure. The purpose of the study was to present the results of the comparative clinical trials referring to the use of BioHPP and Trinia resins as core in fixed prosthetic rehabilitation. The researches were performed on 33 patients in which we realized 71 fixed prosthetic restorations. According to the six evaluation criteria used in research, we conducted biannual monitoring meetings over two and half years period for registrations of comparative results in the use of these two reinforced polymers as core. The results of the study demonstrated that both type of these materials exhibit a certain degree of elasticity and presents many advantages, therefore these represent a beneficial acquisition in patients oral health.

scholarly journals The use of FDI criteria in clinical trials on direct dental restorations: A scoping review

2018 ◽  
Vol 68 ◽  
pp. 1-9 ◽  
Author(s):  
Thomas Marquillier ◽  
Sophie Doméjean ◽  
Justine Le Clerc ◽  
Florence Chemla ◽  
Kerstin Gritsch ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Scoping Review ◽  
Dental Restorations

scholarly journals Eugenol-based temporary luting cement possesses antioxidative properties

2014 ◽  
Vol 142 (11-12) ◽  
pp. 669-674 ◽  
Author(s):  
Dragan Ilic ◽  
Kosovka Obradovic-Djuricic ◽  
Djordje Antonijevic ◽  
Tatjana Todorovic
Keyword(s):  
Dental Materials ◽  
Study Groups ◽  
Biological Tissues ◽  
Gingival Tissue ◽  
Liquid Component ◽  
Dental Cement ◽  
Antioxidative Properties ◽  
Dental Restorations ◽  
Luting Cement ◽  
Anti Inflammatory

Introduction. Antioxidants protect against reactive oxygen species and expose beneficial anti-inflammatory activity when in contact with biological tissues. Dental materials that are used as temporary luting on fixed dental restorations are often in contact with injured gingival tissue, hence they should contain anti-inflammatory characteristics that are essential after prosthetic procedures preceding cementation of final restauration. Objective. The aim of this study was to investigate the antioxidant effect through the oxidation inhibition (OI) of mixed dental cement for temporary luting or their liquid component. Methods. Eight study groups were prepared each by ten samples: 1) ex tempore preparation of zinc-oxide eugenol paste (Kariofil Z Galenika, Serbia), 2) Viko Temp paste (Galenika, Serbia), 3) Temp Bond NE paste (Kerr, Germany), 4) ScutaBond (ESPE, Germany), 5) Cp-CAP paste (Germany, Lege Artis) and oil component of 6) Kariofil Z, 7) Viko Temp and 8) Cp-CAP. The samples were subjected to spectrophotometer to measure OI 2,2?-azino-di-(3-ethyl-benzthiazoline-6-sulphonic acid) (ABTS) using Randox kit, United Kingdom. The control samples were pure ascorbic acid (1% w/v). Results. High values of OI exposed materials (groups 1, 5, 6, 7, 8) with content of eugenol (or its derivates) in the range of 100-88.8% were statistically more significant than the values of non-eugenol substances (groups 2, 3, 4) with the range of 8.2-43.5%. Conclusion. Eugenol containing temporary fixation materials show significant antioxidative properties and therefore they may be used in those clinical situations where surrounding gingival tissue is injured during restorative procedure.

scholarly journals True and false positive rates for different criteria of evaluating statistical evidence from clinical trials

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Don van Ravenzwaaij ◽  
John P. A. Ioannidis
Keyword(s):  
Clinical Trials ◽  
Confidence Intervals ◽  
False Positive ◽  
Evaluation Criteria ◽  
Small Sample ◽  
Statistical Evidence ◽  
Bayes Factors ◽  
True Positive ◽  
Small Sample Sizes ◽  
Meta Analyses

Abstract Background Until recently a typical rule that has often been used for the endorsement of new medications by the Food and Drug Administration has been the existence of at least two statistically significant clinical trials favoring the new medication. This rule has consequences for the true positive (endorsement of an effective treatment) and false positive rates (endorsement of an ineffective treatment). Methods In this paper, we compare true positive and false positive rates for different evaluation criteria through simulations that rely on (1) conventional p-values; (2) confidence intervals based on meta-analyses assuming fixed or random effects; and (3) Bayes factors. We varied threshold levels for statistical evidence, thresholds for what constitutes a clinically meaningful treatment effect, and number of trials conducted. Results Our results show that Bayes factors, meta-analytic confidence intervals, and p-values often have similar performance. Bayes factors may perform better when the number of trials conducted is high and when trials have small sample sizes and clinically meaningful effects are not small, particularly in fields where the number of non-zero effects is relatively large. Conclusions Thinking about realistic effect sizes in conjunction with desirable levels of statistical evidence, as well as quantifying statistical evidence with Bayes factors may help improve decision-making in some circumstances.

scholarly journals Changing the Focus to the Whole Patient instead of One Oral Disease: The Concept of Individualized Prevention

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Gerhard Schmalz ◽  
Dirk Ziebolz
Keyword(s):  
Oral Health ◽  
Preventive Care ◽  
Potential Risk ◽  
De Novo ◽  
Oral Disease ◽  
Oral Diseases ◽  
Prevention Measures ◽  
Dental Restorations ◽  
Related Approach ◽  
The Individual

Oral diseases are highly prevalent and a global burden. Accordingly, their prevention appears essential. Recently, different strategies have been developed, mainly focusing on the presence of singular oral diseases or conditions. This article aims to construct a contemporary concept of individualized preventive care in dentistry whereby the focus is switched from viewing oral health in isolation to viewing the patient as a whole. The basis for individualized prevention measures is the case-oriented profile, including the synthesis of risk- and need-oriented parameters. The risk profile comprises different risk factors within the fields of systemic diseases, medications, and lifestyle that inherently pose a potential risk of complications (e.g., infectious endocarditis) and/or oral diseases (e.g., periodontitis). The needs profile includes factors originating from the aspects of oral diseases, dental restorations/appliances, and dental results with a potential risk of pathogenesis (e.g., the de novo development of caries) and/or the potential progression of oral diseases (e.g., an existing caries lesion). Based on these parameters, the general framework and content of prevention measures, as well as the maintenance interval, should be adapted to the individual patient. The implications of this concept might increase the safety, effectiveness, and efficiency of prevention in dental care. A further area of focus is primary prevention, that is, a focus on the preservation of oral health instead of a disease-related approach. However, clinical validation is needed to prove the benefits of the model presented. Individualized prevention promotes a shift from a disease-focused model to a whole-patient-focused model and provides a potential approach for establishing a contemporary concept for preventive care in dentistry.

scholarly journals Relevance of the Evaluation Criteria Used in Clinical Trials for Alzheimer’s Disease

Therapies ◽  
2009 ◽  
Vol 64 (3) ◽  
pp. 145-148 ◽  
Author(s):  
Philippe Truffinet ◽  
Régis Bordet ◽  
Joël Ménard ◽  
Serge Bakchine ◽  
Luc Buée ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Evaluation Criteria

Measures of Response: RECIST, WHO, and New Alternatives

2006 ◽  
Vol 24 (20) ◽  
pp. 3245-3251 ◽  
Author(s):  
C. Carl Jaffe
Keyword(s):  
Clinical Trials ◽  
Clinical Utility ◽  
Evaluation Criteria ◽  
Response To Therapy ◽  
Added Value ◽  
Molecular Response ◽  
Clinical Events ◽  
Wide Acceptance ◽  
Positron Emission ◽  
Ready Availability

RECIST (Response Evaluation Criteria in Solid Tumors) is a widely employed method introduced in 2000 to assess change in tumor size in response to therapy. The simplicity of the technique, however, contrasts sharply with the increasing sophistication of imaging instrumentation. Anatomically based imaging measurement, although supportive of drug development and key to some accelerated drug approvals, is being pressed to improve its methodologic robustness, particularly in the light of more functionally-based imaging that is sensitive to tissue molecular response such as fluorodeoxyglucose positron emission tomography. Nevertheless ready availability of computed tomography and magnetic resonance imaging machines largely assures anatomically based imaging a continuing role in clinical trials for the foreseeable future. Recent advances in image processing enabled by the computational power of modern clinical scanners open a considerable opportunity to characterize tumor response to therapy as a complement to image acquisition. Various alternative quantitative volumetric approaches have been proposed but have yet to gain wide acceptance by clinical and regulatory communities, nor have these more complex techniques shown incontrovertible evidence of greater reproducibility or predictive value of clinical events and outcome. Unless plans are created for clinical trials that incorporate the design needed to prove the added value and unique clinical utility of these novel approaches, any theoretical benefit of these more elaborate methods could remain unfulfilled.

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