Association of Acrochordons with Diabetes Mellitus - A Hospital based Case Control Study

2021 ◽  
Vol 4 (1) ◽  
pp. 51-60
Author(s):  
Sunita Karki ◽  
Anjan Rai ◽  
Manish Pradhan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Postprandial Glucose ◽  
Early Screening ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk ◽  
Skin Tags ◽  
And Gender ◽  
Control Study

Introduction Acrochordons or skin tags are common benign cutaneous tumors that occur especially over the neck and major flexures. A possible association between diabetes mellitus and dyslipidemia is observed in numerous past studies with varying results. We aim to find out the association of diabetes mellitus with acrochordons Methods: One hundred patients were enrolled in our study. Among them, 50 (27 males and 23 females) with skin tags were selected as cases and 50 with other dermatologic diseases after matching age and gender were taken as controls. Blood glucose levels including both fasting and postprandial glucose levels were determined for both cases and controls and compared. Results: There was a higher frequency of Diabetes Mellitus and impaired glucose tolerance in patients with skin tags in comparison to controls (p<0.001). Moreover, there were higher odds of acquiring skin tags in patient with abnormal blood glucose levels. Conclusions: There is an increased risk of developing DM in patients with skin tags. It is highly recommended that suspicion for Diabetes Mellitus is to be done in patients with skin tags for early screening and diagnosis of Diabetes.

scholarly journals SKIN TAGS IN TYPE 2 DIABETES MELLITUS: A VALUABLE MARKER

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Kshitij Saxena ◽  
Aliza Zaidi ◽  
Harris Ishtiyaq Shaafie ◽  
Nishant Singh ◽  
K K Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Skin Tag ◽  
Skin Tags ◽  
History Of

INTRODUCTION- Acrochordons [Skin Tag (ST)], are common, small, soft, benign connective tissue tumors of the dermis containing loose fibrous connective tissue. They are usually skin colored or brownish pedunculated papules, may be single or multiple, with smooth or irregular surface, ranging 1 mm to 20 mm in diameter. The ST developing in diabetes mellitus (DM) is due to hyperinsulinemia that is increase in insulin-like growth factor-1 (IGF-1) which leads to keratinocyte and fibroblast proliferation. MATERIALS AND METHODS- Patients presenting with skin tags to the dermatology OPD in Era’s Lucknow Medical College and Hospital from a period of December 2018 to May 2019 were taken into account, 110 cases were enrolled whereas same no. of controls were included in the study. The details of the study were explained to all subjects and informed consent was taken. Detailed history taking and examination was done. The site and number of skin tags was recorded and fasting blood glucose levels of both groups were measured to screen them for DM by WHO criteria (Normal Range <126mg/dl) by venous blood sample taken overnight fasting of 8 hrs. RESULT AND DISCUSSION- Total no. of subjects were 220 (110 cases and 110 controls), out of which 63.6% were males and 36.4% were females with average age of 44.05 yrs. Duration of skin tags ranged from 6 months to 180 months however 85.5% cases had a single skin tag. Multiple skin tags were common in males (21.4%). Family history of skin tags was higher in cases (41.8%) than in controls. Family history of diabetes mellitus was seen in 15.6% cases and 13.6% controls. FBG levels ranged from 68mg/dl to 220mg/dl in cases, and 65mg/dl to 178mg/dl in controls, with a mean value of 123mg/dl (cases) and 115mg/dl(controls). CONCLUSION- Association of Type 2 Diabetes Mellitus (high fasting blood glucose levels) and skin tags was positive in our study. We should encourage patients with skin tags to get their blood glucose levels checked to rule out diabetes mellitus.   KEY WORDS- Acrochordons, Skin tags, Diabetes Mellitus

scholarly journals Risk of Elevated Blood Glucose Levels in Tuberculosis Patients with BTA 3+ Levels, Puskesmas Bojong Gede Kabupaten Bogor

2020 ◽  
Vol 7 (2) ◽  
pp. 101
Author(s):  
Febrial Hikmah
Keyword(s):  
Blood Glucose ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk ◽  
History Of ◽  
Level 3 ◽  
And Gender ◽  
Mean Blood Glucose

Tuberculosis (TB) is a contagious infectious disease caused by the bacterium Mycobacterium tuberculosis. TB cases are still high that has attracted many researchers to conduct studies, especially the factors that cause therapy failure. TB patients who undergo therapy will be at risk of experiencing changes in carbohydrate metabolism. This is compounded by the condition of patients who have a history of diabetes mellitus (DM) before. Therefore, examination of blood glucose in TB patients is considered necessary to be a series in therapy. The increased risk was also influenced by several factors, including age and gender. The data was taken cross sectional as many as 57 samples of TB patients with various AFB positivity levels. The results obtained that 75% of TB patients included in the positive category 3 AFB, 46% aged >40 years, and 61% were male. Mean blood glucose level of 165 ± 14 mg/dL. About 19% of patients have glucose levels >200 mg/dL. Of the 19% of these patients 91% of patients were in the BTA positive category 3, 91% were aged >40 years and 73% were male. The conclusion is that there is a risk of an increase in blood glucose levels in TB patients with level 3+ AFB.

Efeitos dos Programas de Treinamento Aeróbio, de Força e Combinado na Glicose Sanguínea em Diabéticos do Tipo 2: uma Revisão Sistemática/ Effects of Aerobic, Strength and Combined Programs Training on Blood Glucose in Type 2 Diabetic: a Systematic Review.

1970 ◽  
Vol 5 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Alexandre de Souza E Silva ◽  
Maria Paula Gonçalves Mota
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Training Program ◽  
Aerobic Training ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pubmed Database

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

scholarly journals Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Musri Musman ◽  
Mauli Zakia ◽  
Ratu Fazlia Inda Rahmayani ◽  
Erlidawati Erlidawati ◽  
Safrida Safrida
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Phyllanthus Emblica ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

Searching for Utopia, the Challenge of Standardized Medical Nutrition Therapy Prescription in Gestational Diabetes Mellitus Management: A Critical Review

2021 ◽  
Author(s):  
Nina Meloncelli ◽  
Shelley A. Wilkinson ◽  
Susan de Jersey
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Lifestyle Modification ◽  
Nutrition Therapy ◽  
Medical Nutrition Therapy ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Medical Nutrition

AbstractGestational diabetes mellitus (GDM) is a common pregnancy disorder and the incidence is increasing worldwide. GDM is associated with adverse maternal outcomes which may be reduced with proper management. Lifestyle modification in the form of medical nutrition therapy and physical activity, as well as self-monitoring of blood glucose levels, is the cornerstone of GDM management. Inevitably, the search for the “ultimate” diet prescription has been ongoing. Identifying the amount and type of carbohydrate to maintain blood glucose levels below targets while balancing the nutritional requirements of pregnancy and achieving gestational weight gain within recommendations is challenging. Recent developments in the area of the gut microbiota and its impact on glycemic response add another layer of complexity to the success of medical nutrition therapy. This review critically explores the challenges to dietary prescription for GDM and why utopia may never be found.

scholarly journals Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4

2017 ◽  
Vol 85 (9) ◽  
Author(s):  
Yuko Ohara-Nemoto ◽  
Manami Nakasato ◽  
Yu Shimoyama ◽  
Tomomi T. Baba ◽  
Takeshi Kobayakawa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Dipeptidyl Peptidase ◽  
Oral Glucose ◽  
Content Type ◽  
Dipeptidyl Peptidase 4 ◽  
Glucose Levels ◽  
Flight Mass Spectrometry ◽  
Blood Glucose Levels ◽  
Molecular Events

ABSTRACT Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is involved in regulation of blood glucose levels by cleaving incretins in humans. We examined the enzymatic characteristics of DPP4 from P. gingivalis as well as two other periodontopathic bacteria, Tannerella forsythia and Prevotella intermedia, and determined whether it is capable of regulating blood glucose levels. Cell-associated DPP4 activity was found in those microorganisms, which was effectively suppressed by inhibitors of human DPP4, and molecules sized 73 kDa in P. gingivalis, and 71 kDa in T. forsythia and P. intermedia were immunologically detected. The k cat/Km values of recombinant DPP4s ranged from 721 ± 55 to 1,283 ± 23 μM−1s−1 toward Gly-Pro-4-methylcoumaryl-7-amide (MCA), while those were much lower for His-Ala-MCA. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) analysis showed His/Tyr-Ala dipeptide release from the N termini of incretins, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide, respectively, with the action of microbial DPP4. Moreover, intravenous injection of DPP4 into mice decreased plasma active GLP-1 and insulin levels, accompanied by a substantial elevation in blood glucose over the control after oral glucose administration. These results are the first to show that periodontopathic bacterial DPP4 is capable of modulating blood glucose levels the same as mammalian DPP4; thus, the incidence of periodontopathic bacteremia may exacerbate diabetes mellitus via molecular events of bacterial DPP4 activities.

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