scholarly journals Applications in Molecular Ultrasound Imaging: Present and Future

2019 ◽  
Vol 3 (3) ◽  
pp. 62
Author(s):  
Thumar, MD Vishal ◽  
Liu, MD Ji-Bin ◽  
Eisenbrey, PhD John
Keyword(s):  
Ultrasound Imaging ◽  
Molecular Ultrasound

Pharmacodynamics of Streptavidin-Coated Cyanoacrylate Microbubbles Designed for Molecular Ultrasound Imaging

2008 ◽  
Vol 43 (3) ◽  
pp. 162-169 ◽  
Author(s):  
Moritz Palmowski ◽  
Bernd Morgenstern ◽  
Peter Hauff ◽  
Michael Reinhardt ◽  
Jochen Huppert ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Molecular Ultrasound

Functional and Molecular Ultrasound Imaging: Concepts and Contrast Agents

2009 ◽  
Vol 16 (5) ◽  
pp. 627-642 ◽  
Author(s):  
F. Kiessling ◽  
J. Huppert ◽  
M. Palmowski
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Molecular Ultrasound

scholarly journals Surface-modified GVs as nanosized contrast agents for molecular ultrasound imaging of tumor

Biomaterials ◽  
2020 ◽  
Vol 236 ◽  
pp. 119803 ◽  
Author(s):  
Guohao Wang ◽  
Lin Song ◽  
Xuandi Hou ◽  
Shashwati Kala ◽  
Kin Fung Wong ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Molecular Ultrasound ◽  
Surface Modified

Molecular ultrasound imaging and its potential for paediatric radiology

2010 ◽  
Vol 41 (2) ◽  
pp. 176-184 ◽  
Author(s):  
Isabel Kiessling ◽  
Jessica Bzyl ◽  
Fabian Kiessling
Keyword(s):  
Ultrasound Imaging ◽  
Paediatric Radiology ◽  
Molecular Ultrasound

scholarly journals Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis

Circulation ◽  
2012 ◽  
Vol 125 (25) ◽  
pp. 3117-3126 ◽  
Author(s):  
Xiaowei Wang ◽  
Christoph E. Hagemeyer ◽  
Jan David Hohmann ◽  
Ephraem Leitner ◽  
Paul C. Armstrong ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Targeted Microbubbles ◽  
Molecular Ultrasound

Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles

2015 ◽  
Vol 18 (2) ◽  
pp. 180-190 ◽  
Author(s):  
Igor Spivak ◽  
Anne Rix ◽  
Georg Schmitz ◽  
Stanley Fokong ◽  
Olga Iranzo ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Low Dose ◽  
Molecular Ultrasound

PM370 Non-Invasive Molecular Ultrasound Imaging For Monitoring And Efficacy Testing Of Targeted Anti-Thrombotic Agents Using Platelet-Targeted Microbubbles

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e136
Author(s):  
Xiaowei Wang ◽  
Jan David Hohmann ◽  
Ephraem Leitner ◽  
Ingo Ahrens ◽  
Christoph Hagemeyer ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Non Invasive ◽  
Targeted Microbubbles ◽  
Molecular Ultrasound

scholarly journals Molecular Ultrasound Imaging

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1935 ◽  
Author(s):  
Gurbet Köse ◽  
Milita Darguzyte ◽  
Fabian Kiessling
Keyword(s):  
Ultrasound Imaging ◽  
Therapy Response ◽  
Radiation Force ◽  
Liver Lesion ◽  
Clinical Translation ◽  
Response Monitoring ◽  
Increased Sensitivity ◽  
Molecular Ultrasound ◽  
Target Binding

In the last decade, molecular ultrasound imaging has been rapidly progressing. It has proven promising to diagnose angiogenesis, inflammation, and thrombosis, and many intravascular targets, such as VEGFR2, integrins, and selectins, have been successfully visualized in vivo. Furthermore, pre-clinical studies demonstrated that molecular ultrasound increased sensitivity and specificity in disease detection, classification, and therapy response monitoring compared to current clinically applied ultrasound technologies. Several techniques were developed to detect target-bound microbubbles comprising sensitive particle acoustic quantification (SPAQ), destruction-replenishment analysis, and dwelling time assessment. Moreover, some groups tried to assess microbubble binding by a change in their echogenicity after target binding. These techniques can be complemented by radiation force ultrasound improving target binding by pushing microbubbles to vessel walls. Two targeted microbubble formulations are already in clinical trials for tumor detection and liver lesion characterization, and further clinical scale targeted microbubbles are prepared for clinical translation. The recent enormous progress in the field of molecular ultrasound imaging is summarized in this review article by introducing the most relevant detection technologies, concepts for targeted nano- and micro-bubbles, as well as their applications to characterize various diseases. Finally, progress in clinical translation is highlighted, and roadblocks are discussed that currently slow the clinical translation.

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