scholarly journals OBESITY IN CHILDREN AS A FACTOR OF MYOCARDIAL REMODELING

2021 ◽  
Vol 06 (01) ◽  
pp. 69-70
Author(s):  
Zhanar Nurgaliyeva Zhanar Nurgaliyeva ◽  
Shahniza Abdraimova Shahniza Abdraimova ◽  
Aliya Mahsutkhanova Aliya Mahsutkhanova ◽  
Nozima Holmirzaeva Nozima Holmirzaeva ◽  
Kamola Khanseitova Kamola Khanseitova ◽  
...  
Keyword(s):  
Risk Group ◽  
Subsequent Development ◽  
Modern Medicine ◽  
Endocrine Disorders ◽  
Keywords Children ◽  
Cardiovascular Pathology ◽  
Fasting Glycemia ◽  
Lv Remodeling ◽  
Children Obesity ◽  
Timely Treatment

The epidemic of childhood obesity with the subsequent development of metabolic syndrome (MS), cardiovascular pathology and endocrine disorders causes the need for early diagnosis and timely treatment of children of this group, which allows us to consider this pathology the most urgent problem of modern medicine. 28 (28.6%) of the examined patients showed an increase in the content of IRI in the blood serum, 5 (5.1%) had fasting glycemia, 6 (6.1%) had impaired glucose tolerance, the excess of the HOMA index was observed in 56 (57.1%), an increase in CS in 6 (6.1%), TG in 18 (18.4%). The combination of these changes includes children under the age of 10 years in the risk group for MS in 84.6 %, and in children 10 years and older; it is possible to diagnose MS in 56.9 % of cases (IDF, 2007). Аctivation of neuro-humoral mechanisms and violation of metabolic processes contributed to the development of arterial hypertension in 24 (24.5%) children, concentric LV remodeling in 18 (18.4%), concentric LV hypertrophy in 8 (8.2%) and eccentric LV hypertrophy in 7 (7.1%) children according to the results of ECHO-KG. Keywords: children, obesity, cardiovascular pathology, remodeling

The Hypothalamo–Pituitary–Adrenocortical Axis—An Overview of the Role of Glucocorticoids in the Pathophysiology of Endocrine Disorders and Perspectives for the Future

2011 ◽  
Vol 07 (01) ◽  
pp. 65
Author(s):  
Christopher D John ◽  
Julia C Buckingham ◽  
◽  
Keyword(s):  
Acute Stress ◽  
Subsequent Development ◽  
Endocrine Disorders ◽  
Adaptive Responses ◽  
Inhibitory Effects ◽  
Cellular Processes ◽  
Physiological Processes ◽  
Wear And Tear ◽  
Adaptive Processes

Glucocorticoids (GCs) are the end products of the hypothalamo–pituitary–adrenocortical axis (HPA) and, via activation of the ubiquitously expressed GC receptor, influence numerous physiological processes. GCs are also involved in the regulation of basal homeostasis as well as mediating adaptive responses to stress that act to restore homeostasis. This article discusses the various factors that are important in regulating plasma and intracellular GC concentrations and describes the genomic and non-genomic mechanisms used by GCs to influence cellular processes. We describe the concept of allostatic overload associated with chronic HPA activation and the subsequent development of tissue dysfunction and disease. While allostasis is associated with acute stress and a restoration of homeostasis, chronic stress is likely to induce allostatic overload owing to the sustained activation of adaptive processes. Increased wear and tear in GC-sensitive tissues can eventually lead to tissue dysfunction and disease. Chronic elevations in GCs can also induce dysfunction or disease associated with decreased tissue function owing to the prolonged inhibitory effects of GCs or the redistribution of metabolic resource away from physiological systems not involved in restoring homeostasis. Numerous endocrine-related disorders are associated with aberrant GC levels and in terms of pathophysiology may be linked with chronic tissue-specific alterations in GC actions.

scholarly journals MINOR CARDIAC ABNORMALITIES IN CHILDREN OF KHARKIV: PECULIARITIES OF STRUCTURE AND DISTRIBUTION

2019 ◽  
Vol 7 (4) ◽  
pp. 365-371
Author(s):  
T. A. Filonova ◽  
V. M. Savvo ◽  
Yu. V. Sorokolat
Keyword(s):  
Cardiovascular Diseases ◽  
Large Scale ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Epidemiological Studies ◽  
Modern Medicine ◽  
Primary Diagnosis ◽  
High Detection Rate ◽  
Cardiovascular Pathology ◽  
Cardiac Abnormalities

Cardiovascular pathology is one of the urgent problems of modern medicine, including children. The peculiarity of most cardiovascular diseases in children lies in their prolonged formation, tendency to chronic course, less apparent clinical manifestations in the first stages of the disease. Objective. In childhood, large-scale clinical epidemiological studies have not yet become widespread. But the available statistics allows analyzing trends and patterns that reflect the features of cardiovascular pathology in childhood, its role in health of the child population, which was the objective of this paper. Materials and methods. The analysis of medical and statistical documents of 1825 children aged 0–18 years followed up for cardiomyopathies of dysplastic genesis (DGC) in healthcare facilities of Kharkiv. The indications for following up were clinical symptoms and cardiac ultrasound findings during outpatient or inpatient examination in the absence of organic cardiovascular diseases. Results. Most often, clinical manifestation and, accordingly, diagnosis were observed from 4 to 11 years. Most minor cardiac abnormalities persist over the lifetime, and clinical significance may increase with age, contributing to the development of pathology or becoming a risk factor for cardiac pathology. Conclusions. The structure of minor cardiac abnormalities among the children of the dispensary group is heterogeneous: prolapse of the mitral valve (mostly isolated), abnormal chords of the left ventricle and open foramen ovale are most frequently recorded; prolapse of other valves and aneurysms of the atrial septum are very rare. Primary diagnosis of minor cardiac abnormalities mainly takes place at age 4 to 11 years. Summarizing the findings, it can be noted that minor cardiac abnormalities have a relatively high detection rate and constitute a large and heterogeneous dispensary monitoring group.

scholarly journals PHARMACOGNOSTIC ANALYSIS OF THE FRUITS OF MOUNTAIN ASH FOR THE PURPOSE OF SUBSEQUENT DEVELOPMENT OF MEDICINAL PRODUCTS BASED ON RAW MATERIALS

ASJ. ◽  
2021 ◽  
Vol 1 (51) ◽  
pp. 9-13
Author(s):  
E. Kozmidi E. ◽  
E. Tyutikova
Keyword(s):  
Raw Materials ◽  
Subsequent Development ◽  
Modern Medicine ◽  
Medicinal Products ◽  
Mountain Ash

In the course of studying scientific articles about the properties of the fruits of mountain ash and their use in modern medicine, it was revealed that the fruits of this plant are rarely used in the development of pharmaceuticals, although mountain ash has many useful properties.

scholarly journals Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness

2003 ◽  
Vol 182 (6) ◽  
pp. 518-524 ◽  
Author(s):  
Murat Yücel ◽  
Stephen J. Wood ◽  
Lisa J. Phillips ◽  
Geoffrey W. Stuart ◽  
Deidre J. Smith ◽  
...  
Keyword(s):  
High Risk ◽  
Anterior Cingulate Cortex ◽  
Risk Group ◽  
Subsequent Development ◽  
Cingulate Cortex ◽  
High Risk Group ◽  
Anterior Cingulate ◽  
Psychotic Illness ◽  
Ultra High Risk ◽  
Morphological Anomalies

BackgroundThe anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder.AimsTo examine whether ACC morphological anomalies are present in a group at ultra-high risk of psychosis and whether such anomalies can be used to predict the subsequent development of a psychotic illness.MethodMagnetic resonance imaging of 75 healthy volunteers and 63 people at ultra-high risk of developing a psychotic disorder (all right-handed males) was used to examine ACC sulcal and gyral features.ResultsCompared with the controls, significantly fewer people in the ultra-high risk group had a well-developed left paracingulate sulcus and significantly more had an interrupted left cingulate sulcus. There was no difference between those who did (n=21) and did not (n=42) subsequently develop a psychotic illness.ConclusionsAlthough ACC anomalies are present in young people considered to be at ultra-high risk of psychosis, they do not identify individuals who subsequently make the transition to psychosis.

Sharing Cases: The Observationes in Early Modern Medicine

2010 ◽  
Vol 15 (3) ◽  
pp. 193-236 ◽  
Author(s):  
Gianna Pomata
Keyword(s):  
Subsequent Development ◽  
Modern Medicine ◽  
Medical Writing ◽  
Academic Learning ◽  
Therapeutic Success ◽  
Core Element ◽  
Early Modern Medicine ◽  
Authorial Identity ◽  
Experienced Observer ◽  
Descriptive Knowledge

AbstractThis paper examines the rise of an epistemic genre, the Observationes, a new form of medical writing that emerged in Renaissance humanistic medicine. The Observationes (collections of case-histories) originated in the second half of the sixteenth century, grew rapidly over the course of the seventeenth, and had become a primary form of medical writing by the eighteenth century. The genre developed initially as a form of self-advertisement by court and town physicians, who stressed success in practice, over and above academic learning, as a core element of their professional identity. This unprecedented emphasis on practice as a source of knowledge remained a key feature of the Observationes in its subsequent development. As the genre evolved, the original emphasis on therapeutic success gave way to a new focus on the descriptive knowledge of disease through detailed observation. The authorial identity projected by the writers of Observationes was increasingly that of the learned and experienced observer, bent on comparing notes and sharing his cases with the fellow members of the res publica medica. This paper charts the development of the genre, examining how its growth contributed to the new epistemological value of observation in the age of the Scientific Revolution.

ERECTILE DYSFUNCTION AS A PREDICTOR AND A COMPANION OF CARDIOVASCULAR DISEASE

2021 ◽  
pp. 178-182
Author(s):  
Анна Сергеевна Смольянникова ◽  
Ирина Сергеевна Добрынина ◽  
Анна Александровна Зуйкова ◽  
Елена Анатольевна Ханина ◽  
Марина Николаевна Муравицкая
Keyword(s):  
Blood Pressure ◽  
Erectile Dysfunction ◽  
Cardiovascular Diseases ◽  
High Strength ◽  
Vascular Lesions ◽  
Control Group ◽  
Endocrine Disorders ◽  
Cardiovascular Pathology ◽  
Relationship Of ◽  
The Relationship

Эректильная дисфункция - патология, связанная не только с наличием у больного урологических, психических или эндокринных нарушений. Нарушению эректильной функции способствуют многочисленные факторы, в том числе кардиоваскулярные заболевания, к которым в частности относится атеросклеротическое поражение сосудов на фоне дислипидемии. Эректильная дисфункция часто является первым симптомом системного атеросклероза. Целью исследования является изучение связи эректильной дисфункции и уровня тестостерона крови с дислипидемией и частными проявлениями сердечно-сосудистой патологии для своевременного выявления и начала лечения латентных форм кардиоваскулярных заболеваний. Была проведена оценка соответствующих показателей у выделенных групп исследуемых: основная группа - больные, обратившиеся за помощью по поводу эректильной дисфункции, контрольная группа - относительно здоровые исследуемые, не предъявляющие жалоб на эректильную функцию. В результате оценки полученных данных между количеством баллов, набранных по тесту-опроснику МИЭФ-5, уровнем тестостерона и показателями сАД, дАД, SCORE, общего холестерина и коэффициентом атерогенности выявлены связи умеренной и высокой силы. Пациенты, обратившиеся за амбулаторной помощью по поводу эректильной дисфункции, имели высокие показатели коэффициента атерогенности, что свидетельствует о высокой вероятности атеросклеротического поражения сосудов и в дальнейшем развития сердечно-сосудистой патологии Erectile dysfunction is a pathology associated not only with the presence of urological, mental or endocrine disorders in the patient. Numerous factors contribute to the development of erectile dysfunction, including cardiovascular diseases, which in particular include atherosclerotic vascular damage on the background of dyslipidemia. Erectile dysfunction caused by arteriosclerosis of the penile arteries is often the first symptom of systemic arteriosclerosis. The aim of this research is to study the relationship of erectile dysfunction and blood testosterone levels with dyslipidemia and particular manifestations of cardiovascular pathology for the timely detection and initiation of treatment of latent forms of cardiovascular diseases. To do this, the corresponding indicators were evaluated in the selected groups of subjects: the main group - patients who sought help for erectile dysfunction, the control group-relatively healthy subjects who did not complain about their erectile function. As a result of evaluating the data obtained between the number of points scored according to the MIEF-5 test-questionnaire, the level of testosterone and indicators of systolic blood pressure, diastolic blood pressure, SCORE, total cholesterol and the coefficient of atherogenicity, moderate and high strength relationships were revealed. Patients seeking outpatient care for erectile dysfunction had high rates of atherogenic coefficient, which indicates a high probability of atherosclerotic vascular lesions and further development of cardiovascular pathology

scholarly journals NUTRITIONAL SUPPORT OF PALLIATIVE CHILDREN WITH SERIOUS NUTRIRION DEFICIT

2018 ◽  
Vol 5 (1) ◽  
pp. 27-31
Author(s):  
T. Kurilina ◽  
T. Marushko ◽  
A. Pysariev ◽  
R. Loboda ◽  
I. Shurygina ◽  
...  
Keyword(s):  
Nutritional Support ◽  
Risk Group ◽  
High Volume ◽  
High Risk Group ◽  
Z Score ◽  
Significant Delay ◽  
Keywords Children ◽  
Extreme Degree ◽  
Definition Of

NUTRITIONAL SUPPORT OF PALLIATIVE CHILDREN WITH SERIOUS NUTRIRION DEFICITT. Kurilina, T. Marushko, A. Pysariev, R. Loboda, I. Shurygina, K. Mashurenko Children with severe injury of nervous system compose high risk group on nutrition deficit. The purpose of the study is to assess the degree of nutrition deficit, calculate its actual requirement in enteric substrate and organization of adequate feeding.   Indices of Broke 2, Pine, Z-score were used for determination of nutrition insufficiency degree. Physiological and actual requirements were defined by Schofield (WН) equation.   Broke 2 index accounted for 40 %, BWI – 9.18, Z-score for BW on age – "-"6, for height on age – "-"12, for BW on height – "-3.5", which attested about extreme degree of nutritive insufficient (cachexia) and significant delay in physical development. High requirements in energy and low tolerance for necessary volume of feeding determine the administration of specialized isocaloric clinical product. Conclusion. Employment of simple standardized indices allows to determine the degree of nutrition deficit in palliative children. The definition of actual, instead physiological, requirements and administration of special clinical products permits to provide adequate nutrition in spite of low tolerance for high volume of feeding.      Keywords:   children, palliative care, nutrition’s deficit, clinical feeding, polymeric enteral products   НУТРИТИВНА ПІДТРИМКА ДІТЕЙ ПАЛІАТИВНОЇ ГРУПИ З ТЯЖКИМ НУТРИТИВНИМ ДЕФІЦИТОМКуріліна Т.В., Марушко Т.В., Писарєв А.О., Лобода Р.Н., Шуригіна І.В., Машуренко К.Ю. Діти з тяжкими ураженнями нервової системи складають групу високого ризику по нутритивному дефіциту. Мета дослідження - оцінка ступеня нутритивного дефіциту у дитини паліативної групи, розрахунок її фактичних потреб у ентеральному субстраті та організація адекватного харчування. Матеріали і методи. Для визначення ступеня нутритивної недостатності використовували індекс Брока, індекс Пін’є, Z-score. Проведено обчислення фізіологічних та фактичних енергетичних потреб за рівнянням Schofield (WН).  Результати: значення індексу Брока 2 у дитини становило 40 %, ІМТ – 9,18, Z-score для маси тіла на вік – "-"6, Z-score для росту на вік – "-"12, Z-score для маси тіла на довжину тіла – "-3,5", що свідчить про крайній ступінь нутритивної недостатності (кахексія) та значне відставання у фізичному розвитку. Високі енергетичні фактичні потреби та низька толерантність до потрібних об’ємів годування обумовили призначення спеціалізованого ізокалорійного клінічного харчування. Висновки. Застосування простих стандартизованих індексів дозволяє визначити ступінь нутритивного дефіциту у дітей паліативної групи. Визначення фактичних, замість фізіологічних потреб, а також застосування продуктів спеціалізованого клінічного харчування дозволяє забезпечити адекватне харчування, незважаючи на низьку толерантність до високих об’ємів їжі.Ключові слова: діти, паліативна допомога, нутритивний дефіцит, клінічне харчування, полімерні ентеральні субстрати  НУТРИТИВНАЯ ПОДДЕРЖКА ДЕТЕЙ ПАЛЛИАТИВНОЙ ГРУППЫ С ТЯЖЕЛЫМ НУТРИТИВНЫМ ДЕФИЦИТОМТ.В. Курилина, Т.В. Марушко, А.А. Писарев, Р.Н. Лобода, И.В. Шурыгина, Е.Ю. МашуренкоДети с тяжелыми повреждениями нервной системы составляют группу высокого риска по нутритивному дефициту. Цель исследования – оценка степени нутритивного дефицита у ребенка паллиативной группы, расчет ее фактических потребностей в энтеральном субстрате и организация адекватного вскармливания. Материал и методы. Для определения степени нутритивной недостаточности использовали индекс Брока 2, индекс Пинье, Z-score. По уравнению Schofield (WН)  определены физиологические и фактические потребности. Результаты: индекс Брока 2 составил 40 %, ИМТ – 9,18, Z-score для массы тела на возраст – "-"6, для роста на возраст – "-"12, для массы тела на рост – "-3,5", что свидетельствует о крайней степени нутритивной недостаточности (кахексия) и значительное отставание в физическом развитии. Высокие  энергетические потребности и низкая толерантность к нужным объемам кормления обусловили назначение специализированного изокалорийного клинического питания. Выводы. Использование простых стандартизированных индексов позволяет определить степень нутритивного дефицита у детей паллиативной группы. Определение фактических, вместо физиологических потребностей, а также использование специализированных продуктов клинического питания позволяет обеспечить адекватное питание, несмотря на низкую толерантность к высоким объемам питания.Ключевые слова: дети, паллиативная помощь, нутритивный дефицит, клиническое питание, полимерные энтеральные субстраты.

scholarly journals Herbal Drugs Used in Diabetes Mellitus

2019 ◽  
Vol 2 (02) ◽  
Author(s):  
Ankit Rana ◽  
Ramandeep Singh
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Diabetes Type 2 ◽  
Modern Medicine ◽  
Treatment Modalities ◽  
Endocrine Disorders ◽  
Herbal Drugs ◽  
Prevalence Of Diabetes Mellitus ◽  
Main Complication

Diabetes mellitus (DM) is the most common of the endocrine disorders. It is an important human ailment, afflicting many, from various walks of life in different countries. The prevalence of diabetes mellitus is expected to reach up to 4.4% in the world by 2030. Among all type of diabetes, type 2 diabetes is main complication. Currently available treatment option in modern medicine have several adverse effects. Therefore, there is a need to develop safe and effective treatment modalities for diabetes. Medicinal plants play an important role in the management of diabetes mellitus especially in developing countries where resources are meager. This article presents a review on some reported anti-diabetic medicinal plants

Efficacy of Herbal Medicine in Treating Metabolic and Endocrine Disorders

2021 ◽  
pp. 236-255
Author(s):  
Chittipolu Ajaykumar
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Herbal Medicine ◽  
Modern Medicine ◽  
Dosage Forms ◽  
Syndrome X ◽  
Endocrine Disorders ◽  
Evidence Based ◽  
The Metabolic Syndrome ◽  
The World

Metabolic syndrome is an interrelated cluster of pathogens such as obesity, impaired glucose tolerance, cancer, and insulin resistance leading to endocrinal disorders. In the 21st century, progression of the disease is rapid increases due to change in the lifestyle of humans having a chance to develop metabolic change, and in some cases, mutations occur, which drastically affects the endocrine functionality and subsequently causes syndrome X. In modern medicine, different medications are available but only to maintain the condition lifetime. For the complete cure, WHO focused on the traditional knowledge in 2004, using the herbal medicine to cure all metabolic aliments. According to ancient medical treatment, metabolic syndromes are completely curable. They divided the disease progression stages and formulated the different dosage forms. All the data obtained from the ancient herbal medicine treatment are not evidence-based. So, the researchers all around the world focused on the evidence-based proofs to confirm whether herbal medicine shows efficacy in curing the metabolic syndrome or not.

Vision problems in children - a review

2017 ◽  
Vol 7 (2) ◽  
pp. 80-84
Author(s):  
L Kourkouta ◽  
E Frantzana ◽  
Ch. Iliadis ◽  
P. Ouzounakis ◽  
A. Monios
Keyword(s):  
Social Inclusion ◽  
Risk Group ◽  
Early Recognition ◽  
Short Review ◽  
High Risk Group ◽  
Vision Impairment ◽  
Keywords Children ◽  
The Subject ◽  
Review Study ◽  
Visual Difficulty

<b>Introduction</b>: A vision problem is a condition which involves not only visual difficulty but also blindness. <b>Purpose</b>: The purpose of this short review study is the early recognition of vision problems in children, the proper treatment as well as their prevention. <b>Materials and methods</b>: The material of the study has been recent articles on the subject that have been found mainly in the electronic database Medline, (HEAL-Link), with the following keywords: children, vision impairment, blindness, treatment, prevention. <b>Review</b>: A high risk group of individuals that frequently presents ophthalmic severe lesions leading to blindness consists of children with prenatal and perinatal adverse effects. <b>Conclusions</b>: Education gives the opportunity of co-existence between the blind and people who are able to see. This is the path to social inclusion of individuals with vision problems. Moreover, it is estimated these two groups would have more points in common than differences between them through this experience.

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