scholarly journals Evaluation of Children with Nephrotic Syndrome: A Single- Center Experience

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Cem Alatas ◽  
Yilmaz Tabel ◽  
Ahmet Taner Elmas ◽  
Senay Zirhli Selcuk
Keyword(s):  
Nephrotic Syndrome ◽  
Single Center ◽  
Single Center Experience

scholarly journals Immunosupressive therapy in children with steroid-resistant nephrotic syndrome: single center experience

2013 ◽  
Vol 35 (3) ◽  
pp. 200-205 ◽  
Author(s):  
Catalina Velez Echeverri ◽  
Gustavo Adolfo Zuluaga Valencia ◽  
Lina Maria Serna Higuita ◽  
Ana Katherina Serrano Gayubo ◽  
Carolina Lucia Ochoa ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Single Center ◽  
Steroid Resistant ◽  
Steroid Resistant Nephrotic Syndrome ◽  
Single Center Experience ◽  
Immunosupressive Therapy

MO291RITUXIMAB IS EFFECTIVE AND SAFE IN ADULTS WITH STEROID-DEPENDENT NEPHROTIC SYNDROME: A LONG-TERM, SINGLE-CENTER EXPERIENCE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Gemma Patella ◽  
Alessandro Comi ◽  
Giuseppe Coppolino ◽  
Nicolino Comi ◽  
Giorgio Fuiano ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Case Series ◽  
Adult Patients ◽  
Single Center ◽  
Single Center Experience ◽  
Steroid Dependent ◽  
The Mean ◽  
Steroid Dependent Nephrotic Syndrome

Abstract Background and Aims Steroid-dependent nephrotic syndrome (SDNS) may require a prolonged multi-drug therapy with risk of drug toxicity and renal failure. Rituximab (RTX) treatment has been found to be helpful in reducing the steroid dosage and the need for immunosuppressants (ISs), but little data are currently available regarding very long-term outcomes in adults. We herein describe a long-term, single-center experience of RTX use in a large series of adults with SDNS. Method We studied 23 adult patients with SDNS (mean age 54.2±17.1 y; 65% male; BMI 28.5±4.7), mostly consequent to membranous (47.8%) or focal glomerulonephritis (30.2 %) who were eligible to start a RTX regimen. Before entering the RTX protocol, proteinuria and eGFR were 7.06±3.87 g/24h and 65.9±28.2 ml/min/1.73 m2, respectively; albumin and CD19/CD20 ratio were 2.9±0.9 g/L and 0.99±0.01 respectively; the mean number of ISs was 2.39±0.89 and the mean annual rate of relapses was 2.2±0.9. Results Patients were followed over a mean follow-up of 64 months (range: 12-144). After RTX (mean dose: 1202.1±372.4 mg) the rate of relapses was virtually nullified (p<0.001). eGFR remained roughly stable (62.1±19.8 ml/min/1.73 m2, p=NS), while proteinuria, albumin, CD19/CD20 and BMI all significantly improved (p ranging from 0.01 to 0.001). The mean number of additional ISs was also reduced (0.44±0.12; p<0.001) and RTX enabled discontinuation of steroids in 13/23 (56.5%) patients. No major adverse events related to therapy were recorded. Conclusion Findings from this large case-series with a remarkable very long follow-up reinforce the role of RTX as an efficient and safe weapon to improve outcomes in adult patients suffering from SDNS.

scholarly journals Mycophenolate Mofetil Treatment in Childhood Steroid-sensitive Nephrotic Syndrome: Single Center Experience

2021 ◽  
pp. 1-5
Author(s):  
Tülin GÜNGÖR ◽  
Fehime KARA EROĞLU ◽  
Evrim KARGIN ÇAKICI ◽  
Fatma YAZILITAŞ ◽  
Gökçe CAN ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Mycophenolate Mofetil ◽  
Single Center ◽  
Single Center Experience ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive

Pathological profile of biopsied Egyptian children with primary nephrotic syndrome: 15-year single center experience

2014 ◽  
Vol 27 (4) ◽  
pp. 419-423 ◽  
Author(s):  
Ashraf Bakr ◽  
Riham Eid ◽  
Amr Sarhan ◽  
Ayman Hammad ◽  
Ahmed Mahmoud El-Refaey ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Single Center ◽  
Primary Nephrotic Syndrome ◽  
Single Center Experience ◽  
Egyptian Children

scholarly journals Second-Line Immunosuppressive Treatment of Childhood Nephrotic Syndrome: A Single-Center Experience

Nephron Extra ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. 8-17 ◽  
Author(s):  
J. Kim ◽  
N. Patnaik ◽  
N. Chorny ◽  
R. Frank ◽  
L. Infante ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Immunosuppressive Treatment ◽  
Second Line ◽  
Single Center ◽  
Childhood Nephrotic Syndrome ◽  
Single Center Experience
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