scholarly journals Phospho-Tau Antibody Delivery Using Virus-Like Nanoparticles as Carriers Enhances Spatial Memory Functions in Tauopathy Model Rats

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Joseph Susheel Kumar ◽  
Vishnuvardhan ◽  
Sushmitha C ◽  
Natraj Usha ◽  
Savithri Handanahal Subbarao ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Functions ◽  
Antibody Delivery

Ten years younger: Practice of chronic aerobic exercise improves attention and spatial memory functions in ageing

2019 ◽  
Vol 117 ◽  
pp. 53-60 ◽  
Author(s):  
Carmen Noguera ◽  
Rubén Sánchez-Horcajo ◽  
Dolores Álvarez-Cazorla ◽  
José Manuel Cimadevilla
Keyword(s):  
Spatial Memory ◽  
Aerobic Exercise ◽  
Memory Functions

scholarly journals The Lacto-Tetrapeptide Gly–Thr–Trp–Tyr, β-Lactolin, Improves Spatial Memory Functions via Dopamine Release and D1 Receptor Activation in the Hippocampus

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2469 ◽  
Author(s):  
Tatsuhiro Ayabe ◽  
Yasuhisa Ano ◽  
Rena Ohya ◽  
Shiho Kitaoka ◽  
Tomoyuki Furuyashiki
Keyword(s):  
Oral Administration ◽  
Spatial Memory ◽  
Dopamine Release ◽  
Receptor Activation ◽  
D1 Receptor ◽  
The Novel ◽  
Memory Functions ◽  
Object Memory ◽  
Novel Object ◽  
Memory Enhancing

Scope: Peptides containing tryptophan–tyrosine sequences, including the lacto-tetrapeptide glycine–threonine–tryptophan–tyrosine (GTWY) and β-lactolin, from β-lactoglobulin in whey enzymatic digestion, enhance hippocampus-dependent memory functions, which are blocked by the systemic administration of dopamine D1-like antagonist. In this study, we investigated the role of the hippocampal dopaminergic system in the memory-enhancing effect of β-lactolin. Methods and Results: The results of in vivo microdialysis revealed that oral administration of β-lactolin increased the extracellular concentration of dopamine in the hippocampus and enhanced both spatial working memory, as measured in the Y-maze test, and spatial reference memory, as measured in the novel object location test. These memory-enhancing effects of β-lactolin, but not the baseline memory functions, were impaired by the knockdown of the dopamine D1 receptor subtype in the hippocampus. β-Lactolin also enhanced object memory, as measured by the novel object recognition test. However, D1 knockdown in the hippocampus spared this memory function either with or without the administration of β-lactolin. Conclusions: The present results indicate that oral administration of β-lactolin increases dopamine release and D1 receptor signaling in the hippocampus, thereby enhancing spatial memory, but it may improve object memory via a separate mechanism.

Coadministration of tramadol with aripiprazole and venlafaxine—The effect on spatial memory functions in male rats

2016 ◽  
Vol 68 (2) ◽  
pp. 451-456 ◽  
Author(s):  
Danuta Szkutnik-Fiedler ◽  
Krzysztof Kus ◽  
Piotr Ratajczak ◽  
Michał Antoniów ◽  
Elżbieta Nowakowska ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Male Rats ◽  
Memory Functions

Hippocampal-dependent spatial memory functions might be lateralized in rats: An approach combining gene expression profiling and reversible inactivation

Hippocampus ◽  
2009 ◽  
Vol 19 (9) ◽  
pp. 800-816 ◽  
Author(s):  
Sandra Klur ◽  
Christophe Muller ◽  
Anne Pereira de Vasconcelos ◽  
Theresa Ballard ◽  
Joëlle Lopez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spatial Memory ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Reversible Inactivation ◽  
Memory Functions

scholarly journals Effects of Centella asiatica L. On Spatial Memory and Bcl-2 Gene Expression in the Hippocampus of Rats Injected With Trimethyltin

2021 ◽  
pp. 141-149
Author(s):  
Sapto Yuliani ◽  
Muhammad Faishal Akbar ◽  
Nurfidho Rochmafihro ◽  
Yosi Uthary ◽  
Lasmi Deslaila
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Spatial Memory ◽  
Memory Function ◽  
Pyramidal Cells ◽  
Centella Asiatica ◽  
Normal Group ◽  
Asiatic Acid ◽  
Memory Functions ◽  
Impaired Memory

Cell death (apoptosis) in the hippocampus is related to impaired memory functions. Gotu kola (Centella asiatica) contains asiatic acid and asiaticoside, which act as antioxidants and improve memory function. This study was intended to determine the effects of gotu kola extracts on Bcl-2 gene expression and spatial memory in rats with impaired memory functions due to trimethyltin (TMT) injection. The rats were subdivided into six groups, each group consisting of 10. The normal group was given sodium carboxymethyl cellulose (CMC-Na); the TMT group was given CMC-Na; the positive group was given 200 mg/kg bw citicoline; the extract groups were given a variation of gotu kola extract at 100 (P100), 200 (P200), and 400 mg/kg bw (P400) doses, respectively. These treatments were conducted for 35 days. TMT was injected intraperitoneally on Day 8 of treatment at a dose of 8 mg/kg bw in all groups except the normal group. On Days 29-35, the Morris water maze (MWM) spatial memory test was conducted. The rats were sacrificed, and their hippocampi were taken for immunohistochemical observation of Bcl-2 gene expression. The results showed TMT injection could lower the spatial memory of rats in the MWM and cause apoptosis of the pyramidal cells of the hippocampus. Gotu kola extract at 100, 200 and 400 mg/kg bw could increase the percentage of time spent (duration) and frequency of rats staying in the target quadrant in the probe trial of the MWM and increase Bcl-2 gene expression in the pyramidal cells of the hippocampus. Overall, the results have confirmed that gotu kola extract has the potential to prevent hippocampal cell death and improve the spatial memory of rats injected by TMT.

scholarly journals Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1βAxis in Microglia

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Da-ming Sui ◽  
Qun Xie ◽  
Wen-jing Yi ◽  
Sahil Gupta ◽  
Xi-ya Yu ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Water Maze ◽  
Microglial Activation ◽  
Cecal Ligation ◽  
Brain Dysfunction ◽  
Tunel Assay ◽  
Sirtuin 1 ◽  
Memory Functions ◽  
Nlrp3 Expression

Sepsis-associated encephalopathy (SAE) is characterized as brain dysfunction associated with sepsis. In this study we sought to investigate the effects of resveratrol in mice with SAE, as well as its effects in NLRP3 inflammasome and IL-1β, which were critical in the pathogenesis of SAE. SAE was induced in mice via cecal ligation and puncture (CLP), and resveratrol was administered at two doses after surgery. Spatial learning memory functions were evaluated by Morris water maze testing. Apoptosis in the hippocampus was quantified using TUNEL assay. Inflammation in the hippocampus was quantified by measuring the levels of microglial activation, NLRP3, and IL-1β. CLP mice treated with resveratrol demonstrated a better spatial memory during water maze training. The TUNEL assay demonstrated significantly attenuated rates of apoptosis, in resveratrol treated mice, while decreasing the number of iba-1 positive microglia in the hippocampus region. NLRP3 expression and IL-1βcleavage were well inhibited by resveratrol dose-dependently. Thein vitroresults showed that in the BV2 cell lines resveratrol prevents ATP induced NLRP3 activation and IL-1βcleavage, which were reversed by the sirtuin 1 inhibitor, nicotinamide. In conclusion, resveratrol improves the spatial memory in mice with SAE and inhibits the NLRP3/IL-1βaxis in the microglia.

scholarly journals The effects of intensity and duration of aerobic exercise on spatial memory function in male Wistar rats

2019 ◽  
Vol 28 (3) ◽  
pp. 223-7
Author(s):  
Neng Tine Kartinah ◽  
Sophie Yolanda ◽  
Tahyatul Bariroh
Keyword(s):  
Spatial Memory ◽  
Aerobic Exercise ◽  
High Intensity ◽  
Wistar Rats ◽  
Memory Function ◽  
Exercise Group ◽  
Memory Functions ◽  
Low Intensity ◽  
Long Duration ◽  
Male Wistar Rats

BACKGROUND Memory is a vital function of the brain. Aerobic exercise has a positive effect on memory’s function, but the appropriate combination of intensity and duration of aerobic exercise is still unknown. This study was aimed to investigate the effect of optimum combinations of intensity and duration of aerobic exercise on spatial memory function.  METHODS In this study, the authors performed in vivo experiment using 20 male Wistar rats (6-month-old). They were randomly divided into four groups: (1) low-intensity and short duration aerobic exercise group (L–S); (2) low-intensity and long duration aerobic exercise group (L–L); (3) high-intensity and short duration aerobic exercise group (H– S); and (4) high-intensity and long duration aerobic exercise group (H–L). The aerobic exercise treatment of each group was conducted for three weeks with a frequency of five days a week. The memory function was assessed with the help of water-E-maze on week 0, 1, 2, and 3 (a total of four times).  RESULTS This study indicates that the central nervous system responds to aerobic exercise as an external stimulus differently depending on the combinations of intensity and duration. Moreover, this study demonstrates that changes in memory functions are best observed in the group with low-intensity and long duration aerobic exercise.  CONCLUSIONS The combination of low-intensity and long duration of aerobic exercise for animal study can improve spatial memory functions better than any other combinations of intensity and duration of aerobic exercises in male Wistar rats.

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