scholarly journals Is there a Change in Clinical Practice in the Imaging of Thoraco-Lumbar Vertebral Injuries? - A Shift in Paradigm to CT Imaging as an Interim Measure

Author(s):  
Chowdhury Debkumar
2005 ◽  
Vol 44 (S 01) ◽  
pp. S58-S60 ◽  
Author(s):  
W. Mohnike

Summary:PET is being considered a diagnostic commodity in clinical practice worldwide and thus receives increasing attention by health insurances and governmental organizations. In Germany, however, neither PET nor PET/CT are subject to reimbursement. This renders clinical PET and PET/CT imaging a challenge both in a general hospital environment and in private practice. This article describes briefly these challenges, which are not solely related to turf battles and associated costs.


2020 ◽  
Vol 38 (29_suppl) ◽  
pp. 268-268
Author(s):  
Brandon Chan ◽  
David Cameron ◽  
Aria Shokoohi ◽  
Dean Regier ◽  
Howard John Lim ◽  
...  

268 Background: Regulatory and Health Technology Assessment (HTA) agencies are increasingly using real world data (RWD) to support real world evidence (RWE), but the readiness of healthcare systems to reliably generate RWE is unknown. As a quality assurance measure we examined the preparedness of a single payer system to provide RWE by evaluating the frequency of CT imaging during standard first line metastatic systemic treatment of breast, colorectal (CRC) and lung cancer. Methods: A 1-year cohort of de novo metastatic breast, CRC, lung cancer patients treated with first line systemic therapy (excluding hormone therapy) referred to BC Cancer in 2016 was retrospectively reviewed. Duration of first line treatment was calculated from first to last dose of therapy. Baseline CT included imaging within 8 weeks prior to and 3 weeks after treatment initiation (first cycle). Last CT included imaging up to 8 weeks after the last dose of therapy. Results: A cohort of 675 patients was identified from the BC Cancer Registry. The distribution of de novo metastatic disease at diagnosis was lung (n = 379), CRC (n = 214) followed by breast cancer (n = 82). Conclusions: In our publicly funded health care system, baseline CT scans within 4 weeks prior to treatment ranged from 57-72%. The median CT imaging interval during first line metastatic treatment was ranged from 7.9-11.3 weeks. RWD from routine clinical practice differs significantly from clinical trials, the gold standard for regulatory and HTA assessments. Population-based data may contribute to RWE with caution due to limitations imposed by clinical practice. [Table: see text]


2018 ◽  
Vol 3 (3) ◽  
pp. 2473011418S0026
Author(s):  
Lucky Jeyaseelan ◽  
Nicholas Cullen ◽  
Andrew Goldberg ◽  
Matthew Welck

Category: Hindfoot Introduction/Purpose: Tibiotalocalcaneal (TTC) arthrodesis using a hindfoot intramedullary nail has been shown to be a safe and reliable technique in patients with severe ankle and hindfoot disease. There is debate about the use of straight nails versus curved nails. Proponents of the curved nail argue that straight nails predispose to greater risk of lateral plantar nerve injury, poor calcaneal bone purchase and inability to maintain satisfactory hindfoot valgus alignment. However, the subtalar joint is a condyloid joint enabling rotation of the talus on the calcaneum to create varus/valgus position of the calcaneal tuberosity. We present a clinical series of patients undergoing TTC fusion using a straight nail assessed by clinical and radiological outcomes to establish whether theoretical risks of straight nails are reflected in clinical practice. Methods: This single centre, retrospective study of prospectively collected data on a sequential series of patients to undergo TTC fusion, with pre and post-operative weight bearing CT imaging. Data was collected on indication for procedure, co-morbidities, post-operative complications, union rate as well as clinical scores, EQ5D and MOXFQ. Weight bearing CT imaging was analysed using the validated TALUS™ (torque ankle lever arm system) method on weight bearing CT, providing calcaneal offset, hindfoot angle and hindfoot alignment. These were used as markers of hindfoot alignment. Results: 65 patients (37 males, 28 females) were included in the study, with an average age of 57 years. Average follow-up was 20 months. Indications for TTC fusion included Charcot arthropathy, talar avascular necrosis, post traumatic arthritis and non-union of previous arthrodeses. Union rate was 91% (59/65). Overall complication rate was 11% (7/65) and most were minor wound complications. There were no plantar nerve injuries noted. There were no nail cut outs from the calcaneum. On all markers of hindfoot alignment, cases showed a more physiological degree of hindfoot valgus compared to pre-operative measures. There were significant improvement in both EQ5D and MOXFQ scores (p<0.05). Conclusion: We present the largest series of TTC fusion using a straight intramedullary nail and the first series to analyse hindfoot alignment using weight bearing 3D CT imaging. Our data regarding correction of hindfoot alignment is supported by biomechanical theories of subtalar varus/valgus, being related to rotatory changes at the subtalar joint, questioning the perceived need for a curved nail. This is particularly at the level of the entry point of the nail. The principles of valgus hindfoot nails are based on biomechanical laboratory studies and cadaveric studies, neither of which reflect our findings in clinical practice.


2006 ◽  
Vol 27 (12) ◽  
pp. 977-987 ◽  
Author(s):  
Paul J. Roach ◽  
Geoffrey P. Schembri ◽  
Ivan A. Ho Shon ◽  
Elizabeth A. Bailey ◽  
Dale L. Bailey

Author(s):  
Else A. Aalbersberg ◽  
Martine M. Geluk-Jonker ◽  
Thirumaraichelvi Young-Mylvaganan ◽  
Linda J. de Wit-van der Veen ◽  
Marcel P. M. Stokkel

2017 ◽  
Author(s):  
◽  
D. E. Rodríguez-Obregón

A method to estimate the pulmonary fibrosis in computed tomography (CT) imaging is presented. A semi-automatic segmentation algorithm based on the Chan-Vese method was used. The proposed method shows a similar fibrosis region with respect to clinical expert. However, the results need to be validated in a bigger data base. The proposed method approximates a fibrosis percentage that allows to achieve this procedure easily in order to support its implementation in the clinical practice minimizing the clinical expert subjectivity and generating a quantitativeestimation of fibrosis region.


2020 ◽  
Vol 21 (12) ◽  
pp. 1320-1330
Author(s):  
Riemer H J A Slart ◽  
Andor W J M Glaudemans ◽  
Olivier Gheysens ◽  
Mark Lubberink ◽  
Tanja Kero ◽  
...  

Abstract With this summarized document we share the standard for positron emission tomography (PET)/(diagnostic)computed tomography (CT) imaging procedures in cardiovascular diseases that are inflammatory, infective, infiltrative, or associated with dysfunctional innervation (4Is) as recently published in the European Journal of Nuclear Medicine and Molecular Imaging. This standard should be applied in clinical practice and integrated in clinical (multicentre) trials for optimal standardization of the procedurals and interpretations. A major focus is put on procedures using [18F]-2-fluoro-2-deoxyglucose ([18F]FDG), but 4Is PET radiopharmaceuticals beyond [18F]FDG are also described in this summarized document. Whilst these novel tracers are currently mainly applied in early clinical trials, some multicentre trials are underway and we foresee in the near future their use in clinical care and inclusion in the clinical guidelines. Diagnosis and management of 4Is related cardiovascular diseases are generally complex and often require a multidisciplinary approach by a team of experts. The new standards described herein should be applied when using PET/CT and PET/magnetic resonance, within a multimodality imaging framework both in clinical practice and in clinical trials for 4Is cardiovascular indications.


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