The Complete Blood Count Modified Results in Patients with Complicated Colorectal Cancer

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Constantin Georgiana Bianca ◽  
Firescu D ◽  
Voicu D ◽  
Șerban Cristina ◽  
Rebegea Laura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Blood Count ◽  
Complete Blood Count

scholarly journals Early Colorectal Cancer Detected by Machine Learning Model Using Gender, Age, and Complete Blood Count Data

2017 ◽  
Vol 62 (10) ◽  
pp. 2719-2727 ◽  
Author(s):  
Mark C. Hornbrook ◽  
Ran Goshen ◽  
Eran Choman ◽  
Maureen O’Keeffe-Rosetti ◽  
Yaron Kinar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Machine Learning ◽  
Count Data ◽  
Blood Count ◽  
Complete Blood Count ◽  
Learning Model ◽  
Early Colorectal Cancer ◽  
Machine Learning Model

scholarly journals P-032 A complete blood count as a prognostic marker in patients with metastatic colorectal cancer (mCRC)

2016 ◽  
Vol 27 ◽  
pp. ii9
Author(s):  
M. Krakowska ◽  
S. Debska-Szmich ◽  
U. Czernek ◽  
R. Czyzykowski ◽  
P. Potemski
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Prognostic Marker ◽  
Blood Count ◽  
Complete Blood Count

scholarly journals P13: THE EFFECT OF PEGFILGRASTIM ON COMPLETE BLOOD COUNT IN COLORECTAL CANCER PATIENTS TREATED WITH FOLFOX OR FOLFIRI CHEMOTHERAPY

2016 ◽  
Vol 64 (3) ◽  
pp. 822.2-822
Author(s):  
V Kremer ◽  
I Shapira ◽  
A Leaf
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Blood Count ◽  
Complete Blood Count ◽  
Phase Iii ◽  
Hematopoietic Stem ◽  
Platelet Counts ◽  
Leukocyte Counts ◽  
The Mean ◽  
Colorectal Cancer Patients

Purpose of StudyIn both FOLFOX and FOLFIRI regimens used for colorectal cancer, the 5-FU is infused over 46 hours every 14 days. Given the 10–20% risk of neutropenic fever, these regimens may be given with pegfilgrastim support. There is evidence to support its use for 21 day cycles, but no phase III trials demonstrating its efficacy and safety for regimens given every 14 days, a potential concern, given the hypothesis that the hematopoietic stem cells mobilized by pegfilgrastim into the peripheral blood may undergo cell cycle arrest, apoptosis and death while under effect of chemotherapy. Pegfilgrastim regulates the proliferation, differentiation, and survival of the myeloid lineage. It mobilizes hematopoietic progenitor cells in the peripheral circulation, has a long half-life, and is given on day 4 of 14-day infusional 5-FU based regimens. Given the fact that cytotoxic chemotherapy is administered on day 11 after pegfilgrastim, we performed a retrospective study evaluating the correlation between decrease in complete blood count and chemotherapy administered at 11 day intervals after pegfilgrastim.Methods UsedThe medical records of colorectal cancer patients were reviewed from 2003–2013. Data collected included age, stage, ethnicity, complete blood count, chemotherapy, and use of pegfilgrastim.Summary of ResultsData from 50 eligible charts was collected. Twenty one patients were treated with chemotherapy and pegfilgrastim, 29 patients had chemotherapy alone. Prior to chemotherapy, both groups had a mean leukocyte count of 6.6×109/L and 6.8×109/L and a mean platelet count of 313,000/mm3 and 255,000/mm3 respectively. At 9 months mean leukocyte counts were 6.3×109/L and 5.4×109/L and the mean platelet counts were 186,000/mm3 and 170,000/mm3 respectively. At 24 months, the mean leukocyte counts were 6.7×109/L and 5.7×109/L and the mean platelet counts were 220,000/mm3 and 196,000 mm3 respectively.ConclusionsWhen given on day 4 of a 14 day cycle, there was no effect of pegfilgrastim on complete blood counts in this small retrospective cohort study; finding a more subtle effect would require a larger sample size.

scholarly journals Correction to: Early Colorectal Cancer Detected by Machine Learning Model Using Gender, Age, and Complete Blood Count Data

2017 ◽  
Vol 63 (1) ◽  
pp. 270-270 ◽  
Author(s):  
Mark C. Hornbrook ◽  
Ran Goshen ◽  
Eran Choman ◽  
Maureen O’Keeffe-Rosetti ◽  
Yaron Kinar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Machine Learning ◽  
Count Data ◽  
Blood Count ◽  
Complete Blood Count ◽  
Learning Model ◽  
Early Colorectal Cancer ◽  
Machine Learning Model
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