scholarly journals Evaluation of Sequential Organ Failure Assessment (SOFA) Performance in Neurocritical Care Patients Overtime: A Retrospective Cohort Study

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Brito Mariana Rabelo de ◽  
Barros Alexandre Guimarães de Almeida ◽  
Valler Lenise ◽  
Cardoso Fabricio Buchdid ◽  
Gasparotto Ana Paula Devite Cardoso ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sequential Organ Failure Assessment ◽  
Organ Failure ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Neurocritical Care ◽  
Failure Assessment

Evaluation of a novel prognostic score based on thrombosis and inflammation in patients with sepsis: a retrospective cohort study

2018 ◽  
Vol 56 (7) ◽  
pp. 1182-1192 ◽  
Author(s):  
Dongze Li ◽  
Yaxiong Zhou ◽  
Jing Yu ◽  
Haifang Yu ◽  
Yiqin Xia ◽  
...  
Keyword(s):  
Emergency Department ◽  
Logistic Regression ◽  
Cohort Study ◽  
Sequential Organ Failure Assessment ◽  
Organ Failure ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Prognostic Score ◽  
Adverse Outcomes ◽  
Failure Assessment

Abstract Background: Inflammation and thrombosis are involved in the development and progression of sepsis. A novel thrombo-inflammatory prognostic score (TIPS), based on both an inflammatory and a thrombus biomarker, was assessed for its ability to predict adverse outcomes of sepsis patients in the emergency department (ED). Methods: This was a retrospective cohort study of sepsis patients. TIPS (range: 0–2) was predictive of adverse outcomes. Multivariable logistic regression analyses were performed to investigate the associations between TIPS and 28-day adverse outcomes. The study end points were mortality, mechanical ventilation (MV), consciousness disorder (CD) and admission to the intensive care unit (AICU). Results: In total, 821 sepsis patients were enrolled; 173 patients died within the 28-day follow-up period. Procalcitonin and D-dimer values were used to calculate TIPS because they had the best performance in the prediction of 28-day mortality by receiver operating characteristic curves. The 28-day mortality and the incidence of MV, CD and AICU were significantly higher in patients with higher TIPS. Multivariable logistic regression analysis indicated TIPS was an independent predictor of 28-day mortality, MV and AICU. TIPS performed better than other prognostic scores, including quick sequential organ failure assessment, Modified Early Warning Score and Mortality in Emergency Department Sepsis Score for predicting 28-day mortality, and similar to the Acute Physiology and Chronic Health Evaluation II, but inferior to sequential organ failure assessment. Conclusions: TIPS is useful for stratifying the risk of adverse clinical outcomes in sepsis patients shortly after admission to the ED.

Evaluation of qSOFA as a Predictor of Mortality Among ICU Patients With Positive Clinical Cultures—A Retrospective Cohort Study

2019 ◽  
Vol 35 (11) ◽  
pp. 1278-1284
Author(s):  
Barry Kelly ◽  
Johann Patlak ◽  
Shahzad Shaefi ◽  
Dustin Boone ◽  
Ariel Mueller ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Hospital Mortality ◽  
Sequential Organ Failure Assessment ◽  
Organ Failure ◽  
Retrospective Cohort ◽  
Primary Outcome ◽  
Assessment Score ◽  
Failure Assessment ◽  
Discriminative Value

Objective: To compare the discriminative value of the quick-sequential organ failure assessment score (qSOFA) to SOFA in a critically ill population, in which a microbial pathogen was isolated within 48 hours of admission to intensive care. Design: Retrospective cohort study. Setting: Academic tertiary referral center from July 2008 to June 2017. Patients: Hospitalized patients admitted to intensive care unit. Interventions: None. Measurements and Main Results: The primary outcome was in-hospital mortality for all patients with confirmed positive microbiological cultures within 48 hours of admission to intensive care unit (ICU). Subgroup analysis was performed on patients with pathogenic bacteremia or positive cultures in cerebrospinal fluid. Of the 11 415 patients analyzed with positive microbiology specimens within 48 hours of admission, 2933 (25.7%) had a qSOFA ≥2. Of these, 16.6% reached the primary outcome of in-hospital mortality. Unsurprisingly, the discriminative value of qSOFA on admission was significantly worse than that of SOFA (0.73 vs 0.76; P = .0004), despite observing a significant association between qSOFA category and in-hospital mortality ( P < .0001). In secondary analyses, similar observations were found using qSOFA within 6 and 24 hours of ICU admission. When analysis was focused on patients with pathogenic bacteremia or positive cerebrospinal fluid (CSF) cultures (n = 1646), there was no significant difference between the discriminative value of qSOFA and SOFA (0.75 vs 0.78; P = .17). Conclusions: Quick-sequential organ failure assessment score at admission was not superior to SOFA in predicting in-hospital mortality in patients with positive clinical cultures within 48 hours of admission to ICU. Quick-sequential organ failure assessment score at admission to the ICU was associated with mortality and showed reasonable calibration and discrimination. When the analysis was focused on patients with pathogenic bacteremia or positive CSF cultures, qSOFA performed similarly to SOFA in discriminatory those who will die from sepsis.

scholarly journals Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study

Critical Care ◽  
2011 ◽  
Vol 15 (1) ◽  
pp. R74 ◽  
Author(s):  
Marius J Terblanche ◽  
Ruxandra Pinto ◽  
Craig Whiteley ◽  
Stephen Brett ◽  
Richard Beale ◽  
...  
Keyword(s):  
Cohort Study ◽  
Organ Failure ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Single Centre ◽  
Icu Patients
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