scholarly journals Perinatal Administration of Caffeine in Mice Affects the Spatial Memory and Motor Coordination Later in Adult Life

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
A Alsayed ◽  
M Jamal ◽  
N Al Hoty ◽  
S Eqab ◽  
N Ahmadi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Motor Coordination ◽  
Adult Life

Perinatal administration of caffeine in mice affects the cognition and spatial memory later in adult life

2016 ◽  
Vol 26 ◽  
pp. S340
Author(s):  
A. Alsayed ◽  
M. Jamal ◽  
N. Al Hoty ◽  
S. Eqab ◽  
N. Ahmadi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Adult Life

scholarly journals Galvanic Vestibular Stimulation Improves Spatial Cognition After Unilateral Labyrinthectomy in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Thanh Tin Nguyen ◽  
Gi-Sung Nam ◽  
Jin-Ju Kang ◽  
Gyu Cheol Han ◽  
Ji-Soo Kim ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Spatial Cognition ◽  
Motor Coordination ◽  
Spatial Working Memory ◽  
Vestibular Stimulation ◽  
Galvanic Vestibular Stimulation ◽  
Control Group ◽  
Y Maze ◽  
Unilateral Labyrinthectomy

Objectives: To investigate the deficits of spatial memory and navigation from unilateral vestibular deafferentation (UVD) and to determine the efficacy of galvanic vestibular stimulation (GVS) for recovery from these deficits using a mouse model of unilateral labyrinthectomy (UL).Methods: Thirty-six male C57BL/6 mice were allocated into three groups that comprise a control group and two experimental groups, UVD with (GVS group) and without GVS intervention (non-GVS group). In the experimental groups, we assessed the locomotor and cognitive behavioral function before (baseline) and 3, 7, and 14 days after surgical UL, using the open field (OF), Y maze, and Morris water maze (MWM) tests. In the GVS group, the stimulations were applied for 30 min daily from postoperative day (POD) 0–4 via the electrodes inserted subcutaneously close to both bony labyrinths.Results: Locomotion and spatial cognition were significantly impaired in the mice with UVD non-GVS group compared to the control group. GVS significantly accelerated recovery of locomotion compared to the control and non-GVS groups on PODs 3 (p < 0.001) and 7 (p < 0.05, Kruskal–Wallis and Mann–Whitney U tests) in the OF and Y maze tests. The mice in the GVS group were better in spatial working memory assessed with spontaneous alternation performance and spatial reference memory assessed with place recognition during the Y maze test than those in the non-GVS group on POD 3 (p < 0.001). In addition, the recovery of long-term spatial navigation deficits during the MWM, as indicated by the escape latency and the probe trial, was significantly better in the GVS group than in the non-GVS group 2 weeks after UVD (p < 0.01).Conclusions: UVD impairs spatial memory, navigation, and motor coordination. GVS accelerated recoveries in short- and long-term spatial memory and navigation, as well as locomotor function in mice with UVD, and may be applied to the patients with acute unilateral vestibular failure.

scholarly journals Dicer Deletion in Astrocytes Inhibits Oligodendroglial Differentiation and Myelination

2021 ◽  
Author(s):  
Kun Liu ◽  
Bin Yu ◽  
Jing-Fei Chen ◽  
Rui-Xue Li ◽  
Lin Chen ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Spatial Memory ◽  
Knockout Mice ◽  
Motor Coordination ◽  
Conditional Knockout ◽  
Tamoxifen Treatment ◽  
Mouse Line ◽  
Reporter Mouse ◽  
Underlying Mechanisms ◽  
Old Mice

AbstractIncreasing evidence has shown that astrocytes are implicated in regulating oligodendrocyte myelination, but the underlying mechanisms remain largely unknown. To understand whether microRNAs in astrocytes function in regulating oligodendroglial differentiation and myelination in the developing and adult CNS, we generated inducible astrocyte-specific Dicer conditional knockout mice (hGFAP-CreERT; Dicer fl/fl). By using a reporter mouse line (mT/mG), we confirmed that hGFAP-CreERT drives an efficient and astrocyte-specific recombination in the developing CNS, upon tamoxifen treatment from postnatal day 3 (P3) to P7. The Dicer deletion in astrocytes resulted in inhibited oligodendroglial differentiation and myelination in the developing CNS of Dicer cKO mice at P10 and P14, and did not alter the densities of neurons or axons, indicating that Dicer in astrocytes is required for oligodendrocyte myelination. Consequently, the Dicer deletion in astrocytes at P3 resulted in impaired spatial memory and motor coordination at the age of 9 weeks. To understand whether Dicer in astrocytes is also required for remyelination, we induced Dicer deletion in 3-month-old mice and then injected lysolecithin into the corpus callosum to induce demyelination. The Dicer deletion in astrocytes blocked remyelination in the corpus callosum 14 days after induced demyelination. Together, our results indicate that Dicer in astrocytes is required for oligodendroglia myelination in both the developing and adult CNS.

scholarly journals Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice

2013 ◽  
Vol 99 ◽  
pp. 32-37 ◽  
Author(s):  
Charlotte M. Wincott ◽  
Seonil Kim ◽  
Roseann F. Titcombe ◽  
David S. Tukey ◽  
Hiwot K. Girma ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Spatial Memory ◽  
Motor Coordination ◽  
Memory Deficits ◽  
Type Ii ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Deficient Mice

Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats

2007 ◽  
Vol 185 (4) ◽  
pp. 595-601 ◽  
Author(s):  
Nicola Simola ◽  
Diego Bustamante ◽  
Annalisa Pinna ◽  
Silvia Pontis ◽  
Paola Morales ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Adult Male ◽  
Motor Coordination ◽  
Perinatal Asphyxia ◽  
Male Rats

Early exercise promotes positive hippocampal plasticity and improves spatial memory in the adult life of rats

Hippocampus ◽  
2010 ◽  
Vol 22 (2) ◽  
pp. 347-358 ◽  
Author(s):  
Sérgio Gomes da Silva ◽  
Nicolas Unsain ◽  
Daniel Hugo Mascó ◽  
Michelle Toscano-Silva ◽  
Henrique Alves de Amorim ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Adult Life ◽  
Hippocampal Plasticity ◽  
Early Exercise

Effect of gabapentin on cognitive processes in rats not exposed and exposed to tobacco smoke during fetal life

2008 ◽  
Vol 27 (12) ◽  
pp. 883-894 ◽  
Author(s):  
A Czubak ◽  
E Nowakowska ◽  
K Kus ◽  
C Sadowski ◽  
A Matschay
Keyword(s):  
Spatial Memory ◽  
Cognitive Deficits ◽  
Tobacco Smoke ◽  
Motor Coordination ◽  
Significant Risk ◽  
Antidepressant Effect ◽  
Anticonvulsant Effect ◽  
Fetal Life ◽  
Memory Processes ◽  
Immobility Time

Cognitive deficits, including memory deficiencies, are currently deemed one of key symptoms of psychopathologic mental disorders or epilepsy. The impairment of neurocognitive processes could be due to the administered therapy, in particular combined therapy or therapy using antiepileptics of older type. Gabapentin (GBP) is one of new antiepileptics with normothymic properties. It is known that epileptic patients run a significant risk of developing depression and mood changes. Smoking may also have a negative effect on memory processes and efficacy of administered drugs. Note that smoking in pregnant women also leads to neurobehavioral changes in their children. The objective of our research was to evaluate the effect of GBP on memory functions and antidepressant effect in rats not exposed and exposed to tobacco smoke in fetal life. We were also intent on finding whether GBP has an anticonvulsant effect in contact and without contact with tobacco smoke, and whether it affects motor coordination in animals if administered in the dose of 25 mg/kg. Spatial memory of the animals was assessed in the Morris test and the antidepressant effect in the Porsolt test. The ED50 value was determined in the Swinyard maximum electric shock test, and the effect on motor coordination was assessed in the chimney test. GBP administered in the dose of 25 mg/kg intraperitoneal (i.p.) significantly reduced the immobility time on days 1 and 7 of the test in animals exposed to tobacco smoke, and on days 7 and 14 of the test in rats not exposed to tobacco smoke. Upon single and multiple administration of GBP to animals not exposed to tobacco smoke, the spatial memory improved, whereas in animals exposed to tobacco smoke in fetal life tolerance for procognitive effect was observed on day 21 of the test. It has been found that in rats not exposed to tobacco smoke, ED50 of GBP was 28.73 mg/kg, whereas in animals exposed to tobacco smoke in fetal life, ED50 was 46.2 mg/kg. Upon 14 and 21 days of drug administration, motor coordination was impaired in both GBP receiving animal groups. In conclusion, GBP beside its anticonvulsant efficacy also improves memory processes and has antidepressant effect. We also proved that GBP may reverse cognitive deficits concerning working memory induced by prenatal exposure to tobacco smoke and may have antidepressant effect in rats exposed to tobacco smoke.

Wechsler Memory Scale, Rivermead Behavioral Memory Test, and Everyday Memory Questionnaire in Healthy Adults and Alzheimer Patients

2002 ◽  
Vol 18 (1) ◽  
pp. 63-77 ◽  
Author(s):  
Anastasia Efklides ◽  
Efterpi Yiultsi ◽  
Theopisti Kangellidou ◽  
Fotini Kounti ◽  
Fotini Dina ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Semantic Memory ◽  
Memory Test ◽  
Healthy Adults ◽  
Gender Effects ◽  
Everyday Memory ◽  
Wechsler Memory Scale ◽  
Everyday Memory Questionnaire ◽  
Behavioral Memory ◽  
Memory Questionnaire

Summary: The Wechsler Memory Scale (WMS) is a laboratory-based memory test that has been criticized for its lack of ecological validity and for not testing long-term memory. A more recent memory test, which aims at testing everyday memory, is the Rivermead Behavioral Memory Test (RBMT); it tests prospective memory and other forms of memory not tapped by WMS. However, even this test does not capture all aspects of everyday memory problems often reported by adults. These problems are the object of the Everyday Memory Questionnaire (EMQ). This study aimed at identifying the relationships between these three memory tests. The differential effect of Alzheimer's disease (AD) on the above relationships was also studied. The sample consisted of 233 healthy adults (20 to 75+ years of age) and 39 AD patients (50 to 75 years of age). Confirmatory factor analysis revealed the following latent factors: Verbal Memory, Visual Reconstruction, Orientation, Message (action embedded in spatial context), Visual Recognition, Spatial Memory, New Learning/Association Forming, Prospective/Episodic Memory, and Metamemory. These first-order factors were further explained by two second-order factors: Semantic Memory and Coordination of Semantic and Visuo-Spatial Memory. This basic structure was preserved in the sample of AD patients, although AD patients performed less well on the WMS and the RBMT. Some interesting findings regarding semantic memory, face recognition, and metamemory in AD patients are also reported. Age, education, but no gender effects on memory performance were also detected.

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