scholarly journals The Impact of School Feeding Programmes in Reducing Iron Deficiency Anaemia among Primary School Children in Developing Countries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Yussif Mustapha Titi ◽  
Vong Lenin ◽  
Pilkington Karen
Keyword(s):  
Systematic Review ◽  
Developing Countries ◽  
Iron Deficiency Anaemia ◽  
Meta Analysis ◽  
Primary School Children ◽  
Controlled Trials ◽  
Deficiency Anaemia ◽  
Randomized Controlled ◽  
School Feeding ◽  
The Impact

scholarly journals The Impact of School Feeding Programmes in Reducing Iron Deficiency Anaemia among Primary School Children in Developing Countries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yussif MT ◽  
Vong L ◽  
Pilkington K
Keyword(s):  
Developing Countries ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Primary School Children ◽  
School Age Children ◽  
School Age ◽  
Micronutrient Deficiencies ◽  
Deficiency Anaemia ◽  
School Feeding ◽  
The Impact

Context: Children in developing countries may survive the critical stage of the first 1000 days of life but may still carry unresolved micronutrient deficiencies into school age. Iron deficiency anaemia is the commonest form of micronutrient deficiency which affects school age children. School feeding programmes may provide an opportunity to reduce the micronutrient deficiencies in the light of limited nutrition interventions that target school age children in developing countries.

Risk of hematological toxicities and febrile neutropenia in patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with CDK 4/6 inhibitors: A systematic review and meta-analysis of randomized controlled trials.

2017 ◽  
Vol 35 (31_suppl) ◽  
pp. 207-207
Author(s):  
Myo Zaw ◽  
Kyaw Zin Thein ◽  
Aung Tun ◽  
Myat M. Han ◽  
Saba Radhi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Febrile Neutropenia ◽  
Randomized Controlled Trials ◽  
Financial Burden ◽  
Meta Analysis ◽  
Neutropenic Fever ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
The Impact

207 Background: Majority of breast cancers express the estrogen receptor or progesterone receptor. CDK4/6 signaling plays a role in endocrine therapy resistance and the benefit of inhibition of these pathways has been proven in studies. Yet the impact of these agents on hematological toxicities and febrile neutropenia is a considerable safety concern. Hence, we performed a systematic review and meta-analysis of randomized controlled trials (RCT). Methods: MEDLINE, EMBASE databases and meeting abstracts from inception through June 2017 were queried. RCTs that mention anemia, thrombocytopenia, leukopenia, neutropenia and neutropenic fever as adverse effects were incorporated in the analysis. Mantel-Haenszel method was used to calculate the estimated pooled risk ratio with 95% confidence interval (CI). Random effects model was applied. Results: Five RCTs (four phase 3 and one phase 2 studies) with a total of 2671 patients were eligible for analysis. The study arm used palbociclib-letrozole, palbociclib-fulvestrant, ribociclib-letrozole and abemaciclib-fulvestrant while the control arm utilized placebo in combination with letrozole or fulvestrant. The relative risks (RR) of all-grade side effects were as follows: anemia, 3.77 (95% CI: 2.47 – 5.75, p < 0.0001); thrombocytopenia, 9.69 (95% CI: 4.26 – 22.04, p < 0.0001); leukopenia, 11.68 (95% CI: 8.19–16.65; p < 0.0001); and neutropenia, 14.09 (95% CI: 10.73–18.49; p < 0.0001). The RR of high-grade adverse effects were as follows: anemia, 2.66 (95% CI: 1.29 – 5.45, p = 0.008); thrombocytopenia, 7.08 (95% CI: 1.95 – 25.74, p = 0.003); leukopenia, 33.58 (95% CI: 14.49–77.77; p < 0.0001); and neutropenia, 40.33 (95% CI: 19.34–84.10; p < 0.001). The pooled risk of neutropenic fever was statistically significant at 4.26 (95% CI: 1.11–16.26; p = 0.034). Conclusions: CDK 4/6 inhibitors based regimen significantly contributed to all hematological toxicities as well as febrile neutropenia. These toxicities affect patients’ quality of life, add financial burden and may lead to drug dosing inconsistencies.

The impact of argan oil on plasma lipids in humans: Systematic review and meta-analysis of randomized controlled trials

2017 ◽  
Vol 32 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Sorin Ursoniu ◽  
Amirhossein Sahebkar ◽  
Maria-Corina Serban ◽  
Maciej Banach ◽  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Plasma Lipids ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Argan Oil ◽  
The Impact
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