scholarly journals THE HYDROALCOHOLIC EXTRACT OF ROSMARINUS OFFICINALIS ATTENUATES LIVER DAMAGE AFTER BILE-DUCT LIGATION IN RATS

2020 ◽  
Vol 31 (2) ◽  
Keyword(s):  
Bile Duct ◽  
Liver Damage ◽  
Bile Duct Ligation ◽  
Rosmarinus Officinalis ◽  
Hydroalcoholic Extract ◽  
Duct Ligation

The hydroalcoholic extract of watercress attenuates protein oxidation, oxidative stress, and liver damage after bile duct ligation in rats

2019 ◽  
Vol 120 (9) ◽  
pp. 14875-14884 ◽  
Author(s):  
Hossein Sadeghi ◽  
Nahid Azarmehr ◽  
Fatemeh Razmkhah ◽  
Heibatollah Sadeghi ◽  
Nazanin Danaei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bile Duct ◽  
Liver Damage ◽  
Protein Oxidation ◽  
Bile Duct Ligation ◽  
Hydroalcoholic Extract ◽  
Duct Ligation

scholarly journals Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Zahra Moslemi ◽  
Hassan Bardania ◽  
Izadpanah Gheitasi ◽  
Zahra Barmoudeh ◽  
Navid Omidifar ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Liver Damage ◽  
Bile Duct Ligation ◽  
Driving Forces ◽  
Protein Carbonyl ◽  
Control Group ◽  
Hydroalcoholic Extract ◽  
Duct Ligation ◽  
Tnf Α

Herbal medicines harbor essential therapeutic agents for the treatment of cholestasis. In this study, we have assessed the anticholestatic potential of Stachys pilifera Benth’s (SPB’s) hydroalcoholic extract encapsulated into liposomes using bile duct ligation- (BDL-) induced hepatic cholestasis in rats. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde (MDA), total thiol (T-SH) content, protein carbonyl (PCO), total bilirubin (TBIL), albumin (ALB), and nitric oxide (NO) metabolite levels were measured in either liver tissue or plasma to assess liver damage. Moreover, expression of proinflammatory cytokines (IL-1β and TNF-α) and liver fibrosis markers (TGF-β and SM-α) which are driving forces of many liver disorders was also determined. The activity of AST, ALT, and ALP was significantly enhanced in the BDL group in comparison to the control group; however, treatment with liposomal (SPB) hydroalcoholic extract significantly reduced AST and ALT’s activity. Increases in MDA, TBIL, and NO levels and T-SH content due to BDL were restored to control levels by liposomal (SPB) hydroalcoholic extract treatment. Similarly, hepatic and plasma oxidative marker MDA levels, significantly enhanced by BDL, were significantly decreased by liposomal (SPB) hydroalcoholic extract treatment. Moreover, histopathological findings further demonstrated a significant decrease in hepatic damage in the liposomal (SPB) hydroalcoholic extract-treated BDL group. In addition, liposomal (SPB) hydroalcoholic extract treatment decreased the liver expression of inflammatory cytokines (IL-1β, TNF-α) and liver fibrosis markers (TGF-β and SM-α). Since liposomal (SPB) hydroalcoholic extract treatment alleviated the BDL-induced injury of the liver and improved the hepatic structure and function more efficiently in comparison to free SPB hydroalcoholic extract, probable liposomal (SPB) hydroalcoholic extract exhibits required potential therapeutic value in protecting the liver against BDL-caused oxidative injury.

scholarly journals Cell-specific regulatory effects of CXCR2 on cholestatic liver injury

2019 ◽  
Vol 317 (6) ◽  
pp. G773-G783 ◽  
Author(s):  
Takanori Konishi ◽  
Rebecca M. Schuster ◽  
Holly S. Goetzman ◽  
Charles C. Caldwell ◽  
Alex B. Lentsch
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Liver Damage ◽  
Chemokine Receptor ◽  
Therapeutic Target ◽  
Bile Duct Ligation ◽  
Wild Type ◽  
Neutrophil Accumulation ◽  
Duct Ligation ◽  
Cholestatic Liver Injury

The CXC chemokine receptor 2 (CXCR2) is critical for neutrophil recruitment and hepatocellular viability but has not been studied in the context of cholestatic liver injury following bile duct ligation (BDL). The present study sought to elucidate the cell-specific roles of CXCR2 on acute liver injury after BDL. Wild-type and CXCR2−/− mice were subjected BDL. CXCR2 chimeric mice were created to assess the cell-specific role of CXCR2 on liver injury after BDL. SB225002, a selective CXCR2 antagonist, was administrated intraperitoneally after BDL to investigate the potential of pharmacological inhibition. CXCR2−/− mice had significantly less liver injury than wild-type mice at 3 and 14 days after BDL. There was no difference in biliary fibrosis among groups. The chemokines CXCL1 and CXCL2 were induced around areas of necrosis and biliary structures, respectively, both areas where neutrophils accumulated after BDL. CXCR2−/− mice showed significantly less neutrophil accumulation in those injured areas. CXCR2Liver+/Myeloid+ and CXCR2Liver−/Myeloid− mice recapitulated the wild-type and CXCR2-knockout phenotypes, respectively. CXCR2Liver+/Myeloid+ mice suffered higher liver injury than CXCR2Liver+/Myeloid− and CXCR2Liver−/Myeloid+; however, only those chimeras with knockout of myeloid CXCR2 (CXCR2Liver+/Myeloid− and CXCR2Liver−/Myeloid−) showed reduction of neutrophil accumulation around areas of necrosis. Daily administration of SB225002 starting after 3 days of BDL reduced established liver injury at 6 days. In conclusion, neutrophil CXCR2 guides the cell to the site of injury, while CXCR2 on liver cells affects liver damage independent of neutrophil accumulation. CXCR2 appears to be a viable therapeutic target for cholestatic liver injury. NEW & NOTEWORTHY This study is the first to reveal cell-specific roles of the chemokine receptor CXCR2 in cholestatic liver injury caused by bile duct ligation. CXCR2 on neutrophils facilitates neutrophil recruitment to the liver, while CXCR2 on liver cells contributes to liver damage independent of neutrophils. CXCR2 may represent a viable therapeutic target for cholestatic liver injury.

Renal dysfunction as a consequence of acute liver damage by bile duct ligation in cirrhotic rats

2006 ◽  
Vol 58 (2-3) ◽  
pp. 185-195 ◽  
Author(s):  
Sandra Rivera-Huizar ◽  
Ana Rosa Rincón-Sánchez ◽  
Amador Covarrubias-Pinedo ◽  
María Cristina Islas-Carbajal ◽  
Genaro Gabriel-Ortíz ◽  
...  
Keyword(s):  
Bile Duct ◽  
Renal Dysfunction ◽  
Liver Damage ◽  
Bile Duct Ligation ◽  
Acute Liver Damage ◽  
Duct Ligation

scholarly journals Comparing distress of mouse models for liver damage

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Guanglin Tang ◽  
Nico Seume ◽  
Christine Häger ◽  
Simone Kumstel ◽  
Kerstin Abshagen ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Animal Models ◽  
Mouse Models ◽  
Liver Damage ◽  
Bile Duct Ligation ◽  
Characteristic Curve ◽  
Support Vector ◽  
Duct Ligation

AbstractIn order to foster animal welfare as well as high quality of research, many countries regulate by law that the severity of animal experiments must be evaluated and considered when performing biomedical research. It is well accepted that multiple parameters rather than a single readout parameter should be applied to describe animal distress or suffering. However, since the performance of readout parameters for animal distress is rarely defined and methods for multivariate analysis have only in rare cases been used, it is not known which methodology is most appropriate to define animal distress. This study used receiver operating characteristic curve analysis to quantify the performance of burrowing activity, body weight change and a distress score of mice after induction of liver damage by bile duct ligation or carbon tetrachloride. In addition, Support Vector Machine classification was used to compare the distress of these mouse models. This approach demonstrated that bile duct ligation causes much more distress than carbon tetrachloride-induced liver damage. This study, therefore, provides a prototype how to compare two animal models by considering several readout parameters. In the future these or similar methods for multivariate analysis will be necessary, when assessing and comparing the severity of animal models.

Increased liver damage after bile duct ligation in interferon-gamma receptor deficient mice: Interferon-gamma as a protective factor

2000 ◽  
Vol 118 (4) ◽  
pp. A1014
Author(s):  
Tom van der Poll ◽  
Fiebo J. ten Kate ◽  
Sander J. van Deventer ◽  
Miguel E. Sewnath ◽  
Huug Obertop ◽  
...  
Keyword(s):  
Bile Duct ◽  
Interferon Gamma ◽  
Liver Damage ◽  
Protective Factor ◽  
Bile Duct Ligation ◽  
Gamma Receptor ◽  
Duct Ligation ◽  
Deficient Mice

scholarly journals Liver Damage Induced by Bile Duct Ligation Affects CYP Isoenzymes Differently in Rats

1998 ◽  
Vol 82 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Tomonori Tateishi ◽  
Minoru Watanabe ◽  
Hironori Nakura ◽  
Masami Tanaka ◽  
Toshio Kumai ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Damage ◽  
Bile Duct Ligation ◽  
Duct Ligation

Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats

2012 ◽  
Vol 30 (9) ◽  
pp. 835-844 ◽  
Author(s):  
Cevat Aktas ◽  
Mehmet Kanter ◽  
Mustafa Erboga ◽  
Rafet Mete ◽  
Mustafa Oran
Keyword(s):  
Oxidative Stress ◽  
Bile Duct ◽  
Liver Damage ◽  
Bile Duct Ligation ◽  
Hepatocyte Apoptosis ◽  
Duct Ligation

scholarly journals Liver damage induced by bile duct ligation affects the expression of CYP isozymes variously in rats

1997 ◽  
Vol 73 ◽  
pp. 261
Author(s):  
Tomonori Tateishi ◽  
Minoru Watanabe ◽  
Masako Asoh ◽  
Hironori Nakura ◽  
Masami Tanaka ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Damage ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Cyp Isozymes
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