Is the desensitization of postsynaptic receptor channels relevant?

2013 ◽  
pp. 32-36
Author(s):  
David Papke ◽  
Claudio Grosman
Keyword(s):  
Postsynaptic Receptor

Demonstration of Postsynaptic Receptor Plasticity in an Amphibian Neuroendocrine Interface

2002 ◽  
Vol 14 (11) ◽  
pp. 843-845 ◽  
Author(s):  
B. G. Jenks ◽  
D. T. W. M. Ouwens ◽  
M. W. Coolen ◽  
E. W. Roubos ◽  
G. J. M. Martens
Keyword(s):  
Postsynaptic Receptor ◽  
Receptor Plasticity

Properties of spontaneous inhibitory synaptic currents in cultured rat spinal cord and medullary neurons

1996 ◽  
Vol 76 (1) ◽  
pp. 448-460 ◽  
Author(s):  
C. A. Lewis ◽  
D. S. Faber
Keyword(s):  
Spinal Cord ◽  
Time Constant ◽  
Decay Time ◽  
Cultured Cells ◽  
Decay Time Constant ◽  
Inhibitory Synapses ◽  
Gamma Aminobutyric Acid ◽  
Postsynaptic Receptor ◽  
Decay Times ◽  
Medullary Neurons

1. To identify the type(s) and properties of inhibitory postsynaptic receptor(s) involved in synaptic transmission in cultured rat embryonic spinal cord and medullary neurons, we have used whole cell patch-clamp techniques to record miniature inhibitory postsynaptic currents (mIPSCs) in the presence of tetrodotoxin, DL-2-amino-5-phosphonovaleric acid, and 6-cyano-7-nitroquinoxaline-2,3-dione. 2. The mIPSCs recorded from both spinal cord and medullary neurons had skewed amplitude distributions. 3. The glycinergic antagonist strychnine and the GABAergic antagonist bicuculline each decreased both the frequency and mean peak amplitudes of mIPSCs. We conclude that both glycine and gamma-aminobutyric acid (GABA) are neurotransmitters at inhibitory synapses in our cultured cells. 4. Most (approximately 96-97%) mIPSCs decay with single-exponential time constants, and decay time distributions were consistently best fitted by the sum of four Gaussians with decay constants as follows: D1 = 5.8 +/- 0.1 (SE) ms (n = 63), D2 = 12.2 +/- 0.2 ms (n = 61), D3 = 23.2 +/- 0.4 ms (n = 54), and D4 = 44.7 +/- 1.0 ms (n = 57). We conclude that the four classes of decay times represent kinetically different inhibitory postsynaptic receptor populations. 5. Strychnine and bicuculline usually had one of two different effects on the mIPSC decay time constant distributions; either selective decreases in the frequency of mIPSCs with decay times in certain classes (i.e., the D1 class was reduced by bicuculline, the D2 class by strychnine, and the D3 and D4 classes by both antagonists) or a nonselective depression in the frequency of mIPSCs with decay times in all four classes. The particular effect observed in a given neuron was correlated with the presence or absence of ATP and guanosine 5'-triphosphate (GTP) in the patch pipette. Namely, in 71% of the antagonist applications where the pipette contained ATP and GTP, the result was a nonselective decrease in mIPSCs in all decay time constant classes. Conversely, in 54% of the antagonist applications in their absence, the result was a selective decrease in the frequency of mIPSCs in specific decay time constant classes. 6. In some experiments, mIPSCs reappeared in antagonist solution after an essentially complete block. Recovery from block in the continued presence of antagonist was never observed in the absence of ATP and GTP (8 neurons), and, at the same time, 5 of 9 neurons patched with ATP and GTP in the pipette did show recovery (56%).

scholarly journals Interaction of Postsynaptic Receptor Saturation with Presynaptic Mechanisms Produces a Reliable Synapse

Neuron ◽  
2002 ◽  
Vol 36 (6) ◽  
pp. 1115-1126 ◽  
Author(s):  
Kelly A. Foster ◽  
Anatol C. Kreitzer ◽  
Wade G. Regehr
Keyword(s):  
Postsynaptic Receptor ◽  
Presynaptic Mechanisms ◽  
Receptor Saturation

scholarly journals Disruption of TrkB-Mediated Signaling Induces Disassembly of Postsynaptic Receptor Clusters at Neuromuscular Junctions

Neuron ◽  
1999 ◽  
Vol 24 (3) ◽  
pp. 567-583 ◽  
Author(s):  
Michael Gonzalez ◽  
Francis P Ruggiero ◽  
Qiang Chang ◽  
Yi-Jun Shi ◽  
Mark M Rich ◽  
...  
Keyword(s):  
Neuromuscular Junctions ◽  
Postsynaptic Receptor ◽  
Receptor Clusters
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