scholarly journals Screening for Lung Cancer with Low Dose Computed Tomography (LDCT)

2021 ◽  
pp. 794-832
Author(s):  
Elena Locci ◽  
Silvia Raymond
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Research Team ◽  
Low Dose ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Cell Death ◽  
Dependent Cell ◽  
Keywords Cancer ◽  
Low Dose Computed Tomography

Using samples of small cell lung tumors, a research team led by biologist Dr. Raymond discovered two new ways to induce tumor cell death. By activating ferroptosis, one of two subtypes of tumor cells can be targeted: first, iron-dependent cell death due to oxidative stress, and second, oxidative stress. Therefore, cell death can also be induced in a different way. Both types of cell death must be caused by drugs at the same time to eliminate the majority of the tumor mass. Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management

scholarly journals Investigation of the Impact of Low–Dose Computed Tomography (LDCT) Screening for Primary Lung Cancer (PLC) on the Risk of Developing Brain Metastasis (BM) after Primary Lung Cancer (PLC) Diagnosis

2021 ◽  
pp. 782-824
Author(s):  
Ricardo Gobato ◽  
Abhijit Mitra
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Cell Death ◽  
Low Dose ◽  
Primary Lung Cancer ◽  
Tumor Cell Death ◽  
Dependent Cell ◽  
Keywords Cancer ◽  
Low Dose Computed Tomography ◽  
The Impact

Using samples of small cell lung tumors, a research team led by biologist Dr. Raymond discovered two new ways to induce tumor cell death. By activating ferroptosis, one of two subtypes of tumor cells can be targeted: first, iron-dependent cell death due to oxidative stress, and second, oxidative stress. Therefore, cell death can also be induced in a different way. Both types of cell death must be caused by drugs at the same time to eliminate the majority of the tumor mass. Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management

Apoptotic tumor-cell death in response to cell proliferation is influenced by p53 status in resected non-small cell lung cancer

Lung Cancer ◽  
2002 ◽  
Vol 36 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Fumihiro Tanaka ◽  
Tetsuya Takata ◽  
Tomoko Yamada ◽  
Kazuhiro Yanagihara ◽  
Yosuke Otake ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Death ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Cell Death ◽  
Apoptotic Tumor Cell ◽  
P53 Status

Interference With Netrin-1 and Tumor Cell Death in Non–Small Cell Lung Cancer

2009 ◽  
Vol 101 (4) ◽  
pp. 237-247 ◽  
Author(s):  
Céline Delloye-Bourgeois ◽  
Elisabeth Brambilla ◽  
Marie-May Coissieux ◽  
Céline Guenebeaud ◽  
Rémy Pedeux ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Cell Death

scholarly journals Circulating Biomarkers for Early Stage Non-Small Cell Lung Carcinoma Detection: Supplementation to Low‐Dose Computed Tomography

2021 ◽  
Vol 11 ◽  
Author(s):  
Chin Fung Kelvin Kan ◽  
Graham D. Unis ◽  
Luke Z. Li ◽  
Susan Gunn ◽  
Li Li ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Early Diagnosis ◽  
Low Dose ◽  
Small Cell ◽  
Screening Methods ◽  
Circulating Biomarkers ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Low Dose Computed Tomography

Lung cancer is currently the leading cause of cancer death in both developing and developed countries. Given that lung cancer has poor prognosis in later stages, it is essential to achieve an early diagnosis to maximize patients’ overall survival. Non-small cell lung cancer (NSCLC) is the most common form of primary lung cancer in both smokers and non-smokers. The current standard screening method, low‐dose computed tomography (LDCT), is the only radiological method that demonstrates to have mortality benefits across multiple large randomized clinical trials (RCT). However, these RCTs also found LDCT to have a significant false positive rate that results in unnecessary invasive biopsies being performed. Due to the lack of both sensitive and specific screening methods for the early detection of lung cancer, there is an urgent need for alternative minimally or non-invasive biomarkers that may provide diagnostic, and/or prognostic information. This has led to the identification of circulating biomarkers that can be readily detectable in blood and have been extensively studied as prognosis markers. Circulating microRNA (miRNA) in particular has been investigated for these purposes as an augmentation to LDCT, or as direct diagnosis of lung cancer. There is, however, a lack of consensus across the studies on which miRNAs are the most clinically useful. Besides miRNA, other potential circulating biomarkers include circulating tumor cells (CTCs), circulating tumor DNA (ctDNAs) and non-coding RNAs (ncRNAs). In this review, we provide the current outlook of several of these biomarkers for the early diagnosis of NSCLC.

scholarly journals Screening with Low-Dose Computed Tomography Does Not Improve Survival of Small Cell Lung Cancer

2016 ◽  
Vol 11 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Mario Silva ◽  
Carlotta Galeone ◽  
Nicola Sverzellati ◽  
Alfonso Marchianò ◽  
Giuseppina Calareso ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Low Dose ◽  
Small Cell ◽  
Small Cell Lung ◽  
Low Dose Computed Tomography

scholarly journals Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Geetika Kaur ◽  
B. V. Sunil Kumar ◽  
Baljit Singh ◽  
R. S. Sethi
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Lung Inflammation ◽  
Low Dose ◽  
Small Cell ◽  
Dichlorophenoxyacetic Acid ◽  
Small Cell Lung ◽  
Qrt Pcr ◽  
Histological Score ◽  
2,4 Dichlorophenoxyacetic Acid

Abstract Background Pesticide residues in food and environment along with airborne contaminants such as endotoxins pose health risk. Although herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) has been associated with increased risk of lung cancers such as small cell lung cancer (SCLC) among agricultural workers, there are no data on the SCLC signaling pathway upon 2,4-D exposure without LPS or in combination with endotoxin. Methods We exposed Swiss albino mice (N = 48) orally to high (9.58 mg kg− 1) and low (5.12 mg kg− 1) dosages of 2,4-D dissolved in corn oil for 90 days followed by E. coli lipopolysaccharide (LPS) or normal saline solution (80 μl/animal). Lung samples and broncho-alveolar fluid (BALF) were subjected to Total histological score (THS) and total leucocyte count (TLC) and differential leucocytes count (DLC) analyses, respectively. We used microarray and bioinformatics tools for transcriptomic analyses and differentially expressed genes were analyzed to predict the top canonical pathways followed by validation of selected genes by qRT-PCR and immunohistochemistry. Results Total histological score (THS) along with BALF analyses showed lung inflammation following long term dietary exposure to high or low doses of 2,4-D individually or in combination with LPS. Microarray analysis revealed exposure to high dose of 2,4-D without or with LPS upregulated 2178 and 2142 and downregulated 1965 and 1719 genes, respectively (p < 0.05; minimum cut off 1.5 log fold change). The low dose without or with LPS upregulated 2133 and 2054 and downregulated 1838 and 1625 genes, respectively. Bioinformatics analysis showed SCLC as topmost dysregulated pathway along with differential expression of Itgb1, NF-κB1, p53, Cdk6 and Apaf1. Immunohistological and quantitative real time PCR (qRT-PCR) analyses also supported the transcriptomic data. Conclusions Taken together, the data show exposures to high and low dose of 2,4-D with/without LPS induced lung inflammation and altered pulmonary transcriptome profile with the involvement of the SCLC pathway. The data from the study provide the insights of the potential damage on lungs caused by 2,4-D and help to better understand the mechanism of this complex relation.

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