scholarly journals THE GENESE OF PREDICTIVE-PERSONIFIED MEDICINE AND THE PROBLEMS OF ITS IMPLEMENTATION IN UKRAINE

2019 ◽  
Vol 72 (1) ◽  
pp. 99-102
Author(s):  
Olena O. Terzi
Keyword(s):  
Modern Medicine ◽  
State Funding ◽  
Population Increase ◽  
Early Assessment ◽  
Legal Documents ◽  
Medical Institutions ◽  
Priority Direction ◽  
History Of ◽  
New Treatments ◽  
Therapy Reduction

The concepts, content and significance of predictive-personified medicine that are able to improve the quality of treatment, using genetic information when choosing the medical procedures that are necessary for a particular person are considered. Characteristic of the principles of predictive-personified medicine and its fundamental foundations are carried out: genomics; proteomics; metabolism; bioinformatics The history of the formation and development of predictive-personified medicine in the world is investigated, the relevant legal documents are analyzed. The main advantages of predictive-personified medicine are determined: detection of an illness at an earlier stage, when its treatment is more efficient and cheaper; division of patients into similar groups for the choice of optimal therapy; reduction of adverse reactions to drugs by more effective early assessment of individual negative reactions; improvement of the selection of new biochemical indicators, allowing to control the action of medicinal products; reducing the time, cost, and the number of failures in clinical trials of new treatments. It is noted that in Ukraine none of the well-known projects approved by the American and European committees on gene therapy are implemented. However, the priority direction of research in the field of genetics is chosen annually by more and more medical institutions of Ukraine. Examples of the introduction of predictive-personified medicine into medical institutions and scientific institutes in Ukraine are presented. It is concluded that ensuring the effectiveness of this direction of modern medicine depends on the elimination of many problems of socio-managerial and regulatory nature. In addition to their solution, the priority tasks in this area include the carrying out of significant informational and enlightening work with the population; increase of state funding for the development of preventive medicine; creation of public-private partnership of base centers.

Law in Common

2019 ◽  
Author(s):  
Tom Johnson
Keyword(s):  
Fifteenth Century ◽  
Social History ◽  
Social Practice ◽  
Local Governance ◽  
Common People ◽  
Legal Documents ◽  
Economic Practice ◽  
History Of ◽  
History Of Law ◽  
Late Medieval England

There were tens of thousands of different local law-courts in late-medieval England, providing the most common forums for the working out of disputes and the making of decisions about local governance. While historians have long studied these institutions, there have been very few attempts to understand this complex institutional form of ‘legal pluralism’. Law in Common provides a way of apprehending this complexity by drawing out broader patterns of legal engagement. The first half of the book explores four ‘local legal cultures’ – in the countryside, towns and cities, the maritime world, and Forests – that grew up around legal institutions, landscapes, and forms of socio-economic practice in these places, and produced distinctive senses of law. The second half of the book turns to examine ‘common legalities’, widespread forms of social practice that emerge across these different localities, through which people aimed to invoke the power of law. Through studies of the physical landscape, the production of legitimate knowledge, the emergence of English as a legal vernacular, and the proliferation of legal documents, it offers a new way to understand how common people engaged with law in the course of their everyday lives. Drawing on a huge body of archival research from the plenitude of different local institutions, Law in Common offers a new social history of law that aims to explain how common people negotiated the transformational changes of the long fifteenth century through legality.

scholarly journals The application of a new laminitis scoring method to model the rate and pattern of improvement from equine endocrinopathic laminitis in a clinical setting

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
A. Meier ◽  
J. McGree ◽  
R. Klee ◽  
J. Preuß ◽  
D. Reiche ◽  
...  
Keyword(s):  
Best Practice ◽  
Clinical Status ◽  
Clinical Signs ◽  
Scoring Method ◽  
Pain Medications ◽  
Exponential Decay Model ◽  
History Of ◽  
Consistent Method ◽  
Foot Disease ◽  
New Treatments

Abstract Background Endocrinopathic, or hyperinsulinaemia-associated laminitis (HAL) is a common and debilitating equine foot disease, and although no pharmacological treatments are registered, several are under development. To evaluate the effect of such treatments, an accurate and consistent method is needed to track the clinical signs of laminitis over time, and the natural history of the disease, in terms of a ‘normal’ pattern of improvement, needs to be understood. This study examined the improvement pattern in clinical cases of naturally-occurring HAL subjected to a range of best-practice interventions, using two different scoring methods. Eighty horses and ponies with suspected HAL were enrolled in a study conducted at 16 veterinary practices across Germany. The severity of laminitis was assessed by independent veterinarians using both the traditional Obel method and a modified Obel method developed by Meier and colleagues. Assessments were made on the day of diagnosis (d 0), then on days 4, 9, 14, 25 and 42 during the intervention period. Pain medications were withheld for 24 h prior to clinical examination in all cases. Results Time to marked improvement from laminitis varied between individuals, but was difficult to monitor accurately using the Obel method, with the median grade being 2/4 on days 0 and 4, then 0/4 from d 9 onwards. More subtle changes could be identified using the Meier method, however, and the median scores were seen to follow the form of an exponential decay model in most horses, improving from 8/12 on d 0, to 0/12 on d 25. Within this composite scoring method, considerable variation was observed in the rate of improvement of individual clinical signs, with the average time taken for each sign to reach a median score of 0 ranging from 4 days (foot lift and weight shifting) to 25 days (gait when turned in a circle) across all 80 horses. Conclusions The Meier method provides a reliable and consistent method for monitoring the clinical status of horses with HAL, and despite the variability, the pattern of improvement described here should provide a useful benchmark against which individual cases and new treatments can be assessed.

scholarly journals Introduction: Some ponderings on the use of the law in the writing of histories

2001 ◽  
Vol 16 (2) ◽  
pp. 169-175
Author(s):  
NIMROD HURVITZ ◽  
EDWARD FRAM
Keyword(s):  
Legal Doctrine ◽  
Legal Cases ◽  
Legal Documents ◽  
Historical Significance ◽  
Partial Reconstruction ◽  
The Social ◽  
The Hours ◽  
History Of ◽  
The Subject ◽  
The Law

Professional jurists are often inquisitive about the subject matter of their calling and in the course of their careers may well develop fascinating insights into the law and those who interpret it. Their employers, however, be they governments, corporations, firms, or private clients, rarely show similar enthusiasm for such insights unless the hours spent pondering the social or historical significance of this or that legal view have a contemporary value that justifies the lawyer's fee.Thankfully, other members of society are rewarded for mining the legal records of the past. For legal historians, the search often focuses on the changing legal ideas and how legal doctrine develops over time to meet the changing needs of societies. Yet because the law generally deals with concrete matters – again, because jurists are paid by people who are unlikely to remunerate those who simply while away their hours making up legal cases – it offers a reservoir of information that can be used, albeit with caution, in fields other than just the history of the law.A partial reconstruction of the law of any given time and place is among the more obvious historical uses of legal documents but statutes, practical decisions, and even theoretical texts can be used to advance other forms of the historical endeavour. Legal works often reflect the values both of jurists and society-at-large, for while the law creates social values it is not immune to changes in these very values.

Detection of Viruses: insides of antibody-antigen interactions and Multifunctional Lab-On-particle for SARS CoV-2 detection

Coronaviruses ◽  
2021 ◽  
Vol 02 ◽  
Author(s):  
Martin Amé ◽  
Esraa Samy Abu Serea ◽  
Ahmed Esmail Shalan ◽  
A. Guillermo Bracamonte
Keyword(s):  
Fast Response ◽  
Clinical Analysis ◽  
New Drugs ◽  
Detection Systems ◽  
Current State ◽  
History Of ◽  
Non Covalent Interactions ◽  
Genomic Factor ◽  
New Treatments ◽  
Covalent Interactions

: The design of new Drugs, Molecules, Nano-, and Microstructures for targeted applications along the pass of the time within the history of Chemistry and Clinical Analysis showed to be of high impact on Life Sciences. In this context, and mainly for the actual Corona Virus Pandemic status, it should be highlighted the importance of a fast response. Thus, the developments of differents approaches looking for improved and higher sensitive solutions in the Biodetection field accompanied with new treatments of SARS CoV-2 are required. In this way, in this short communication based on the latest Research publications it was afforded and discussed the following topics: i) the importance of non-covalent interactions from antibody-antigen recognition events, ii) the genomic factor, and iii) the use of non-covalent interactions in different Optical detection systems and Lab-On particles. Moreover, it was afforded the theme related with the importance of new treatments in progress, such development of new vaccines; and current state of the pandemic situation. So, it was discussed and stimulated the improvement of innovative Multifunctional Nanophotonic approaches intended for SARS CoV-2 detection accompanied with potential targeted treatments.

History of the formation and development of the institute of intellectual property in Japan

2021 ◽  
Vol 2021 (04-2) ◽  
pp. 207-213
Author(s):  
Viktor Shestak ◽  
Angelina Anikanova
Keyword(s):  
Intellectual Property ◽  
Legal System ◽  
State Policy ◽  
Property Law ◽  
Patent Office ◽  
High Court ◽  
Advanced Technologies ◽  
Economic Culture ◽  
Priority Direction ◽  
History Of

The development of the legal system of any country is impossible without the protection of intellectual property. Japan, as a country with an economic culture of exporting technologies and equipment, pays special attention to this issue. First of all, this is due to the priority direction of the state policy of Japan, a country of advanced technologies and innovations. The whole system of creation and protection of the intellectual property in Japan is regulated by the Copyright Act (Act No. 48 of 1970), Intellectual Property (Law No.122 of 2002), disputes shall be resolved in the Intellectual Property High Court, and the registration procedure takes place in the Japan Patent Office.

Creative communication of artistic systems M. Tsvetaeva and B. Pasternak

2021 ◽  
Vol 6 (2) ◽  
pp. 74-82
Author(s):  
Anastasia Valerievna Sebeleva
Keyword(s):  
Comparative Analysis ◽  
Comparative Studies ◽  
Mutual Influence ◽  
Integrated Approach ◽  
Literary Studies ◽  
Textual Information ◽  
Priority Direction ◽  
Literary Process ◽  
History Of ◽  
Mutual Communication

This article proceeds from the fact that the problem of interaction and mutual influence is quite acute in literary studies. In this regard, the relevance of the research is due, firstly, to the correspondence to the priority direction of modern literary studies associated with the comparative analysis of the text, and secondly, to the need to disclose the deep theoretical and artistic content of creative communication of such artistic personalities of the XX century as M. Tsvetaeva and B. Pasternak, whose legacy still contains many lacunae. The methodological basis of the research is an integrated approach, including comparative-historical, historical-literary, comparative-typological, system-analytical and biographical methods, as well as the method of comparative studies, which allows to study literary analogies and connections of different national literatures, their refraction in the texts of the authors studied. Hermeneutics contributed to the mental comprehension of the analyzed texts, the mental processing of textual information. An important episode in the history of world poetry was the correspondence-dialogue of iconic poets for their time: M. Tsvetaeva and B. Pasternak. Correspondence is valuable not only because it shows us the life of poets in relation to time. The creative aspect of correspondence is very important. The rapprochement manifested in it and at the same time the repulsion was deeply creative and left deep traces in the legacy of all its participants. Poets, albeit to varying degrees, concentrated and passionately, sought to define for themselves the essence of life and poetry. In the course of the research, the author of the article comes to the conclusion that, firstly, the literary process is characterized by a systematic nature in which authors and their works are in certain relationships to each other. Secondly, the thirteen-year correspondence of M. Tsvetaeva with B. Pasternak was very significant for literature. Thanks to mutual communication, creative interaction, the poets created unique, emotionally deep works.

scholarly journals HISTORY OF INDIAN TRADITIONAL MEDICINE: A MEDICAL INHERITANCE.

2018 ◽  
Vol 11 (1) ◽  
pp. 421 ◽  
Author(s):  
Partha Pradip Adhikari ◽  
Satya Bhusan Paul
Keyword(s):  
Traditional Medicine ◽  
Web Search ◽  
Care Service ◽  
Health Care Service ◽  
Modern Medicine ◽  
Traditional Medicines ◽  
Regional Effects ◽  
Practice Of Medicine ◽  
History Of ◽  
Traditional Approaches

 Objective: Indian Traditional Medicine, the foundation of age-old practice of medicine in the world, has played an essential role in human health care service and welfare from its inception. Likewise, all traditional medicines are of its own regional effects and dominant in the West Asian nations; India, Pakistan, Tibet, and so forth, East Asian nations; China, Korea, Japan, Vietnam, and so forth, Africa, South and Central America. This article is an attempt to illuminate Indian traditional medical service and its importance, based on recent methodical reviews.Methods: Web search engines for example; Google, Science Direct and Google Scholar were employed for reviews as well as for meta-analysis.Results: There is a long running debate between individuals, who utilize Indian Traditional Medicines for different ailments and disorders, and the individuals who depend on the present day; modern medicine for cure. The civil argument between modern medicine and traditional medicines comes down to a basic truth; each person, regardless of education or sickness, ought to be educated about the actualities concerning their illness and the associated side effects of medicines. Therapeutic knowledge of Indian traditional medicine has propelled various traditional approaches with similar or different theories and methodologies, which are of regional significance.Conclusion: To extend research exercises on Indian Traditional Medicine, in near future, and to explore the phytochemicals; the current review will help the investigators involved in traditional medicinal pursuit.

scholarly journals A Revised Late Holocene Culture History for Moloka'i Island, Hawai'i

Radiocarbon ◽  
2007 ◽  
Vol 49 (3) ◽  
pp. 1273-1322 ◽  
Author(s):  
Mark D McCoy
Keyword(s):  
Initial Period ◽  
Oral Traditions ◽  
Population Increase ◽  
Radiocarbon Age ◽  
Subsistence Economies ◽  
Culture History ◽  
The Social ◽  
Social Landscape ◽  
Strong Material ◽  
History Of

Building directly upon a previous summary of 45 dates (Weisler 1989), this paper presents radiocarbon age determinations for 175 samples from archaeological and natural contexts and a revised culture history of Moloka'i Island, Hawai'i (cal AD 800 and 1795). Significant culture historical trends include an early settlement pattern apparently generalized with respect to ecozone; a remarkably long initial period of marine and endemic bird exploitation; strong material evidence for the concurrent intensification of subsistence economies, population increase, and the structuring of the social landscape through ritual; and links between island politics as described in oral traditions and site construction. Moreover, these results support a late chronology for the colonization of Hawai'i and demonstrate the value of spatial technology for building large chronometric databases.

scholarly journals Usage of Mushrooms in Culinary and Medicinal Purposes

2022 ◽  
Vol 6 (1) ◽  
pp. 01-07
Author(s):  
Mohammad Azizur Rahman ◽  
Tawhidur Rahman ◽  
Moshiur Rahman ◽  
Mirza Arif
Keyword(s):  
Nutritional Value ◽  
Radical Scavenging ◽  
Modern Medicine ◽  
Free Radical Scavenging ◽  
Biologically Active ◽  
Current Status ◽  
The World ◽  
Future Aspect ◽  
History Of ◽  
Distinct Role

The present article reviews the history of mushroom uses in culinary, food and medicinal values; current status and future aspect of mushroom research. Mushrooms contain biologically active polysaccharides, lipid and proteins in fruit bodies, each of them has a distinct role in health as either nutritional value or medicinal elements. Immunostimulating polysaccharides found in mushrooms, are most important for modern medicine. Several of the mushroom biomolecules have undergone phase I, II, and III clinical trials and are used extensively and successfully throughout the world for the treatment of various cancers and other diseases. Medicinal functions played by the mushrooms include antitumor, antibacterial, antioxidant, antiparasitic, antidiabetic, detoxification, cardiovascular, antihypercholesterolemia, antiviral, antifungal, hepatoprotective, immunomodulating and free radical scavenging. The present review draws attention to nutritional and medicinal importance of mushroom as well as the problems and opportunity in the future development of mushroom research.

scholarly journals The Hippocratic Oath and deontology in modern medicine

2022 ◽  
Vol 99 (7-8) ◽  
pp. 409-413
Author(s):  
P. E. Krynyukov ◽  
V. B. Simonenko ◽  
V. G. Abashin ◽  
G. R. Musailov
Keyword(s):  
Medical Ethics ◽  
Gender Relations ◽  
Modern Medicine ◽  
Hippocratic Oath ◽  
Induced Abortion ◽  
History Of

The article deals with the history of the origin of Hippocratic Oath, the main issues of professional medical (medical) ethics (bioethics) from the standpoint of modern trends in the development of medicine: euthanasia, induced abortion, gender relations and transgender transition.

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