Treatment Peculiarity of the Chronic Trophic Ulcers with Different Pathogenic Mechanism

2020 ◽  
Vol 62 (1) ◽  
pp. 12-16
Author(s):  
Oksana K. Melekhovets ◽  
Tetyana O. Kharchenko ◽  
Victor F. Orlovskiy ◽  
Iuirii V. Melekhovets ◽  
Alevtina S. Radko ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Healing Process ◽  
Modern Medicine ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Second Stage ◽  
Group 2

Introduction: Trophic ulcers of the lower extremities are an unresolved problem of modern medicine. The treatment of this pathology requires new methods that optimize care regimens and improve patients’ quality of life. Aim: The study to improve efficacy of treatment of the patients with trophic ulcers of the lower limbs with consideration to pathogenesis. M aterials and Methods: The study included 32 patients with chronic venous disease C6 (1st group) and 31 with diabetes mellitus type 2, moderate severity, compensation stage with diabetic foot syndrome II stage according to Wagner’s classification (2nd group). In addition to basic therapy in both groups photodynamic therapy was added at the first stage of the study, and at the second stage plasma rich in growth factors was prescribed. Results: At baseline evaluating of the chronic venous disease demonstrates that a total score in patient of the 1st group was 20,9 points on a modified VCSS scale; after two weeks – 15,71 points (improvement by 24.83%), and 6 weeks after–9,72 points (improvement by 53.49%). In patients with DM (2nd group) at the baseline a total score average was 13,91 points according to S(AD)SAD-1 scale; after 2 weeks – 12,29 (improvement by 11,65%), after 6 weeks – 6,39 points (improvement by 54,06%). Conclusions: The inclusion of photodynamic therapy and plasmatherapy in complex therapy in both groups led to a significant improvement of the healing process and helps to reduce the depth and area of the wound surface. However, the wound healing in patients in group 2 was slower.

scholarly journals Sulodexide in Patients with Chronic Venous Disease of the Lower Limbs: Clinical Efficacy and Impact on Quality of Life

2016 ◽  
Vol 33 (9) ◽  
pp. 1536-1549 ◽  
Author(s):  
Nizar Elleuch ◽  
◽  
Hichem Zidi ◽  
Zied Bellamine ◽  
Abdelaziz Hamdane ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Efficacy ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease

scholarly journals Improvement the quality of life of patients with trophic ulcers of venous etiology in the application of photodynamic therapy

2019 ◽  
Keyword(s):  
Quality Of Life ◽  
Photodynamic Therapy ◽  
Standard Treatment ◽  
Pain Syndrome ◽  
Lower Limbs ◽  
Life Assessment ◽  
Quality Of Life Research ◽  
Survey System ◽  
Group 2

Purpose. To analyze quality of life dynamics of patients with trophic venous ulcers of the lower limbs after the treatment with the use of photodynamic therapy. Materials and methods. Quality of life research was conducted in 57 patients with trophic ulcers of venous etiology. The first group included 30 patients who received standard treatment, the second group — 27 patients, in which standard treatment was combined with a course of photodynamic therapy. To assess the quality of life of the patients in both groups, a questionnaire was conducted using the EuroQol-5D-5L survey system and the visual analogue scale EQ-VAS. The quality of life assessment was carried out at the beginning of treatment, 10 days and 6 weeks after starting treatment. Results. The results indicate a significant improvement in the quality of life in both groups, but the degree of improvement in this indicator in group 2 was 20.7 % higher.An analysis of the dynamics of improvement in quality of life showed an increase in the mean of the indicator 10 days after the beginning of treatment in patients in the first group of 26.7 %, the second group by 43 %, and in 6 weeks, its increase was achieved in patients in the first group by 32.7 %, in the second group — by 53.4 %. Conclusions. The use of photodynamic therapy in the treatment of venous trophic ulcers significantly affects the quality of life, which is manifested in the anti-inflammatory effect and reduction of pain syndrome in the shorter term (by 76.2 %), compared with patients in the first group.

scholarly journals Quality of life in chronic venous disease women

2018 ◽  
Vol 23 ◽  
pp. 1-5
Author(s):  
Dalton de Lima-Junior ◽  
Ozeas Lins-Filho ◽  
Jessica da Silva ◽  
Giselly Leite ◽  
Luana Gusmão ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Physical Domain ◽  
Upper Limbs ◽  
Chair Stand ◽  
Stand Test ◽  
Chair Stand Test

The aim of the study was to verify the relationship between physical function and quality of life in women with chronic venous disease. Physical function was evaluated by the tests: chair stand test (lower limbs strength), arm curl (upper limbs strength), 6-minute walk (aerobic fitness), back scratch (upper limbs flexibility), sit and reach (lower limbs flexibility), and time up-and-go (agility). Quality of life was assessed by e World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire, which is composed by physical, psychologic, social, environmental, and global domains. For statistical analysis, the Pearson correlation coefficient was used with an alpha of 5%. Patients evaluated were 32 (61.27 ± 7.78 years). A significant correlation was observed between the physical domain of quality of life with the chair stand test (r = 0.46; p = 0.001), arm curl (r = 0.39, p = 0.002), and 6-minute walk test (r = 0.45; p = 0.001). Also, chair stand test presented low correlation with global quality of life (r = 0.36, p = 0.004). The physical domain of quality of life measured by the WHOQOL-BREF questionnaire is related to lower and upper limbs strength and physical fitness in women with chronic venous disease but presented weak correlation with the global domain of quality of life. Thus, in women with CVD, the muscular strength of lower and upper limbs, and physical fitness is correlated with the physical domain of quality of life.

scholarly journals Quality of life in chronic venous patients who do or do not wear compressive stockings

2015 ◽  
Vol 14 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Bruno Vieira Melo ◽  
Priscilla Gabriela Moreira Dantas Tojal ◽  
Flávia de Jesus Leal ◽  
Renata Cardoso Couto
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Statistical Significance ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Sf 36 ◽  
Elastic Stockings ◽  
Disease Specific

BACKGROUND: Wearing elastic compression stockings is of considerable significance for patients with chronic venous disease (CVD), since their physiological effect is to improve venous hemodynamic parameters, making them a good treatment option that can impact on patients' quality of life. OBJECTIVE: To assess quality of life in patients with chronic venous disease who do or do not wear elastic stockings. METHODS: This was a cross-sectional observational study assessing a sample of 50 CVD patients of both sexes, divided into two groups, one who wear elastic stockings and another who do not. Primary variables were the domains of the SF-36 (Medical Outcomes Study Short-form 36) and AVVQ (Aberdeen Varicose Veins Questionnaire) and secondary variables were: age; sex; physical activity; educational level; profession; wearing elastic stockings (frequency, pressure and type); elevation of lower limbs; itching and CEAP classification. The SF-36 and AVVQ quality of life questionnaires were administered to patients. Statistical significance was set at p<0.05. RESULTS: Wearing elastic stockings proved beneficial for the quality of life of people with chronic venous disease. For the AVVQ disease-specific questionnaire the greatest improvements were in overall score (p=0.0028) and the extent of varicosity domain (p=0.000). The SF-36 domains role emotional (p=0.017) and functional capacity (p=0.000) both improved. CONCLUSIONS: Wearing elastic stockings is an effective treatment for CVD that improves disease-specific quality of life and also leads to improvements in general quality of life.

scholarly journals Rehabilitation of patients with venous diseases of the lower limbs: State of the art

2018 ◽  
Vol 33 (10) ◽  
pp. 663-671 ◽  
Author(s):  
Alberto Caggiati ◽  
Marianne De Maeseneer ◽  
Attilio Cavezzi ◽  
Giovanni Mosti ◽  
Nick Morrison
Keyword(s):  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Motor Deficits ◽  
Venous Disease ◽  
Complex Issue ◽  
Surgical Interventions ◽  
Venous Diseases ◽  
Psychosocial Conditions ◽  
Venous Disorders

Background To date, no document comprehensively focused on the complex issue of the rehabilitation of chronic venous diseases of the lower limbs. Method This article overviews and summarizes current strategies concerning venous rehabilitation of lower limbs. Results Venous rehabilitation is based on four main strategies: (1) lifestyle adaptations and occupational therapies; (2) physical therapies; (3) adapted physical activities; (4) psychological and social support. Rehabilitative protocols must be tailored to the specific needs of each patient, depending on the severity of chronic venous disease and on the location and pattern of venous lesion(s), but also on age, motor deficits, co-morbidities and psychosocial conditions. Conclusions Venous rehabilitation consists of non-pharmacologic and non-surgical interventions aiming at prevention of venous disease progression and complications, reduction of symptoms and improvement of quality of life. Well-designed clinical trials are required to evaluate the efficacy of the described rehabilitative protocols in influencing the evolution of venous disorders.

scholarly journals Chronic Venous Disorders: A Contemporary Review

2019 ◽  
Vol 12 (1) ◽  
pp. 59-63
Author(s):  
Abul Hasan Muhammad Bashar
Keyword(s):  
Medical Condition ◽  
Indian Subcontinent ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Common Medical Condition ◽  
Advanced Stages ◽  
Venous Disorders ◽  
Life Work

Chronic venous disease is a common medical condition of the lower limbs that affects a large number of people in every part of the world including the Indian subcontinent. The disease is insidious in nature and therefore often ignored in the early stages. In advanced stages, it causes significant discomfort in the affected limbs which adversely influences quality of life, work hours and treatment expenses. The present article reviews the various aspects of the disease including its pathophysiology and recent management updates. Cardiovasc. j. 2019; 12(1): 59-63

scholarly journals Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease

2020 ◽  
Vol 9 (5) ◽  
pp. 1251 ◽  
Author(s):  
Daniel P. Zalewski ◽  
Karol P. Ruszel ◽  
Andrzej Stępniewski ◽  
Dariusz Gałkowski ◽  
Jacek Bogucki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mononuclear Cells ◽  
Varicose Veins ◽  
Expression Profiles ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Operating Characteristics ◽  
Potential Biomarker ◽  
Pathologic Features

Chronic venous disease (CVD) is a vascular disease of lower limbs with high prevalence worldwide. Pathologic features include varicose veins, venous valves dysfunction and skin ulceration resulting from dysfunction of cell proliferation, apoptosis and angiogenesis. These processes are partly regulated by microRNA (miRNA)-dependent modulation of gene expression, pointing to miRNA as a potentially important target in diagnosis and therapy of CVD progression. The aim of the study was to analyze alterations of miRNA and gene expression in CVD, as well as to identify miRNA-mediated changes in gene expression and their potential link to CVD development. Using next generation sequencing, miRNA and gene expression profiles in peripheral blood mononuclear cells of subjects with CVD in relation to healthy controls were studied. Thirty-one miRNAs and 62 genes were recognized as potential biomarkers of CVD using DESeq2, Uninformative Variable Elimination by Partial Least Squares (UVE-PLS) and ROC (Receiver Operating Characteristics) methods. Regulatory interactions between potential biomarker miRNAs and genes were projected. Functional analysis of microRNA-regulated genes revealed terms closely related to cardiovascular diseases and risk factors. The study shed new light on miRNA-dependent regulatory mechanisms involved in the pathology of CVD. MicroRNAs and genes proposed as CVD biomarkers may be used to develop new diagnostic and therapeutic methods.

Duplex ultrasound investigation of the veins in chronic venous disease of the lower limbs – UIP Consensus Document. Part II: Anatomy

2006 ◽  
Vol 21 (4) ◽  
pp. 168-179 ◽  
Author(s):  
A Cavezzi ◽  
N Labropoulos ◽  
H Partsch ◽  
S Ricci ◽  
A Caggiati ◽  
...  
Keyword(s):  
Lower Limb ◽  
Duplex Ultrasound ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Specific Reference ◽  
Venous Disease ◽  
Perforating Veins ◽  
Consensus Document ◽  
Wide Range ◽  
Ultrasound Investigation

Objectives: Duplex ultrasound investigation has become the reference standard in assessing the morphology and haemodynamics of the lower limb veins. The project described in this paper was an initiative of the Union Internationale de Phlébologie (UIP). The aim was to obtain a consensus of international experts on the methodology to be used for assessment of the anatomy of superficial and perforating veins in the lower limb by ultrasound imaging. Design: Consensus conference leading to a consensus document. Methods: The authors performed a systematic review of the published literature on duplex anatomy of the superficial and perforating veins of the lower limbs. Afterwards, they invited a group of experts from a wide range of countries to participate in this project. Electronic submissions from the authors and the experts (text and images) were made available to all participants via the UIP website. The authors prepared a draft document for discussion at the UIP Chapter meeting held in San Diego, USA, in August 2003. Following this meeting, a revised manuscript was circulated to all participants and further comments were received by the authors and included in subsequent versions of the manuscript. Eventually, all participants agreed on the final version of the paper. Results: The experts have made detailed recommendations concerning the methods to be used for duplex ultrasound examination as well as the interpretation of images and measurements obtained. This document provides a detailed methodology for complete ultrasound assessment of the anatomy of the superficial and perforating veins in the lower limbs. Conclusions: The authors and a large group of experts have agreed on a methodology for the investigation of the lower limbs venous system, by duplex ultrasonography, with specific reference to the anatomy of the main superficial veins and perforators of the lower limbs in healthy and varicose subjects.

Linguistic validation of the 20 item-chronic venous disease quality-of-life questionnaire (CIVIQ-20)

2013 ◽  
Vol 29 (7) ◽  
pp. 484-487 ◽  
Author(s):  
R Launois ◽  
A Mansilha ◽  
F Lozano
Keyword(s):  
Quality Of Life ◽  
Mother Tongue ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Life Questionnaire ◽  
Linguistic Validation ◽  
Semantic Equivalence ◽  
Quality Of Life Questionnaire ◽  
Venous Ulcers

Our objective was to review the linguistic validation of the 20 item-ChronIc Venous dIsease quality-of-life Questionnaire (CIVIQ-20) in the countries that have used it since its publication in 1996. Seventeen linguistic versions of CIVIQ-20 were validated using forward/backward methodology in patients presenting with chronic venous disease, stages C0s to C4 of the CEAP (clinical, aetiological, anatomical and pathological) classification (patients with venous ulcers were excluded). Most obstacles in the cross-cultural validation of CIVIQ-20 related to content and semantic equivalence. Confirmation of cultural relevance by experts with the native language as their mother tongue and the use of forward/backward translation methodology partly resolved these difficulties. CIVIQ-20 is valid for the assessment of treatment effects in multinational studies.

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