scholarly journals THE ROLE OF FINANCE IN OUR LIVES

2021 ◽  
pp. 30-34
Author(s):  
Shahbaz Khalid
Keyword(s):  
Financial Analysis ◽  
Critical Role ◽  
Investment Risk ◽  
Financial Success ◽  
Financial Forecasting ◽  
Daily Stress ◽  
Individual Resilience ◽  
The Right ◽  
High Level

The article presents a comprehensive economics and financial analysis that plays a critical role in all areas of life. It plays an important role in individual resilience. This study includes financial and economical planning factors, revenue analysis, investment risk and financial forecasting. It includes budgeting, spending and saving. Healthy finances simply emphasize many of the goals of my life because healthy investments keep my daily stress level low, allow me to focus on doing other things, and open up opportunities to move forward. In other words, having the right level of financial success is one of the factors I measure in my life. How your financial skills help you understand how much you earn, what your monthly expenses are, and how it helps you budget for that income. The concept is that the sensitivity of investment to investment should be measured taking into account the amount of solid assets that can be used as collateral. High-level firms in the capital had high levels of investment sensitivity during the pre-crisis crisis, while post-crisis firms were less sensitive to cash flow when investing. Finance involves managing finances. KEYWORDS: finance, importance of finance, learning finance, finance and accounting, life with finance, recognizing finance, roles of finance

Exosomal miR-214-5p Released from Glioblastoma Cells Modulates Inflammatory Response of Microglia after Lipopolysaccharide Stimulation through Targeting CXCR5

2019 ◽  
Vol 18 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Jian-kai Yang ◽  
Hong-jiang Liu ◽  
Yuanyu Wang ◽  
Chen Li ◽  
Ji-peng Yang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Critical Role ◽  
Luciferase Reporter ◽  
Clinical Prognosis ◽  
Direct Target ◽  
And Migration ◽  
High Level ◽  
Cxcr5 Expression ◽  
Proliferation And Migration

Background and Objective: Exosomes communicate inter-cellularly and miRNAs play critical roles in this scenario. MiR-214-5p was implicated in multiple tumors with diverse functions uncovered. However, whether miR-214-5p is mechanistically involved in glioblastoma, especially via exosomal pathway, is still elusive. Here we sought to comprehensively address the critical role of exosomal miR-214-5p in glioblastoma (GBM) microenvironment.Methods:The relative expression of miR-214-5p was determined by real-time PCR. Cell viability and migration were measured by MTT and transwell chamber assays, respectively. The secretory cytokines were measured with ELISA kits. The regulatory effect of miR-214-5p on CXCR5 expression was interrogated by luciferase reporter assay. Protein level was analyzed by Western blot.Results:We demonstrated that miR-214-5p was aberrantly overexpressed in GBM and associated with poorer clinical prognosis. High level of miR-214-5p significantly contributed to cell proliferation and migration. GBM-derived exosomal miR-214-5p promoted inflammatory response in primary microglia upon lipopolysaccharide challenge. We further identified CXCR5 as the direct target of miR-214- 5p in this setting.Conclusion:Overexpression of miR-214-5p in GBM modulated the inflammatory response in microglia via exosomal transfer.

The role of financial analysis using financial models to predict the financial stumble on the Saudi public utilities sector: An applied study: دور التحليل المالي باستخدام النماذج المالية للتنبؤ بالتعثر المالي على قطاع المرافق العامة السعودية: دراسة تطبيقية

2020 ◽  
Vol 4 (14) ◽  
Author(s):  
Najla Ibrahim Abdulrahman, Fatimah Ibrahim Alkhamis
Keyword(s):  
Capital Market ◽  
Analytical Approach ◽  
Financial Models ◽  
Financial Analysis ◽  
Public Utilities ◽  
The Public ◽  
Insurance Sector ◽  
Applied Study ◽  
The Right

This study aimed to find out the role of financial analysis using financial models to predict the financial stumble on the Saudi public utilities sector. The study was based on the financial analysis of the financial lists published by the sample of the study of the Gas and Manufacturing Company (Gasco) and the Saudi Electricity Company listed in the Saudi Capital Market Authority. During the period (2009-2018) I followed the descriptive analytical approach. The study found the effectiveness of the Abdul Rahman model to predict the financial stumble on the public utilities sector, and the low effectiveness of the Altman model and the Kida model to predict financial stumbles on the utility sector. The study also recommended encouraging audit offices to add financial analysis services to the possibility of predicting and addressing financial stumbles, directing companies using financial models that help predict financial stumbles, encouraging investors to use financial models that help predict financial stumbles to make the right decision, and directing researchers in the study of financial default forecasting on the insurance sector using the Abdul Rahman model.

scholarly journals Role of Amygdala-Infralimbic Cortex Circuitry in Glucocorticoid-Induced Facilitation of Auditory Fear Memory Extinction

2021 ◽  
pp. 1-22
Author(s):  
Masoomeh Dadkhah ◽  
◽  
Abbas Ali Vafaei ◽  
Ali Rashidy-Pour ◽  
Parnia Trahomi ◽  
...  
Keyword(s):  
Critical Role ◽  
Fear Memory ◽  
Fear Extinction ◽  
Freezing Behavior ◽  
Extinction Training ◽  
Male Rats ◽  
Memory Extinction ◽  
The Right ◽  
Fear Expression

Purpose: The basolateral amygdala (BLA) and infralimbic area (IL) of medial prefrontal cortex (mPFC) are two inter-connected brain structures that mediate both fear memory expression and extinction. Besides the well-known role of the BLA in the acquisition and expression of fear memory, projections from IL to BLA inhibit fear expression and have a critical role in fear extinction. However, the details of IL-BLA interaction remain unclear. Here, we aimed to investigate the role of functional reciprocal interactions between BLA and IL in mediating fear memory extinction. Methods: Using lidocaine (LID), male rats underwent unilateral or bilateral inactivation of the BLA and then unilateral intra-IL infusion of CORT, prior to extinction training of auditory fear conditioning paradigm. Freezing behavior was reported as an index for the measurement of conditioned fear. Infusions were performed before the extinction training, allowing to examine the effects on fear expression and also further extinction memory. Experiments 1-3 investigated the effects of left or right infusion of CORT into IL, and LID unilaterally into BLA on fear memory extinction. Results: Results showed that intra-IL infusion of CORT in the right hemisphere reduced freezing behavior when administrated before the extinction training. Auditory fear memory extinction was impaired by asymmetric inactivation of BLA and CORT infusion in the right IL; however, the same effect was not observed with symmetric inactivation of BLA. Conclusion: It is concluded that that the IL-BLA neural circuit may provide additional evidence to contribution of this circuit in auditory fear extinction. This study demonstrate dissociable roles for right or left BLA in subserving the auditory fear extinction. Our finding also raise the possibility that left BLA-IL circuitry may contribute in mediating auditory fear memory extinction via underlying mechanisms, however further research is required.

The Taming of the Shrill: From Indicators to Indicatorization

2015 ◽  
Vol 12 (1) ◽  
pp. 81-115
Author(s):  
Siobhán Airey
Keyword(s):  
Human Rights ◽  
Task Force ◽  
Economic Relations ◽  
Right To Development ◽  
International Economic Relations ◽  
Rights Discourse ◽  
The Right ◽  
High Level ◽  
Human Rights Discourse

This article addresses the specific norm-generation function of indicators in a human rights context, focusing on ways that indicators foreground and legitimize as ‘truth’ particular worldviews or values. It describes the stakes of this process through elaborating on the concept of ‘indicatorization’, focusing on one moment in which the relationship between human rights and development was defined through indicators: the indicatorization of the Right to Development by a un High Level Task Force in 2010. In this initiative, different perspectives on human rights, equality, participation and development from within the un and the World Bank were brought together. This resulted in a subtle but significant re-articulation of ideas contained in the 1986 un Declaration on the Right to Development. The article argues that how indicatorization happens, matters, and has important implications for the potential role of human rights discourse within international economic relations.

scholarly journals The use of Polar Coordinates in the analysis of motor interaction in football according to the result.

2018 ◽  
Vol 19 (1) ◽  
pp. 60-75 ◽  
Author(s):  
Rómulo Díaz Díaz ◽  
Juan Manuel García Manso ◽  
Teresa Valverde Esteve ◽  
Enrique Arriaza Ardiles ◽  
Eduardo José Ramos Verde
Keyword(s):  
Ad Hoc ◽  
Polar Coordinates ◽  
Favorable Result ◽  
Observation Instrument ◽  
Football Team ◽  
Dual Character ◽  
The Right ◽  
High Level ◽  
The Relationship

The interactions of a Spanish football team of the Second A (10 official games) are analyzed, evaluating possible behavioral patterns that appear in a regular way in high level football. Observational methodology was used, by Polar Coordinates Analysis, to discover and evaluate the relationships generated between a considered focal behavior and the different conditioned categories, describing behavioral masses among the players. The matches were observed and recorded with an ad hoc observation instrument. The relations of dual character between the players taken as (focal behaviors) right midfielder and forward and the other players (conditioned conducts) were analyzed. The results show differences in the relationship established based on the outcome of the match. Matches that end with a favorable result, the right midfielder takes center stage, as a node of intermediation between the right centre back, left center back, left midfielder, and second striker. In these, the forward is clear receiver in the actions of completion. With the result of the unfavorable match, the connection networks change, generating a network of reciprocal interaction wider and different between the aforementioned player, right midfielder and the rest of the components, with special relation in the players that occupy the right back, left back, right centre back, right winger, left winger, second striker and forward. In these games the striker acquires a role of greater collaboration in the creation in offensive phases, participating as a node in the game network with intermediation functions. The interactions of a Spanish football team of the Second A (10 official games) are analyzed, evaluating possible behavioral patterns that appear in a regular way in high level football. Observational methodology was used, by Polar Coordinates Analysis, to discover and evaluate the relationships generated between a considered focal behavior and the different conditioned categories, describing behavioral masses among the players. The matches were observed and recorded with an ad hoc observation instrument. The relations of dual character between the players taken as (focal behaviors) right midfielder and forward and the other players (conditioned conducts) were analyzed. The results show differences in the relationship established based on the outcome of the match. Matches that end with a favorable result, the right midfielder takes center stage, as a node of intermediation between the right centre back, left center back, left midfielder, and second striker. In these, the forward is clear receiver in the actions of completion. With the result of the unfavorable match, the connection networks change, generating a network of reciprocal interaction wider and different between the aforementioned player, right midfielder and the rest of the components, with special relation in the players that occupy the right back, left back, right centre back, right winger, left winger, second striker and forward. In these games the striker acquires a role of greater collaboration in the creation in offensive phases, participating as a node in the game network with intermediation functions.

scholarly journals Thrombomodulin Is Silenced in Malignant Mesothelioma by a Poly(ADP-ribose) Polymerase-1-mediated Epigenetic Mechanism

2011 ◽  
Vol 286 (22) ◽  
pp. 19478-19488 ◽  
Author(s):  
Linda Nocchi ◽  
Marco Tomasetti ◽  
Monica Amati ◽  
Jiri Neuzil ◽  
Lory Santarelli ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Malignant Mesothelioma ◽  
Promoter Methylation ◽  
Dna Methyltransferase ◽  
Critical Role ◽  
Gene Promoter ◽  
Epigenetic Mechanism ◽  
Heterogeneous Expression ◽  
High Level

Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process. Heterogeneous expression of TM has been observed in cancer, and low or no TM expression in cancer cells is associated with poor prognosis. In this study, we analyzed TM expression in biopsies of MM patients and compared them with normal mesothelial tissue. The role of DNA methylation-associated gene silencing in TM expression was investigated. To evaluate poly(ADP-ribose) polymerase-1 (PARP1) as responsible for gene promoter epigenetic modifications, nonmalignant mesothelial cells (Met-5A) and MM cells (H28) were silenced for PARP1 and the DNA methylation/acetylation-associated TM expression evaluated. A correlation between low TM expression and high level of TM promoter methylation was found in MM biopsies. Low expression of TM was restored in MM cells by their treatment with 5-aza-2′-deoxycytidine and, to a lesser extent, with trichostatin, whereas the epigenetic agents did not affect TM expression in Met-5A cells. Silencing of PARP1 resulted in a strong down-regulation of TM expression in Met-5A cells, while restoring TM expression in H28 cells. PARP1 silencing induced TM promoter methylation in Met-5A cells and demethylation in MM cells, and this was paralleled by corresponding changes in the DNA methyltransferase activity. We propose that methylation of the TM promoter is responsible for silencing of TM expression in MM tissue, a process that is regulated by PARP1.

scholarly journals Right Place at the Right Time: How Changes in Protocadherins Affect Synaptic Connections Contributing to the Etiology of Neurodevelopmental Disorders

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2711
Author(s):  
Maria Mancini ◽  
Silvia Bassani ◽  
Maria Passafaro
Keyword(s):  
Cell Adhesion ◽  
Neurodevelopmental Disorders ◽  
Synapse Formation ◽  
Large Fraction ◽  
Critical Role ◽  
Basic Research ◽  
Axon Pathfinding ◽  
Neurite Initiation ◽  
The Right

During brain development, neurons need to form the correct connections with one another in order to give rise to a functional neuronal circuitry. Mistakes during this process, leading to the formation of improper neuronal connectivity, can result in a number of brain abnormalities and impairments collectively referred to as neurodevelopmental disorders. Cell adhesion molecules (CAMs), present on the cell surface, take part in the neurodevelopmental process regulating migration and recognition of specific cells to form functional neuronal assemblies. Among CAMs, the members of the protocadherin (PCDH) group stand out because they are involved in cell adhesion, neurite initiation and outgrowth, axon pathfinding and fasciculation, and synapse formation and stabilization. Given the critical role of these macromolecules in the major neurodevelopmental processes, it is not surprising that clinical and basic research in the past two decades has identified several PCDH genes as responsible for a large fraction of neurodevelopmental disorders. In the present article, we review these findings with a focus on the non-clustered PCDH sub-group, discussing the proteins implicated in the main neurodevelopmental disorders.

scholarly journals The Critical Role of Biliary Candidiasis in Development of Surgical Site Infections after Pancreatoduodenectomy: Results of Prospective Study Using a Selective Culture Medium for Candida Species

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Hiroyuki Kato ◽  
Yusuke Iizawa ◽  
Kei Nakamura ◽  
Kazuyuki Gyoten ◽  
Aoi Hayasaki ◽  
...  
Keyword(s):  
Risk Factor ◽  
Candida Species ◽  
Critical Role ◽  
Significant Risk ◽  
Surgical Site Infections ◽  
Preoperative Assessment ◽  
Significant Risk Factor ◽  
High Level ◽  
New Evidence

In accordance with previous reports, the incidence of biliary candidiasis (BC) after pancreaticoduodenectomy (PD) was reported to be 0 to 5%, and the clinical significance of BC still has been elusive. In this study, we prospectively evaluated the precise incidence of BC after PD using the CHROMagar Candida plate in an attempt to elucidate whether BC has a significant impact on the clinical outcomes after PD.Patients and Method. From November 2014 to March 2016, the consecutive 51 patients who underwent PD were enrolled for this study. The bile juice was prospectively collected through the biliary stent tube on postoperative days (POD) 3, 7, and 14 and directly incubated onto the CHROMagar Candida plate for the cultivation of various Candida species. In the presence or absence of BC, we compared the incidence of SSIs.Results. The incidence of postoperative BC was 15% on POD 3, 24% on POD 7, and 39% on POD 14, respectively. Taken together, 22 patients out of 51 (43.1%) developed BC after PD. Moreover, the incidence of SSIs was significantly higher in patients with BC than in those without it (71% versus 7%, p=0.005). BC was selected as the only significant risk factor of SSIs after PD among the various risk factors. Even though a cause of BC is unknown, high level of alkaline phosphatase (cut-off line >300 IU/L) was selected as the only preoperative risk factor of the development of BC.Conclusion. We elucidated new evidence in which BC could be the independent cause of SSIs after PD and should not be recognized as just contamination artifacts. Preoperative assessment for identifying carriers of Candida species might be essential for reducing the incidence of SSIs after PD.

Perspectives

1990 ◽  
Vol 15 (4) ◽  
pp. 3-10
Author(s):  
Jayanth R Varma ◽  
N Venkiteswaran
Keyword(s):  
Capital Market ◽  
Economic Activity ◽  
Critical Role ◽  
Regulatory Agencies ◽  
Recent Past ◽  
Positive Direction ◽  
Emerging Trends ◽  
The Government ◽  
The Right

The Indian capital market has shown signs of buoyancy and dynamism in the recent past. There is a very real need, therefore, to nurture and to give positive direction to the emerging trends in this sphere of economic activity. It is in this context that regulatory agencies have a critical role in providing the right kind of support to avoid bunching of issues as well as in protecting investors against manipulation by unscrupulous investors. Have Indian regulatory agencies risen to the occasion by formulating appropriate and adequate policies to facilitate the development of the capital markets in India? In this article, Varma and Venkiteswaran examine the role of Indian regulatory agencies and evaluate the methodology spelt out in the official guidelines for valuation of equity shares made public by the Government of India.

scholarly journals Persepsi dan Tahap Pengetahuan Peserta Dan Agen Takaful Terhadap Pelaksanaan Zakat Takaful: Kajian Di Shah Alam, Selangor (Perceptions and Knowledge Levels of Takaful Participants and Agencies towards Implementation of Takaful Zakat: A Study In Shah Alam, Selangor)

2019 ◽  
Vol 6 (2-2) ◽  
Author(s):  
Nur Amirah Jaafar ◽  
Hairunnizam Wahid ◽  
Mohd Ali Mohd Noor
Keyword(s):  
Sampling Method ◽  
The Body ◽  
Permanent Disability ◽  
Level Of Knowledge ◽  
The Mean ◽  
The Right ◽  
High Level ◽  
Push Factor ◽  
Knowledge And Acceptance

When it comes to zakat obligations, people only know certain types of zakat that are obligated to be issued. There are two types of zakat; zakat fitrah and zakat property. However, zakat’s division may vary according to the state's fatwa. In Selangor, Lembaga Zakat Selangor (LZS) is the body that governs the administration and implementation of Zakat. The breakdown of zakat property is Zakat on Income, Zakat on Business, Zakat on Savings, Zakat on Gold and Silver, Zakat on Investments and Shares, Zakat on KWSP, Zakat on Paddy, Zakat on Agriculture, Zakat on Wealth and Treasure, and the Zakat on Takaful. However, this study will only focus on Zakat Takaful. Under Zakat Takaful, there are several divisions which are Zakat Wang Takaful/Takaful Investment, Zakat on Maturity Policy, Takaful Compensation, Tabarruq Fund, Benefit of Total and Permanent Disability, and Compensation of Conventional Insurance Policy. Each of these sections has its calculation method which will be explained further. This study was conducted to identify the level of knowledge and acceptance of Takaful Muslim consumers on the implementation of Zakat Takaful that has been introduced by LZS. Besides, this study will also look at the knowledge of Takaful agents and their willingness to disseminate information of Zakat Takaful to their customers. This study was conducted by using the sampling method and descriptive data analysis. The study found that on average, respondents' knowledge on Zakat Takaful is low with a mean of 2.32. However, the mean for acceptance is 3.93 which is set at a high level thus showed a good acceptance of the survey respondents. Through this study, it can be concluded that knowledge and acceptance are both very important in achieving the objective of implementing Zakat Takaful. Knowledge by Takaful participants who are also assisted by agents who play the role of conveying knowledge of Zakat Takaful is directly perceived to have a more effective effect in addition to the behavior/attitude that forms the intention of Takaful participnts to accept the implementation and to pay Zakah Takaful. This study is also expected to be the push factor among the zakat agents to play a role in disseminating the right information about Zakat Takaful to their customers, which also can be regarded as one of the da'wah forms.

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