scholarly journals IMMUNOTROPIC ACTIVITY OF SOUR MILK FERMENTEDCULTURES HYDROLISATE

2010 ◽  
Vol 7 (6) ◽  
pp. 31-33
Author(s):  
G S Garanyan ◽  
E T Oganesyan ◽  
R A Khanferyan
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Phagocytic Activity ◽  
Immunotropic Activity ◽  
Neutrophilic Granulocyte ◽  
Sour Milk ◽  
Cell Immunity

The object of research is the hydrolysate of the lactobacteria components of the polycomponent sour milk stock BKUglich №4 . The hydrolysate has been obtained by the fermentative hydrolysis with microbial rennin «eito» The biological activity of obtained hydrolysate has been examined. Bacteria lysate immunotropic effects have been found to be due to the increase of neutrophilic granulocyte phagocytic activity. It was supposed that the earlier studied hydrolysate antioxidant activity caused by the normalization of the phagocyte superxide anionradical production leads to the cell immunity normalization.

scholarly journals Impact of Harvest Conditions and Host Tree Species on Chemical Composition and Antioxidant Activity of Extracts from Viscum album L.

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3741
Author(s):  
Wioleta Pietrzak ◽  
Renata Nowak
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Chemical Composition ◽  
Tree Species ◽  
Plant Material ◽  
Plant Secondary Metabolites ◽  
Host Tree ◽  
Host Tree Species ◽  
High Antioxidant Activity ◽  
Mistletoe Extracts

The content of plant secondary metabolites is not stable, and factors such as the region/location effect and seasonal variations have an impact on their chemical composition, especially in parasitic plants. Research in this area is an important step in the development of quality parameter standards of medicinal plants and their finished products. The effects of the time and place of harvest and the host tree species on the chemical composition and antioxidant activity of mistletoe extracts were investigated. Statistical tools were used to evaluate the results of the spectrophotometric and LC-ESI-MS/MS studies of the phenolic composition and antioxidant activity. The investigations indicate that the qualitative and quantitative composition, influencing the biological activity of mistletoe extracts, largely depends on the origin of the plant. The mistletoe extracts exhibited a rich phenol profile and high antioxidant activity. The chemometric analysis indicated that mistletoe collected from conifers (Viscum abietis and Viscum austriacum) had the most advantageous chemical composition and antioxidant activity. Moreover, the chemical profile and biological activity of the plant material were closely related to the climatic conditions and location of the harvested plant. Higher levels of phenolic compounds and high antioxidant activity were found in extracts obtained from plant material collected in cold weather with the presence of snow and less sunshine (autumn–winter period).

Aktywność biologiczna ekstraktów z propolisu

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Magdalena Woźniak ◽  
Anna Kwiatkowska ◽  
Elżbieta Hołderna-Kędzia ◽  
Katarzyna Sosnowska ◽  
Lucyna Mrówczyńska ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Phenolic Compounds ◽  
Propylene Glycol ◽  
Ethyl Alcohol ◽  
Antiradical Activity ◽  
Colorimetric Method ◽  
Biological Properties ◽  
Bioactive Substances ◽  
Dpph Test

Introduction. Propolis, also known as bee glue, is a resinous material collected by honeybees with numerous biological properties, including antibacterial, antifungal, antioxidant and anticancer effects. Due to its health-promoting properties, propolis is a component of many products, including dietary supplements, cosmetics and healthy food. Aim. The aim of the study was to determine the antibacterial, antifungal and antioxidant activity of propolis extracts, as well as to compare the biological activity of propolis extracts, depending on the solvent used – ethyl alcohol or propylene glycol. Material and methods. Two propolis extracts were used in the research – the first was prepared in ethyl alcohol, and the second in propylene glycol. The antimicrobial activity of the examined extracts was determined against S. aureus, E. coli and C. albicans. The antioxidant activity was determined on the basis of the evaluation of their antiradical activity in the DPPH· test and Fe2+ chelating activity. Moreover, the total content of phenolic compounds and flavonoids in the tested extracts was determined using the colorimetric method. Results. The tested propolis extracts, regardless of the solvent used (ethyl alcohol or propylene glycol), showed high antibacterial (against S. aureus), antifungal (against C. albicans) and antioxidant (antiradical activity in the DPPH· test and ferrous iron chelating potency in the ferrozine test) activity. Moreover, both tested extracts were characterized by a high and similar content of bioactive compounds – phenolic compounds and flavonoids. Conclusions. The results of the conducted tests showed that the solvent used did not affect determined biological activity and the content of bioactive substances in the tested propolis extracts.

scholarly journals Phenolic Fractions from Vaccinium vitis-idaea L. and Their Antioxidant and Anticancer Activities Assessment

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1261
Author(s):  
Gabriele Vilkickyte ◽  
Lina Raudone ◽  
Vilma Petrikaite
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Cell Lines ◽  
Radical Scavenging ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Anticancer Activities ◽  
Cell Renal Cell Carcinoma ◽  
Human Malignant Melanoma ◽  
Ht 29

Lingonberry leaves and fruits are associated with a range of potential bioactivities related to their phenolic content and composition, but the identification of major biological activity markers remains limited. The present study aimed at the isolation of lingonberry phenolic fractions and biological activity evaluation of them. Crude dry extracts of lingonberry leaves and fruits were fractionated by chromatography using Sephadex LH-20 and analyzed by validated HPLC-PDA method. For each fraction, the anticancer activity against human clear cell renal cell carcinoma (CaKi-1), human colon adenocarcinoma (HT-29), and human malignant melanoma (IGR39) cell lines was determined using MTT assay, and the radical scavenging, reducing, and chelating activities were investigated using ABTS, FRAP, and FIC assays, respectively. Further, 28 phenolics were identified and quantified in the crude extract of lingonberry leaves and 37 in the extract of fruits. These compounds, during fractionation steps, were selectively eluted into active fractions, enriched with different groups of phenolics—monophenols, anthocyanins, phenolic acids, catechins, flavonols, or proanthocyanidins. Fractions of lingonberry leaves and fruits, obtained by the last fractionation step, proved to be the most active against tested cancer cell lines and possessed the greatest antioxidant activity. In this perspective, the predominant compounds of these fractions—polymeric and mainly A-type dimeric proanthocyanidins—also quercetin can be considered to be anticancer and antioxidant activity markers of lingonberries.

Synthesis and characterization of a new natural product analog, 132-173-bacteriochlorophyllone a

2014 ◽  
Vol 18 (03) ◽  
pp. 188-199 ◽  
Author(s):  
Áron Roxin ◽  
Thomas D. MacDonald ◽  
Gang Zheng
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Photodynamic Therapy ◽  
Natural Product ◽  
Synthesis And Characterization ◽  
Facile Synthesis ◽  
H Nmr ◽  
F Ring ◽  
C Nmr

Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and is an analog of previously described natural exocyclic F-ring-containing porphyrins (1–4) and chlorins (5–10). The structure of 12 was confirmed using a combination of 1D 1 H NMR, 2D COSY 1 H NMR, Jmod 13 C NMR and HRMS analysis. The biological activity of 12 was explored, and we found that this compound does not possess strong antioxidant activity like its natural product counterparts, but is a capable photosensitizer for photodynamic therapy.

scholarly journals The effect of incorporating carboxylic acid functionalities into 2,2′-bipyridine on the biological activity of the complexes formed: synthesis, structure, DNA/protein interaction, antioxidant activity and cytotoxicity

RSC Advances ◽  
2017 ◽  
Vol 7 (27) ◽  
pp. 16428-16443 ◽  
Author(s):  
Thangavel Sathiya Kamatchi ◽  
Nataraj Chitrapriya ◽  
Sarvana Loganthan Ashok Kumar ◽  
Jang Yoon Jung ◽  
Horst Puschmann ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Carboxylic Acid ◽  
Protein Binding ◽  
Binding Affinity ◽  
Protein Interaction ◽  
Acid Group ◽  
Carboxylic Acid Group ◽  
Dna Protein Interaction

Incorporation of carboxylic acid group in the bipyridine moiety has resulted in showing differences in DNA/protein binding affinity, efficiency in antioxidant activity and cytotoxicity.

scholarly journals DETERMINATION OF BIOLOGICAL ACTIVITY, ANTIOXIDANT ACTIVITY AND SYNTHESIS OF TRIAZOLOPYRIMIDINES

2020 ◽  
Vol 13 (04) ◽  
pp. 2249-2255
Author(s):  
V. P. Gilava ◽  
P. K. Patel ◽  
H. K. Ram ◽  
J. H. Chauhan
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity

scholarly journals Biotechnological aspects of obtaining biologically active substances of Adonis vernalis

2021 ◽  
Vol 4 (1) ◽  
pp. 126-130
Author(s):  
V. R. Hamada ◽  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Raw Materials ◽  
Callus Cultures ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
In Vitro Cultivation ◽  
Plant Raw Materials ◽  
Active Substances

This article shows the possibility of using a biotechnological method to obtain biologically active compounds based on in vitro cultivation of callus cultures. The callus biomass of Adonis vernalis was obtained in vitro by using the biotechnological method. The extracts based on callus biomass of Adonis vernalis were obtained. The content of flavonoids and phenolic compounds was determined. The antioxidant activity of callus biomass of Adonis vernalis has also been studied. The research results show that the content of biologically active substances and biological activity in callus biomass does not differ from plant raw materials.

Functionalized polysaccharides with aminoguaiacol: a competition between associative behavior and antibacterial and antioxidant activities

2020 ◽  
Vol 92 (2) ◽  
pp. 323-333
Author(s):  
Virginie Dulong ◽  
Marie-Carole Kouassi ◽  
Luc Picton
Keyword(s):  
Staphylococcus Aureus ◽  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Antioxidant Activities ◽  
Antibacterial Activities ◽  
Associative Behavior ◽  
Intramolecular Association

AbstractIn a previous study, we presented the development of a series of functionalized carboxymethylpullulan (CMP) grafted with aminoguaiacol (derivative of guaiacol with known antibacterial and antioxidant activities) leading to CMP-G derivatives with various degrees of substitution [DS(Ga)] from 0.16 to 0.58. Our results have shown the efficiency of the grafting both with the evidence of antioxidant and antibacterial activities (Staphylococcus aureus) of the CMP-G derivatives. Nevertheless, an important result has shown surprisingly that such biological activity was not clearly improved with the DS(Ga) unlike the antioxidant activity. These results were probably correlated with a peculiar associative behavior of the derivative (i.e. amphiphilic character) due to the grafted hydrophobic guaiacol groups leading to preferential intramolecular association which was particularly important in the more concentrated regime (polysoap behavior). To complete this study, we propose here two strategies in order to diminish the associative character and notably the polysoap behavior: (i) decrease the DS(Ga) of CMP derivative with a CMP-G0.05 [grafted with a DS(Ga) = 0.05], (ii) conduct the functionalization onto a more rigid polysaccharide backbone as alginate. Our results show a good correlation of the associative physicochemical behaviors with both antioxidant and antibacterial activities. They also confirm the availability of these strategies mainly for the first one (i.e. CMP-G0.05). The main result indicates that the lower is the DS(Ga), the better is the antibacterial activity thanks to a lower associative character. Finally, this study also shows that the grafting of aminoguaiacol is possible onto another anionic polysaccharide (i.e. alginate).

scholarly journals Changes in the Content of Some Groups of Phenolic Compounds and Biological Activity of Extracts of Various Parts of Heather (Calluna vulgaris (L.) Hull) at Different Growth Stages

Plants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 926
Author(s):  
Victoria Chepel ◽  
Valery Lisun ◽  
Liubov Skrypnik
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Biological Activity ◽  
Phenolic Compounds ◽  
Calluna Vulgaris ◽  
Growth Stages ◽  
Flowering Stage ◽  
Leaf Extracts ◽  
Frap Assay ◽  
Different Growth Stages

Heather (Calluna vulgaris (L.) Hull.) is noted for a diverse chemical composition and a broad range of biological activity. The current study was aimed at monitoring changes in the accumulation of certain groups of phenolic compounds in various organs of heather (leaves, stems, roots, rhizomes, flowers, and seeds) at different growth stages (vegetative, floral budding, flowering, and seed ripening) as well as studying antioxidant (employing the DPPH and FRAP assays) and antibacterial activity of its extracts. The highest total amount of phenolic compounds, tannins, flavonoids, hydroxycinnamic acids, and proanthocyanidins was detected in leaves and roots at all growth stages, except for the flowering stage. At the flowering stage, the highest content of some groups of phenolic compounds (flavonoids, proanthocyanidins, and anthocyanins) was observed in flowers. Highest antioxidant activity was recorded for the flower extracts (about 500 mg of ascorbic acid equivalents per gram according to the DPPH assay) and for the leaf extract at the ripening stage (about 350 mg of ascorbic acid equivalents per gram according to the FRAP assay). Strong correlation was noted between antioxidant activity (DPPH) and the content of anthocyanins (r = 0.75, p ≤ 0.01) as well as between antioxidant activity (FRAP) and the total content of phenolic compounds (r = 0.77, p ≤ 0.01). Leaf extracts and stem extracts turned out to perform antibacterial action against both gram-negative and gram-positive bacteria, whereas root extracts appeared to be active only against B. subtilis, and rhizome extracts against E. coli.

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