scholarly journals Experience of lordestin (desloratadine) use in patients with seasonal allergic rhinitis

2012 ◽  
Vol 9 (1) ◽  
pp. 79-83
Author(s):  
N I Ilyina ◽  
K S Pavlova

The article presents the results of the study of the Lordestin's (desloratadine) efficacy and safety in patients with seasonal allergic rhinitis. The results showed that Lordestin is highly effective in reducing of the severity of nasal and ocular symptoms in patients with hay fever, has a good safety profile and may be recommended as a monotherapy or as a component of combination therapy in patients with allergic rhinitis.

2018 ◽  
Vol 141 (2) ◽  
pp. AB173 ◽  
Author(s):  
Frank C. Hampel ◽  
Andrew J. Pedinoff ◽  
Robert L. Jacobs ◽  
Aurora Breazna ◽  
Cynthia F. Caracta ◽  
...  

2019 ◽  
Vol 7 (3) ◽  
pp. 1068-1070.e3 ◽  
Author(s):  
Yoshimasa Imoto ◽  
Tetsuji Takabayashi ◽  
Masafumi Sakashita ◽  
Takahiro Tokunaga ◽  
Taiyo Morikawa ◽  
...  

1996 ◽  
Vol 76 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Francisque Leynadier ◽  
Jean Bousquet ◽  
Margarita Murrieta ◽  
Pierre Attali

2011 ◽  
Vol 49 (3) ◽  
pp. 272-280
Author(s):  
T. Schafer ◽  
M. Schnoor ◽  
M. Wagenmann ◽  
L. Klimek ◽  
C. Bachert

Background: Intranasal corticosteroids (INS) are the first line treatment for allergic rhinitis (AR). To guide clinical decision-making, we created a therapeutic index (TIX) for INS reflecting efficacy and safety. Methods: A Medline search (1966 to June 2009) was carried out to identify all placebo-controlled randomized trials, and observational reports for safety issues, with Dexamethasone, Budesonide (BUD), Fluticasone propionate (FP), Fluticasone furoate (FF), Flunisolide, Mometasone furoate (MF), Triamcinolone (TRIAM), and Beclomethasone dipropionate (BDP) as treatment for AR. Data on three efficacy (nasal symptoms, ocular symptoms, global assessment) and three safety outcomes (epistaxis, growth, systemic ocular effects) were extracted. Meta analyses were performed for each INS and outcome and results were categorised into scores by quartiles. Scores of the three efficacy and safety outcomes were summed up to create summation scores for efficacy (ES) and side effects (AES), respectively with a maximum of 9 points. The TIX was then defined as the ratio of ES and AES. Results: Data of 84 studies were extracted. Based on availability of data, a TIX was calculated for 6 substances. BUD showed the highest efficacy score followed by MF and TRIAM. The lowest scores for side effects were achieved by MF and TRIAM followed by FP. These findings resulted in TIX scores of 7 and 5 for MF and TRIAM, respectively, indicating a high efficacy and low potential of adverse events. Medium scores were reached by BUD and FP and lower scores by BDP and FF. Conclusion: Although safety and efficacy is proven for all available INS by multiple studies, the systematic aggregation and analysis of data allows for a differentiated summary on clinically important features.


1996 ◽  
Vol 97 (1) ◽  
pp. 435-435 ◽  
Author(s):  
D TINKELMAN ◽  
C FALLIERS ◽  
E BRONSKY ◽  
H KAISER ◽  
J MASON

2012 ◽  
Vol 33 (5) ◽  
pp. 386-396 ◽  
Author(s):  
Julius H. van Bavel ◽  
Paul H. Ratner ◽  
Niran J. Amar ◽  
Frank C. Hampel ◽  
Amy Melchior ◽  
...  

2019 ◽  
Vol 122 (6) ◽  
pp. 630-638.e3 ◽  
Author(s):  
Gary N. Gross ◽  
Gary Berman ◽  
Niran J. Amar ◽  
Cynthia F. Caracta ◽  
Sudeesh K. Tantry

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