scholarly journals EFFECT OF MULTILEVEL AIR CLEANING FOR PATIENTS WITH SEASONAL ALLERGIC RHINITIS AND ASTHMA

2012 ◽  
Vol 9 (5) ◽  
pp. 60-68
Author(s):  
A V Averyanov ◽  
O G Elisyutma ◽  
E S Fedenko ◽  
S I Sokurenko ◽  
T V Borisova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Lung Function ◽  
Clinical Improvement ◽  
Seasonal Allergic Rhinitis ◽  
Pollen Grains ◽  
Controlled Study ◽  
Comprehensive Treatment ◽  
Air Cleaning ◽  
Air Space ◽  
Cleaning Technology

A randomized placebo-controlled study to evaluate the effectiveness of the air cleaning technology with device IQAir HealthPro Series Model 250 (Switzerland) for comprehensive treatment of patients with seasonal allergic rhinitis and bronchial asthma was carried out. The significant reduction in the number of pollen grains in the air space and the clinical improvement was demonstrated, but no effect on lung function, blood and nasal mucus eosinophilia was revealed.

scholarly journals Evaluation of efficacy and safety of montelukast and levocetirizine FDC tablet compared to montelukast and levocetirizine tablet in patients with seasonal allergic rhinitis: a randomized, double blind, multicentre, phase III trial

2020 ◽  
Vol 7 (1) ◽  
pp. 83
Author(s):  
Sagar Panchal ◽  
Saiprasad Patil ◽  
Hanmant Barkate
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Phase Iii ◽  
Fixed Dose ◽  
Controlled Study ◽  
Global Evaluation ◽  
Double Blind ◽  
Nasal Symptoms

<p class="abstract"><strong>Background:</strong> To evaluate efficacy, safety and tolerability of Montelukast 10 mg+levocetirizine 5 mg  FDC compared to either montelukast 10 mg or levocetirizine 5 mg given alone in seasonal allergic rhinitis (SAR) patients.</p><p class="abstract"><strong>Methods:</strong> Phase III, multicentre, randomized, double blind, parallel group, active controlled study was conducted in 279 SAR patients at 16 sites across India. Efficacy was assessed using daytime nasal symptoms score (Primary efficacy outcome), night-time symptoms score, daytime eye symptom score, patient's global evaluation, physician's global evaluation, rhino-conjunctivitis quality-of-life score.  </p><p class="abstract"><strong>Results:</strong> At end of treatment there was statistically significant evidence from the per protocol analysis that patients on FDC had a greater improvement in change from baseline in daytime nasal symptoms score than patients who received Montelukast (p=0.0266) or Levocetirizine (p=0.0409). These results were consistent with the Intent to treat analysis. Analysis of the secondary efficacy endpoints provided numerically greater improvement in the nighttime symptoms score, daytime eye symptoms score, and rhinoconjunctivitis quality-of-life scores in the FDC group as compared to the Montelukast group or Levocetirizine group. The FDC of Montelukast and Levocetirizine was found to be safe and generally well tolerated. The majority of adverse events were mild in severity, resolved without treatment and were unrelated to study medication.</p><p class="abstract"><strong>Conclusions:</strong> Fixed dose combination of Montelukast and Levocetirizine was safe, generally well tolerated and superior on efficacy compared to Montelukast or Levocetirizine in patients of seasonal allergic rhinitis.</p>

scholarly journals Effectiveness of Ischia Thermal Water Nasal Aerosol in Children with Seasonal Allergic Rhinitis: A Randomized and Controlled Study

2011 ◽  
Vol 24 (4) ◽  
pp. 1103-1109 ◽  
Author(s):  
M. Miraglia Del Giudice ◽  
F. Decimo ◽  
N. Maiello ◽  
S. Leonardi ◽  
G. Parisi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Thermal Water ◽  
Controlled Study

scholarly journals Results of pollen monitoring and features of seasonal allergic rhinitis in Samara

2014 ◽  
Vol 11 (2) ◽  
pp. 32-36
Author(s):  
M V Manzhos ◽  
K Y Bahentsev ◽  
L R Khabibulina ◽  
N V Vlasova ◽  
L M Kavelenova
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Gravimetric Method ◽  
Pollen Grains ◽  
Taxonomic Diversity ◽  
Quantitative Composition ◽  
Summer Period ◽  
Pollen Monitoring ◽  
Autumn Period ◽  
Number Of Patients

Background. The objective was to study the taxonomic diversity of the concentration of pollen, its changes and peculiarities of the course of seasonal allergic rhinitis in Samara city. Methods. Pollen was located with gravimetric method on the glass, covered with a special mixture. Clinical and allergological examination conducted among 775 children aged from 5 to 18 years and 692 adults with symptoms of rhinitis. Results. Registered three periods of increase of concentration of pollen: spring period, summer period and summer-autumn period. The major taxa in the spring was pollen Populus - 49% and Betula - 27% during this period. In the summer period dominated pollen was Pinus - 37%, Poaceae - 28% and Betula - 22%. In summer-autumn period prevailed pollen grains Ambrosia - 63% and Artemisia - 10%, of the total number of pollen grains for this period. Clinical and allergological studies have shown that the proportion of patients with seasonal allergic rhinitis is 78% among the total number of patients with allergic rhinitis. Isolated form of seasonal allergic rhinitis was diagnosed in 22% of children and in 20% of adults. Patients of this group are allergic to pollen, weeds and compositae revealed in 68%, trees - 20%, cereals - 12% of cases. Conclusion. Qualitative and quantitative composition of aeropalynologic spectrum was established and showed the peculiarities of the course of seasonal allergic rhinitis in Samara city.

scholarly journals From clinical guidelines to practice. Clinical experience in treatment of patients with allergic rhinitis

2021 ◽  
pp. 62-67
Author(s):  
A. Y. Ovchinnikov ◽  
N. A. Miroshnichenko ◽  
E. M. Khon ◽  
N. P. Jimsheleishvili ◽  
V. A. Simsovа ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Inflammatory Diseases ◽  
Nasal Congestion ◽  
Controlled Study ◽  
Double Blind ◽  
Entire Treatment Period ◽  
Treatment Groups ◽  
Histamine H1 Receptors ◽  
To Receive

Introduction. Antihistamines are the most commonly prescribed class of medications for the treatment of allergic rhinitis (AR). However, they are also widely used in the treatment of inflammatory diseases of the ENT organs. One such drug is levocytirizine, (R) an enantiomer of cetirizine, which is a selective antagonist of peripheral histamine H1-receptors. This article analyzes the properties of levocytirizine in terms of safety and efficacy in allergic rhinitis.Aim of the study is to assess the efficacy of levocetirizine in patients with seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) versus placebo, and safety for patients with allergic rhinitis.Materials and methods. In this, double-blind, placebo-controlled study, 52 patients with year-round allergic rhinitis and 28 patients with seasonal allergic rhinitis were randomized to receive levocetirizine 5 mg/day once or placebo. Mean overall measures of five symptoms (nasal congestion, nasal itching, itchy eyes, rhinorrhea, and sneezing) were compared between treatment groups at 1, 2, and 4 weeks. All individual symptom scores were also examined.Results. Levocetirizine showed a significant improvement in the condition of patients with CAR and SAR over the entire treatment period compared to placebo. Assessment of individual symptoms showed statistically significant differences in favor of levocetirizine. Conclusion. Levocetirizine is an effective, safe, and well-tolerated drug for the treatment of allergic rhinitis.

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