scholarly journals Assessment of prevalence of allergic rhinitis and bronchial asthma in Samara region

2012 ◽  
Vol 9 (4) ◽  
pp. 18-25
Author(s):  
K V Blachentsev ◽  
M V Manzhos ◽  
E S Fedenko ◽  
T I Kaganova
Keyword(s):  
Allergic Rhinitis ◽  
General Practitioners ◽  
Bronchial Asthma ◽  
Russian Federation ◽  
Epidemiological Studies ◽  
Treatment And Prevention ◽  
High Prevalence ◽  
The Russian Federation ◽  
Region Form

Background. The purpose of this study was to investigate the prevalence and incidence of allergic rhinitis (AR) and bronchial asthma (BA) among different groups of population of Samara region during 2001—2010. Methods. Material for analysis was taken from the statistic forms of municipality hospitals of Samara and the Samara region (form No. 12) during 2001—2010 in comparison with the corresponding indicators of Volga federal region (PFO) and the Russian Federation. Results. Prevalence of BAin all groups of patients in the Samara region in 2009 was revealed. These indicators were more than such indicators in Russian Federation — among children on 25%, in teenagers on 38%, in adult on 50%. Prevalence of AR among children and teenagers exceeded indicators in Russian Federation — among children on 44%, teenagers — on 68%. The incidence of asthma in adults is 2,5 times higher than the incidence of AR (95,8—30,5 per 100 thousand). Conclusion. High prevalence of AR and asthma in the Samara region with a tendency to increase, the discrepancy indices studied data from epidemiological studies that require further implementation of international recommendations for diagnosis, treatment and prevention of AR among general practitioners.

Reactive Arthritis: Modern Aspects of Diagnosis and Treatment

2020 ◽  
Vol 65 (7-8) ◽  
pp. 63-70
Author(s):  
B. S. Belov ◽  
R. M. Balabanova
Keyword(s):  
Russian Federation ◽  
Clinical Picture ◽  
Reactive Arthritis ◽  
Epidemiological Data ◽  
Controlled Trials ◽  
Antimicrobial Drugs ◽  
Randomized Controlled ◽  
Laboratory Techniques ◽  
High Prevalence ◽  
The Russian Federation

Currently, the problem of reactive arthritis (ReA) retains its importance due to the fairly high prevalence of the disease, primarily in Russia. Analysis of epidemiological data allows us to put forward a number of possible reasons explaining the different frequency of ReA in certain regions of the Russian Federation and in other countries. The lecture describes the clinical picture of the disease, as well as analyzes the significance of various laboratory techniques aimed at identifying the causative agent of ReA. The Russian diagnostic criteria for ReA are presented. The main approaches to the therapy of ReA are outlined with an emphasis on the use of antimicrobial drugs. The effectiveness and safety of drug immunocorrection (inducers of interferon, polyoxidonium, immunofan, etc.) in the treatment of urogenital chlamydia in patients with ReA have not been confirmed by data from randomized controlled trials.

Prospects for immunomodulatory therapy of bronchial asthma

1998 ◽  
Vol 79 (5) ◽  
pp. 388-391
Author(s):  
G. V. Cherepnev ◽  
Y. D. Slabnov ◽  
I. E. Zimakova
Keyword(s):  
Bronchial Asthma ◽  
Russian Federation ◽  
Mechanisms Of Action ◽  
Immunomodulatory Therapy ◽  
Immune Homeostasis ◽  
Clinical Use ◽  
Immunological Reactivity ◽  
The Past ◽  
The Russian Federation ◽  
Pharmacological Correction

The relevance of pharmacological correction of immunological reactivity is obvious: many socially significant diseases are accompanied by an imbalance in immune homeostasis. In the past few years, a number of reviews on the classification and mechanisms of action of immunotropic drugs approved for clinical use in the Russian Federation have been published in the domestic press.

scholarly journals CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION

2021 ◽  
Vol 23 (4) ◽  
pp. 921-926
Author(s):  
N. N. Zhukova ◽  
M. V. Manzhos ◽  
L. R. Khabibulina ◽  
E. Yu. Syrtsova
Keyword(s):  
Allergic Rhinitis ◽  
Russian Federation ◽  
Allergic Diseases ◽  
Ambrosia Artemisiifolia ◽  
Control Group ◽  
Ambrosia Trifida ◽  
Results Of Treatment ◽  
Amb A 1 ◽  
The Russian Federation ◽  
Time Changes

Allergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed. The aim of the study was to evaluate the clinical and immunological efficacy of ASIT with the allergen Ambrosia artemisiifolia in patients sensitized to Ambrosia trifida in the Samara region. Patients with proven sensitization to Ambrosia trifida was held immunotherapy with Ambrosia artemisiifolia allergoid preseason. After treatment, patients had a decrease in the severity of symptoms of allergic rhinitis according to VAS (p = 0.00001), a decrease in the need for medications (p = 0.0003), as well as the need for corticosteroids against the background of therapy from 34.6% to 0% (p = 0.00001). In 8% of cases, the result of treatment was good, in 69% satisfactory, in 23% unsatisfactory. In the control group, there were no changes in the severity of symptoms (p = 0.858). Also, in the control group, the need for medications remained unchanged and 14.3% of patients continued to use corticosteroids.After ASIT, there was a decrease in the level of IL-4 (p = 0.002), and a decrease in the ratio of IL-4/ IL-10 (p = 0.0063); at the same time, changes in the level of other cytokines (IL-10; IFNγ) were statistically insignificant (p > 0.05). Before treatment, the levels of IL-4/ IL-10 in both groups were comparable, and after treatment, the differences became statistically significant (p = 0.031). We did not get a statistically significant change in the level of IgG4 Amb a 1 or IgG4 Amb trifida. There was no correlation between the level of individual cytokines and the results of treatment. As a result of the conducted ASIT, positive clinical and immunological results were obtained. In most patients, the disease has acquired a controlled course. At the same time, the lack of excellent and low number of good results of ASIT is probably due to the intraspecific allergenic properties of ragweed. 

scholarly journals PLANNING AND EVALUATION OF BIOEQUIVALENCE STUDIES OF ATAZANAVIR PRODUCTS

2018 ◽  
Vol 8 (3) ◽  
pp. 151-157
Author(s):  
N. E. Uvarova ◽  
N. N. Eremenko ◽  
G. V. Ramenskaya ◽  
D. V. Goryachev
Keyword(s):  
Study Design ◽  
Russian Federation ◽  
Generic Drugs ◽  
Drug Of Choice ◽  
Treatment And Prevention ◽  
Antiretroviral Drug ◽  
The Russian Federation ◽  
The Government ◽  
Mother To Child ◽  
Prevention Of Hiv

The Government of the Russian Federation approved the State strategy of combating the spread of HIV aimed at prevention of HIV epidemic. One of the goals of the Strategy is to increase the coverage of antiretroviral therapy for people infected with HIV, which includes extensive use of generic drugs. In order for a generic drug to be authorised, the applicant has to submit a report on the results of the bioequivalence studies in which the generic product was compared to the reference product. Atazanavir is an antiretroviral drug, which is also the drug of choice for the treatment and prevention of mother-to-child transmission of HIV. The aim of this study was to analyze the protocols and reports of atazanavir products bioequivalence studies, which were submitted for expert examination  to the FSBI “SCEEMP” of the Ministry of Health of the Russian Federation, and to prepare recommendations  for planning of bioequivalence studies of atazanavir products. The analysis of a number of studies revealed significant differences in the study design and number of subjects. The main reason for these differences is the conflicting data on the intrasubject coefficient of variation of atazanavir, which means that atazanavir may be considered a highly variable drug. The analysis helped to formulate  recommendations for the design of bioequivalence  studies of atazanavir products,  including studies of the maximum dose, studies under fed conditions, and consideration  of atazanavir variation when planning the study design.

Influence of VDR gene polymorphisms on vitamin D supply in patients with bronchial asthma in the Russian Federation

2021 ◽  
Author(s):  
Elena Loshkova ◽  
Elena Kondratyeva ◽  
Yuri Mizernitsky ◽  
Natalia Ilyenkova ◽  
Svetlana Dyakova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bronchial Asthma ◽  
Russian Federation ◽  
Gene Polymorphisms ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms ◽  
The Russian Federation

PRS4 HEALTH TECHNOLOGY ASSESSMENT OF DUPILUMAB IN SEVERE BRONCHIAL ASTHMA IN THE RUSSIAN FEDERATION

2019 ◽  
Vol 19 ◽  
pp. S77
Author(s):  
S.V. Nedogoda ◽  
M.Y. Frolov ◽  
A.S. Salasyuk ◽  
I.N. Barikina ◽  
V.O. Smirnova ◽  
...  
Keyword(s):  
Health Technology Assessment ◽  
Bronchial Asthma ◽  
Russian Federation ◽  
Technology Assessment ◽  
Health Technology ◽  
The Russian Federation

scholarly journals THE DYNAMICS AND STRUCTURE OF THE DETECTION OF HIV INFECTION AT THE STAGE OF RECRUITMENT OF CITIZENS FOR MILITARY SERVICE AND DURING THEIR MILITARY SERVICE IN THE ARMED FORCES OF THE RUSSIAN FEDERATION

2012 ◽  
Vol 17 (3) ◽  
pp. 23-27
Author(s):  
V. G. Akimkin ◽  
M. Zh. Parshin ◽  
C. V. Zemlyakov
Keyword(s):  
Hiv Infection ◽  
Russian Federation ◽  
Military Service ◽  
Armed Forces ◽  
Hiv Disease ◽  
Major Threat ◽  
High Prevalence ◽  
The Russian Federation ◽  
Structural Indices ◽  
Epidemiological Situation

HIV infection is a major threat to national security of the Russian Federation. Unfavorable epidemiological situation of HIV infection and drug addiction in Russia leads to a significant increase in the number of conscripts, recognized unfitfor military service on health grounds in connection with this disease. The quantitative and structural indices of detection of HIV infection in people at the stage of recruitment and during the period of their service in the Armed Forces of the Russian Federation in the dynamics have been analyzed. The most detection rate of HIV infection in soldiers in the regions of the Russian Federation with high prevalence of HIV = disease has been established. With aim to prevent the carrying and further spread of HIV infection in the Armed Forces of the Russian Federation the performance of the mandatory medical examination ofpersons qualifying for induction has been suggested.

scholarly journals PROCEDURE FOR ASSESSING RISK OF DEVELOPING AN ADVERSE EPIDEMIC SITUATION FOR ENTEROBIASIS IN THE CONSTITUENT ENTITIES OF THE RUSSIAN FEDERATION

2020 ◽  
pp. 16-24
Author(s):  
И.А. Абрамов ◽  
◽  
O.P. Chernjavskaja ◽  
Keyword(s):  
Russian Federation ◽  
Rapid Assessment ◽  
Epidemiological Surveillance ◽  
Moscow Oblast ◽  
Omsk Oblast ◽  
Unknown Risk ◽  
High Prevalence ◽  
Risk Areas ◽  
The Russian Federation ◽  
The Republic

The article presents a method for assessing the risk of an unfavorable epidemic situation for a parasitic disease using the example of enterobiasis in the constituent entities of the Russian Federation and a forecast for 2020. The method is based on a point assessment of internal risks developed on the basis of the document «Rapid assessment of events posing an immediate threat to public health. WHO-2012». All constituent entities of the Russian Federation were assessed and divided into three categories: high, medium and low risk of an unfavorable epidemic situation for enterobiasis. According to the results of the assessment, the «risk areas» in 2020 are Moscow, St. Petersburg, Sevastopol, the Republic of Tatarstan, Sverdlovsk Oblast, Khanty-Mansi Autonomous Okrug, Arkhangelsk Oblast, Kemerovo Oblast, Moscow Oblast, Omsk Oblast, Chelyabinsk Oblast. In the Republic of Sakha (Yakutia) and the Republic of Altai, a high prevalence of the population was revealed with low indicators of other criteria, which may indicate an insufficient epidemiological surveillance of enterobiasis, or about unaccounted or unknown risk factors for the disease.

scholarly journals Risk-Based surveillance as a strategic tool to improve food safety in the russian consumer market

2021 ◽  
Vol 99 (12) ◽  
pp. 1398-1406
Author(s):  
Nina V. Zaitseva ◽  
Irina V. May
Keyword(s):  
Food Safety ◽  
Russian Federation ◽  
Potential Risk ◽  
Large Scale ◽  
Food Products ◽  
Epidemiological Studies ◽  
Dynamic State ◽  
Legal Method ◽  
The Russian Federation

Introduction. Protecting consumers’ lives and health in a condition when the number of producers and the variety of food products is continually growing is one of the state’s strategic tasks and the goals of the administrative reform in the Russian Federation. Material and methods. The work uses methods of analysis, synthesis, comparison, and generalization of the existing in international practice methodological approaches and criteria to assess product safety in planning control and supervision activities, assessing the risk of harm to human health, applied the comparative legal method, methods of mathematical modeling and other methods used when searching legal and analytical research. Results. A risk-oriented model of control and supervisory activities for food safety is proposed and tested. The model is built under the general principles of the risk assessment methodology and is based on the analysis of the results of previous checks, studies and trials, data from epidemiological studies and relevant scientific literature. The model assumes three successively implemented stages: the categorization (classification) of the economic entity’s activities according to the potential risk of harm to health. Target - to select facilities for the most frequent and in-depth inspections by the supervisory authorities. The second stage is the classification of food products according to the potential risk to consumer health to justify the types of food products subject to priority supervision during scheduled inspections of economic entities. The third stage is constructing “risk profiles” of certain products to optimize laboratory control of food safety. Discussion. The construction of risk-oriented control based on the principle of step-by-step substantiation and clarification of supervision objects was shown to ensure the targeting of authority and an increase in inspection pressure on precisely those objects that are characterized by the most frequent violations of legal requirements with the most severe and large-scale consequences for health. Increasing the control density at the highest risk categories’ facilities does not require additional resources from the regulator. It is still implemented by removing facilities with moderate or low risk from planned supervision and optimizing laboratory support. Conclusion. Work out and implement a risk-based food safety surveillance model corresponds to the strategic vector of development of state control (supervision) in the Russian Federation. The system assumes that “risky” goods are unsafe for the consumer’s health. Accordingly, their producers, distributors, and sellers should be under robust inspection, including laboratory supervision, and precisely according to those indicators for which these risks are most significant. The system is in a dynamic state and development.

Sign in / Sign up

Export Citation Format

Share Document