scholarly journals New delivery device for inhaled drugs for bronchial asthma treatment. Multidose Easyhaler dry powder inhaler

2014 ◽  
Vol 11 (2) ◽  
pp. 37-40
Author(s):  
T G Vilegzhanina
Keyword(s):  
Bronchial Asthma ◽  
Drug Administration ◽  
Dry Powder Inhaler ◽  
Life Quality ◽  
Asthma Treatment ◽  
Inhaled Drugs ◽  
Airway Diseases ◽  
Poorly Soluble ◽  
Systemic Side Effects ◽  
Gastrointestinal Canal

According to current conception of bronchial asthma treatment, the main goals are symptoms control and good life quality. Inhalation is the preferred route of drug administration for patients with airway diseases such as asthma. Inhalation delivers drugs directly to the airways and thereby the effective dose can be small compared with oral therapy (in 20 times), the risk of systemic side effects is reduced, it could be used for poorly soluble drugs which are not absorbed in the gastrointestinal canal. Inhalation is the route of drug administration and can be used for delivery of bronchodilators, mucolytics, steroids, and cromoglicate acid drugs as well.

scholarly journals Evaluation of Life Quality and Dyspnea Intensity on Chronic Airway Diseases Patients in Pulmonary Rehabilitation Program

2016 ◽  
Vol 04 (01) ◽  
pp. 10-15
Author(s):  
Kathleen Julia Silva ◽  
Giseli Domingues Cordeiro ◽  
Caroline Rossinoli ◽  
Maurício Longo Galhardo ◽  
Márcia Maria Faganello
Keyword(s):  
Pulmonary Rehabilitation ◽  
Life Quality ◽  
Rehabilitation Program ◽  
Airway Diseases ◽  
Pulmonary Rehabilitation Program ◽  
Chronic Airway

scholarly journals Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Ashwin J. Mali ◽  
Atmaram P. Pawar ◽  
Ravindra N. Purohit
Keyword(s):  
Side Effects ◽  
Active Site ◽  
Lung Diseases ◽  
Dry Powder Inhaler ◽  
Deposition Efficiency ◽  
Therapeutic Delivery ◽  
Drug Molecules ◽  
Systemic Side Effects ◽  
The Subject

The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

Magnesium deficiency correction for improvement of children bronchial asthma treatment results

2015 ◽  
Author(s):  
Ivan Shishimorov ◽  
Vladimir Petrov ◽  
Olga Magnitskaya ◽  
Aleksey Perminov ◽  
Igor Nefedov
Keyword(s):  
Bronchial Asthma ◽  
Magnesium Deficiency ◽  
Asthma Treatment ◽  
Treatment Results

scholarly journals Inhaled drug airflow patterns and particles deposition in the paediatric respiratory tract

2020 ◽  
Vol 22 (2) ◽  
Author(s):  
Zbigniew Tyfa ◽  
Paulina Jóźwik ◽  
Damian Obidowski ◽  
Piotr Reorowicz ◽  
Daniel Jodko ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Particle Deposition ◽  
Particle Diameter ◽  
Bronchial Tree ◽  
Primary Objective ◽  
Patient Specific ◽  
Asthma Treatment ◽  
Inhaled Drugs ◽  
Old Patients ◽  
Treatment Personalization

Purpose: The effectiveness of inhaled drugs is strictly related to areas reachable by drug particles. Unless particles reach the desired part of the bronchial tree, their influence might not meet the expectations. Consequently, the disease progress might not be stopped or even slowed down. Therefore, the primary objective of this research was to analyze the airflow patterns and particle deposition of a standard inhaled drug using computational fluid dynamics. Methods: The study was devoted to the analysis of the particle Diameter influence on their deposition areas within the entire respiratory tract. Two patient-specific respiratory tract models, for 6 and 12-year-old patients, were reconstructed based on the computed tomography examinations. Numerical analyses were carried out as stationary ones with the constant inflow of the particles of various diameters (within the range of 1–50 μm). It was proven that depending on the particle size, their deposition within the respiratory tract varies significantly. Results: The vast majority of the particles with diameters over 20 μm is gathered on the walls of the throat, whereas particles of diameters 5–15 μm are accumulated mainly on the trachea walls, leaving the alveoli insufficiently supplied with the drug particles. Conclusions: The inhaled drug size cannot be treated as negligible factor during the drug spraying. An improper distribution of the particles might not inhibit the symptoms of the asthma. Numerical simulations may improve drugs selection and visualize their distribution along the airways, which might accelerate asthma treatment personalization.

scholarly journals Systemic Effects of Inhaled Corticosteroids: An Overview

2014 ◽  
Vol 8 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Dhruti Pandya ◽  
Amar Puttanna ◽  
Viswanatha Balagopal
Keyword(s):  
Inhaled Corticosteroids ◽  
Oral Candidiasis ◽  
Systemic Effects ◽  
Systemic Complications ◽  
Inhaled Steroids ◽  
Airway Diseases ◽  
Increased Risk ◽  
Oral Corticosteroids ◽  
Systemic Side Effects ◽  
Obstructive Airway Diseases

Inhaled corticosteroids (ICS) are common medications, used in respiratory medicine for controlling conditions such as asthma and other obstructive airway diseases. The systemic effects of oral corticosteroids are well known and established; inhaled steroids have been known to cause relatively minor and localized adverse effects such as oral candidiasis. However, less attention has been paid to their systemic effects. Although currently there is a paucity of prospective studies demonstrating the systemic effects of inhaled corticosteroids, there are numerous retrospective studies adding evidence to this link. Inhaled corticosteroids can affect the hypothalamo-pituitary-adrenal axis, bone density and growth, eyes, skin and immunity including an increased risk of pneumonia. Clinicians are recommended to aim for the lowest possible dose to avoid these systemic side effects. Fluticasone is more likely to cause systemic effects compared to budesonide. Newer ICS molecules such as ciclesonide may be more beneficial in reducing such systemic complications on prolonged use. This paper provides an updated overview of the common systemic effects encountered with ICS treatment.

scholarly journals The analysis of efficiency of international recommendations introduction on the treatment of a bronchial asthma on an outpatient basis

2007 ◽  
Vol 4 (3) ◽  
pp. 25-29
Author(s):  
A Yu Petukhova ◽  
E K Bel'tyukov ◽  
A U Petukhova ◽  
E K Beltyukov
Keyword(s):  
Drug Therapy ◽  
Bronchial Asthma ◽  
Emergency Service ◽  
Central City ◽  
Direct Costs ◽  
Hospital Treatment ◽  
Outpatient Basis ◽  
City Hospital ◽  
Asthma Treatment ◽  
Selection Of

The purpose of the research: to study the clinic-economical efficiency of the program of observation the patients with a bronchial asthma (POPB) in the district polyclinic of the Central City Hospital №6 in Yekaterinburg. Materials and methods. The research was carried out in 2004-2005. The direct cost for the bronchial asthma (BA) treatment during a year before and a year after the POPB introduction was analyzed. The group under study (n=70; women - 41, men - 29, mean age - 52,6 year.) was formed by random selection of 164 asthmatics who were registered in 2005. Results. The costs on dispensary drug therapy (43%) and hospital treatment (31%) have prevailed among the direct costs before the POPB introduction. The treatment of severe BA needed the maximum costs (1, 070 $ for one asthmatic in a year), the treatment of mild intermittent bronchial asthma needed minimal costs (37 $ for one asthmatic in a year). The costs of dispensary drug therapy increased to 72% and the costs of hospital treatment decreased 7% after a year of the POPB introduction. The decrease of the costs of mild intermittent bronchial asthma treatment (2.3 times) was observed comparing the severe ВА (1,2 times). Conclusions. The direct costs of the BA treatment were 462$ for one asthmatic in a year. The POPB introduction brought to the reduction of direct costs 1,4 times (334$ for one asthmatics in a year) at the expense of the decrease the costs of hospitalization (6,5 times) and calls the emergency service (5.7 times). The denominated decrease of costs for mild intermittent bronchial asthma, by comparison the severe BA, was noted.

scholarly journals STUDY OF EFFICACY OF METERED DOSE INHALER (MDI) AND DRY POWDER INHALER (DPI) FOR DELIVERY OF SALBUTAMOL IN TREATMENT OF ACUTE EXACERBATION OF ASTHMA IN PATIENTS, ATTENDING IN TERTIARY CARE HOSPITAL AT, PATNA

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Ajit Kumar ◽  
Raj Narayan Seth
Keyword(s):  
Acute Exacerbation ◽  
Bronchial Asthma ◽  
Tertiary Care ◽  
Dry Powder Inhaler ◽  
Dose Inhaler ◽  
Care Hospital ◽  
Metered Dose Inhaler ◽  
Dry Powder ◽  
Accessory Muscle ◽  
Metered Dose

Objective: Present study was undertaken to compare the efficacy of Metered dose inhaler (MDI) with spacer and with Dry powder inhaler (DPI) for delivery of salbutamol in acute exacerbation of bronchial asthma. It is a randomized controlled trial study. Material and Methods: A total of 78 children in the age group of 6-14 years who presented with a mild or moderate acute exacerbation of asthma were included in the study. Salbutamol dose of 400µg were given to all the children’s by either a MDI with spacer or a DPI in randomized pattern. All the changes in the wheezing and accessory muscle scores, Sa02, and PEFR were noted. Results: Out of 78 children, 42 were assigned to the MDI spacer group and 36 to rotahaler (DPI) group. After receiving treatment, the PEFR improved by about 14% in both the groups. The oxygen saturation increased by 2.1% in both the groups. Within each group, the improvement in PEFR, Sa02, wheeze and accessory muscle score after the treatment was statistically significant. Conclusion: Metered dose inhaler with spacer and Dry powder inhaler are equally effective in delivering salbutamol in therapy of mild to moderate acute exacerbations of bronchial asthma in children between 6-14 years of age Keyword: DPI, Salbutamol, Treatment, Asthma, Children, MDI, PEFR

scholarly journals Possible Way of Bronchial Asthma Treatment Through The Effects of Acupuncture Point Li4

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Dorko František ◽  
Durďaková Radka ◽  
Durďák Radomír
Keyword(s):  
Bronchial Asthma ◽  
Acupuncture Point ◽  
Asthma Treatment
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