scholarly journals Clinical and allergological characteristic of children with allergic rhinitis receiving allergen-specific immunotherapy in Altai region

2015 ◽  
Vol 12 (2) ◽  
pp. 64-67
Author(s):  
N V Shakhova ◽  
V V Gordeev ◽  
U F Lobanov ◽  
T S Ardatova ◽  
M V Surcova
Keyword(s):  
Allergic Rhinitis ◽  
Medical Record ◽  
Allergic Conjunctivitis ◽  
Specific Immunotherapy ◽  
Primary Diagnosis ◽  
House Dust Mites ◽  
Allergen Specific Immunotherapy ◽  
Altai Region ◽  
Persistent Allergic Rhinitis ◽  
Record Card

The purpose of this study. To investigate clinical characteristics of the allergic rhinitis in children receiving allergen-specific immunotherapy. Methods. The epidemiologic observational multicenter study was conducted with the allergists of Altai region. The participating allergists filled out the specially designed medical record card on children with allergic rhinitis receiving ASIT. The study lasted from October 2013 to March 2014. Results. Allergists have filled out medical record cards of 165 children with allergic rhinitis receiving ASIT. The average age of children was 10,5±2,3 years, with the average of 4,8±2,5 years of allergic rhinitis prior to the start of ASIT. 159 (96,2%) children had moderate/severe allergic rhinitis, and 121 (73,3%) children had persistent allergic rhinitis. In 123 (74,5%) children rhinitis was accompanied by allergic conjunctivitis, and in 70 (42,2%) children - by bronchial asthma. 69 (41,8%) children receiving ASIT were mono-sensitized, 96 (58,2%) children were polysensitized. 48,5% of children were sensitized to house dust mites, 63,6% to tree pollen, 48,5% to meadow grass pollen, 30,9% to weed pollen, and in 21,8% sensitization to epidermal allergens was found. Conclusion. The findings of the study showed that in most cases (96,2%), children with allergic rhinitis receiving ASIT had moderate/severe rhinitis and in 73,3% symptoms were persistent. In 74,5% of cases, allergic rhinitis was accompanied by allergic conjunctivitis. Most part of children receiving ASIT had multiple sensitization (58,2%). Also a delayed beginning of ASIT was observed - 4,8±2,5 year from primary diagnosis to ASIT initiation.

scholarly journals EFFICIANCY OF IMMUNOTHERAPY IN PATIENTS WITH PERSISTENT ALLERGIC RHINITIS

2018 ◽  
Vol 1 (70) ◽  
pp. 32-37
Author(s):  
Марина Антонюк ◽  
Marina Antonyuk ◽  
С Сулейманов ◽  
S Suleymanov ◽  
Татьяна Гвозденко ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Immune System ◽  
Inflammatory Cytokines ◽  
Proinflammatory Cytokines ◽  
Specific Immunotherapy ◽  
Low Doses ◽  
Allergen Specific Immunotherapy ◽  
Specific Diagnosis ◽  
Persistent Allergic Rhinitis ◽  
Effect Of Treatment

The dynamics of parameters of cytokine status in patients with allergic rhinitis in view of efficiency of allergen-specific immunotherapy (ASIT) was studied in this work. 62 subjects with moderate persistent rhinitis at the age of 18-40 years old were included in the study. For specific diagnosis and treatment there we used standard allergens. ASIT was performed by the classical scheme. The concentrations of IL-4, IL-5, IL-6, IL-8 in the blood serum were measured by the enzyme immunoassay. A good or excellent effect of treatment with ASIT was achieved in 62.9% of cases, and satisfactory one in 37.1% of cases. The analysis of the dynamics of IL-4, IL-5, IL-6, IL-8 concentrations showed that the efficiency of ASIT in patients with allergic rhinitis depends on the ability of the immune system to activation by low doses of the allergen, quite fast suppression of proinflammatory cytokines induced by them, and active functioning of the system of anti-inflammatory cytokines.

scholarly journals Analysis of the dynamics of clinical indicators in patients with allergic rhinitis with sensitization to pollen and household allergens using combined allergen-specific immunotherapy

2021 ◽  
Vol 26 (4) ◽  
pp. 87-93
Author(s):  
S.V. Biletska ◽  
E.M. Dytyatkovska ◽  
M.A. Nikolaychuk
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
High Efficiency ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
House Dust Mites ◽  
Skin Tests ◽  
Pollen Allergens ◽  
Allergen Specific Immunotherapy

The aim of this study was to evaluate the clinical efficacy of combined allergen-specific immunotherapy (ASIT) in patients with allergic rhinitis (AR) with combined sensitization to pollen and household allergens. To achieve this goal, 49 patients with AR of working age were examined – 35.5±1.5 years with clinical manifestations of seasonal rhinoconjunctival syndrome with a long period of 9.2±1.1 years, among which there were 25 (51.0%) males and 24 (49%) females. All patients were divided into 2 homogeneous groups by age, sex, duration of the disease, the average number of etiologically significant allergens: the main one – 31 patients who received combined ASIT with solutions of pollen and household allergens and a comparison group – 18 patients for whom only pollen allergens were used. Allergological examination included anamnesis, skin tests with pollen allergens (wormwood, ragweed, quinoa, corn, etc.) and household (house dust, mites, epidermal agents) and / or molecular research methods using the ALEX technology. The quantitative integral assessment of the intensity of AR clinical symptoms was calculated as a total score for the main symptoms. The maximum score for the severity of nasal symptoms – 12, eye - 6, total – 18. The results obtained and their analysis indicate that under the influence of ASIT pollen and household allergens in patients there is a significant and reliable decrease in the intensity of clinical manifestations of seasonal rhinoconjunctive syndrome: nasal manifestations – by 52,2%, conjunctival – by 60%, integral – by 54.3% and an increase of 2.2 times in the percentage of patients in the main group with the disappearance or minimization of clinical symptoms of the disease after treatment compared with patients from the comparison group, which convincingly proves and confirms high efficiency of the selected type of therapy in patients with AR in combination with sensitization to pollen and household allergens.

Dynamics of basophil reactivity in the patients with allergic rhinitis on the background of allergen-specific immunotherapy

2021 ◽  
Vol 17 (4) ◽  
pp. 75-84
Author(s):  
Liudmila Yu. Barycheva ◽  
Liudmila V Dushina ◽  
Marina V. Golubeva ◽  
Milana M. Minasyan ◽  
Yulia N. Medvedenko
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Stimulation Index ◽  
Basophil Activation Test ◽  
Basophil Activation ◽  
House Dust Mites ◽  
Allergen Specific Immunotherapy ◽  
Activation Test ◽  
Positive Treatment

BACKGROUND: Allergen-specific immunotherapy (ASIT) helps to reduce spontaneous and to induce basophil reactivity, which is one of the major mechanisms of its effectiveness. A number of studies, though, have not confirmed the informative value of the basophil activation test (BAT), in case of ASIT, with house dust mites, meadow grass pollen, and wasp venom. BAT outcomes are likely to be influenced by the properties of the sensitizing allergen, the duration of ASIT, and the BAT markers that are used. AIMS: To evaluate the basophils reactivity in the patients sensitized to weed pollen and treated with allergen-specific therapy. MATERIALS AND METHODS: The study involved 60 patients (aged 1655) with allergic rhinitis sensitized to weed pollen. The diagnosis was based on the skin test outcomes as well as on identifying specific antibodies to major allergens of ragweed, wormwood, timothy, and birch. The pre-seasonal ASIT involved water-salted extracts of pollen allergens during 2 years. Clinical symptoms and the immunotherapy effectiveness were evaluated 6 and 18 months after the ASIT started. BATs were made before the treatment, after the first and second courses of pre-seasonal ASIT, which corresponded to zero, the 3rd and the 15th months of the treatment. The activated basophils were identified based on the CRTH2pos CD203brightCD3neg phenotype. RESULTS: The first treatment course was completed by 52 patients, while the second one by 43 patients. A statistically significant decrease in spontaneous basophil reactivity was detected only after the second course of ASIT. The decrease in the allergen-induced basophil activation was identified in 67.4% of the samples obtained after the first ASIT course, and in 67.6% of samples taken after the second immunotherapy course. A decrease in the BAT stimulation index (BAT SI) was identified mainly in the patients featuring positive treatment outcomes. CONCLUSIONS: ASIT influences on the basophil reactivity indicators in the patients sensitized to weed pollen. The basophil activation test may be considered as a potential predictor of ASIT effectiveness.

scholarly journals The peculiarities of cytokine status in children suffering from persistent allergic rhinitis during early stages of allergenspecific immunotherapy

2009 ◽  
Vol 7 (5) ◽  
pp. 38-42
Author(s):  
E B Belan ◽  
T L Sadchikova ◽  
Uy V Antonov
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Serum Levels ◽  
Cytokine Level ◽  
Treatment Results ◽  
Allergen Specific Immunotherapy ◽  
Early Stages ◽  
Results Of Treatment ◽  
Long Duration ◽  
Persistent Allergic Rhinitis

Background. To study dynamics of cytokine status during early stages of allergen-specific immunotherapy (ASIT) in children suffering from persistent allergic rhinitis (PAR). Methods. 30 children suffering from PAR have received complete course of ASIT. Serum levels ofILL-4, -5, -6, -8, -12, -13, sIL-2R were studied in 0, 7, 30 and 90 days and have been analyzed differentially in groups with good/excellent and incomplete effectiveness of treatment. Results. Good/excellent effectiveness of completed course of ASIT has been demonstrated in 17/30 (56,7%) children, partial effectiveness has been demonstrated for 13/30 (43,3%) ones.The decreased IL-12 and IL-6 levels and the increase of sIL-2R production were described for good/excellent results of treatment, but insufficient effectiveness was characterized by delayed dynamics of these cytokines. IL-8 level was increased in both groups but decreased effectiveness was associated with early start and long duration of it. IL-4 production was decreased in the good/ excellent group while on the second one changes of cytokine level were absent. IL-13 and IL-5 synthesis were increased in both groups. Conclusion. The effectiveness of ASIT in PAR patients depends on synthesis dynamics of ILL-4, -6, -8, -12, sIL-2R at the early treatment stages.

Dynamic Changes, Correlation of Basophils, and the Therapeutic Effect in Patients With Allergic Rhinitis During Allergen-specific Immunotherapy

2021 ◽  
pp. 194589242110270
Author(s):  
Meixu Huo ◽  
Susu Tang ◽  
Daihua Wang ◽  
Xiaoqing Liu ◽  
Qianxu Liu
Keyword(s):  
Allergic Rhinitis ◽  
Therapeutic Effect ◽  
House Dust ◽  
Peripheral Blood ◽  
Specific Immunotherapy ◽  
House Dust Mites ◽  
Dust Mites ◽  
Allergen Specific Immunotherapy ◽  
Time Points ◽  
Activation Rate

Background The role of basophils in allergic rhinitis (AR) has been studied extensively; however, there are very few reports on changes in basophils after allergen-specific immunotherapy (SIT). Objective To examine the changes and correlation of peripheral blood basophils and the therapeutic effect in patients with AR during allergen-SIT. Methods A total of 77 patients with AR who were allergic only to house dust mites received allergen-SIT. At 3 time points, patients underwent testing for the percentage and activation rate of basophils in peripheral blood, skin index (SI) measurement, visual analog scale (VAS) assessment, and rhinoconjunctivitis quality of life questionnaire (RQLQ) evaluation. The results were compared to a control group with congenital preauricular fistula. Results (1) Before treatment, the percentage and activation rate of basophils in patients with AR were significantly higher than those in controls. There was no significant difference in the percentages and activation rates of basophils at the 3 time points. (2) The SIs, VAS, and RQLQ scores of the patients immediately after treatment and 2 years posttreatment decreased significantly compared to those before treatment; the SI, VAS, and RQLQ scores of the patients 2 years posttreatment increased significantly compared with those immediately after treatment. (3) There was no correlation between the patients’ basophil activation rate and percentage and the SI, VAS, and RQLQ scores at all time points. Conclusion The percentage and activation rate of basophils were higher in patients with AR than in controls. The values did not change significantly after allergen-SIT and showed no correlation with treatment effectiveness. Therefore, the frequency and activation rate of basophils cannot be used as criteria for assessing the effectiveness of allergen-SIT for house dust mites. Allergen-SIT is effective for the management of AR, but the effect declines after the completion of therapy.

scholarly journals ALLERGIC RHINITIS IN PRE-SCHOOL CHILDREN LIVING IN URBAN SETTINGS OF THE ALTAI REGION: A POPULATION-BASED CROSS-SECTIONAL STUDY

2018 ◽  
Vol 17 (3) ◽  
pp. 236-243
Author(s):  
Natalia V. Shakhova ◽  
Elena M. Kamaltynova ◽  
Yuriy Ph. Lobanov ◽  
Tatyana S. Ardatova
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Family History ◽  
School Children ◽  
Vitamin D3 ◽  
House Dust Mites ◽  
Urban Settings ◽  
Altai Region ◽  
History Of

Background.It is necessary to study the prevalence and risk factors of allergic rhinitis (AR) among pre-school children in order to develop a disease prevention strategy.Objective.Our aim was to study the prevalence, clinical and allergological features, and risk factors for AR in pre-school children living in urban settings of the Altai Region.Methods.At the screening stage, the study enrolled children aged 3–6 years attending pre-school educational institutions in 5 cities of the Altai Region. AR symptoms were determined using the ISAAC questionnaire. The AR was diagnosed if ≥ 2 symptoms (rhinorrhea, nasal breathing difficulty, itching in the nasal cavity, repetitive sneezing) lasted ≥ 1 h with a positive prick test and/or a blood level of specific IgE > 0.35 kU/L to at least one allergen (total 11).Results.The prevalence of AR in urban children aged 3–6 years (n = 3,205) was 10.6%; 48% of them were previously diagnosed with AR. 85% of children had a persistent course of the disease; 69% had mild AR. Most often, there was established sensitization to house dust mites (61.6%), birch pollen (40.9%), and cat fur (19.4%). The risk factors for AR were family history of allergies [odds ratio (OR) 4.2; 95% confidence interval (CI) 3.5–5.9], masculine (OR 2.8, 95% CI 1.9–4.0), smoking parents (OR 1.8, 95% CI 1.2–2.9), nonadherence to a regimen/dosage of vitamin D3 intake in infancy (OR 1.8, 95% CI 1.2–2.8), presence of asthma-like symptoms (OR 10.2, 95% CI 7.2–14.5), and manifestations of atopic dermatitis (OR 6.0, 95% CI 4.2–8.5).Conclusion.AR occurs in every tenth pre-school child (mainly of mild severity and persistent course), every second disease among them was diagnosed for the first time. Sensitization occurs to typical for childhood allergens. The risk factors for AR are family history of allergies, masculine, passive smoking, ignoring the recommendations of taking vitamin D3 in infancy, the presence of atopic dermatitis, and asthma-like symptoms.

Nasal Nitric Oxide and Nasal Cytology as Predictive Markers of Short-Term Sublingual Allergen-Specific Immunotherapy Efficacy in Children with Allergic Rhinitis

2021 ◽  
pp. 194589242110605
Author(s):  
Giuseppe Fabio Parisi ◽  
Sara Manti ◽  
Maria Papale ◽  
Melania Amato ◽  
Amelia Licari ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Allergic Rhinitis ◽  
Conventional Therapy ◽  
House Dust Mites ◽  
Dust Mites ◽  
Short Term ◽  
Allergen Specific Immunotherapy ◽  
Nasal Nitric Oxide ◽  
Nasal Cytology ◽  
Term Response

Background Few studies have been conducted on the short-term response to sublingual immunotherapy (SLIT). Objective The purpose of our experimental trial was to evaluate if two markers such as nasal nitric oxide (nNO) and nasal cytology could be useful to identify a precocious clinical efficacy of SLIT treatment. Methods We enrolled 34 children aged 6 to 14 years old with diagnosis of allergic rhinitis (AR) and documented sensitization towards house dust mites. We started allergoid-monomeric tablets immunotherapy along with any conventional therapy for AR and we evaluated at baseline (T0), after one (T1), two (T2), three (T3), and six months (T6) the effects of the treatment through the study of: i) a visual analogue scale (VAS 1-10); ii) measurement of nNO; iii) measurement of FeNO; iv) nasal cytology; v) spirometry; and vi) evaluation of any conventional therapy. Results We observed an improvement in symptoms evaluated by global VAS (T0 vs. T6: 47.13 vs. 17.57; p < .05) and a statistically significant reduction of nNO (1035.2 ± 956.08 vs. 139.2 ± 59.01; p < .05). In this case, significance was reached when the patients completed the 6 months of treatment. Cytological evaluation revealed significant reduction in nasal eosinophils (T0 vs. T6: 87% vs. 16%; p < .01). Moreover, at T0, 56% of patients had also neutrophils that were reduced up to the 8% at T6 (p < .05). Conclusions Our data confirm the effectiveness of SLIT treatment from a clinical perspective and identifies two biomarkers, such as nNO and nasal cytology, as predictive of treatment efficacy in the short term.

Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis

2011 ◽  
Vol 22 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Cengiz Kirmaz ◽  
Ozlem Ozenturk Kirgiz ◽  
Papatya Bayrak ◽  
Ozge Yilmaz ◽  
Seda Vatansever ◽  
...  
Keyword(s):  
T Cells ◽  
Allergic Rhinitis ◽  
Regulatory T Cells ◽  
Seasonal Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy

scholarly journals Could FeNO Predict Asthma in Patients with House Dust Mites Allergic Rhinitis?

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 235
Author(s):  
Ioana Adriana Muntean ◽  
Ioana Corina Bocsan ◽  
Stefan Vesa ◽  
Nicolae Miron ◽  
Irena Nedelea ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
Immunoglobulin E ◽  
Biological Evaluation ◽  
House Dust Mites ◽  
Dust Mites ◽  
Persistent Allergic Rhinitis ◽  
Tnf Α ◽  
One Year ◽  
High Level

Background and Objectives: The evolution of allergic rhinitis to asthma is a part of “atopic march”. The aim of this study was to analyze possible predictive markers for asthma occurrence in patients with allergic rhinitis to house dust mites (HDM). Materials and Methods: Fifty-eight patients with persistent allergic rhinitis (PAR) were included. The clinical, biological evaluation and fractionated exhaled nitric oxide (FeNO) measurement were performed at enrolment. The patients were clinically evaluated after one year to determine asthma occurrence. Results: The severity of rhinitis symptoms, levels of total immunoglobulin E (IgE), ICAM-1, VCAM-1, E-selectin and IL-6, but not IL-8 and TNF-α were higher in patients with allergic rhinitis who developed asthma compared to non-asthmatics, but the differences were not significant to considered them as predictive factors for asthma occurrence. The risk of asthma was independently influenced by patients aged over 30 years ((OR-3.74; CI95% 0.86–16.31; p = 0.07), a duration of allergic rhinitis over 12 months ((OR-4.20; CI95% 0.88–20; p = 0.07) and a basal FeNO over 28 parts per billion (pbb) ((OR-18.68; CI95% 3.79–92.05; p < 0.001). Conclusion: Clinical and biological parameters may predict asthma occurrence in patients with persistent allergic rhinitis to HDM. Adult patients with a longer duration of rhinitis symptoms and a high level of FeNO have a greater risk to develop asthma.

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