scholarly journals Epidermal barrier defect in atopic dermatitis children and its role in the development of allergic sensitization and respiratory allergy

2015 ◽  
Vol 12 (5) ◽  
pp. 39-48
Author(s):  
N B Migacheva ◽  
A V Zhestkov ◽  
T I Kaganova ◽  
O G Elisutina ◽  
G I Bibarsova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Young Children ◽  
Allergic Disease ◽  
Allergic Sensitization ◽  
Respiratory Allergy ◽  
Allergy Prevention ◽  
Barrier Defect ◽  
Allergic March ◽  
Near Future ◽  
New Strategies

Atopic dermatitis (AD) is the most common allergic disease in young children which is often (almost in half of cases) the beginning of so-called «allergic march», followed by the addition of respiratory allergy symptoms. In this review we present some studies to explain one of the possible mechanisms for the realization of allergic march associated with transepidermal sensitization in atopic dermatitis infants. Perhaps, the data may help in establishment of new strategies for allergy prevention in the near future.

scholarly journals Fibrin(ogen) Mechanistically Contributes to Atopic Dermatitis Pathogenesis and Allergic Sensitization

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 2097-2097
Author(s):  
Alyssa Filuta ◽  
Peter K Amezcua ◽  
Brandy Ruff ◽  
Hua He ◽  
Lisa J Martin ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Allergic Disease ◽  
Immunoglobulin E ◽  
Critical Role ◽  
Allergic Sensitization ◽  
Skin Barrier Function ◽  
P Value ◽  
Increased Risk ◽  
The Impact

Abstract Adults with atopic dermatitis (AD) have an increased risk for thromboembolic events. While coagulation is critical for almost all healing responses, dysregulated clotting and fibrin(ogen) deposition lead to inflammation that exacerbates tissue damage and impairs tissue repair. While plasma fibrin(ogen) has been associated with established asthma, fibrin(ogen)'s mechanistic role in AD pathogenesis and allergic sensitization has not been investigated. Here we show that fibrinogen plays a critical role in a murine model atopic dermatitis pathogenesis by markedly attenuating disease severity, barrier dysfunction, and allergic sensitization. To determine if fibrinogen impacts AD pathogenesis, we used mice with complete fibrinogen deficiency (Fib -/-), partial deficiency (Fib +/-), and wildtype controls (Fib WT) in our established model of AD. This model uses repeated cutaneous allergen sensitization with heat-killed Aspergillus fumigatus (Asp) extract. Notably, Fib +/- mice produce approximately half as much fibrinogen as Fib WT mice. After each patch and at sacrifice each mouse underwent an objective disease severity assessment as well as transepidermal water loss (TEWL) measurements to assess skin barrier function. Our results show that complete and partial fibrinogen deficiency abrogated AD development. We found that Fib -/-and Fib +/- mice had markedly attenuated TEWL (P-value <0.0001) and disease severity (P-value <0.0001) compared with controls (Figure 1). In addition, we found that the TEWL and disease severity in Fib -/- and Fib +/- were comparable to unchallenged controls. There was also no difference in either outcome between Fib -/- and Fib +/- mice within the experimental group. Lastly, none of the Fib -/- and Fib +/- mice developed spontaneous bleeding. Next, to elucidate the impact of fibrinogen on allergic sensitization we measured plasma allergen specific immunoglobulin E (sIgE) to Asp in all mice in our AD model at sacrifice. We found that Fib -/- and Fib +/- mice had significantly lower Asp sIgE compared with controls (p-value <0.0001 and 0.0002, respectively; Figure 2). In addition, we found that the amount of sIgE to Asp produced was comparable between Fib -/- and Fib +/- mice as well as with unchallenged controls. Thus, our findings suggest that fibrin(ogen) plays a critical mechanistic role in driving AD development and allergic sensitization. While fibrinogen's role in established allergic disease has been shown, these novel findings suggest a critical role for fibrinogen in allergic disease pathogenesis which may allow for additional therapeutic targets to treat atopic dermatitis and other allergic diseases. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

Features of nursing care for atopic eatures of nursing care for atopic dermatitis in young children

2020 ◽  
pp. 20-26
Author(s):  
Anna Pinigina
Keyword(s):  
Atopic Dermatitis ◽  
Young Children ◽  
Nursing Care ◽  
Diagnosis And Treatment

The article presents the results of research and synthesis of information on nursing assistance in prevention, diagnosis and treatment of atopic dermatitis in children.

A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis

2004 ◽  
Vol 15 (6) ◽  
pp. 558-561 ◽  
Author(s):  
Ting Fan Leung ◽  
Kwok Chiu Ma ◽  
Lorena T. F. Cheung ◽  
Christopher W. K. Lam ◽  
Eric Wong ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Amino Acid ◽  
Young Children ◽  
Crossover Study ◽  
Milk Formula ◽  
Single Blind

scholarly journals Association analysis of allergic sensitization susceptibility loci with atopic dermatitis in Chinese population

2015 ◽  
Vol 80 (3) ◽  
pp. 217-220 ◽  
Author(s):  
Jinping Gao ◽  
Yuemei Ma ◽  
Yujun Sheng ◽  
Xianbo Zuo ◽  
Wenjun Wang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Association Analysis ◽  
Chinese Population ◽  
Allergic Sensitization ◽  
Susceptibility Loci

scholarly journals Food Sensitization in Infants and Young Children with Atopic Dermatitis

2004 ◽  
Vol 45 (5) ◽  
pp. 803 ◽  
Author(s):  
Dong Ki Han ◽  
Myung Kwan Kim ◽  
Jae Eun Yoo ◽  
Sung Yon Choi ◽  
Byoung Chul Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Young Children ◽  
Food Sensitization ◽  
Infants And Young Children

scholarly journals The Role of Hydrolyzed Formula in Allergy Prevention

2017 ◽  
Vol 70 (Suppl. 2) ◽  
pp. 38-45 ◽  
Author(s):  
Michael D. Cabana
Keyword(s):  
Allergic Rhinitis ◽  
Food Allergy ◽  
Infant Formula ◽  
Allergic Disease ◽  
Clinical Studies ◽  
Atopic Disease ◽  
Allergy Prevention ◽  
Preventive Effect ◽  
History Of ◽  
Hydrolyzed Formula

Asthma, eczema, food allergy, and allergic rhinitis are some of the most common pediatric, chronic conditions in the world. Breastfeeding is the optimal way to feed all infants. For those infants who are exposed to infant formula, some studies suggest that certain partially hydrolyzed or extensively hydrolyzed formulas may decrease the risk of allergic disease compared to nonhydrolyzed formulas for children with a family history of atopic disease. Overall, there is some evidence to suggest that partially hydrolyzed whey formulas and extensively hydrolyzed casein formulas may decrease the risk of developing eczema for infants at high risk of allergic disease. The evidence for a preventive effect of hydrolyzed formulas on allergic rhinitis, food allergy, and asthma is inconsistent and insufficient. Finally, the qualitative changes to the peptides by the method of hydrolysis, not just the degree of protein hydrolysis, may have a large influence on the preventive effect of a particular infant formula for the potential risk of allergic disease. As a result, it may be difficult to generalize findings from clinical studies using a specific infant formula to other infant formulas from different manufacturers using different methods of hydrolysis. Further clinical studies are needed to help clinicians identify which infants may benefit from early intervention, as well as which specific hydrolyzed formulas are best suited to decrease the risk of future allergic disease.

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