scholarly journals New opportunities for the combined therapy of allergic rhinitis in real clinical practice

2019 ◽  
Vol 16 (1) ◽  
pp. 85-89
Author(s):  
E V Nazarova
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Practice ◽  
Nasal Congestion ◽  
Combined Therapy ◽  
Nasal Breathing ◽  
Interferon Alpha 2B ◽  
Eye Symptoms ◽  
Low Incidence ◽  
The Given ◽  
Real Clinical Practice

This paper assesses the efficacy of the original combined medication Allergoferon® beta (betamethasone + interferon alpha-2b) in real clinical practice among patients with seasonal allergic rhinitis (AR). The research program results demonstrated a good efficacy of the given medication: there were a decrease in nasal congestion as well as restoration of nasal breathing and in patients with concomitant allergic conjunctivitis - a reduction in the severity of eye symptoms. A low incidence of side effects was observed. It was shown that Allergoferon® beta can be recommended as monotherapy for patients with mild and moderate AR and in complex therapy for patients with severe AR.

НОВЫЕ ВОЗМОЖНОСТИ КОМБИНИРОВАННОЙ ТЕРАПИИ АЛЛЕРГИЧЕСКОГО РИНИТА В УСЛОВИЯХ РЕАЛЬНОЙ КЛИНИЧЕСКОЙ ПРАКТИКИ

2019 ◽  
Author(s):  
E.V. Nazarova
Keyword(s):  
Allergic Conjunctivitis ◽  
Nasal Congestion ◽  
Nasal Breathing ◽  
Interferon Alpha 2B ◽  
Complex Therapy ◽  
Eye Symptoms ◽  
Low Incidence ◽  
The Given ◽  
Combined Medication ◽  
Real Clinical Practice

Статья представляет собой обзор исследовательской программы по оценке эффективности оригинального комбинированного лекарственного препарата Аллергоферон бета (бетаметазон интерферон альфа-2b) в условиях реальной клинической практики у больных сезонным аллергическим ринитом (АР). Результаты программы продемонстрировали хорошую эффективность препарата: при низкой частоте побочных эффектов наблюдалось снижение заложенности носа и восстановление носового дыхания, у пациентов с сопутствующим аллергическим конъюнктивитом отмечалось снижение выраженности глазных симптомов. Было показано, что Аллергоферон бета может быть рекомендован в качестве монотерапии у больных АР с легким и среднетяжелым течением заболевания и в комплексной терапии при тяжелом течении АР.This paper assesses the efficacy of the original combined medication Allergoferon beta (betamethasone interferon alpha-2b) in real clinical practice among patients with seasonal allergic rhinitis (AR). The research program results demonstrated a good efficacy of the given medication: there were a decrease in nasal congestion as well as restoration of nasal breathing and in patients with concomitant allergic conjunctivitis - a reduction in the severity of eye symptoms. A low incidence of side effects was observed. It was shown that Allergoferon beta can be recommended as monotherapy for patients with mild and moderate AR and in complex therapy for patients with severe AR.

Effect of Shadbindu Taila and Haridra Khanda in Pratishyaya (Allergic Rhinitis)

The Healer ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 58-60
Author(s):  
Sadhana Parajuli ◽  
Pramod Bhatta ◽  
D.L Bharkher
Keyword(s):  
Immune Response ◽  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Significant Role ◽  
Vital Sign ◽  
Nasal Congestion ◽  
Combined Therapy ◽  
Nasal Discharge ◽  
Before And After ◽  
Airborne Allergens

Allergic rhinitis (AR) is an immune response of the nasal mucosa to airborne allergens and involves nasal congestion, watery nasal discharge, itching of the nose, and sneezing. Ayurveda describes Pratishyaya as one of the most important diseases among the 31 Nasarogas. Acharya Sushruta clearly mentioned that Pratishyaya is the condition in which vata kapha dusti was observed. Haridra Khanda is one of the prominent anti allergic drugs mentioned in ayurveda. Pratimarsha nasya has significant role in the prevention of urdhvajatrugata rogas. Ancient acharya has told to try shadbindu taila and Haridra khanda both locally and systematically in the management of pratishyaya. Here 30 patients were selected open randomly in shalakya opd of ayurveda campus kirtipur. They were given pratimarsha nasya with sadhbindu taila and internally haridra khanda for 30 days. The vital sign and symptom of pratishyaya like nasa srava, nasa kandu, kshavatu, nasa kandu and shira shula were studied before and after the treatment. The result of the study indicated that the combined therapy of internally Haridra Khanda and external pratimarsha narsha with sadbindu tail has given significant result in the treatment of Allergic Rhinitis (Pratishyaya).

scholarly journals Modern possibilities of pathogenetic therapy of patients with allergic rhinitis

2020 ◽  
pp. 101-106
Author(s):  
V. M. Svistushkin ◽  
G. N. Nikiforova ◽  
P. S. Artamonova ◽  
E. A. Shevchik
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Nasal Congestion ◽  
Clinical Manifestations ◽  
Allergic Inflammation ◽  
Good Alternative ◽  
Nasal Breathing ◽  
Oral Medications ◽  
Pathogenetic Therapy ◽  
Modern Classification

The incidence of allergic rhinitis has been increasing rapidly worldwide in recent years. About 40% of the world’s population suffer from allergic inflammation of the nasal mucous membrane. Clinical manifestations of allergic rhinitis are absence or difficulty of nasal breathing, itching, sneezing, nasal congestion and rhinorrhoea, as well as swelling of the face, the presence of dermatitis in the region of the nasal wings, general malaise, smell disturbance. Manifestations of allergies by ENT organs in most cases do not pose a threat to life, but they can cause the development of other pathological processes, bad sleep, irritability, decreased efficiency, mood swings, which, in turn, adversely affects human health and reduces the quality of life. The pathogenesis of allergic rhinitis is based on an immediate hypersensitivity. According to the modern classification, depending on the nature of the course of the disease it is common to identify intermittent and persistent forms.At present, the drugs of choice in the treatment of patients with allergic rhinitis are intranasal glucocorticosteroids. However, the presence of a concomitant pathology of the nasal cavity in the patient, such as deviated septum, not only significantly impairs the course of nasal inflammatory process, but also creates obstacles to adequate delivery of topical drugs to all parts of the nasal cavity, which, in turn, reduces their effectiveness.For patients suffering from allergic rhinitis in combination with other pathology of the nasal cavity, combined oral medications may be a good alternative to intranasal sprays. Certain interest for doctors is caused by the appearance of a combined antihistamine drug on the Russian market, which includes a blocker of leukotrienes and H1-histamine receptors of the second generation – montelukast and levocetirizine. The drug can be used both in adults and children from 15 years old for treatment of intermittent and persistent forms of allergic rhinitis.Timely and properly performed therapy of allergic rhinitis allows to eliminate symptoms of the disease and prevent the development of complications.

scholarly journals The modern view of treatment of allergic rhinitis and it’s combination with bronchial asthma

2021 ◽  
pp. 92-98
Author(s):  
D. S. Smirnov ◽  
O. M. Kurbacheva
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Inflammatory Diseases ◽  
Nasal Congestion ◽  
Combined Therapy ◽  
Correct Diagnosis ◽  
Economic Problem ◽  
Atrophic Rhinitis ◽  
Significant Treatment ◽  
Adequate Treatment

In recent years, there has been a significant increase in the prevalence of diseases of the nose and paranasal sinuses. Inflammatory diseases of the mucous membrane nasal cavities (rhinitis) are most commonly characterized as a syndrome in which the patient experiences some combination of persistent nasal symptoms, including rhinorrhea, sneezing, nasal congestion, itching and burning in the nasal cavity. Among the chronic forms of rhinitis, allergic rhinitis occupies a large place along with vasomotor, infectious, hypertrophic, catarrhal and atrophic rhinitis. Allergic rhinitis is a significant social and medico-economic problem, since it significantly reduces the quality of life of patients and requires significant treatment costs. This nosology is found in the practice of doctors of all specialties, however, the correct diagnosis and the appointment of adequate therapy can take many months and years. Currently, the concept of “common airways” is widely discussed, which demonstrates the close relationship between allergic rhinitis and bronchial asthma and proves that the inflammatory response can be supported and enhanced by interrelated mechanisms. Therefore, patients with allergic rhinitis should be examined for the presence of bronchial asthma. In turn, patients with bronchial asthma need to diagnose allergic rhinitis, and treatment should be aimed at suppressing allergic inflammation in both the upper and lower respiratory tract. This article discusses modern diagnostic and therapeutic approaches to patients with these diseases, which make it possible to efficiently and timely identify allergic rhinitis and initiate appropriate adequate treatment. The article also discusses the feasibility of using combined therapy with levocetirizine and montelukast in the above nosologies.

scholarly journals Narrow-Band UVB Therapy and Topical Calcineurin Inhibitors for the Treatment of Paediatric Vitiligo in Real Clinical Practice

2021 ◽  
Vol 75 (3) ◽  
pp. 200-205
Author(s):  
Ilona Hartmane ◽  
Ingmārs Mikažāns ◽  
Iveta Ivdra ◽  
Irēna Mirzajanova ◽  
Andra Dērveniece ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Surface Area ◽  
Outcome Measures ◽  
Clinical Efficacy ◽  
Narrow Band ◽  
Therapy Group ◽  
Combined Therapy ◽  
Calcineurin Inhibitors ◽  
Secondary Outcome ◽  
Real Clinical Practice

Abstract Vitiligo is an acquired chronic skin disease, characterised by progressing, usually symmetric, depigmented areas in human skin. Vitiligo affects 0.5% of the human population, however, optimal treatment combination real clinical practice has yet to be found. The aim of the study was to assess whether combined therapy with ultraviolet B (UVB) therapy and calcineurin inhibitors (CNI) provides superior response in vitiligo patients, compared with phototherapy or topical CNI monotherapy. We performed a retrospective cohort study of children treated for vitiligo from January 2016 to December 2019. Primary outcome measures include clinical efficacy defined by area of repigmentation — good clinical efficacy (re-pigmentation of ≥ 50% of lesion surface area), positive clinical efficacy and poor clinical efficacy (re-pigmentation of < 15% of lesion surface area). Secondary outcome measures included reduction of lesion size and tolerability of therapy. A total of 114 patients were recruited in the study, 46 allocated to the topical CNI therapy group, 36 to the narrow band (Nb-UVB), and 32 to the combined therapy group. All treatments statistically significantly decreased lesion surface area compared to the baseline (mean, SD). Local therapy reduced lesions from 8.5 (5.7) to 5.3 (4.2) by 37.3% (p < 0.0001), phototherapy reduced lesions from 9.8 (5.4) to 5.7 (3.92) by 42.3% (p < 0.0001), and combined therapy reduced lesions from 14.2 (4.8) to 6.58 (3.5) by 53.6% (p < 0.0001), with combined therapy showing superior numerical efficacy. Clinical efficacy for CNI monotherapy was 67.4%, for phototherapy — 80.5%, and for combined therapy 93.7%. The safety profile of therapies was consistent with other studies. Our results support the use of combined therapy in vitiligo patients.

In real clinical practice osteoporosis drugs are taken for a very short period: analysis of persistence in the campania region

2013 ◽  
Author(s):  
Giovanni Iolascon ◽  
Annarita Capaldo ◽  
Valentina Orlando ◽  
Enrica Menditto ◽  
Francesca Gimigliano
Keyword(s):  
Clinical Practice ◽  
Campania Region ◽  
Period Analysis ◽  
Short Period ◽  
Real Clinical Practice

PCSK9 inhibitors as an add on for the treatment of dislipemia in real clinical practice

2018 ◽  
Author(s):  
Carmen Hernandez Garcia ◽  
Cristina Maria Diaz Perdigones ◽  
Miguel Damas Fuentes ◽  
Clara Estaun Martinez ◽  
Andrea Sanchez Ramos ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Pcsk9 Inhibitors ◽  
Real Clinical Practice

ПАТОЛОГИЯ ЛИЧНОСТИ В ТЕОРЕТИЧЕСКИХ ПОСТРОЕНИЯХ ПРЕДСТАВИТЕЛЕЙ ОТЕЧЕСТВЕННОЙ МЕТАФИЗИЧЕСКОЙ ТРАДИЦИИ В ПСИХОЛОГИИ

1970 ◽  
Vol 7 (1) ◽  
pp. 208-215
Author(s):  
Александр Бреусенко-Кузнецов
Keyword(s):  
Clinical Practice ◽  
Subject Matter ◽  
Clinical Psychology ◽  
History Of Psychology ◽  
History Of ◽  
Metaphysical Tradition ◽  
The Given

Статья посвящена проблеме восстановления искусственно прерванной метафизической традиции в отечественной персонологии. Данная проблема принадлежит областям истории психологии и психологии личности, но имеет выходы и в предметные области многих других психологических наук, в частности – клинической психологии. Указана важность соотнесения персонологических концептуализаций учёных-метафизиков с клинической практикой в процессе их опытной верификации. Проведена реконструкция и анализ взглядов на психопатологию и психотерапию представителей метафизической традиции в отечественной психологии личности. Согласно данным взглядам, суть патологии личности – в её уклонении от своего назначения, от подлинного бытия ради неподлинных, онтологически неоправданных форм жизнедеятельности. The article is devoted to the problem of restoration of artificialy interrupted metaphysical tradition in domestic personology. The given problem belongs to the areas of history of psychology and psychology of personality, but provides outcomes in subject matter of many other psychological sciences, in clinical psychology in particular. Importance of correlation between personological conceptualizations of scientists-metaphysicists and clinical practice in the process of their skilled verification is pointed out. The reconstruction and analysis of views at psychopathology and psychotherapy by representatives of metaphysical tradition in domestic psychology of personality have been made. According to the mentioned views, the essence of pathology of personality is in its evasion from the purpose, from original life for the sake of not original, ontologically unjustified forms of ability to live.

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