Prospects for studying of FOXP3 and its isoforms expression in allergic diseases

2017 ◽  
Vol 14 (2) ◽  
pp. 22-29
Author(s):  
D S Smirnov ◽  
O M Kurbacheva ◽  
S A Polner ◽  
K S Pavlova
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Allergic Diseases ◽  
Specific Marker ◽  
Exon 2

In this review we describe FOXP3 (a specific marker of regulatory T-cells), nature of FOXP3 isoforms (with or without exon 2) expression and cooperation with other transcription factors under various immunopathological conditions and discuss the prospects for studying of FOXP3 isoforms expression in CD4+ T-cells in allergic diseases.

Suppression of Pathogenic Autoreactive CD4+ T Cells by CD137-mediated Expansion of CD4+CD25+ Regulatory T Cells in Graves' Disease

2007 ◽  
Vol 22 (5) ◽  
pp. 332
Author(s):  
Eun Sook Kim ◽  
Hyo Won Jung ◽  
Jung Il Choi ◽  
Il Seung Nam-Goong ◽  
Soon Hyung Hong ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Graves Disease

scholarly journals Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Mark Engel ◽  
Tom Sidwell ◽  
Ajithkumar Vasanthakumar ◽  
George Grigoriadis ◽  
Ashish Banerjee
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
T Cell ◽  
Regulatory T Cells ◽  
Immune Tolerance ◽  
Regulatory T Cell ◽  
T Cell Development ◽  
Signalling Pathways ◽  
Treg Development

Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.

scholarly journals Interleukin-30 Suppresses Not Only CD4+ T Cells but Also Regulatory T Cells in Murine Primary Biliary Cholangitis

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1031
Author(s):  
Hung-Wen Chen ◽  
Chia-I. Lin ◽  
Ya-Hui Chuang
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Primary Biliary Cholangitis ◽  
Autoimmune Cholangitis ◽  
Liver Inflammation ◽  
Adeno Associated Virus ◽  
Cytokines And Chemokines ◽  
Ifn Γ

Primary biliary cholangitis (PBC) is a chronic liver autoimmune disease with augmented T helper (Th) 1 and corresponding cytokine IFN-γ immune responses. Using 2-octynoic acid (2-OA) coupled to OVA (2-OA-OVA)-induced mouse models of autoimmune cholangitis (inducible chemical xenobiotic models of PBC), our previous study demonstrated that overexpression of IFN-γ in the model mice enhanced liver inflammation upon disease initiation, but subsequently led to the suppression of chronic inflammation with an increase in interleukin-30 (IL-30) levels. In this study, we investigated whether IL-30 had an immunosuppressive function and whether it could be part of an immune therapeutic regimen for PBC, by treating model mice with murine IL-30-expressing recombinant adeno-associated virus (AAV-mIL-30). We first defined the effects of AAV-mIL-30 in vivo by administering it to a well-known concanavalin A (ConA)-induced hepatitis model of mice and found that AAV-mIL-30 reduced the numbers of activated CD25+CD4+ T cells and the levels of serum IFN-γ and IL-12. In autoimmune cholangitis, decreased numbers of activated CD4+ T cells and Foxp3+ regulatory T cells were noted in the mice treated with AAV-mIL-30 at 3 weeks after the 2-OA-OVA immunization. Treatment with IL-30 did not change the features of autoimmune cholangitis including autoantibodies, cell infiltration, and collagen deposition in the liver at 11 weeks of examination. However, increased levels of cytokines and chemokines were observed. These results suggest that IL-30 suppresses not only CD4+ T cells but also regulatory T cells. Additionally, the administration of IL-30 did not suppress liver inflammation in the murine model of PBC.

scholarly journals Dendritic Cells With TGF-β1 and IL-2 Differentiate Naive CD4+ T Cells Into Alloantigen-Specific and Allograft Protective Foxp3+ Regulatory T Cells

2012 ◽  
Vol 93 (6) ◽  
pp. 580-588 ◽  
Author(s):  
Hua Yang ◽  
Elaine Y. Cheng ◽  
Vijay K. Sharma ◽  
Mila Lagman ◽  
Christina Chang ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Tgf Β1

scholarly journals Selective expansion of memory CD4+ T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells

2008 ◽  
Vol 38 (6) ◽  
pp. 1522-1532 ◽  
Author(s):  
Manisha Singh ◽  
Sreemanti Basu ◽  
Christina Camell ◽  
Jacob Couturier ◽  
Rodolfo J. Nudelman ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Cytokines ◽  
Cd4 T Cells ◽  
Memory Cd4 T Cells
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