scholarly journals THE ROLE OF MODERN ANTIHISTAMINES IN THE TREATMENT OF ALLERGIC DISEASES

2017 ◽  
Vol 14 (4-5) ◽  
pp. 80-88
Author(s):  
N M Nenasheva
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Second Generation ◽  
Allergic Diseases ◽  
Pharmaceutical Market ◽  
Common Diseases ◽  
First Choice ◽  
Antihistamine Drug

Allergic rhinitis and urticaria - are common diseases which influence on the quality of life of patients reducing day activity and educability. The second generation of antihistamines are the first choice in the treatment of these diseases. At Russian pharmaceutical market a few dozens of different preparations of this group are available. Most of them are generic forms. The purpose of this article is to show the place of modern antihistamines in allergic rhinitis and urticaria therapy and to find out the best equivalent of generic antihistamine drug in comparison with the original one.

scholarly journals Сlinical features of changes in the microcirculation system among children with allergic rhinitis, depending on the severity of dysfunction of the autonomic nervous system

2021 ◽  
Vol 23 (1) ◽  
pp. 169-172
Author(s):  
N. S. Tataurschikova ◽  
P. V. Berezhansky
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Adaptive Systems ◽  
Allergic Diseases ◽  
The Body ◽  
Individual Treatment ◽  
Autonomic Nervous

In recent years, there has been an increase in the prevalence of allergic diseases in children. Allergic rhinitis (AR) ranks first among other allergic diseases in terms of prevalence and impact on the health and quality of life patients. In various countries of the world, according to various sources, from 10 to 40% of the population suffers. Allergic rhinitis is a serious medical, social and economic problem. In addition, allergic rhinitis, especially with multiple sensitization and insufficiently controlled course, is an independent risk factor for recurrence of respiratory infections and the development of bronchial asthma, and also significantly reduces the quality of life patients.AR is a multifactorial disease in the development of which many factors play a role. The basis of the pathological process in AR is IgE--dependent mucosal inflammation, which is realized under the influence of specific and nonspecific mechanisms and has a Th2 character. The tissues and organs involved in the process determine the formation of complex mechanisms of interaction between the immune, microcirculatory and autonomic nervous systems.The inflammatory process in AR is characterized by a number of features, for example, the presence of minimal persistent inflammation and the priming effect, which in turn is a predisposing factor for the clinical onset and progression of AR. Microcirculatory mechanisms are of great pathogenetic significance in the development of allergic inflammation, including in AR.Depending on the leading pathognomonic trait, it is now customary to distinguish individual phenotypes and endotypes of AR.The phenotype covers the clinically significant properties of AR, but does not reveal the detailed mechanisms of its development, on the basis of which a personalized algorithm for prevention, treatment and prognosis can be created.And the autonomic nervous system is responsible for setting links between the body, ambient and internal environment through the regulation of metabolism, functioning of organs and tissues based on changes in this environment; it also provides the integration of all organs into a single whole acting as one of the main body’s adaptive systems.Since the autonomic nervous system governs the body and homeostasis uniting separate pathogenetic links of disease progression and sets the basis for structural and functional unity. In light of this, the failure of neuroregulatory mechanisms takes the lead among the causes of systemic changes in the microvasculature, which, in turn, reflects general pathogenetic processes in the body. The regulatory mechanism is implemented through nerves and reflexes by different neurohumoral factors, their nature has been studied under experimental conditions and is beyond doubt to date.The study of the main indicators of microcirculation and the autonomic nervous system among children with allergic rhinitis in various combinations with concomitant pathology will highlight new AR phenotypes and select an individual treatment and rehabilitation plan for these children.

scholarly journals The Role of Probiotics in Preventing Allergic Disease

Children ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 24 ◽  
Author(s):  
Helen T. Wang ◽  
Sara Anvari ◽  
Katherine Anagnostou
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Optimal Dosing ◽  
Atopic Individual ◽  
Prevention And Treatment ◽  
Microbiome Research ◽  
Allergic Disorders

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment. In this review, we discuss recently published studies examining the benefits, risks, and role of probiotics in preventing atopic dermatitis, asthma, allergic rhinitis, and food allergy.

Allergic Diseases, Quality of Life, and the Role of the Dietitian

2008 ◽  
Vol 43 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Mark Boguniewicz ◽  
Nancy Moore ◽  
Kylie Paranto
Keyword(s):  
Quality Of Life ◽  
Allergic Diseases

scholarly journals Second-generation androgen receptor inhibitors in therapy of non-metastatic castration resistant prostate cancer: role of safety profile and effect on quality of life

2021 ◽  
Vol 67 (2) ◽  
pp. 217-226
Author(s):  
Elena Ushkalova ◽  
Sergey Zyryanov ◽  
Irina Gopienko
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Safety Profile ◽  
Second Generation ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Clinically Significant

The article discusses the role of second-generation androgen receptor inhibitors (ARi) in therapy of non-metastatic castration resistant prostate cancer (nmCRPC). The phase 3 trials PROSPER (enzalutamide), SPARTAN (apalutamide) and ARAMIS (darolutamide) showed that these medicines if used in combination with androgen deprivation therapy (ADT) make possible to significantly improve, as compared with placebo, metastasis-free survival and overall survival of patients with nmCRPC. An important role in choosing a certain medicine of the group is played by its safety profile, including its drug-drug interaction potential and effect on patient’s quality of life. In this respect, darolutamide has a number of advantages over apalutamide or enzlutamide. The frequency of CNS (cognitive, psychiatric, convulsive) and other adverse drug reactions that significantly worsen the patients’ quality of life (falls, fractures, hypertension, etc.) in therapy with darolutamide does not differ from that with placebo. Moreover, this medicine retains its antagonistic effects to all clinically significant androgen receptor mutations that develop resistance to enzalutamide and apalutamide.

scholarly journals Achievments of control of seasonal allergic rhinitis symptoms: the results of open, randomized comparative study of second generation antihistamines

2017 ◽  
Vol 14 (2) ◽  
pp. 37-46
Author(s):  
O S Bodnya ◽  
N M Nenasheva ◽  
G V Andrenova ◽  
D O Siniavkin ◽  
Y V Bodnya ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Second Generation ◽  
Day Treatment ◽  
Allergic Diseases ◽  
Adult Patients ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
First Choice ◽  
Baseline Values

Seasonal allergic rhinitis (SAR) is one of the most common allergic diseases. The first choice for control of SAR symptoms is the second-generation antihistamines (AHP-II). The aim of this study was to evaluate the comparative efficacy of ebastine 20 mg/day, cetirizine 10 mg/day, and loratadine 10 mg/day in adult patients with mild symptoms of SAR due to pollen grass allergy. 30 patients aged 18 to 65 years who received treatment for 14 days took part in the study. The duration of the study for one patient varied from 25 to 28 days. As a result, the efficiency of all three AHP II in the control of mild symptoms of SAR was demonstrated. However, the analysis of the scales (TNSS and TNNSS) after the end of the 14-day treatment period revealed that compared to patients treated with loratadine and cetirizine (TNSS scale (p=0,0303), TNNSS (p=0,0091) the best results were observed in the group of patients taking ebastine. Moreover, patients who received the ebastine experienced a statistically insignificant but steady tendency to decrease the level of eosinophilic cationic protein (ECP) in nasal flushing (-37,9% of the baseline values), in contrast to loratadine and cetirizine. All drugs showed a high safety profile. To conclude, the investigated AHPs -II are effective and safe in control of mild symptoms of SAR in adult patients, though the rate of onset of the effect and its level for nasal and non nasal symptoms was significantly higher in patients receiving ebastine 20 mg compared to cetirizine 10 mg and loratadine 10 mg.

scholarly journals Hubungan kadar leptin serum dengan derajat rinitis alergi

2011 ◽  
Vol 41 (1) ◽  
pp. 30
Author(s):  
Ahmad Dian Wahyudiono ◽  
Endang Retnoningsih ◽  
Pudji Rahaju
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Cross Sectional ◽  
Serum Leptin ◽  
Sensitization Process ◽  
Cross Sectional Design ◽  
The Relationship ◽  
Global Health Problem

Background: Allergic rhinitis is a global health problem that could impair the patient’s quality of life. Recent studies had showed the role of leptin, a hormone that produced by adipose tissue, on sensitization process which can increase the serum level of B cells and IgE. Purpose: To define the relationship between serum leptin level with the degree of allergic rhinitis based on ARIA and VAS.Methods: This study involved 38 subjects with cross sectional design. Statistical analysis included t-test, logistic regression and Kruskal-Wallis. Results: This study showed serum leptin level has correlation with the degree of allergic rhinitis based on ARIA (p<0.05), specifically on the intensity of allergic rhinitis (p<0.05), but not with the degree of allergic rhinitis based on VAS. Conclusion: Serum leptin level has a role on the degree of allergic rhinitis specifically on the intensity but not on the severity of allergic rhinitis symptoms. Controlling the serum leptin level can be considered as health promotion for patient with allergic rhinitis. Further research focusing on controlling serum leptin level for allergic rhinitis symptoms is recommended. Keywords: allergic rhinitis, serum leptin level, degree of allergic rhinitis   Abstrak :  Latar belakang: Rinitis alergi merupakan masalah kesehatan global dan dapat mengganggu kualitas hidup penderitanya. Beberapa penelitian telah menunjukkan peran leptin, hormon yang diproduksi oleh jaringan lemak, pada proses sensitisasi yang ditandai dengan kemampuan leptin meningkatkan sel B dan IgE. Tujuan: Penelitian ini bertujuan mengetahui hubungan kadar leptin serum dengan derajat rinitis alergi. Metode: Penelitian ini melibatkan 38 subjek dengan desain potong lintang untuk mengetahui hubungan kadar leptin serum dengan derajat rinitis alergi pada penderita rinitis alergi. Analisis statistik yang digunakan adalah uji t, uji regresi dan Kruskal-Wallis.Hasil: Penelitian ini menunjukkan bahwa kadar leptin serum berhubungan dengan derajat rinitis alergi berdasarkan ARIA (p<0,05) khususnya dengan intensitas keluhannya (p<0,05), namun tidak berhubungan dengan derajat rinitis berdasarkan VAS. Kesimpulan: Kadar leptin serum berhubungan dengan derajat rinitis alergi terutama pada intensitas keluhan dan bukan pada beratnya keluhan. Pengendalian kadar leptin serum dapat dipertimbangkan sebagai upaya memperbaiki kesehatan penderita rinitis alergi. Penelitian lebih lanjut yang menekankan pada pengendalian kadar serum leptin disarankan untuk mengendalikan keluhan rinitis alergi. Kata kunci: rinitis alergi, kadar leptin serum, derajat rinitis alergi

Fibromyalgia in the Patients With Allergic Rhinitis: Its Prevalence and Impact on the Quality of Life

2019 ◽  
Vol 33 (6) ◽  
pp. 716-722 ◽  
Author(s):  
Selcan Gultuna ◽  
Nihal Tezel ◽  
Funda Seher Ozalp Ates
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Negative Impact ◽  
Nottingham Health Profile ◽  
Allergic Diseases ◽  
Life Questionnaire ◽  
American College Of Rheumatology ◽  
Individual Domain ◽  
Impaired Quality

Background Allergic rhinitis (AR) is a common allergic diseases which affect a patient’s quality of life. Another important disease which has a negative impact on quality of life is fibromyalgia (FM). Some studies have suggested that a probable relationship exists between atopic diseases and FM. Objectives This study was designed to determine the prevalence of FM and its impact on quality of life among AR patients. Methods One hundred five consecutive adult patients with AR who were between 18 and 57 years old were prospectively recruited in this study between April 2017 and May 2018. All patients were evaluated for the presences of FM. Patients were diagnosed with FM according to the classification criteria of the 2010 American College of Rheumatology. The patients’ quality of life was evaluated by Turkish versions of the Rhinoconjunctivitis Quality of Life Questionnaire and the Nottingham Health Profile (NHP). Results Thirty-four patients were diagnosed as having FM (32.4%). The percentage of FM was considerably higher than in the general population (2%–5%). Median individual domain scores except practical problems ( P = .108) and eyes symptoms ( P = .227) were significantly higher in AR with FM patients ( P < .001). All median levels of the NHP domains were significantly higher in AR with FM patients ( P < .001). Conclusion We would like to suggest that FM may be considered as one of the overlooked comorbid conditions in AR patients. Physicians should be aware of the occurrence of FM, especially in patients with impaired quality of life.

scholarly journals The current state of the problem with the diagnosis and treatment of allergic rhinitis in pediatric practice

2021 ◽  
Vol 16 (5) ◽  
pp. 375-383
Author(s):  
T.O. Kruchko ◽  
O.Ya. Tkachenko ◽  
V.V. Sherbak ◽  
I.O. Kolenko ◽  
L.M. Bubyr
Keyword(s):  
Allergic Rhinitis ◽  
Pollen Allergy ◽  
Allergic Diseases ◽  
Individual Characteristics ◽  
Diagnosis And Treatment ◽  
Cochrane Library ◽  
Upper Respiratory Tract ◽  
Pediatric Practice

Among all allergic diseases in pediatric practice, allergic rhinitis is one of the most common pathologies of the upper respiratory tract. This review deals with the problem of modern principles for the diagnosis and treatment of allergic rhinitis in children based on the analysis of literature sources using electronic databases PubMed, Web of Science, MedLine, the Cochrane Library. Allergic rhinitis is an important medical and social problem of our time the importance of which has increased significantly in recent years. The growing number of people sensitized to pollen, the variety of symptoms and the negative impact on the quality of life of patients make pollen allergy one of the major problems in pediatrics. Despite the development of international national protocols and clinical guidelines, in many countries the control of allergic rhinitis in children remains insufficient. Therefore, it is necessary to take into account the individual characteristics of patients, pay attention to both nasal and extranasal symptoms, consider all pathognomonic diagnostic aspects, because the underdiagnosis of this allergic disease leads to inadequate therapy, complications, more severe atopy and reduced quality of children’s life in general. Recently, there is growing evidence of the need for personalized selection of the most effective therapy for allergic rhinitis in children. In-depth study of the pathogenetic role of circadian molecular clock in children with seasonal allergic rhinitis using informative molecular genetic methods may allow characterizing in detail the mechanism of regulation of allergic inflammation of the upper airway mucosa and evaluating the role of circadian genes in the development of allergic diseases, in particular allergic rhinitis. In the future, these studies may become an alternative to improve control over the course of allergy and the organization of a comprehensive monitoring system, development of new strategies for the treatment and prevention of allergic rhinitis in children.

scholarly journals Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Eli O. Meltzer ◽  
Nelson Augusto Rosario ◽  
Hugo Van Bever ◽  
Luiz Lucio
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Second Generation ◽  
Safety Data ◽  
Negative Effects ◽  
Intranasal Corticosteroids ◽  
Ocular Symptoms ◽  
Cardiovascular Side Effects ◽  
Favorable Safety

AbstractAllergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased productivity. Additionally, untreated AR predisposes children to asthma and other chronic conditions. Although intranasal corticosteroids are the most effective pharmacologic treatment for AR, oral antihistamines are often preferred. First-generation antihistamines may be chosen to relieve AR symptoms as they are inexpensive and widely available; however, they cause sedative and cardiovascular negative effects due to poor receptor selectivity. Therefore, second-generation antihistamines were developed to reduce adverse effects while retaining efficacy. There are fewer clinical trials in children than adults, therefore, efficacy and safety data is limited, particularly in children under 6 years, highlighting the need to generate these data in young children with AR. Fexofenadine, a highly selective second-generation antihistamine, effectively alleviates symptoms of AR, is non-sedating due to decreased blood–brain barrier permeability, and is devoid of cardiovascular side effects. Importantly, fexofenadine relieves the ocular symptoms of allergic conjunctivitis, which occur concomitantly with AR, improving quality of life. Overall, fexofenadine displays a favorable safety profile and results in greater treatment satisfaction in children compared with other second-generation antihistamines. This review aimed to evaluate and compare the safety and efficacy of fexofenadine with other available first- and second-generation antihistamines in children with AR.

Sleepiness, Quality of Life and Objective Sleep Patterns in Seasonal Allergic Rhinitis

2006 ◽  
Vol 18 (03) ◽  
pp. 120-126
Author(s):  
Boris Stuck ◽  
Karl Hörmann ◽  
Joachim Maurer ◽  
Anna-Eva Hagner ◽  
Julia Johnson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Sleep Patterns
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