Development of the concept of exosome in assessing the interaction between the internal and external environment in allergy

2021 ◽  
Vol 18 (1) ◽  
pp. 41-55
Author(s):  
Natalia G. Astafieva
Keyword(s):  
Treatment Effectiveness ◽  
External Environment ◽  
Human Diseases ◽  
Environment Factors ◽  
New Approaches ◽  
Treatment And Prevention ◽  
Complex Interactions ◽  
Research Programmes ◽  
Allergy Treatment ◽  
Innovative Approaches

This publication extends RAACI education in the field of allergology and immunology for allergologists, immunologists and other specialists, as well as for practitioners. It presents recent data and innovative approaches to the study of complex interactions of genetic, non-genetic and environment factors in allergies. It explains the importance of exposome-oriented approaches aimed to increase the treatment effectiveness and to decrease risks of allergy in addition to genome-oriented models of human diseases. Exposome concepts can be integrated into existing research programmes which are crucial in shaping new approaches to allergy treatment and prevention

Innovative approaches to the training of specialists in the field of occupational medicine

2020 ◽  
pp. 704-704
Author(s):  
T. V. Morozova
Keyword(s):  
Distance Learning ◽  
Occupational Medicine ◽  
Professional Training ◽  
Educational Programs ◽  
Learning Technologies ◽  
New Approaches ◽  
Interactive Training ◽  
Distance Learning Technologies ◽  
Network Form ◽  
Innovative Approaches

New approaches of professional training of specialists in the field of occupational medicine (network form of educational programs, electronic and interactive training, distance learning technologies, etc.) are presented.

Infant Formulas for Food Allergy Treatment and Prevention

2016 ◽  
Vol 45 (4) ◽  
pp. e150-e156 ◽  
Author(s):  
Hetu Parekh ◽  
Sami L. Bahna
Keyword(s):  
Food Allergy ◽  
Infant Formulas ◽  
Treatment And Prevention ◽  
Allergy Treatment

The Change of Real Estate Enterprises' Strategic Plan under New Situation

2012 ◽  
Vol 174-177 ◽  
pp. 3393-3396
Author(s):  
Jing Zhang ◽  
Ming Yue Hu ◽  
Ying Peng
Keyword(s):  
Real Estate ◽  
External Environment ◽  
Current Situation ◽  
Great Change ◽  
Real Estate Industry ◽  
Environment Factors ◽  
The Real ◽  
The Real Estate ◽  
Real Estate Enterprises ◽  
New Situation

Government strictly regulates real estate industry by a series of policy recently. Because of the great change of polices, the real estate industry was taken a big knock. In order to find out the solution of real estate enterprises keep developing under new situation. By analyzing the external environment factors of real estate enterprises, the study deduces that the change of real estate enterprises’ strategy plane is inevitable. Elaborate the current situation of real estate enterprises from five aspects of strategy plane, and make a conclusion that how to change it. Therefore, ensure that real estate enterprises could avoid policies risk, and keep developing.

scholarly journals New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models

2011 ◽  
Vol 10 (5) ◽  
pp. 258-265 ◽  
Author(s):  
P. N. Schofield ◽  
J. P. Sundberg ◽  
R. Hoehndorf ◽  
G. V. Gkoutos
Keyword(s):  
Animal Models ◽  
Human Diseases ◽  
New Approaches

Anaerobes in prostate cancer: New approaches to treatment and prevention.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13606-e13606
Author(s):  
Tim RTD Oliver ◽  
Roshni Bhudia ◽  
Frank Chinegwundoh ◽  
Mark Wilks
Keyword(s):  
Prostate Cancer ◽  
Checkpoint Inhibitors ◽  
Exact Test ◽  
Fisher's Exact Test ◽  
New Approaches ◽  
Treatment And Prevention ◽  
Fisher’S Exact Test ◽  
Rising Incidence ◽  
H Pylori

e13606 Background: The sun-sensitive microaerophylic bacterium C. acnes, is linked with prostate cancer (PC) in 9 studies 3 of which are cohort studies of 289,043 men followed for 30 years from puberty. That circumcision reduces PC risk further supports a role for anaerobes as they are reduced on the circumcised glans penis. A 1988 study linked anaerobes with PC but considered them opportunists. Reports that H. pylori, linked to stomach cancer, is also a microaerophilic bacterium led us to reinvestigate the association of PC and anaerobes. Methods: The MOLDI-TOF methodology for analysing anaerobes in 18 post rectal exam urine samples has been previously reported ( https://www.nature.com/articles/s41598-017-13782-6 ). This report analyses outcome after a further 21 patients were recruited and follow up was extended from 1 month to a median of 43 months. In total there were 21 diagnosed as PC and 18 BPH. Results: Of the 29 anaerobic isolates, 19 were Chlostridiales family, 2 Prevotella and 7 Actinomycoses (includes C.acnes) family. 12 cases had obligate anaerobes, 7 microaerophylic bacteria and 20 none of these. In 27 patients with PSA > 1.5, 56% had anaerobes, while in 12 with PSA = < 1.5 it was 17% (p < 0.037 Fisher’s exact test) In the 21 with prostate cancer, 7 (64%) of 11 without anaerobes and 2 of 10 (20% ) with anaerobes remain on Active Surveillance (p = 0.08 Fisher’s exact test) vs in 18 without cancer, 10/11 (91%) without and 5/7 (71%) with anaerobes remain without the need of TURP intervention. Conclusions: This is a small study and needs expanding. Given the rising incidence of antibiotic resistance more resources should be focused on the immune deficiency associated with chronic bacterial infection. Expansion of technology used to produce bacterial vaccines to treat women with recurrent cystitis could offer new approaches to prevention of PC and to treat patients with raised PSA and negative biopsy. Modern approaches to immunotherapy against these bacteria with checkpoint inhibitors could be used in combination with androgen suppression and chemotherapy.

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