scholarly journals Features of immunopathogenesis of atopic dermatitis

2020 ◽  
Vol 17 (2) ◽  
pp. 74-80
Author(s):  
Olga O. Pobezhimova ◽  
Alexsander V. Zhestkov ◽  
Olga S. Sidorova ◽  
Vera V. Kulagina
Keyword(s):  
Early Childhood ◽  
Atopic Dermatitis ◽  
Immune Cells ◽  
Gradual Increase ◽  
Allergic Diseases ◽  
High Rate ◽  
Skin Disorders ◽  
Traditional Therapies ◽  
Genetically Determined ◽  
Chronic Course

Atopic dermatitis is one of the most common allergic diseases with severe course, which affects the skin. This disease is genetically determined and has a chronic course. Atopic dermatitis is also one of the commonest diseases (between 20% and 40% of all skin disorders) and affects patients of both sexes across the globe. Such high rate of morbidity, onset in early childhood, often continuous relapsing course and a trend toward gradual increase of tolerance to traditional therapies makes the issue of detalization of pathogenesis of atopic dermatitis particularly topical. Immune cells play one of the major roles in the pathogenesis of atopic dermatitis. This article will systematically review the main available to date information on participation immune cells in the pathogenesis of atopic dermatitis.

scholarly journals Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

2018 ◽  
Vol 17 (2) ◽  
pp. 114-120
Author(s):  
E. E. Varlamov ◽  
A. N. Pampura ◽  
A. N. Asmanov
Keyword(s):  
Allergic Rhinitis ◽  
Early Childhood ◽  
Atopic Dermatitis ◽  
Primary Prevention ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
The State ◽  
Older Age ◽  
Epidermal Barrier ◽  
Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

scholarly journals Extracellular Vesicles from SOD3-Transduced Stem Cells Exhibit Improved Immunomodulatory Abilities in the Murine Dermatitis Model

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1165
Author(s):  
Ji Won Yang ◽  
Yoojin Seo ◽  
Tae-Hoon Shin ◽  
Ji-Su Ahn ◽  
Su-Jeong Oh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Atopic Dermatitis ◽  
Antioxidant Enzyme ◽  
Extracellular Vesicles ◽  
Immune Cells ◽  
Genetic Manipulation ◽  
Allergic Diseases ◽  
Extracellular Superoxide Dismutase ◽  
Therapeutic Benefits ◽  
Superoxide Dismutase 3

The immunoregulatory abilities of mesenchymal stem cells (MSCs) have been investigated in various autoimmune and allergic diseases. However, the therapeutic benefits observed in preclinical settings have not been reproducible in clinical trials. This discrepancy is due to insufficient efficacy of MSCs in harsh microenvironments, as well as batch-dependent variability in potency. Therefore, to achieve more beneficial and uniform outcomes, novel strategies are required to potentiate the therapeutic effect of MSCs. One of simple strategies to augment cellular function is genetic manipulation. Several studies showed that transduction of antioxidant enzyme into cells can increase anti-inflammatory effects. Therefore, we evaluated the immunoregulatory abilities of MSCs introduced with extracellular superoxide dismutase 3 (SOD3) in the present study. SOD3-overexpressed MSCs (SOD3-MSCs) reduced the symptoms of murine model of atopic dermatitis (AD)-like inflammation, as well as the differentiation and activation of various immune cells involved in AD progression. Interestingly, extracellular vesicles (EVs) isolated from SOD3-MSCs delivered SOD3 protein. EVs carrying SOD3 also exerted improved therapeutic efficacy, as observed in their parent cells. These results suggest that MSCs transduced with SOD3, an antioxidant enzyme, as well as EVs isolated from modified cells, might be developed as a promising cell-based therapeutics for inflammatory disorders.

To evaluate the efficacy of Jalaukavacharana followed by Khadira Prayoga in Vicharchika w.s.r to Eczema

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Kulkarni Sharad ◽  
Syeda Ather Fathima ◽  
Naveen B. S.
Keyword(s):  
Incidence Rate ◽  
Clinical Features ◽  
Skin Disease ◽  
Skin Disorder ◽  
Age Groups ◽  
High Rate ◽  
Main Line ◽  
Treatment Modalities ◽  
Skin Disorders

Vicharchika (Eczema) is a skin disorder with predominance of Pitta Kapha Dosha, with clinical features like Kandu, Srava, Pidaka, Shyavata, Rookshata, Raji, Ruja and Daha mainly in the extremities. It is the second commonest skin disease affecting all age groups, with incidence rate of 2-3% and high rate of recurrence. Ayurveda emphasizes Shodhana therapy as the main line of treatment in skin disorders. Raktamokshana is indicated as Rakta is mainly involved in Vicharchika. In the present study, two treatment modalities were selected to find out which is more appropriate.

scholarly journals The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

2021 ◽  
Vol 22 (13) ◽  
pp. 7227
Author(s):  
Lai-San Wong ◽  
Yu-Ta Yen ◽  
Chih-Hung Lee
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Immune Responses ◽  
Immune Cells ◽  
Inflammatory Disease ◽  
Targeted Therapies ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Inflammatory Molecules

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.

scholarly journals 268 Expression of Interleukin-33 by resident and immune cells in the skin of patients with atopic dermatitis

2016 ◽  
Vol 136 (9) ◽  
pp. S207
Author(s):  
L. Smith ◽  
B. Moran ◽  
H. Rea ◽  
M. Raverdeau ◽  
I. McDonald ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Immune Cells ◽  
Interleukin 33

scholarly journals Incidence Trends of Atopic Dermatitis in Infancy and Early Childhood in a Nationwide Prescription Registry Study in Norway

2018 ◽  
Vol 1 (7) ◽  
pp. e184145 ◽  
Author(s):  
Cathrine H. Mohn ◽  
Hege Salvesen Blix ◽  
Jon Anders Halvorsen ◽  
Per Nafstad ◽  
Morten Valberg ◽  
...  
Keyword(s):  
Early Childhood ◽  
Atopic Dermatitis ◽  
Registry Study ◽  
Incidence Trends ◽  
Infancy And Early Childhood

scholarly journals APPLICATION OF VITAMIN D IN DIFFERENT DOSAGE TO TREAT CHILDREN WITH ALLERGIC DISEASES

2020 ◽  
Vol 73 (7) ◽  
pp. 1377-1383
Author(s):  
Olexandra V. Tiazhka ◽  
Zoriana V. Selska
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Vitamin D3 ◽  
Allergic Diseases ◽  
Acute Disease ◽  
Disease Remission ◽  
Significant Difference ◽  
Different Doses

The aim: To study the dynamics of the level of 25(ОН)D, ІL-4, ІL-10, and IgG in the blood serum of children with allergic diseases and to study the clinical effect of vitamin D3 administration n different dosage in this category of patients. Materials and methods: 153 children aged 3-16 with such allergic diseases as bronchial asthma, atopic dermatitis and allergic rhinitis have been examined. The level of 25(ОН) D was determined using the electrochemiluminescence method, while the levels of ІL-4, ІL-10 and IgG were assessed using enzyme-linked immunoassay. Results: In the contrasting of the initial level of 25(ОН)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higher doses (4,000–5,000 IU) over 2 months, significant difference was established between the indicators by the Friedman criterion (λ2 = 41.211; P < 0.05). In the similar contrasting of ІL-4 indicators, a significant difference between them was traced (P < 0.05) in the period of acute disease as well as the downward tendency in the period of remission. In the similar contrasting of ІL-10 indicators, a significant difference between them was traced (P < 0.05) in the acute period and in the period of disease remission. In the similar contrasting of IgG indicators, a downward tendency was traced in the period of acute disease and significant decrease (P < 0.05) – in the period of disease remission. In the contrasting of 25(ОН)D and ІL-4, ІL-10 figures a strong reverse correlation relationship was traced. The therapeutic effect of the administration of vitamin D3 medication in different doses in children with allergic diseases was traced. Conclusions: The data obtained shows that in the treatment of children with bronchial asthma, allergic rhinitis and atopic dermatitis the complex therapy should include vitamin D3 medications in different doses within a long-term course of treatment.

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