The role of atopy patch test with aeroallergens in allergic diseases diagnostics

2021 ◽  
Vol 17 (4) ◽  
pp. 30-37
Author(s):  
Eugeniy V. Smolnikov ◽  
Alla O. Litovkina ◽  
Ksenia I. Kolykhalova ◽  
Olga G. Elisyutina ◽  
Elena S. Fedenko
Keyword(s):  
Patch Test ◽  
Allergic Diseases ◽  
Atopy Patch Test ◽  
Global Epidemic ◽  
Public Health Burden ◽  
Respiratory Allergies ◽  
Different Types ◽  
Allergy Diagnostics ◽  
Genetic And Environmental Factors

Allergic diseases are increasingly becoming a global epidemic and pose a considerable and growing public health burden. Allergy is a systemic T2-dependent inflammatory reaction to an allergen that results from a complex interaction between genetic and environmental factors. Allergic diseases occur through a T2-dependent type of allergic reaction, some of them, in particular atopic dermatitis (AD) and asthma, develop involving different types of hypersensitivity or their combination and require revision of allergy diagnostics. Atopy patch test (APT) can be informative in establishing a role of cell-mediated hypersensitivity in pathogenesis of allergic diseases. The review presents the recent data on the significance of APT in the diagnostics of skin and respiratory allergies.

scholarly journals The Role of Allergens in Atopic Dermatitis

2020 ◽  
Author(s):  
Suna Asilsoy ◽  
Serdar Al
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Atopic Diseases ◽  
Chronic Skin ◽  
Genetic And Environmental Factors ◽  
Inhalant Allergens ◽  
Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease caused by genetic and environmental factors. Often it begins in early childhood. It is located at the first step of the process we refer to as atopic march. This feature is a precursor of the development of other allergic diseases such as asthma and allergic rhinitis. Especially in patients with atopy of food and inhalant allergens, the occurrence of other atopic diseases is more common. Although the role of these sensitivities in AD is controversial, it has been determined that some patients may trigger eczematous skin lesions. In this report, the role of allergens in atopic dermatitis are reviewed in the light of current literature.

Abstract 333: Cardiomyocyte Death and Fibrotic Scarring in the Infarcted Neonatal Mouse Heart

2020 ◽  
Vol 127 (Suppl_1) ◽  
Author(s):  
Mary Mohr ◽  
Ge Tao ◽  
Shuang Li ◽  
Patrick Roddy
Keyword(s):  
Cell Death ◽  
The United States ◽  
Artery Occlusion ◽  
Scar Formation ◽  
Mouse Heart ◽  
Public Health Burden ◽  
Regulated Cell Death ◽  
Different Types ◽  
Neonatal Cardiomyocyte

As one the leading causes of death in the United States, myocardial infarction (MI) occurs every 40 seconds, causing severe public health burden. Following MI, the loss of healthy cardiomyocytes leads to decreased contractility and eventually heart failure. Mature mammalian cardiomyocytes have a low turnover rate at only 0.5-2% per year, insufficient for repopulating damaged myocardium after MI. However, a contradictory discovery was made showing that the neonatal mammalian heart is regenerative, although this reparative ability is lost within days after birth. A great amount of effort is needed to understand the mechanisms underlying neonatal cardiomyocyte regeneration. In the current project, we attempt to profile different types of cell death in regenerating and non-regenerating mouse models following MI, in order to gain insights into a favorable type of cardiomyocyte death during regeneration. We induced MI in postnatal day 1 (P1, regenerative), and postnatal day 7 (P7, non-regenerative) mouse hearts by left anterior descending artery occlusion (LAD-O). The progressive scar formation was assessed using Masson’s Trichrome staining at multiple timepoints up to 14 days after MI. At each time point, we profile three major types of regulated cell death, apoptosis, necroptosis, and ferroptosis, using immunofluorescence staining. We also used AC16, a human cardiomyocyte cell line, to investigate the role of cell density in the regulation of ferroptosis. We found that the scar formation was most dynamic between 2 and 3 days after MI and that the course of scar formation varied greatly between P1 and P7 hearts. Immunofluorescence of different cell death markers reveal differentially progressed cell death between P1 and P7 hearts after MI. Our results indicate a different pattern of cardiomyocyte death in the regenerative P1 heart compared to the non-regenerative P7 heart, that could be more favorable for myocardial regeneration.

scholarly journals The atopic desease development in infants and preschool children in Lesnoy town of Sverdlovsk region

2015 ◽  
Vol 12 (2) ◽  
pp. 59-63
Author(s):  
N A Volkova ◽  
I A Tuzankina ◽  
V N Shershnev
Keyword(s):  
Preschool Children ◽  
Clinical Symptoms ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Atopic Diseases ◽  
Different Types ◽  
Specific Ige Antibodies ◽  
Airborne Allergens

The aim of study. To determine the structure of atopic diseases and characterization of different allergens in their progression in infants and preschool children in Lesnoy town. Material and methods. We studied a spectrum of allergen-specific IgE antibodies in children’s blood with different allergic diseases. Comparative analysis of the results was conducted with methods of mathematical statistics. Results. Our data demonstrate the different stages of formation of atopic diseases in children. We revealed that clinical symptoms of atopic diseases and relevance of allergens were changing gradually as children were getting older. Our results showed that the role of nutrition allergens is reduced while airborne allergens came to the fore. Conclusion. Formation and progression of atopic diseases are determined by various allergens. The temporary relevance of different types of allergens indicates a diversity of multivalent sensibilization during affection of the «shock» organ; the result of this phenomenon appears as atopic march. Detection the relevant causative allergens is important for prevention of progression of allergic diseases.

scholarly journals Atopy Patch Test in the Diagnosis of Food Allergy in Children with Atopic Dermatitis

2006 ◽  
Vol 49 (4) ◽  
pp. 199-201 ◽  
Author(s):  
Miloš Jeseňák ◽  
Peter Bánovčin
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Patch Test ◽  
Task Force ◽  
Allergic Diseases ◽  
Food Allergies ◽  
Controlled Clinical Trial ◽  
Atopy Patch Test ◽  
Food Allergens ◽  
Additional Tool

Atopic eczema/dermatitis syndrome (AEDS) is one of the most common chronic allergic diseases in children. Among the allergens found to be relevant in AEDS, aeroallergens and food allergens are the most important. The exposure of these patients to their relevant protein allergens can trigger an exacerbation or maintain the disease. AEDS is frequently associated with food allergy, which complicates the management in approximately 40% of these children. Atopy patch test (APT) can help in detecting food allergies in children with AEDS. The earliest publication on patch testing in eczema was described in 1937 by Rostenberg, but the first controlled clinical trial was provided by Mitchell in 1982. APT with food allergens were introduced into clinical use in 1996 by the group of Isolauri. APT test is performed epicutaneously with typical immediate-type allergens (aeroallergens or foods). As a number of apparently minor test modifications greatly influence the sensitivity, specificity, and reproducibility of the APT, the European Task Force on Atopic Dermatitis (ETFAD) has developed a standardized APT technique. APT has developed into a valuable additional tool in the diagnostic work-up of food allergy in infants and children with atopic dermatitis.

A twin study of antisocial and neurotic symptoms in childhood

1996 ◽  
Vol 26 (6) ◽  
pp. 1111-1118 ◽  
Author(s):  
Anita Thapar ◽  
Peter McGuffin
Keyword(s):  
Environmental Factors ◽  
Psychiatric Symptoms ◽  
Antisocial Behaviour ◽  
Shared Environment ◽  
Childhood And Adolescence ◽  
Different Types ◽  
Genetic And Environmental Factors ◽  
Using Data ◽  
Variance Explained

SynopsisThere is some evidence to suggest that the role of genetic and environmental influences may vary for different types of psychiatric symptoms in childhood. The aim of this study was to examine to what extent genetic and environmental factors influence parent-rated conduct and neurotic symptoms in childhood and adolescence, using data obtained from a systematically ascertained sample of twins (198 same sex pairs) aged between 8 and 16 years. For symptoms of antisocial behaviour, transmission could be explained entirely by shared environmental factors. Social class effects were also found to have a significant influence on antisocial behaviour, although these effects only accounted for a small proportion of the variance explained by shared environmental factors. In contrast, transmission of neurotic symptoms was best explained by additive genetic influences alone with no contribution from shared environment. Non-shared environmental factors accounted for a substantial component of the variation for both antisocial behaviour and neurotic symptoms.

The ‘Atopy Patch Test’ in Evaluating the Role of Aeroallergens in Atopic Eczema

1997 ◽  
Vol 113 (1-3) ◽  
pp. 379-383 ◽  
Author(s):  
Johannes Ring ◽  
Ulf Darsow ◽  
Michael Gfesser ◽  
Dieter Vieluf
Keyword(s):  
Patch Test ◽  
Atopic Eczema ◽  
Atopy Patch Test

scholarly journals The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Haocheng Zheng ◽  
Yi Zhang ◽  
Jiachuang Pan ◽  
Nannan Liu ◽  
Yu Qin ◽  
...  
Keyword(s):  
Environmental Changes ◽  
Premature Death ◽  
Allergic Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Public Health Burden ◽  
Activation Pathways ◽  
New Treatments

Allergic diseases are significant diseases that affect many patients worldwide. In the past few decades, the incidence of allergic diseases has increased significantly due to environmental changes and social development, which has posed a substantial public health burden and even led to premature death. The understanding of the mechanism underlying allergic diseases has been substantially advanced, and the occurrence of allergic diseases and changes in the immune system state are known to be correlated. With the identification and in-depth understanding of innate lymphoid cells, researchers have gradually revealed that type 2 innate lymphoid cells (ILC2s) play important roles in many allergic diseases. However, our current studies of ILC2s are limited, and their status in allergic diseases remains unclear. This article provides an overview of the common phenotypes and activation pathways of ILC2s in different allergic diseases as well as potential research directions to improve the understanding of their roles in different allergic diseases and ultimately find new treatments for these diseases.

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